Comparison of diagnostics for the detection of asymptomatic Plasmodium falciparum infections to inform control and elimination strategies.

abstract：:Birds can perceive the reflectance of ultraviolet light by biological structures. Here we show that the skin of the mouth and body of starling nestlings substantially reflects light in the ultraviolet range and that young in which this reflectance is reduced will gain less mass than controls, despite low background le...

journal_title：Nature

authors： Jourdie V,Moureau B,Bennett AT,Heeb P

更新日期：2004-09-16 00:00:00

abstract：:Cyclic GMP-AMP synthase (cGAS) is an innate immune sensor for cytosolic microbial DNA1. After binding DNA, cGAS synthesizes the messenger 2'3'-cyclic GMP-AMP (cGAMP)2-4, which triggers cell-autonomous defence and the production of type I interferons and pro-inflammatory cytokines via the activation of STING5. In addit...

journal_title：Nature

authors： Michalski S,de Oliveira Mann CC,Stafford CA,Witte G,Bartho J,Lammens K,Hornung V,Hopfner KP

更新日期：2020-11-01 00:00:00

abstract：:Histone post-translational modifications (PTMs) are associated with epigenetic states that form the basis for cell-type-specific gene expression1,2. Once established, histone PTMs can be maintained by positive feedback involving enzymes that recognize a pre-existing histone modification and catalyse the same modificat...

journal_title：Nature

authors： Yu R,Wang X,Moazed D

更新日期：2018-06-01 00:00:00

abstract：:The terminal differentiation of myogenic cells initiates in the proximal portion of the limb bud whereas the distal region remains undifferentiated and proliferative. The apical ectodermal ridge maintains the progress zone in an undifferentiated state and induces proliferation of limb mesenchymal cells. Hox-7.1, a hom...

journal_title：Nature

authors： Song K,Wang Y,Sassoon D

更新日期：1992-12-03 00:00:00

abstract：:Piwi-associated RNAs (piRNAs), a specific class of 24- to 30-nucleotide-long RNAs produced by the Piwi-type of Argonaute proteins, have a specific germline function in repressing transposable elements. This repression is thought to involve heterochromatin formation and transcriptional and post-transcriptional silencin...

journal_title：Nature

authors： Rouget C,Papin C,Boureux A,Meunier AC,Franco B,Robine N,Lai EC,Pelisson A,Simonelig M

更新日期：2010-10-28 00:00:00

abstract：:The assimilation and mineralization of dissolved organic carbon (DOC) by marine bacterioplankton is a major process in the ocean carbon cycle. However, little information exists on the specific metabolic functions of participating bacteria and on whether individual taxa specialize on particular components of the marin...

journal_title：Nature

authors： Mou X,Sun S,Edwards RA,Hodson RE,Moran MA

更新日期：2008-02-07 00:00:00

abstract：:A central aspect of neuronal function is how each nerve cell translated synaptic input into a sequence of action potentials that carry information along the axon, coded as spike frequency. When transduction from a graded depolarizing input to spikes is studied by injecting a depolarizing current, there is often a rema...

journal_title：Nature

authors： Storm JF

更新日期：1988-11-24 00:00:00

abstract：:For hundreds of years, scientists have tracked the changing appearance of Mars, first by hand drawings and later by photographs. Because of this historical record, many classical albedo patterns have long been known to shift in appearance over time. Decadal variations of the martian surface albedo are generally attrib...

journal_title：Nature

authors： Fenton LK,Geissler PE,Haberle RM

更新日期：2007-04-05 00:00:00

abstract：:Since the origins of agriculture, the scale of human cooperation and societal complexity has dramatically expanded. This fact challenges standard evolutionary explanations of prosociality because well-studied mechanisms of cooperation based on genetic relatedness, reciprocity and partner choice falter as people increa...

journal_title：Nature

authors： Purzycki BG,Apicella C,Atkinson QD,Cohen E,McNamara RA,Willard AK,Xygalatas D,Norenzayan A,Henrich J

更新日期：2016-02-18 00:00:00

abstract：:It has been suggested, on the basis of modern hydrology and fully coupled palaeoclimate simulations, that the warm greenhouse conditions that characterized the early Palaeogene period (55-45 Myr ago) probably induced an intensified hydrological cycle with precipitation exceeding evaporation at high latitudes. Little f...

journal_title：Nature

authors： Brinkhuis H,Schouten S,Collinson ME,Sluijs A,Sinninghe Damsté JS,Dickens GR,Huber M,Cronin TM,Onodera J,Takahashi K,Bujak JP,Stein R,van der Burgh J,Eldrett JS,Harding IC,Lotter AF,Sangiorgi F,van Konijnenburg-van Citte

更新日期：2006-06-01 00:00:00

abstract：:Eukaryotic transfer RNA genes have two internal discontinuous control regions, the A and B blocks, which correspond approximately to the D-stem and the pseudo-U arm of tRNA. In reconstituted transcription systems at least two components are required to direct accurate initiation by RNA polymerase (refs 4,5). However, ...

