Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk.

abstract：: ...

journal_title：Nature

authors： Del Bello L

更新日期：2018-12-01 00:00:00

abstract：:Neurotransmitter/sodium symporters (NSSs) couple the uptake of neurotransmitter with one or more sodium ions, removing neurotransmitter from the synaptic cleft. NSSs are essential to the function of chemical synapses, are associated with multiple neurological diseases and disorders, and are the targets of therapeutic ...

journal_title：Nature

authors： Piscitelli CL,Krishnamurthy H,Gouaux E

更新日期：2010-12-23 00:00:00

abstract：:The ability to differentiate stimuli predicting positive or negative outcomes is critical for survival, and perturbations of emotional processing underlie many psychiatric disease states. Synaptic plasticity in the basolateral amygdala complex (BLA) mediates the acquisition of associative memories, both positive and n...

journal_title：Nature

authors： Namburi P,Beyeler A,Yorozu S,Calhoon GG,Halbert SA,Wichmann R,Holden SS,Mertens KL,Anahtar M,Felix-Ortiz AC,Wickersham IR,Gray JM,Tye KM

更新日期：2015-04-30 00:00:00

abstract：:Carbon chemistry exhibits a rich variety in bonding patterns, with homo- or heteronuclear multiple bonds involving sp-hybridized carbon atoms as found in molecules such as acetylenes, nitriles, allenes and carbon dioxide. Carbon's heavier homologues in group 14 of the periodic table--including silicon, germanium and t...

journal_title：Nature

authors： Ishida S,Iwamoto T,Kabuto C,Kira M

更新日期：2003-02-13 00:00:00

abstract：:Surface melt on the Greenland ice sheet has shown increasing trends in areal extent and duration since the beginning of the satellite era. Records for melt were broken in 2005, 2007, 2010 and 2012. Much of the increased surface melt is occurring in the percolation zone, a region of the accumulation area that is perenn...

journal_title：Nature

authors： Harper J,Humphrey N,Pfeffer WT,Brown J,Fettweis X

更新日期：2012-11-08 00:00:00

abstract：:To explain the lower atmospheric CO2 concentrations during glacial periods, it has been suggested that the productivity of marine phytoplankton was stimulated by an increased flux of iron-bearing dust to the oceans. One component of this theory is that iron-an essential element/nutrient for nitrogen-fixing organisms-w...

journal_title：Nature

authors： Ganeshram RS,Pedersen TF,Calvert S,François R

更新日期：2002-01-10 00:00:00

abstract：:T lymphocytes, essential for the generation of a normal immune response, require the presence of the lymphokine interleukin-2 (IL-2) in order to proliferate. Cells that respond to IL-2 possess a surface receptor glycoprotein specific for this lymphokine. We have recently purified and chemically characterized the IL-2 ...

journal_title：Nature

authors： Cosman D,Cerretti DP,Larsen A,Park L,March C,Dower S,Gillis S,Urdal D

更新日期：1984-12-20 00:00:00

abstract：:The alpha beta T-cell receptors (TCRs) react with complex ligands composed of peptides bound to major histocompatibility complex (MHC) proteins. In the absence of foreign antigens the peptides bound to MHC molecules come from the proteins of the host itself. Interactions between TCRs and these self-peptide-MHC ligands...

journal_title：Nature

authors： Kozono H,White J,Clements J,Marrack P,Kappler J

更新日期：1994-05-12 00:00:00

abstract：:Membrane remodelling plays an important role in cellular tasks such as endocytosis, vesiculation and protein sorting, and in the biogenesis of organelles such as the endoplasmic reticulum or the Golgi apparatus. It is well established that the remodelling process is aided by specialized proteins that can sense as well...

journal_title：Nature

authors： Reynwar BJ,Illya G,Harmandaris VA,Müller MM,Kremer K,Deserno M

更新日期：2007-05-24 00:00:00

abstract：:The mammary gland is composed of multiple types of epithelial cells, which are generated by mammary stem cells (MaSCs) residing at the top of the hierarchy. However, the existence of these multipotent MaSCs remains controversial and the nature of such cells is unknown. Here we demonstrate that protein C receptor (Proc...

journal_title：Nature

authors： Wang D,Cai C,Dong X,Yu QC,Zhang XO,Yang L,Zeng YA

更新日期：2015-01-01 00:00:00

abstract：:In developed societies, chronic diseases such as diabetes, obesity, atherosclerosis and cancer are responsible for most deaths. These ailments have complex causes involving genetic, environmental and nutritional factors. There is evidence that a group of closely related nuclear receptors, called peroxisome proliferato...

