Abstract:
:The mechanism of self-tolerance is studied in T-cell-receptor transgenic mice expressing a receptor in many of their T cells for the male (H-Y) antigen in the context of class I H-2Db MHC antigens. Autospecific T cells are deleted in male mice. The deletion affects only transgene-expressing cells with a relatively high surface-density of CD8 molecules, including nonmature CD4+ CD8+ thymocytes, and is not caused by anti-idiotype cells.
journal_name
Naturejournal_title
Natureauthors
Kisielow P,Blüthmann H,Staerz UD,Steinmetz M,von Boehmer Hdoi
10.1038/333742a0subject
Has Abstractpub_date
1988-06-23 00:00:00pages
742-6issue
6175eissn
0028-0836issn
1476-4687journal_volume
333pub_type
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