Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers.

abstract：:Alkaloids, secondary metabolites that contain basic nitrogen atoms, are some of the most well-known biologically active natural products in chemistry and medicine. Although efficient laboratory synthesis of alkaloids would enable the study and optimization of their biological properties, their preparation is often com...

journal_title：Nature

authors： Parr BT,Economou C,Herzon SB

更新日期：2015-09-24 00:00:00

abstract：:Among the ten subtypes of mammalian voltage-gated calcium (Cav) channels, Cav3.1-Cav3.3 constitute the T-type, or the low-voltage-activated, subfamily, the abnormal activities of which are associated with epilepsy, psychiatric disorders and pain1-5. Here we report the cryo-electron microscopy structures of human Cav3....

journal_title：Nature

authors： Zhao Y,Huang G,Wu Q,Wu K,Li R,Lei J,Pan X,Yan N

更新日期：2019-12-01 00:00:00

abstract：:In the unactivated Limulus sperm, a 60- micro m-long bundle of actin filaments crosslinked by the protein scruin is bent and twisted into a coil around the base of the nucleus. At fertilization, the bundle uncoils and fully extends in five seconds to support a finger of membrane known as the acrosomal process. This bi...

journal_title：Nature

authors： Schmid MF,Sherman MB,Matsudaira P,Chiu W

更新日期：2004-09-02 00:00:00

abstract：:The hydroxyl radical (OH) is a key oxidant involved in the removal of air pollutants and greenhouse gases from the atmosphere. The ratio of Northern Hemispheric to Southern Hemispheric (NH/SH) OH concentration is important for our understanding of emission estimates of atmospheric species such as nitrogen oxides and m...

journal_title：Nature

authors： Patra PK,Krol MC,Montzka SA,Arnold T,Atlas EL,Lintner BR,Stephens BB,Xiang B,Elkins JW,Fraser PJ,Ghosh A,Hintsa EJ,Hurst DF,Ishijima K,Krummel PB,Miller BR,Miyazaki K,Moore FL,Mühle J,O'Doherty S,Prinn RG,Steele

更新日期：2014-09-11 00:00:00

abstract：:Protein aggregates are the hallmark of stressed and ageing cells, and characterize several pathophysiological states. Healthy metazoan cells effectively eliminate intracellular protein aggregates, indicating that efficient disaggregation and/or degradation mechanisms exist. However, metazoans lack the key heat-shock p...

journal_title：Nature

authors： Nillegoda NB,Kirstein J,Szlachcic A,Berynskyy M,Stank A,Stengel F,Arnsburg K,Gao X,Scior A,Aebersold R,Guilbride DL,Wade RC,Morimoto RI,Mayer MP,Bukau B

更新日期：2015-08-13 00:00:00

abstract：:The role of magnetic domains (and the walls between domains) in determining the electrical properties of ferromagnetic materials has been investigated in great detail for many years, not least because control over domains offers a means of manipulating electron spin to control charge transport in 'spintronic' devices....

journal_title：Nature

authors： Kummamuru RK,Soh YA

更新日期：2008-04-17 00:00:00

abstract：:Protein modification by the conjugation of ubiquitin moieties--ubiquitination--plays a major part in many biological processes, including cell cycle and apoptosis. The enzymes that mediate ubiquitin-conjugation have been well-studied, but much less is known about the ubiquitin-specific proteases that mediate de-ubiqui...

journal_title：Nature

authors： Brummelkamp TR,Nijman SM,Dirac AM,Bernards R

更新日期：2003-08-14 00:00:00

abstract：:Macrophages and dendritic cells have key roles in viral infections, providing virus reservoirs that frequently resist antiviral therapies and linking innate virus detection to antiviral adaptive immune responses. Human immunodeficiency virus 1 (HIV-1) fails to transduce dendritic cells and has a reduced ability to tra...

journal_title：Nature

authors： Hrecka K,Hao C,Gierszewska M,Swanson SK,Kesik-Brodacka M,Srivastava S,Florens L,Washburn MP,Skowronski J

更新日期：2011-06-29 00:00:00

abstract：:Division of spermatogonial stem cells produces daughter cells that either maintain their stem cell identity or undergo differentiation to form mature sperm. The Sertoli cell, the only somatic cell within seminiferous tubules, provides the stem cell niche through physical support and expression of surface proteins and ...

journal_title：Nature

authors： Chen C,Ouyang W,Grigura V,Zhou Q,Carnes K,Lim H,Zhao GQ,Arber S,Kurpios N,Murphy TL,Cheng AM,Hassell JA,Chandrashekar V,Hofmann MC,Hess RA,Murphy KM

更新日期：2005-08-18 00:00:00

abstract：:A complex between HLA-DR3 and a fragment of invariant chain called CLIP was isolated from a human cell line defective in antigen presentation and its X-ray crystal structure determined. Previous data indicate that this complex is an intermediate in class II histocompatibility maturation, occurring between invariant ch...