journal_title：Nature

authors： Kersten S,Desvergne B,Wahli W

更新日期：2000-05-25 00:00:00

abstract：:Genotypic variation among independent isolates of human immunodeficiency virus type-1 (HIV-1) is well known, but its molecular basis and biological consequences are poorly understood. We examined the genesis of molecular variation in HIV-1 by sequential virus isolations from two chronically infected individuals and an...

journal_title：Nature

authors： Saag MS,Hahn BH,Gibbons J,Li Y,Parks ES,Parks WP,Shaw GM

更新日期：1988-08-04 00:00:00

abstract：:Uridine at the first anticodon position (U34) of glutamate, lysine and glutamine transfer RNAs is universally modified by thiouridylase into 2-thiouridine (s2U34), which is crucial for precise translation by restricting codon-anticodon wobble during protein synthesis on the ribosome. However, it remains unclear how th...

journal_title：Nature

authors： Numata T,Ikeuchi Y,Fukai S,Suzuki T,Nureki O

更新日期：2006-07-27 00:00:00

abstract：:In vitro mutagenesis of sequences required for the self-catalysed cleavage of a plant virus satellite RNA has allowed definition of an RNA segment with endoribonuclease activity. General rules have been deduced for the design of new RNA enzymes capable of highly specific RNA cleavage, and have been successfully tested...

journal_title：Nature

authors： Haseloff J,Gerlach WL

更新日期：1988-08-18 00:00:00

abstract：:Embryonic stem (ES) cells are pluripotent and characterized by open chromatin and high transcription levels, achieved through auto-regulatory and feed-forward transcription factor loops. ES-cell identity is maintained by a core of factors including Oct4 (also known as Pou5f1), Sox2, Klf4, c-Myc (OSKM) and Nanog, and f...

journal_title：Nature

authors： Pijnappel WW,Esch D,Baltissen MP,Wu G,Mischerikow N,Bergsma AJ,van der Wal E,Han DW,Bruch Hv,Moritz S,Lijnzaad P,Altelaar AF,Sameith K,Zaehres H,Heck AJ,Holstege FC,Schöler HR,Timmers HT

更新日期：2013-03-28 00:00:00

abstract：:The Tasmanian devil, a large carnivorous Australian marsupial, is under threat from a widespread fatal disease in which a malignant oral-facial tumour obstructs the animal's ability to feed. Here we show that the chromosomes in these tumours have undergone a complex rearrangement that is identical for every animal stu...

journal_title：Nature

authors： Pearse AM,Swift K

更新日期：2006-02-02 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-11-01 00:00:00

abstract：:Recent seismological discoveries have indicated that the Earth's core-mantle boundary is far more complex than a simple boundary between the molten outer core and the silicate mantle. Instead, its structural complexities probably rival those of the Earth's crust. Some regions of the lowermost mantle have been observed...

journal_title：Nature

authors： Rost S,Garnero EJ,Williams Q,Manga M

更新日期：2005-06-02 00:00:00

abstract：:Somatic mutations in the small GTPase K-Ras are the most common activating lesions found in human cancer, and are generally associated with poor response to standard therapies. Efforts to target this oncogene directly have faced difficulties owing to its picomolar affinity for GTP/GDP and the absence of known alloster...

journal_title：Nature

authors： Ostrem JM,Peters U,Sos ML,Wells JA,Shokat KM

更新日期：2013-11-28 00:00:00

abstract：:Autosomal recessive juvenile parkinsonism (AR-JP) is an early-onset form of Parkinson's disease characterized by motor disturbances and dopaminergic neurodegeneration. To address its underlying molecular pathogenesis, we generated and characterized loss-of-function mutants of Drosophila PTEN-induced putative kinase 1 ...

journal_title：Nature

authors： Park J,Lee SB,Lee S,Kim Y,Song S,Kim S,Bae E,Kim J,Shong M,Kim JM,Chung J

更新日期：2006-06-29 00:00:00

abstract：:During cell division, chromosomes are segregated to nascent daughter cells by attaching to the microtubules of the mitotic spindle through the kinetochore. Kinetochores are assembled on a specialized chromatin domain called the centromere, which is characterized by the replacement of nucleosomal histone H3 with the hi...

