Identification of multipotent mammary stem cells by protein C receptor expression.

abstract：:The Duchenne muscular dystrophy (DMD) locus has been localized to the short arm of the human X chromosome (Xp21) by detection of structural abnormalities and by genetic linkage studies. A library highly enriched for human DNA from Xp21 was constructed using DNA isolated from a male patient who had a visible deletion a...

journal_title：Nature

authors： Monaco AP,Bertelson CJ,Middlesworth W,Colletti CA,Aldridge J,Fischbeck KH,Bartlett R,Pericak-Vance MA,Roses AD,Kunkel LM

更新日期：1985-08-29 00:00:00

abstract：:RNA is involved in many biological functions, ranging from information storage and transfer to the catalysis of reactions involving both nucleic acids and proteins. Previous crystallographic studies on RNA oligomeric chains provide only averaged structures or information limited in resolution. The oligomer [U(U-A)6A]2...

journal_title：Nature

authors： Dock-Bregeon AC,Chevrier B,Podjarny A,Moras D,deBear JS,Gough GR,Gilham PT,Johnson JE

更新日期：1988-09-22 00:00:00

abstract：:Complex-oxide materials exhibit a vast range of functional properties desirable for next-generation electronic, spintronic, magnetoelectric, neuromorphic, and energy conversion storage devices1-4. Their physical functionalities can be coupled by stacking layers of such materials to create heterostructures and can be f...

journal_title：Nature

authors： Kum HS,Lee H,Kim S,Lindemann S,Kong W,Qiao K,Chen P,Irwin J,Lee JH,Xie S,Subramanian S,Shim J,Bae SH,Choi C,Ranno L,Seo S,Lee S,Bauer J,Li H,Lee K,Robinson JA,Ross CA,Schlom DG,Rzchowski MS,Eom CB,Kim J

更新日期：2020-02-01 00:00:00

abstract：:Spectacular fossils from the Early Cretaceous Jehol Group of northeastern China have greatly expanded our knowledge of the diversity and palaeobiology of dinosaurs and early birds, and contributed to our understanding of the origin of birds, of flight, and of feathers. Pennaceous (vaned) feathers and integumentary fil...

journal_title：Nature

authors： Zhang F,Kearns SL,Orr PJ,Benton MJ,Zhou Z,Johnson D,Xu X,Wang X

更新日期：2010-02-25 00:00:00

abstract：:In response to environmental cues that promote IP3 (inositol 1,4,5-trisphosphate) generation, IP3 receptors (IP3Rs) located on the endoplasmic reticulum allow the 'quasisynaptical' feeding of calcium to the mitochondria to promote oxidative phosphorylation. However, persistent Ca2+ release results in mitochondrial Ca2...

journal_title：Nature

authors： Kuchay S,Giorgi C,Simoneschi D,Pagan J,Missiroli S,Saraf A,Florens L,Washburn MP,Collazo-Lorduy A,Castillo-Martin M,Cordon-Cardo C,Sebti SM,Pinton P,Pagano M

更新日期：2017-06-22 00:00:00

abstract：:The primary function of the nerve cell is to process electrical signals. Over the past fifteen years there has been renewed interest in the detailed spatial analysis of signalling in individual neurons owing to experimental evidence that the regional electrical properties of neurons are complex. Thus the behaviour of ...

journal_title：Nature

authors： Zecević D

更新日期：1996-05-23 00:00:00

abstract：:Superantigens bind class II major histocompatibility proteins and stimulate powerful proliferative responses of T lymphocytes bearing particular V beta sequences as part of their alpha beta antigen receptor. Exogenous bacterial superantigens are responsible for food poisoning and toxic shock syndrome. Murine virus-enc...

journal_title：Nature

authors： Lafon M,Lafage M,Martinez-Arends A,Ramirez R,Vuillier F,Charron D,Lotteau V,Scott-Algara D

更新日期：1992-08-06 00:00:00

abstract：:Recent studies have shown that normal cellular sequences on chromosome 13 are lost during the development of retinoblastomas and that sequences on chromosome 11 are similarly lost during the development of Wilms' kidney tumours and embryonal tumours. Cells from these tumors have been found to contain either the patern...

journal_title：Nature

authors： Fearon ER,Feinberg AP,Hamilton SH,Vogelstein B

更新日期：1985-11-28 00:00:00

abstract：:Angiotensin-converting enzyme (ACE) is a dipeptidyl carboxy-peptidase that generates the vasoconstricting peptide angiotensin II and inactivates the vasodilating peptide bradykinin. The gene encoding ACE is composed of two homologous regions and codes for both a somatic and testis isoenzyme. Experiments with hypertens...

journal_title：Nature

authors： Krege JH,John SW,Langenbach LL,Hodgin JB,Hagaman JR,Bachman ES,Jennette JC,O'Brien DA,Smithies O

