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NATURE文献大全abstract::Stimulus-evoked oscillatory synchronization of activity has been observed in many neural systems, including the cerebral cortex of mammals and the brain of insects. The possible functions of such rhythmic synchronization in neural coding, however, remain largely speculative. In the locust, odours evoke activity in dyn...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/384162a0
更新日期:1996-11-14 00:00:00
abstract::The tuatara (Sphenodon punctatus)-the only living member of the reptilian order Rhynchocephalia (Sphenodontia), once widespread across Gondwana1,2-is an iconic species that is endemic to New Zealand2,3. A key link to the now-extinct stem reptiles (from which dinosaurs, modern reptiles, birds and mammals evolved), the ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2561-9
更新日期:2020-08-01 00:00:00
abstract::Hepatocellularcarcinoma (HCC) that occur in woodchucks chronically infected with woodchuck hepatitis virus (WHV) were screened for activation of cellular oncogenes. Enhanced expression and allelic alterations of the c-myc oncogene were found in three HCC out of nine. Variations in the size of the c-myc transcripts, ra...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/324276a0
更新日期:1986-11-20 00:00:00
abstract::Multiplicative operations are important in sensory processing, but their biophysical implementation remains largely unknown. We investigated an identified neuron (the lobula giant movement detector, LGMD, of locusts) whose output firing rate in response to looming visual stimuli has been described by two models, one o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01190
更新日期:2002-11-21 00:00:00
abstract::Autism spectrum disorder (ASD) is a group of conditions characterized by impaired social interaction and communication, and restricted and repetitive behaviours. ASD is a highly heritable disorder involving various genetic determinants. Shank2 (also known as ProSAP1) is a multi-domain scaffolding protein and signallin...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11208
更新日期:2012-06-13 00:00:00
abstract::Non-coding apurinic/apyrimidinic (AP) sites in DNA are continually created in cells both spontaneously and by damage-specific DNA glycosylases. The biologically critical human base excision repair enzyme APE1 cleaves the DNA sugar-phosphate backbone at a position 5' of AP sites to prime DNA repair synthesis. Here we r...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35000249
更新日期:2000-01-27 00:00:00
abstract::Null mutations of glass specifically remove photoreceptor cells, leaving other cell types intact. We have isolated the glass gene and have shown that its transcript encodes a putative protein of 604 amino acids with five zinc-fingers. The glass product may be a transcription factor required for the development of a si...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/340531a0
更新日期:1989-08-17 00:00:00
abstract::BINDING of the TATA-binding protein (TBP) to the TATA box is required for transcription from many eukaryotic promoters in gene expression. Regulation of this binding is therefore likely to be an important determinant of promoter activity. Incorporation of the TATA sequence into nucleosomes dramatically reduces transcr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/370481a0
更新日期:1994-08-11 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 社论
doi:10.1038/d41586-018-06975-0
更新日期:2018-10-01 00:00:00
abstract::Gap junction channels are structurally distinct from other ion channels in that they comprise two hemichannels which interact head-to-head to form an aqueous channel between cells. Intercellular voltage differences together with increased intracellular concentrations of H+ and Ca2+ cause closure of these normally pate...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/365847a0
更新日期:1993-10-28 00:00:00
abstract::Highly correlated electronic systems--such as transition-metal oxides that are doped Mott insulators--are complex systems which exhibit puzzling phenomena, including high-temperature superconductivity and colossal magnetoresistivity. Recent studies suggest that in such systems collective electronic phenomena are impor...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35021018
更新日期:2000-08-17 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 新闻
doi:10.1038/d41586-018-07631-3
更新日期:2018-12-01 00:00:00
abstract::Dusty disks around young stars are formed out of interstellar dust that consists of amorphous, submicrometre grains. Yet the grains found in comets and meteorites, and traced in the spectra of young stars, include large crystalline grains that must have undergone annealing or condensation at temperatures in excess of ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08032
更新日期:2009-05-14 00:00:00
abstract::The assessment of uncertainties in global warming projections is often based on expert judgement, because a number of key variables in climate change are poorly quantified. In particular, the sensitivity of climate to changing greenhouse-gas concentrations in the atmosphere and the radiative forcing effects by aerosol...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/416719a
更新日期:2002-04-18 00:00:00
abstract::A conserved heterotrimeric membrane protein complex, the Sec61 or SecY complex, forms a protein-conducting channel, allowing polypeptides to be transferred across or integrated into membranes. We report the crystal structure of the complex from Methanococcus jannaschii at a resolution of 3.2 A. The structure suggests ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02218
更新日期:2004-01-01 00:00:00