journal_title：Nature

authors： Smagowicz W,Ruet A,Camier S,Sentenac A,Fromageot P,Sternbach H

更新日期：1983-08-25 00:00:00

abstract：:The yeast [PSI+] element represents a new type of genetic inheritance, in which changes in phenotype are transmitted by a 'protein only' mechanism reminiscent of the 'protein-only' transmission of mammalian prion diseases. The underlying molecular mechanisms for both are poorly understood and it is not clear how simil...

journal_title：Nature

authors： Liu JJ,Lindquist S

更新日期：1999-08-05 00:00:00

abstract：:Conjugate (or 1,4-) additions of carbanionic species to α,β-unsaturated carbonyl compounds are vital to research in organic and medicinal chemistry, and there are several chiral catalysts that facilitate the catalytic enantioselective additions of nucleophiles to enoates. Nonetheless, catalytic enantioselective 1,6-co...

journal_title：Nature

authors： Meng F,Li X,Torker S,Shi Y,Shen X,Hoveyda AH

更新日期：2016-09-15 00:00:00

abstract：:Humans differ from other primates in their significantly lengthened growth period. The persistence of a fetal pattern of brain growth after birth is another important feature of human development. Here we present the results of an analysis of the 1.8-million-year-old Mojokerto child (Perning 1, Java), the only well pr...

journal_title：Nature

authors： Coqueugniot H,Hublin JJ,Veillon F,Houët F,Jacob T

更新日期：2004-09-16 00:00:00

abstract：:Although a few cancer genes are mutated in a high proportion of tumours of a given type (>20%), most are mutated at intermediate frequencies (2-20%). To explore the feasibility of creating a comprehensive catalogue of cancer genes, we analysed somatic point mutations in exome sequences from 4,742 human cancers and the...

journal_title：Nature

authors： Lawrence MS,Stojanov P,Mermel CH,Robinson JT,Garraway LA,Golub TR,Meyerson M,Gabriel SB,Lander ES,Getz G

更新日期：2014-01-23 00:00:00

abstract：:Below water depths of about 300 metres, pressure and temperature conditions cause methane to form ice-like crystals of methane hydrate. Marine deposits of methane hydrate are estimated to be large, amassing about 10,000 gigatonnes of carbon, and are thought to be important to global change and seafloor stability, as w...

journal_title：Nature

authors： Wood WT,Gettrust JF,Chapman NR,Spence GD,Hyndman RD

更新日期：2002-12-12 00:00:00

abstract：:The adult mammalian heart is incapable of regeneration following cardiomyocyte loss, which underpins the lasting and severe effects of cardiomyopathy. Recently, it has become clear that the mammalian heart is not a post-mitotic organ. For example, the neonatal heart is capable of regenerating lost myocardium, and the ...

journal_title：Nature

authors： Nakada Y,Canseco DC,Thet S,Abdisalaam S,Asaithamby A,Santos CX,Shah AM,Zhang H,Faber JE,Kinter MT,Szweda LI,Xing C,Hu Z,Deberardinis RJ,Schiattarella G,Hill JA,Oz O,Lu Z,Zhang CC,Kimura W,Sadek HA

更新日期：2017-01-12 00:00:00

abstract：:Therapeutic antibodies that block the programmed death-1 (PD-1)-programmed death-ligand 1 (PD-L1) pathway can induce robust and durable responses in patients with various cancers, including metastatic urothelial cancer. However, these responses only occur in a subset of patients. Elucidating the determinants of respon...

journal_title：Nature

authors： Mariathasan S,Turley SJ,Nickles D,Castiglioni A,Yuen K,Wang Y,Kadel EE III,Koeppen H,Astarita JL,Cubas R,Jhunjhunwala S,Banchereau R,Yang Y,Guan Y,Chalouni C,Ziai J,Şenbabaoğlu Y,Santoro S,Sheinson D,Hung J,Giltna

更新日期：2018-02-22 00:00:00

abstract：:The Rho-family GTPase, Cdc42, can regulate the actin cytoskeleton through activation of Wiskott-Aldrich syndrome protein (WASP) family members. Activation relieves an autoinhibitory contact between the GTPase-binding domain and the carboxy-terminal region of WASP proteins. Here we report the autoinhibited structure of...

journal_title：Nature

authors： Kim AS,Kakalis LT,Abdul-Manan N,Liu GA,Rosen MK

更新日期：2000-03-09 00:00:00

abstract：:The onsert of neuronal differentiation is characterised by intensive neurite growth; because microtubule formation is strictly required during this process, in vitro assembly of the tubulin present in the rat brain has been studied at different stages of development: the rate of assembly is very slow in the early stag...