journal_title：Nature

authors： Ghosh P,Amaya M,Mellins E,Wiley DC

更新日期：1995-11-30 00:00:00

abstract：:Among the pathological effects in man following infection with Mycoplasma pneumoniae is a transient autoimmune disorder characterized by the presence of high-titre erythrocyte autoantibodies (cold agglutinins). These autoantibodies are usually directed against the carbohydrate antigen termed I (ref. 3) which consists ...

journal_title：Nature

authors： Loomes LM,Uemura K,Childs RA,Paulson JC,Rogers GN,Scudder PR,Michalski JC,Hounsell EF,Taylor-Robinson D,Feizi T

更新日期：1984-02-09 00:00:00

abstract：:Thermodynamics predicts that transmembrane voltage modulates membrane tension and that this will cause movement. The magnitude and polarity of movement is governed by cell stiffness and surface potentials. Here we confirm these predictions using the atomic force microscope to dynamically follow the movement of voltage...

journal_title：Nature

authors： Zhang PC,Keleshian AM,Sachs F

更新日期：2001-09-27 00:00:00

abstract：:The microscopic origin of superconductivity in the high-transition-temperature (high-T(c)) copper oxides remains the subject of active inquiry; several of their electronic characteristics are well established as universal to all the known materials, forming the experimental foundation that all theories must address. T...

journal_title：Nature

authors： Schaak RE,Klimczuk T,Foo ML,Cava RJ

更新日期：2003-07-31 00:00:00

abstract：:A significant fraction of patients with advanced prostate cancer treated with androgen deprivation therapy experience relapse with relentless progression to lethal metastatic castration-resistant prostate cancer (mCRPC). Immune checkpoint blockade using antibodies against cytotoxic-T-lymphocyte-associated protein 4 (C...

journal_title：Nature

authors： Lu X,Horner JW,Paul E,Shang X,Troncoso P,Deng P,Jiang S,Chang Q,Spring DJ,Sharma P,Zebala JA,Maeda DY,Wang YA,DePinho RA

更新日期：2017-03-30 00:00:00

abstract：:Magma intrusions and eruptions commonly produce abrupt changes in seismicity far from magma conduits that cannot be associated with the diffusion of pore fluids or heat. Such 'swarm' seismicity also migrates with time, and often exhibits a 'dog-bone'-shaped distribution. The largest earthquakes in swarms produce after...

journal_title：Nature

authors： Toda S,Stein RS,Sagiya T

更新日期：2002-09-05 00:00:00

abstract：:The innate immune defence of multicellular organisms against microbial pathogens requires cellular collaboration. Information exchange allowing immune cells to collaborate is generally attributed to soluble protein factors secreted by pathogen-sensing cells. Cytokines, such as type I interferons (IFNs), serve to alert...

journal_title：Nature

authors： Ablasser A,Schmid-Burgk JL,Hemmerling I,Horvath GL,Schmidt T,Latz E,Hornung V

更新日期：2013-11-28 00:00:00

abstract：:Measurements of the cosmic microwave background (CMB) radiation can reveal with remarkable precision the conditions of the Universe when it was approximately 400,000 years old. The three most fundamental properties of the CMB are its frequency spectrum (which determines the temperature), and the fluctuations in both t...

journal_title：Nature

authors： Leitch EM,Kovac JM,Pryke C,Carlstrom JE,Halverson NW,Holzapfel WL,Dragovan M,Reddall B,Sandberg ES

更新日期：2002-12-19 00:00:00

abstract：:Tuberculosis remains second only to HIV/AIDS as the leading cause of mortality worldwide due to a single infectious agent. Despite chemotherapy, the global tuberculosis epidemic has intensified because of HIV co-infection, the lack of an effective vaccine and the emergence of multi-drug-resistant bacteria. Alternative...

journal_title：Nature

authors： Mayer-Barber KD,Andrade BB,Oland SD,Amaral EP,Barber DL,Gonzales J,Derrick SC,Shi R,Kumar NP,Wei W,Yuan X,Zhang G,Cai Y,Babu S,Catalfamo M,Salazar AM,Via LE,Barry CE 3rd,Sher A

更新日期：2014-07-03 00:00:00

abstract：:SEVERAL dioecious marine brown algae have been valuable in studying chemical communication during sexual reproduction. For example, female gametes of Ectocarpus siliculosus, Cutleria multifida and Fucus serratus secrete olefinic hydrocarbons into the seawater to attract male gametes(1-3). A more complex system is foun...

journal_title：Nature

authors： Müller DG,Gassmann G,Lüning K

更新日期：1979-05-31 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are zinc endopeptidases that are required for the degradation of extracellular matrix components during normal embryo development, morphogenesis and tissue remodelling. Their proteolytic activities are precisely regulated by endogenous tissue inhibitors of metalloproteinases (TIMPs). D...

journal_title：Nature

authors： Gomis-Rüth FX,Maskos K,Betz M,Bergner A,Huber R,Suzuki K,Yoshida N,Nagase H,Brew K,Bourenkov GP,Bartunik H,Bode W

