Abstract:
:The terminal differentiation of myogenic cells initiates in the proximal portion of the limb bud whereas the distal region remains undifferentiated and proliferative. The apical ectodermal ridge maintains the progress zone in an undifferentiated state and induces proliferation of limb mesenchymal cells. Hox-7.1, a homeobox-containing gene, is expressed throughout the limb bud when limb outgrowth begins, whereas transcripts are later restricted to distal limb mesenchyme which is the proposed site of positional specification. Transplantation of proximal limb bud tissue into the distal portion of the limb results in a re-expression of Hox-7.1 in the transplanted mesenchyme. Similar grafts result in a positional reassignment to distal structures as well as de-differentiation of the grafted proximal tissue. Because of the association of Hox-7.1 expression with proliferative and undifferentiated cells, we tested whether Hox-7.1 regulates differentiation by transfection of Hox-7.1 complementary DNA into determined myogenic cells which represent one mesenchymal lineage in the limb. Here we report that forced expression of Hox-7.1 blocks terminal differentiation and results in a corresponding decrease in steady-state levels of MyoD1. Consistent with the association of Hox-7.1 with proliferation, Hox-7.1-expressing cells also acquire a transformed phenotype. Forced expression of Hox-8.1, a related Hox-gene, does not affect terminal differentiation indicating that the effects of Hox-7.1 are specific.
journal_name
Naturejournal_title
Natureauthors
Song K,Wang Y,Sassoon Ddoi
10.1038/360477a0keywords:
subject
Has Abstractpub_date
1992-12-03 00:00:00pages
477-81issue
6403eissn
0028-0836issn
1476-4687journal_volume
360pub_type
杂志文章相关文献
NATURE文献大全abstract::Temperature is a key factor in controlling the distribution of marine organisms and is particularly important at hydrothermal vents, where steep thermal gradients are present over a scale of centimetres. The thermophilic worm Alvinella pompejana, which is found at the vents of the East Pacific Rise (2,500-m depth), ha...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35099674
更新日期:2001-10-18 00:00:00
abstract::Sea-level histories during the two most recent deglacial-interglacial intervals show substantial differences1-3 despite both periods undergoing similar changes in global mean temperature4,5 and forcing from greenhouse gases6. Although the last interglaciation (LIG) experienced stronger boreal summer insolation forcing...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/s41586-020-1931-7
更新日期:2020-01-01 00:00:00
abstract::Understanding crystal growth is essential for controlling the crystallization used in industrial separation and purification processes. Because solids interact through their surfaces, crystal shape can influence both chemical and physical properties. The thermodynamic morphology can readily be predicted, but most part...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04173
更新日期:2005-11-03 00:00:00
abstract::The recent discovery of more than a thousand planets outside our Solar System, together with the significant push to achieve inertially confined fusion in the laboratory, has prompted a renewed interest in how dense matter behaves at millions to billions of atmospheres of pressure. The theoretical description of such ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13526
更新日期:2014-07-17 00:00:00
abstract::We have investigated age-related reactivation of the X chromosome by devising a model in which reactivation of a single gene in one cell among many can be identified. We have used mice with an X-autosomal translocation giving consistent non-random inactivation of the normal X (as judged by biochemical and cytogenetic ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/327725a0
更新日期:1987-06-25 00:00:00
abstract::The interplay of evolution and development has been at the heart of evolutionary theory for more than a century. Heterochrony—change in the timing or rate of developmental events—has been implicated in the evolution of major vertebrate lineages such as mammals, including humans. Birds are the most speciose land verteb...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11146
更新日期:2012-07-12 00:00:00
abstract::The overexpression of defined transcription factors in somatic cells results in their reprogramming into induced pluripotent stem (iPS) cells. The extremely low efficiency and slow kinetics of in vitro reprogramming suggest that further rare events are required to generate iPS cells. The nature and identity of these e...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08285
更新日期:2009-08-27 00:00:00
abstract::The seemingly endless studies of the ethical connotations of genetics serve a valuable role in general understanding even if the ethical problems involved are often insubstantial. ...
