相关文献
NATURE文献大全abstract::Mutations in phosphatase and tensin homologue (PTEN) or genomic alterations in the phosphatidylinositol-3-OH kinase-signalling pathway are the most common genetic alterations reported in human prostate cancer. However, the precise mechanism underlying how indolent tumours with PTEN alterations acquire metastatic poten...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11674
更新日期:2013-01-10 00:00:00
abstract::The inner ear contains sensory epithelia that detect head movements, gravity and sound. It is unclear how to develop these sensory epithelia from pluripotent stem cells, a process that will be critical for modelling inner ear disorders or developing cell-based therapies for profound hearing loss and balance disorders....
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12298
更新日期:2013-08-08 00:00:00
abstract::The discovery of a plume of water vapour and ice particles emerging from warm fractures ('tiger stripes') in Saturn's small, icy moon Enceladus raised the question of whether the plume emerges from a subsurface liquid source or from the decomposition of ice. Previous compositional analyses of particles injected by the...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10175
更新日期:2011-06-22 00:00:00
abstract::The two-dimensional electron system is a powerful laboratory for investigating the physics of interacting particles. Application of a large magnetic field produces massively degenerate quantum levels known as Landau levels; within a Landau level the kinetic energy of the electrons is suppressed, and electron-electron ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08941
更新日期:2010-03-25 00:00:00
abstract::The subsidence history of the Bahamian Platform points to a non-uniform rate of sea-floor spreading since the beginning of the Cretaceous. Lower Cretaceous rates of perhaps 5 cm/yr led to an active trench system at the boundary between the American and Caribbean lithosphere plates, and the rapid subsidence of the cont...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/2251226a0
更新日期:1970-03-28 00:00:00
abstract::The sensitivity of soil carbon to warming is a major uncertainty in projections of carbon dioxide concentration and climate. Experimental studies overwhelmingly indicate increased soil organic carbon (SOC) decomposition at higher temperatures, resulting in increased carbon dioxide emissions from soils. However, recent...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03226
更新日期:2005-01-20 00:00:00
abstract::One of the main unanswered questions in solar physics is why the Sun's outer atmosphere is hotter than its surface. Theory predicts abundant production of high-frequency (10-50 mHz) acoustic waves in subsurface layers of the Sun, and such waves are believed by many to constitute the dominant heating mechanism of the c...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03695
更新日期:2005-06-16 00:00:00
abstract::The clinical success of the ABL tyrosine kinase inhibitor imatinib in chronic myeloid leukaemia (CML) serves as a model for molecularly targeted therapy of cancer, but at least two critical questions remain. Can imatinib eradicate leukaemic stem cells? What are the dynamics of relapse due to imatinib resistance, which...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03669
更新日期:2005-06-30 00:00:00
abstract::The Indian Ocean dipole is a prominent mode of coupled ocean-atmosphere variability, affecting the lives of millions of people in Indian Ocean rim countries. In its positive phase, sea surface temperatures are lower than normal off the Sumatra-Java coast, but higher in the western tropical Indian Ocean. During the ext...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13327
更新日期:2014-06-12 00:00:00
abstract::The commitment of non-dividing cells (in G0) to enter division can be studied using primary cultures of lymphocytes. The cells are stable in G0 unless stimulated by mitogen such as concanavalin A (Con A). Commitment to enter the division cycle depends on the expression of gene(s) induced by Con A and the synthesis of ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/310143a0
更新日期:1984-07-12 00:00:00
abstract::Anomalies in temperature and precipitation in northern Russia over the past few years have been viewed as manifestations of anthropogenic climate change, prompting suggestions that this may also account for exceptional forest fires in the region. Here we examine the number of forest-fire events across the boreal Russi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/440436a
更新日期:2006-03-23 00:00:00
abstract::Long-term synaptic potentiation (LTP) is thought to be a key process in cortical synaptic network plasticity and memory formation. Hebbian forms of LTP depend on strong postsynaptic depolarization, which in many models is generated by action potentials that propagate back from the soma into dendrites. However, local d...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13664
更新日期:2014-11-06 00:00:00
abstract::Evolutionary relationships among the eight major lineages of Mollusca have remained unresolved despite their diversity and importance. Previous investigations of molluscan phylogeny, based primarily on nuclear ribosomal gene sequences or morphological data, have been unsuccessful at elucidating these relationships. Re...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10382
更新日期:2011-09-04 00:00:00
abstract::Visible-light absorption and transport of the resultant electronic excitations to a reaction centre through Förster resonance energy transfer1-3 (FRET) are critical to the operation of biological light-harvesting systems4, and are used in various artificial systems made of synthetic dyes5, polymers6 or nanodots7,8. Th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-03081-y
更新日期:2021-01-01 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 社论