journal_title：Nature

authors： Guse A,Carroll CW,Moree B,Fuller CJ,Straight AF

更新日期：2011-08-28 00:00:00

abstract：:Knowledge of the contribution that individual countries have made to global radiative forcing is important to the implementation of the agreement on "common but differentiated responsibilities" reached by the United Nations Framework Convention on Climate Change. Over the past three decades, China has experienced rapi...

journal_title：Nature

authors： Li B,Gasser T,Ciais P,Piao S,Tao S,Balkanski Y,Hauglustaine D,Boisier JP,Chen Z,Huang M,Li LZ,Li Y,Liu H,Liu J,Peng S,Shen Z,Sun Z,Wang R,Wang T,Yin G,Yin Y,Zeng H,Zeng Z,Zhou F

更新日期：2016-03-17 00:00:00

abstract：:Homologous recombination is a molecular process that has multiple important roles in DNA metabolism, both for DNA repair and genetic variation in all forms of life. Generally, homologous recombination involves the exchange of genetic information between two identical or nearly identical DNA molecules; however, homolog...

journal_title：Nature

authors： Keskin H,Shen Y,Huang F,Patel M,Yang T,Ashley K,Mazin AV,Storici F

更新日期：2014-11-20 00:00:00

abstract：:The idea that natural selection on genes might be detected using only a single genome has been put forward by Plotkin and colleagues, who present a method that they claim can detect selection without the need for comparative data and which, if correct, would confer greater power of analysis with less information. Here...

journal_title：Nature

authors： Hahn MW,Mezey JG,Begun DJ,Gillespie JH,Kern AD,Langley CH,Moyle LC

更新日期：2005-01-20 00:00:00

abstract：:Recognition of modified histone species by distinct structural domains within 'reader' proteins plays a critical role in the regulation of gene expression. Readers that simultaneously recognize histones with multiple marks allow transduction of complex chromatin modification patterns into specific biological outcomes....

journal_title：Nature

authors： Tsai WW,Wang Z,Yiu TT,Akdemir KC,Xia W,Winter S,Tsai CY,Shi X,Schwarzer D,Plunkett W,Aronow B,Gozani O,Fischle W,Hung MC,Patel DJ,Barton MC

更新日期：2010-12-16 00:00:00

abstract：:Activation of a visual pigment molecule to initiate phototransduction requires a minimum energy, Ea, that need not be wholly derived from a photon, but may be supplemented by heat. Theory predicts that absorbance at very long wavelengths declines with the fraction of molecules that have a sufficient complement of ther...

journal_title：Nature

authors： Koskelainen A,Ala-Laurila P,Fyhrquist N,Donner K

更新日期：2000-01-13 00:00:00

abstract：:The nucleotide sequence of the RNA polymerase binding site at a promotor on fd RF DNA has been determined in comparison with the starting sequence of RNA initiated at this promoter. The RNA polymerase binding site contained the startpoint of transcription in the centre and a region with twofold symmetry in the non-tra...

journal_title：Nature

authors： Sugimoto K,Okamoto T,Sugisaki H,Takanami M

更新日期：1975-02-06 00:00:00

abstract：:Acetylcholine (ACh) released on vagal stimulation reduces the heart rate by increasing K+ conductance of pacemaker cells in the sinoatrial (S-A) node. Fluctuation analysis of ACh-activated currents in pacemaker tissue showed this to be due to opening of a separate class of K+ channels gated by muscarinic ACh receptors...

journal_title：Nature

authors： Sakmann B,Noma A,Trautwein W

更新日期：1983-05-19 00:00:00

abstract：:Only about 1% of human XO conceptuses survive to birth and these usually have the characteristics of Turner's syndrome, with a complex and variable phenotype including short stature, gonadal dysgenesis and anatomical defects. Both the embryonic lethality and Turner's syndrome are thought to be due to monosomy for a ge...

journal_title：Nature

authors： Ashworth A,Rastan S,Lovell-Badge R,Kay G

更新日期：1991-05-30 00:00:00

abstract：:The discovery of a repeating fast radio burst (FRB) source1,2, FRB 121102, eliminated models involving cataclysmic events for this source. No other repeating FRB has hitherto been detected despite many recent discoveries and follow-ups3-5, suggesting that repeaters may be rare in the FRB population. Here we report the...

journal_title：Nature

authors： CHIME\/FRB Collaboration.

更新日期：2019-02-01 00:00:00