A black-hole mass measurement from molecular gas kinematics in NGC4526.

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature

authors： DeRocher KA,Smeets PJM,Goodge BH,Zachman MJ,Balachandran PV,Stegbauer L,Cohen MJ,Gordon LM,Rondinelli JM,Kourkoutis LF,Joester D

更新日期：2020-08-01 00:00:00

abstract：:A key step in the elimination of pathogens from the body is the covalent binding of complement proteins C3 and C4 to their surfaces. Proteolytic activation of these proteins results in a conformational change, and an internal thioester is exposed which reacts with amino or hydroxyl groups on the target surface to form...

journal_title：Nature

authors： Dodds AW,Ren XD,Willis AC,Law SK

更新日期：1996-01-11 00:00:00

abstract：:The European Commission has made good progress in gathering support for its new programme of basic and applied research. Now Europe's industries and heads of state need to fulfill promises made two years ago. ...

journal_title：Nature

authors：

更新日期：2002-01-31 00:00:00

abstract：:Estimates of the effect of increasing atmospheric CO2 concentrations on future global plant production rely on the physiological response of individual plants or plant communities when exposed to high CO2 (refs 1-6). Plant populations may adapt to the changing atmosphere, however, such that the evolved plant communiti...

journal_title：Nature

authors： Collins S,Bell G

更新日期：2004-09-30 00:00:00

abstract：:Hox genes are essential for growth and patterning of the tetrapod limb skeleton. Mice mutant for the Hoxd-13 gene have an important delay in morphogenesis owing to reduced proliferation. Based on the appearance of atavisms in such mice, we suggested that modifications of Hox gene regulation may have been a source of m...

journal_title：Nature

authors： Sordino P,van der Hoeven F,Duboule D

更新日期：1995-06-22 00:00:00

abstract：:Phelan-McDermid syndrome (PMDS) is a complex neurodevelopmental disorder characterized by global developmental delay, severely impaired speech, intellectual disability, and an increased risk of autism spectrum disorders (ASDs). PMDS is caused by heterozygous deletions of chromosome 22q13.3. Among the genes in the dele...

journal_title：Nature

authors： Shcheglovitov A,Shcheglovitova O,Yazawa M,Portmann T,Shu R,Sebastiano V,Krawisz A,Froehlich W,Bernstein JA,Hallmayer JF,Dolmetsch RE

更新日期：2013-11-14 00:00:00

abstract：:Bacterial adhesion pili are designed to bind specifically and maintain attachment of bacteria to target cells. Uropathogenic P-pili are sufficiently mechanically resilient to resist the cleansing action of urine flow that removes most other bacteria. P-pili are 68 A in diameter and approximately 1 micron long, and are...

journal_title：Nature

authors： Bullitt E,Makowski L

更新日期：1995-01-12 00:00:00

abstract：:The global burden of malaria has been substantially reduced over the past two decades. Future efforts to reduce malaria further will require moving beyond the treatment of clinical infections to targeting malaria transmission more broadly in the community. As such, the accurate identification of asymptomatic human inf...

journal_title：Nature

authors： Wu L,van den Hoogen LL,Slater H,Walker PG,Ghani AC,Drakeley CJ,Okell LC

更新日期：2015-12-03 00:00:00

abstract：:Numerous reports have emphasized the need for major changes in the global food system: agriculture must meet the twin challenge of feeding a growing population, with rising demand for meat and high-calorie diets, while simultaneously minimizing its global environmental impacts. Organic farming—a system aimed at produc...

journal_title：Nature

authors： Seufert V,Ramankutty N,Foley JA

更新日期：2012-05-10 00:00:00

abstract：:Landscapes modified by glacial erosion show a distinct distribution of surface area with elevation (hypsometry). In particular, the height of these regions is influenced by climatic gradients controlling the altitude where glacial and periglacial processes are the most active, and as a result, surface area is focused ...

journal_title：Nature

authors： Pedersen VK,Egholm DL

更新日期：2013-01-10 00:00:00

abstract：:Type II DNA topoisomerases are ubiquitous ATP-dependent enzymes capable of transporting a DNA through a transient double-strand break in a second DNA segment. This enables them to untangle DNA and relax the interwound supercoils (plectonemes) that arise in twisted DNA. In vivo, they are responsible for untangling repl...

journal_title：Nature

authors： Strick TR,Croquette V,Bensimon D

更新日期：2000-04-20 00:00:00

abstract：:Inflammasomes are intracellular protein complexes that drive the activation of inflammatory caspases. So far, four inflammasomes involving NLRP1, NLRP3, NLRC4 and AIM2 have been described that recruit the common adaptor protein ASC to activate caspase-1, leading to the secretion of mature IL-1β and IL-18 proteins. The...