doi:10.1038/d41586-018-07033-5
更新日期:2018-10-01 00:00:00
abstract::Although freeze-fracture electron microscopy is normally analysed with the presumption that particles represent proteins embedded within the membrane, particles which appeared to represent inverted lipid micelles within membranes have been reported. I have now confirmed the occurrence of particles in protein-free lipo...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/287166a0
更新日期:1980-09-11 00:00:00
abstract::The generation of a local chromatin topology conducive to transcription is a key step in gene regulation. The yeast SWI/SNF complex is the founding member of a family of ATP-dependent remodelling activities capable of altering chromatin structure both in vitro and in vivo. Despite its importance, the pathway by which ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/23506
更新日期:1999-08-19 00:00:00
abstract::High biodiversity has been shown to enhance ecological stability on small spatial scales and over intervals of weeks to decades. It remains unclear, however, whether this diversity-stability relationship can be scaled up to regional scales, or to longer timescales. Without empirical validation at larger scales, the im...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature03152
更新日期:2005-01-27 00:00:00
abstract::Called the "mystery of mysteries" by Darwin, speciation is still a little-understood area of evolution. Genetic analysis, however, has yielded new generalizations about speciation and suggests promising avenues of research. ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/355511a0
更新日期:1992-02-06 00:00:00
abstract::Interferon-induced proteins with tetratricopeptide repeats (IFITs) are innate immune effector molecules that are thought to confer antiviral defence through disruption of protein-protein interactions in the host translation-initiation machinery. However, it was recently discovered that IFITs can directly recognize vir...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11783
更新日期:2013-02-07 00:00:00
abstract::Protein design provides a rigorous test of our knowledge about proteins and allows the creation of novel enzymes for biotechnological applications. Whereas progress has been made in designing proteins that mimic native proteins structurally, it is more difficult to design functional proteins. In comparison to recent s...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08620
更新日期:2009-12-24 00:00:00
abstract::The mammalian central nervous system (CNS) contains a remarkable array of neural cells, each with a complex pattern of connections that together generate perceptions and higher brain functions. Here we describe a large-scale screen to create an atlas of CNS gene expression at the cellular level, and to provide a libra...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02033
更新日期:2003-10-30 00:00:00
abstract::Intracellular responses recorded in vitro from the cochleas of anaesthetized mammals have shown that the mechanoreceptive inner and outer hair cells are sharply tuned, accounting for many of the properties of the afferent fibres in the auditory nerve. However, in vivo it has not been possible to measure directly the e...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/321517a0
更新日期:1986-05-29 00:00:00
abstract::The CD4 molecule is a high-affinity cell-surface receptor for the human immunodeficiency virus (HIV-1) and a soluble truncated form of CD4 produced by recombinant DNA technology is a potent inhibitor of HIV-1 replication and HIV-1-induced cell fusion in vitro. Rhesus monkeys infected with the simian immunodeficiency v...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/337267a0
更新日期:1989-01-19 00:00:00
abstract::Glycosaminoglycans such as heparan sulphate and chondroitin sulphate are extracellular sugar chains involved in intercellular signalling. Disruptions of genes encoding enzymes that mediate glycosaminoglycan biosynthesis have severe consequences in Drosophila and mice. Mutations in the Drosophila gene sugarless, which ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01635
更新日期:2003-05-22 00:00:00
abstract::The insulins of New World hystricomorph rodents exhibit many novel amino acid changes in primary structure when compared with other mammalian insulins. These changes give rise to unusual properties (low potency, failure to self-associate) not shared by other naturally-occurring insulins. We report here on the primary ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/286822a0
更新日期:1980-08-21 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 新闻
doi:10.1038/d41586-018-07667-5
更新日期:2018-12-01 00:00:00
abstract::Transplantation surgery, which is limited by the supply and short-term viability of fresh donor organs, would be revolutionized if these could survive freezing, but early claims of cryopreservation were never realized. Here we describe the successful transplantation in rats of ovaries, fallopian tubes and the upper se...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/415385a
更新日期:2002-01-24 00:00:00
abstract::Measuring the completeness of the fossil record is essential to understanding evolution over long timescales, particularly when comparing evolutionary patterns among biological groups with different preservational properties. Completeness measures have been presented for various groups based on gaps in the stratigraph...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/18872
更新日期:1999-04-01 00:00:00
abstract::Increasing population and consumption are placing unprecedented demands on agriculture and natural resources. Today, approximately a billion people are chronically malnourished while our agricultural systems are concurrently degrading land, water, biodiversity and climate on a global scale. To meet the world's future ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10452
更新日期:2011-10-12 00:00:00