abstract::Experimental realization of a universal set of quantum logic gates is the central requirement for the implementation of a quantum computer. In an 'all-geometric' approach to quantum computation, the quantum gates are implemented using Berry phases and their non-Abelian extensions, holonomies, from geometric transforma...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13729
更新日期:2014-10-02 00:00:00
abstract::Oocytes arrested in the G2 phase of the cell cycle contain a p34cdc2/cyclin B complex which is kept in an inactive form by phosphorylation of its p34cdc2 subunit on tyrosine, threonine and perhaps serine residues. The phosphatase(s) involved in p34cdc2 dephosphorylation is unknown, but the product of the fission yeast...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/351242a0
更新日期:1991-05-16 00:00:00
abstract::Translation initiation determines both the quantity and identity of the protein that is encoded in an mRNA by establishing the reading frame for protein synthesis. In eukaryotic cells, numerous translation initiation factors prepare ribosomes for polypeptide synthesis; however, the underlying dynamics of this process ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1561-0
更新日期:2019-09-01 00:00:00
abstract::A grand challenge of systems biology is to predict the kinetic responses of living systems to perturbations starting from the underlying molecular interactions. Changes in the nutrient environment have long been used to study regulation and adaptation phenomena in microorganisms and they remain a topic of active inves...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature24299
更新日期:2017-11-02 00:00:00
abstract::Vaccination has proved a powerful defence against a range of infectious diseases of humans and animals. However, its potential to control major epidemics of foot-and-mouth disease (FMD) in livestock is contentious. Using an individual farm-based model, we consider either national prophylactic vaccination campaigns in ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01343
更新日期:2003-01-09 00:00:00
abstract::Scientific fraud, much in the news recently, is not a new phenomenon. What follows is a personal account of a particular case. ...
journal_title:Nature
pub_type: 传,历史文章,杂志文章
doi:10.1038/357434a0
更新日期:1992-06-11 00:00:00
abstract::When an individual molecule, nanocrystal, nanotube or lithographically defined quantum dot is attached to metallic electrodes via tunnel barriers, electron transport is dominated by single-electron charging and energy-level quantization. As the coupling to the electrodes increases, higher-order tunnelling and correlat...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature00790
更新日期:2002-06-13 00:00:00
abstract::Excision of introns from nuclear precursors to messenger RNAs (pre-mRNAs) by the spliceosome requires two distinct phosphodiester transfer (transesterification) reactions: exchange of a 3'-5' for a 2'-5' bond in the first step (lariat formation) and exchange of one 3'-5' phosphodiester for another in the second step (...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/365364a0
更新日期:1993-09-23 00:00:00
abstract::Early sensory experience instructs the maturation of neural circuitry in the cortex. This has been studied extensively in the primary visual cortex, in which loss of vision to one eye permanently degrades cortical responsiveness to that eye, a phenomenon known as ocular dominance plasticity (ODP). Cortical inhibition ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12485
更新日期:2013-09-26 00:00:00
abstract::Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis, is a major cause of morbidity and mortality worldwide. Efforts to control it are hampered by difficulties with diagnosis, prevention and treatment. Most people infected with M. tuberculosis remain asymptomatic, termed latent TB, with a 10% lifetim...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09247
更新日期:2010-08-19 00:00:00
abstract::S-100 protein, one of the unique proteins found in the nervous system, has recently been discovered unexpectedly in the rat anterior pituitary. Immunocytochemistry reveals that stellate, follicular and folliculostellate cells, and marginal cells of the rat anterior pituitary contain this protein; however, as far as we...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/303711a0
更新日期:1983-06-23 00:00:00
abstract::Calcium (Ca(2+))-activated chloride channels are fundamental mediators in numerous physiological processes including transepithelial secretion, cardiac and neuronal excitation, sensory transduction, smooth muscle contraction and fertilization. Despite their physiological importance, their molecular identity has remain...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07313
更新日期:2008-10-30 00:00:00
abstract::Naive lymphocytes continually enter and exit lymphoid organs in a recirculation process that is essential for immune surveillance. During immune responses, the egress process can be shut down transiently. When this occurs locally it increases lymphocyte numbers in the responding lymphoid organ; when it occurs systemic...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04606
更新日期:2006-03-23 00:00:00
abstract::The spacing of opening-mode fractures in layered materials--such as certain sedimentary rocks and laminated engineering materials--is often proportional to the thickness of the fractured layer. Experimental studies of this phenomenon show that the spacing initially decreases as extensional strain increases in the dire...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35001550
更新日期:2000-02-17 00:00:00
abstract::Direct lineage reprogramming represents a remarkable conversion of cellular and transcriptome states. However, the intermediate stages through which individual cells progress during reprogramming are largely undefined. Here we use single-cell RNA sequencing at multiple time points to dissect direct reprogramming from ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature18323
更新日期:2016-06-16 00:00:00