journal_title：Nature

authors： Mareck A,Fellous A,Francon J,Nunez J

更新日期：1980-03-27 00:00:00

abstract：:Synapse assembly requires trans-synaptic signals between the pre- and postsynapse, but our understanding of the essential organizational molecules involved in this process remains incomplete. Teneurin proteins are conserved, epidermal growth factor (EGF)-repeat-containing transmembrane proteins with large extracellula...

journal_title：Nature

authors： Mosca TJ,Hong W,Dani VS,Favaloro V,Luo L

更新日期：2012-03-18 00:00:00

abstract：:Interferon-induced proteins with tetratricopeptide repeats (IFITs) are innate immune effector molecules that are thought to confer antiviral defence through disruption of protein-protein interactions in the host translation-initiation machinery. However, it was recently discovered that IFITs can directly recognize vir...

journal_title：Nature

authors： Abbas YM,Pichlmair A,Górna MW,Superti-Furga G,Nagar B

更新日期：2013-02-07 00:00:00

abstract：:The crystal structure of a soluble form of the T lymphocyte antigen CD2 provides the first complete view of the extracellular region of a cell adhesion molecule. The topology of the molecule, which comprises two immunoglobulin-like domains, is the same as that of the first two domains of CD4 but the relative domain or...

journal_title：Nature

authors： Jones EY,Davis SJ,Williams AF,Harlos K,Stuart DI

更新日期：1992-11-19 00:00:00

abstract：:The masses of the supermassive black holes found in galaxy bulges are correlated with a multitude of galaxy properties, leading to suggestions that galaxies and black holes may evolve together. The number of reliably measured black-hole masses is small, and the number of methods for measuring them is limited, holding ...

journal_title：Nature

authors： Davis TA,Bureau M,Cappellari M,Sarzi M,Blitz L

更新日期：2013-02-21 00:00:00

abstract：:Gigantopithecus blacki was a giant hominid that inhabited densely forested environments of Southeast Asia during the Pleistocene epoch1. Its evolutionary relationships to other great ape species, and the divergence of these species during the Middle and Late Miocene epoch (16-5.3 million years ago), remain unclear2,3....

journal_title：Nature

authors： Welker F,Ramos-Madrigal J,Kuhlwilm M,Liao W,Gutenbrunner P,de Manuel M,Samodova D,Mackie M,Allentoft ME,Bacon AM,Collins MJ,Cox J,Lalueza-Fox C,Olsen JV,Demeter F,Wang W,Marques-Bonet T,Cappellini E

更新日期：2019-12-01 00:00:00

abstract：:Presenilin and signal peptide peptidase (SPP) are intramembrane aspartyl proteases that regulate important biological functions in eukaryotes. Mechanistic understanding of presenilin and SPP has been hampered by lack of relevant structural information. Here we report the crystal structure of a presenilin/SPP homologue...

journal_title：Nature

authors： Li X,Dang S,Yan C,Gong X,Wang J,Shi Y

更新日期：2013-01-03 00:00:00

abstract：:Medulloblastoma, the most common malignant paediatric brain tumour, arises in the cerebellum and disseminates through the cerebrospinal fluid in the leptomeningeal space to coat the brain and spinal cord. Dissemination, a marker of poor prognosis, is found in up to 40% of children at diagnosis and in most children at ...

journal_title：Nature

authors： Wu X,Northcott PA,Dubuc A,Dupuy AJ,Shih DJ,Witt H,Croul S,Bouffet E,Fults DW,Eberhart CG,Garzia L,Van Meter T,Zagzag D,Jabado N,Schwartzentruber J,Majewski J,Scheetz TE,Pfister SM,Korshunov A,Li XN,Scherer SW,Ch

更新日期：2012-02-15 00:00:00

abstract：:The DNA polymerase V (pol V) and RecA proteins are essential components of a mutagenic translesion synthesis pathway in Escherichia coli designed to cope with DNA damage. Previously, it has been assumed that RecA binds to the DNA template strand being copied. Here we show, however, that pol-V-catalysed translesion syn...

journal_title：Nature

authors： Schlacher K,Cox MM,Woodgate R,Goodman MF

更新日期：2006-08-24 00:00:00

abstract：:Features that were once considered exclusive to modern birds, such as feathers and a furcula, are now known to have first appeared in non-avian dinosaurs. However, relatively little is known of the early evolutionary history of the hyperinflated brain that distinguishes birds from other living reptiles and provides th...

journal_title：Nature

authors： Balanoff AM,Bever GS,Rowe TB,Norell MA

更新日期：2013-09-05 00:00:00

abstract：:Deep chlorophyll maxima (DCMs) are widespread in large parts of the world's oceans. These deep layers of high chlorophyll concentration reflect a compromise of phytoplankton growth exposed to two opposing resource gradients: light supplied from above and nutrients supplied from below. It is often argued that DCMs are ...

journal_title：Nature

authors： Huisman J,Pham Thi NN,Karl DM,Sommeijer B

更新日期：2006-01-19 00:00:00