更新日期：1997-09-04 00:00:00

abstract：:oop RNA, which is initiated at the po promoter and is 81 nucleotides long, can function as a leader sequence for the lambda immunity establishment transcription, previously believed to originate at a special promoter pre located in the y region. Thus, oop RNA seems to have a dual role, either favouring the lytic cycle...

journal_title：Nature

authors： Honigman A,Hu SL,Chase R,Szybalski W

更新日期：1976-07-08 00:00:00

abstract：:The protein TFIIB is a general transcription initiation factor that interacts with a promoter complex (D.DNA) containing the TATA-binding subunit (TFIID tau, or TBP) of TFIID to facilitate subsequent interaction with RNA polymerase II (ref. 2) through the associated TFIIF (ref. 3). The potential bridging function of T...

journal_title：Nature

authors： Hisatake K,Roeder RG,Horikoshi M

更新日期：1993-06-24 00:00:00

abstract：:Many biomolecules are characterized by surfaces containing extended nonpolar regions, and the aggregation and subsequent removal of such surfaces from water is believed to play a critical role in the biomolecular assembly in cells. A better understanding of the hydrophobic hydration of biomolecules may therefore yield...

journal_title：Nature

authors： Cheng YK,Rossky PJ

更新日期：1998-04-16 00:00:00

abstract：:The purification, renewal and differentiation of native cardiac progenitors would form a mechanistic underpinning for unravelling steps for cardiac cell lineage formation, and their links to forms of congenital and adult cardiac diseases. Until now there has been little evidence for native cardiac precursor cells in t...

journal_title：Nature

authors： Laugwitz KL,Moretti A,Lam J,Gruber P,Chen Y,Woodard S,Lin LZ,Cai CL,Lu MM,Reth M,Platoshyn O,Yuan JX,Evans S,Chien KR

更新日期：2005-02-10 00:00:00

abstract：:The creation of neural circuits depends on the formation of synapses between specific sets of neurons. Little is known, however, of the molecular mechanisms governing synaptic choice. A mutation in the unc-4 gene alters the pattern of synaptic input to one class of motor neurons in the Caenorhabditis elegans ventral n...

journal_title：Nature

authors： Miller DM,Shen MM,Shamu CE,Bürglin TR,Ruvkun G,Dubois ML,Ghee M,Wilson L

更新日期：1992-02-27 00:00:00

abstract：:Increased levels of brain amyloid-beta, a secreted peptide cleavage product of amyloid precursor protein (APP), is believed to be critical in the aetiology of Alzheimer's disease. Increased amyloid-beta can cause synaptic depression, reduce the number of spine protrusions (that is, sites of synaptic contacts) and bloc...

journal_title：Nature

authors： Kessels HW,Nguyen LN,Nabavi S,Malinow R

更新日期：2010-08-12 00:00:00

abstract：:When present in single-stranded DNA, palindromic or quasi-palindromic sequences have the potential to form complex secondary structures, including hairpins, which may facilitate interstrand misalignment of direct repeats and be responsible for diverse types of replication-based mutations, including deletions, addition...

journal_title：Nature

authors： Trinh TQ,Sinden RR

更新日期：1991-08-08 00:00:00

abstract：:Males and females share many traits that have a common genetic basis; however, selection on these traits often differs between the sexes, leading to sexual conflict. Under such sexual antagonism, theory predicts the evolution of genetic architectures that resolve this sexual conflict. Yet, despite intense theoretical ...

journal_title：Nature

authors： Barson NJ,Aykanat T,Hindar K,Baranski M,Bolstad GH,Fiske P,Jacq C,Jensen AJ,Johnston SE,Karlsson S,Kent M,Moen T,Niemelä E,Nome T,Næsje TF,Orell P,Romakkaniemi A,Sægrov H,Urdal K,Erkinaro J,Lien S,Primmer CR

更新日期：2015-12-17 00:00:00

abstract：:The formation of condensed (compacted) protein phases is associated with a wide range of human disorders, such as eye cataracts, amyotrophic lateral sclerosis, sickle cell anaemia and Alzheimer's disease. However, condensed protein phases have their uses: as crystals, they are harnessed by structural biologists to elu...

journal_title：Nature

authors： Van Driessche AES,Van Gerven N,Bomans PHH,Joosten RRM,Friedrich H,Gil-Carton D,Sommerdijk NAJM,Sleutel M

更新日期：2018-04-04 00:00:00

abstract：:During endocytosis, clathrin and the clathrin adaptor protein AP-2, assisted by a variety of accessory factors, help to generate an invaginated bud at the cell membrane. One of these factors is Eps15, a clathrin-coat-associated protein that binds the alpha-adaptin subunit of AP-2. Here we investigate the function of E...

journal_title：Nature

authors： Chen H,Fre S,Slepnev VI,Capua MR,Takei K,Butler MH,Di Fiore PP,De Camilli P

更新日期：1998-08-20 00:00:00