更新日期：1995-05-11 00:00:00

abstract：:Galactic cosmic rays (CRs) are widely believed to be accelerated by shock waves associated with the expansion of supernova ejecta into the interstellar medium. A key issue in this long-standing conjecture is a theoretical prediction that the interstellar magnetic field can be substantially amplified at the shock of a ...

journal_title：Nature

authors： Uchiyama Y,Aharonian FA,Tanaka T,Takahashi T,Maeda Y

更新日期：2007-10-04 00:00:00

abstract：:The dopamine-containing projection from the ventral tegmental area of the midbrain to the nucleus accumbens is critically involved in mediating the reinforcing properties of cocaine. Although neurons in this area respond to rewards on a subsecond timescale, neurochemical studies have only addressed the role of dopamin...

journal_title：Nature

authors： Phillips PE,Stuber GD,Heien ML,Wightman RM,Carelli RM

更新日期：2003-04-10 00:00:00

abstract：:The innate immune system is critical for the early detection of invading pathogens and for initiating cellular host defence countermeasures, which include the production of type I interferon (IFN). However, little is known about how the innate immune system is galvanized to respond to DNA-based microbes. Here we show ...

journal_title：Nature

authors： Ishikawa H,Ma Z,Barber GN

更新日期：2009-10-08 00:00:00

abstract：:Protein engineering is being developed for mapping the energetics and pathway of protein folding. From kinetic studies on wild-type and mutant proteins, the sequence and energetics of formation of tertiary interactions of side chains can be mapped and the formation of secondary structure inferred. Here we cross-check ...

journal_title：Nature

authors： Bycroft M,Matouschek A,Kellis JT Jr,Serrano L,Fersht AR

更新日期：1990-08-02 00:00:00

abstract：:There are major impediments to finding improved DEET alternatives because the receptors causing olfactory repellency are unknown, and new chemicals require exorbitant costs to determine safety for human use. Here we identify DEET-sensitive neurons in a pit-like structure in the Drosophila melanogaster antenna called t...

journal_title：Nature

authors： Kain P,Boyle SM,Tharadra SK,Guda T,Pham C,Dahanukar A,Ray A

更新日期：2013-10-24 00:00:00

abstract：:The realization of superfluidity in a dilute gas of fermionic atoms, analogous to superconductivity in metals, represents a long-standing goal of ultracold gas research. In such a fermionic superfluid, it should be possible to adjust the interaction strength and tune the system continuously between two limits: a Barde...

journal_title：Nature

authors： Greiner M,Regal CA,Jin DS

更新日期：2003-12-04 00:00:00

abstract：:Protein G is a cell-surface protein from Streptococcus which binds to IgG molecules from a wide range of species with an affinity comparable to that of antigen. The high affinity of protein G for the Fab portion of IgG poses a particular challenge in molecular recognition, given the variability of heavy chain subclass...

journal_title：Nature

authors： Derrick JP,Wigley DB

更新日期：1992-10-22 00:00:00

abstract：:Nerve growth factor (NGF) is involved in a variety of processes involving signalling, such as cell differentiation and survival, growth cessation and apoptosis of neurons. These events are mediated by NGF as a result of binding to its two cell-surface receptors, TrkA and p75. TrkA is a receptor with tyrosine kinase ac...

journal_title：Nature

authors： Wiesmann C,Ultsch MH,Bass SH,de Vos AM

更新日期：1999-09-09 00:00:00

abstract：:In this Letter, the statement 'I.I. and A.B. performed computations at the NCI Australia' was missing from the Acknowledgements section. This has been corrected online. ...

journal_title：Nature

authors： Sainadh US,Xu H,Wang X,Atia-Tul-Noor A,Wallace WC,Douguet N,Bray A,Ivanov I,Bartschat K,Kheifets A,Sang RT,Litvinyuk IV

更新日期：2019-05-01 00:00:00

abstract：:Fixed nitrogen (N) often limits the growth of organisms in terrestrial and aquatic biomes, and N availability has been important in controlling the CO2 balance of modern and ancient oceans. The fixation of atmospheric dinitrogen gas (N2) to ammonia is catalysed by nitrogenase and provides a fixed N for N-limited envir...

journal_title：Nature

authors： Zehr JP,Waterbury JB,Turner PJ,Montoya JP,Omoregie E,Steward GF,Hansen A,Karl DM

更新日期：2001-08-09 00:00:00

abstract：:Recent studies have suggested a critical role of specific gene loss in several embryonic tumours and certain adult cancers. In retinoblastoma, hemizygosity or homozygosity of a recessive mutant allele results in the loss of normal gene product, and this seems to cause the manifestation of the disorder. Familial polypo...