journal_title:Nature
pub_type: 社论
doi:10.1038/356365a0
更新日期:1992-04-02 00:00:00
abstract::RNA polymerase II (RNAP II) is responsible for transcribing all messenger RNAs in eukaryotic cells during a highly regulated process that is conserved from yeast to human, and that serves as a central control point for cellular function. Here we investigate the transcription dynamics of single RNAP II molecules from S...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05701
更新日期:2007-04-12 00:00:00
abstract::Mammal-like reptiles of the order Therapsida document the emergence of mammals from more primitive synapsids and are of unique zoological and palaeontological interest on that account. Therapsids, first appearing in the Early Permian, were thought to become extinct in the Middle Jurassic, soon after the Late Triassic ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/358233a0
更新日期:1992-07-16 00:00:00
abstract::Information from the human genome sequence will eventually alter many aspects of clinical practice. It will increase through our understanding of disease mechanisms, and guide the development of new drugs and therapeutic procedures. In the short term, however, knowledge of the genome will have a profound clinical impa...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature02624
更新日期:2004-05-27 00:00:00
abstract::Type 2 diabetes (T2D) is a result of complex gene-environment interactions, and several risk factors have been identified, including age, family history, diet, sedentary lifestyle and obesity. Statistical models that combine known risk factors for T2D can partly identify individuals at high risk of developing the dise...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12198
更新日期:2013-06-06 00:00:00
abstract::Serine proteases are present in virtually all organisms and function both inside and outside the cell; they exist as two families, the 'trypsin-like' and the 'subtilisin-like', that have independently evolved a similar catalytic device characterized by the Ser, His, Asp triad, an oxyanion binding site, and possibly ot...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/332564a0
更新日期:1988-04-07 00:00:00
abstract::Mass spectrometry is a powerful technology for the analysis of large numbers of endogenous proteins. However, the analytical challenges associated with comprehensive identification and relative quantification of cellular proteomes have so far appeared to be insurmountable. Here, using advances in computational proteom...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07341
更新日期:2008-10-30 00:00:00
abstract::There have been many reports that eukaryotic cells contain ring-shaped 19S or 20S particles which are composed of numerous polypeptide subunits ranging in size between 25 and 35 kilodaltons. Because these particles seemed to copurify with inactive mRNA, they were assumed to function in regulating mRNA translation and ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/331192a0
更新日期:1988-01-14 00:00:00
abstract::Trophic control over the expression and membrane distribution of voltage-dependent ion channels is one of the principal organizing events underlying the maturation of excitable cells. The myelin sheath is a major structural determinant of regional ion channel topography in central axons, but the exact molecular signal...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/352431a0
更新日期:1991-08-01 00:00:00
abstract::CRISPR-Cas genome-editing nucleases hold substantial promise for developing human therapeutic applications1-6 but identifying unwanted off-target mutations is important for clinical translation7. A well-validated method that can reliably identify off-targets in vivo has not been described to date, which means it is cu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0500-9
更新日期:2018-09-01 00:00:00
abstract::Deep chlorophyll maxima (DCMs) are widespread in large parts of the world's oceans. These deep layers of high chlorophyll concentration reflect a compromise of phytoplankton growth exposed to two opposing resource gradients: light supplied from above and nutrients supplied from below. It is often argued that DCMs are ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04245
更新日期:2006-01-19 00:00:00
abstract::Climate change is predicted to increase both drought frequency and duration, and when coupled with substantial warming, will establish a new hydroclimatological model for many regions. Large-scale, warm droughts have recently occurred in North America, Africa, Europe, Amazonia and Australia, resulting in major effects...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature11836
更新日期:2013-02-21 00:00:00
abstract::Understanding how ecological communities are organized and how they change through time is critical to predicting the effects of climate change. Recent work documenting the co-occurrence structure of modern communities found that most significant species pairs co-occur less frequently than would be expected by chance....
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature16447
更新日期:2016-01-07 00:00:00
abstract::The 37-amino-acid calcitonin gene-related peptide (CGRP) occurs as a result of alternative processing of mRNA from the calcitonin gene. The potency of CGRP as a vasodilator and the occurrence of the peptide in nerves associated with blood vessels suggest an important role for CGRP in the regulation of blood flow. The ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/335073a0
更新日期:1988-09-01 00:00:00
abstract::The identical structure of two racially distinct alpha 1-globin alleles and the high degree of homology between the alpha 1- and alpha 2-globin loci indicate that mechanisms exist for suppression of allelic polymorphisms and for exchange of genetic information within the alpha-globin gene complex. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/290026a0
更新日期:1981-03-05 00:00:00
abstract::The assimilation and mineralization of dissolved organic carbon (DOC) by marine bacterioplankton is a major process in the ocean carbon cycle. However, little information exists on the specific metabolic functions of participating bacteria and on whether individual taxa specialize on particular components of the marin...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06513
更新日期:2008-02-07 00:00:00
abstract::Mesolimbic dopamine-releasing neurons appear to be important in the brain reward system. One behavioural paradigm that supports this hypothesis is intracranial self-stimulation (ICS), during which animals repeatedly press a lever to stimulate their own dopamine-releasing neurons electrically. Here we study dopamine re...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/18019
更新日期:1999-03-04 00:00:00
abstract::The versatility of Ca2+ signals derives from their spatio-temporal organization. For Ca2+ signals initiated by inositol-1,4,5-trisphosphate (InsP3), this requires local interactions between InsP3 receptors (InsP3Rs) mediated by their rapid stimulation and slower inhibition\ by cytosolic Ca2+. This allows hierarchical ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07763
更新日期:2009-04-02 00:00:00
abstract::The mechanism of self-tolerance is studied in T-cell-receptor transgenic mice expressing a receptor in many of their T cells for the male (H-Y) antigen in the context of class I H-2Db MHC antigens. Autospecific T cells are deleted in male mice. The deletion affects only transgene-expressing cells with a relatively hig...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/333742a0
更新日期:1988-06-23 00:00:00
abstract::When chemical reactions whose rate increases with the concentration of a product species are carried out in imperfectly mixed systems, a variety of complex behaviours can occur. These phenomena, which have relevance for biological processes as well, include chaotic and stochastic behaviour and selection of one final s...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/374321a0
更新日期:1995-03-23 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 新闻
doi:10.1038/d41586-018-06989-8
更新日期:2018-10-01 00:00:00
abstract::Bacterial adhesion pili are designed to bind specifically and maintain attachment of bacteria to target cells. Uropathogenic P-pili are sufficiently mechanically resilient to resist the cleansing action of urine flow that removes most other bacteria. P-pili are 68 A in diameter and approximately 1 micron long, and are...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/373164a0
更新日期:1995-01-12 00:00:00
abstract::Approximately 2% of colorectal cancer is linked to pre-existing inflammation known as colitis-associated cancer, but most develops in patients without underlying inflammatory bowel disease. Colorectal cancer often follows a genetic pathway whereby loss of the adenomatous polyposis coli (APC) tumour suppressor and acti...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11465
更新日期:2012-11-08 00:00:00