journal_title：Nature

authors： Okamoto M,Sasaki M,Sugio K,Sato C,Iwama T,Ikeuchi T,Tonomura A,Sasazuki T,Miyaki M

更新日期：1988-01-21 00:00:00

abstract：:Autism spectrum disorder (ASD) is a group of conditions characterized by impaired social interaction and communication, and restricted and repetitive behaviours. ASD is a highly heritable disorder involving various genetic determinants. Shank2 (also known as ProSAP1) is a multi-domain scaffolding protein and signallin...

journal_title：Nature

authors： Won H,Lee HR,Gee HY,Mah W,Kim JI,Lee J,Ha S,Chung C,Jung ES,Cho YS,Park SG,Lee JS,Lee K,Kim D,Bae YC,Kaang BK,Lee MG,Kim E

更新日期：2012-06-13 00:00:00

abstract：:The NMDA (N-methyl-D-aspartate) receptor transduces the binding of glutamate and glycine, coupling it to the opening of a calcium-permeable ion channel 1 . Owing to the lack of high-resolution structural studies of the NMDA receptor, the mechanism by which ion-channel blockers occlude ion permeation is not well unders...

journal_title：Nature

authors： Song X,Jensen MØ,Jogini V,Stein RA,Lee CH,Mchaourab HS,Shaw DE,Gouaux E

更新日期：2018-04-01 00:00:00

abstract：:In mammals, enlargement of the heart during embryonic development is primarily dependent on the increase in cardiomyocyte numbers. Shortly after birth, however, cardiomyocytes stop proliferating and further growth of the myocardium occurs through hypertrophic enlargement of the existing myocytes. As a consequence of t...

journal_title：Nature

authors： Eulalio A,Mano M,Dal Ferro M,Zentilin L,Sinagra G,Zacchigna S,Giacca M

更新日期：2012-12-20 00:00:00

abstract：:The central nervous system has extraordinary plasticity in early life. This is thought to involve N-methyl-D-aspartate (NMDA) receptors which, along with the non-NMDA receptors, mediate fast excitatory synaptic transmission. Although NMDA receptors may be transiently enhanced early in life, it has not been possible to...

journal_title：Nature

authors： Hestrin S

更新日期：1992-06-25 00:00:00

abstract：:Methyl chloride is the largest natural source of ozone-depleting chlorine compounds, and accounts for about 15 per cent of the present atmospheric chlorine content. This contribution was likely to have been relatively greater in pre-industrial times, when additional anthropogenic sources-such as chlorofluorocarbons-we...

journal_title：Nature

authors： Yokouchi Y,Ikeda M,Inuzuka Y,Yukawa T

更新日期：2002-03-14 00:00:00

abstract：:The global burden of malaria has been substantially reduced over the past two decades. Future efforts to reduce malaria further will require moving beyond the treatment of clinical infections to targeting malaria transmission more broadly in the community. As such, the accurate identification of asymptomatic human inf...

journal_title：Nature

authors： Wu L,van den Hoogen LL,Slater H,Walker PG,Ghani AC,Drakeley CJ,Okell LC

更新日期：2015-12-03 00:00:00

abstract：:A central aspect of neuronal function is how each nerve cell translated synaptic input into a sequence of action potentials that carry information along the axon, coded as spike frequency. When transduction from a graded depolarizing input to spikes is studied by injecting a depolarizing current, there is often a rema...

journal_title：Nature

authors： Storm JF

更新日期：1988-11-24 00:00:00

abstract：:Archaeal and eukaryotic translation elongation factor 2 contain a unique post-translationally modified histidine residue called diphthamide, which is the target of diphtheria toxin. The biosynthesis of diphthamide was proposed to involve three steps, with the first being the formation of a C-C bond between the histidi...

journal_title：Nature

authors： Zhang Y,Zhu X,Torelli AT,Lee M,Dzikovski B,Koralewski RM,Wang E,Freed J,Krebs C,Ealick SE,Lin H

更新日期：2010-06-17 00:00:00

abstract：:Intraplate magmatic provinces found away from plate boundaries provide direct sampling of the composition and heterogeneity of the Earth's mantle. The chemical heterogeneities that have been observed in the mantle are usually attributed to recycling during subduction1-3, which allows for the addition of volatiles and ...

journal_title：Nature

authors： Mazza SE,Gazel E,Bizimis M,Moucha R,Béguelin P,Johnson EA,McAleer RJ,Sobolev AV

更新日期：2019-05-01 00:00:00

abstract：:A decision is a commitment to a proposition or plan of action based on evidence and the expected costs and benefits associated with the outcome. Progress in a variety of fields has led to a quantitative understanding of the mechanisms that evaluate evidence and reach a decision. Several formalisms propose that a repre...

journal_title：Nature

authors： Resulaj A,Kiani R,Wolpert DM,Shadlen MN

更新日期：2009-09-10 00:00:00