journal_title：Nature

authors： He Y,Zeng MY,Yang D,Motro B,Núñez G

更新日期：2016-02-18 00:00:00

abstract：:The collagens represent an interesting example of a structurally related but genetically distinct family of proteins. Type I, the most abundant of the vertebrate collagens, comprises two pro alpha 1(I) chains and one pro alpha 2(I) chain, each containing terminal propeptides and a central domain of 338 (Gly, X, Y) rep...

journal_title：Nature

authors： Chu ML,de Wet W,Bernard M,Ding JF,Morabito M,Myers J,Williams C,Ramirez F

更新日期：1984-07-26 00:00:00

abstract：:In associative learning, the activated neurones undergo a variety of concomitant functional alterations--increases or decreases of firing activity and modifications of membrane potential or resistance and of synaptic responsiveness. Synaptic transmission which can be strengthened only when there is paired activity in ...

journal_title：Nature

authors： Baranyi A,Fehér O

更新日期：1981-04-02 00:00:00

abstract：:Molecular approaches to understanding the functional circuitry of the nervous system promise new insights into the relationship between genes, brain and behaviour. The cellular diversity of the brain necessitates a cellular resolution approach towards understanding the functional genomics of the nervous system. We des...

journal_title：Nature

authors： Lein ES,Hawrylycz MJ,Ao N,Ayres M,Bensinger A,Bernard A,Boe AF,Boguski MS,Brockway KS,Byrnes EJ,Chen L,Chen L,Chen TM,Chin MC,Chong J,Crook BE,Czaplinska A,Dang CN,Datta S,Dee NR,Desaki AL,Desta T,Diep E,Dol

更新日期：2007-01-11 00:00:00

abstract：:Some bacteria are capable of extracellular electron transfer, thereby enabling them to use electron acceptors and donors without direct cell contact. Beyond the micrometre scale, however, no firm evidence has previously existed that spatially segregated biogeochemical processes can be coupled by electric currents in n...

journal_title：Nature

authors： Nielsen LP,Risgaard-Petersen N,Fossing H,Christensen PB,Sayama M

更新日期：2010-02-25 00:00:00

abstract：:Human apolipoprotein E has three isoforms: APOE2, APOE3 and APOE4. APOE4 is a major genetic risk factor for Alzheimer's disease and is associated with Down's syndrome dementia and poor neurological outcome after traumatic brain injury and haemorrhage. Neurovascular dysfunction is present in normal APOE4 carriers and i...

journal_title：Nature

authors： Bell RD,Winkler EA,Singh I,Sagare AP,Deane R,Wu Z,Holtzman DM,Betsholtz C,Armulik A,Sallstrom J,Berk BC,Zlokovic BV

更新日期：2012-05-16 00:00:00

abstract：:Flash spectra of the total solar eclipse throughout all its phases have been obtained in the extreme ultraviolet for the first time. ...

journal_title：Nature

authors： Speer RJ,Garton WR,Morgan JF,Nicholls RW,Goldberg L,Parkinson WH,Reeves EM,Jones TJ,Paxton HJ,Shenton DB,Wilson R

更新日期：1970-04-18 00:00:00

abstract：:The protein TFIIB is a general transcription initiation factor that interacts with a promoter complex (D.DNA) containing the TATA-binding subunit (TFIID tau, or TBP) of TFIID to facilitate subsequent interaction with RNA polymerase II (ref. 2) through the associated TFIIF (ref. 3). The potential bridging function of T...

journal_title：Nature

authors： Hisatake K,Roeder RG,Horikoshi M

更新日期：1993-06-24 00:00:00

abstract：:Mitogen-activated protein kinases, MAP kinases or ERKs (extracellular signal-regulated kinases) are rapidly stimulated by growth-promoting factors acting on a variety of cell-surface receptors. In turn, ERKs phosphorylate and regulate key intracellular enzymes and transcription factors involved in the control of cellu...

journal_title：Nature

authors： Crespo P,Xu N,Simonds WF,Gutkind JS

更新日期：1994-06-02 00:00:00

abstract：:The Ca2+ + Mg2+-activated ATPase of the sarcoplasmic reticulum is responsible for the active Ca2+ transport of this membrane system, the key feature of which is the formation of an energy-rich phosphorylated transport enzyme (EP) and its conversion. To understand the Ca2+-transport mechanism, it is essential to clarif...

journal_title：Nature

authors： Takisawa H,Makinose M

更新日期：1981-03-19 00:00:00

abstract：:Caste differentiation and division of labour are the hallmarks of insect societies and at the root of their ecological success. Kin selection predicts that caste determination should result from environmentally induced differences in gene expression, a prediction largely supported by empirical data. However, two excep...

journal_title：Nature

authors： Helms Cahan S,Keller L

更新日期：2003-07-17 00:00:00

abstract：:Cutaneous malignant melanoma is a highly aggressive and frequently chemoresistant cancer, the incidence of which continues to rise. Epidemiological studies show that the major aetiological melanoma risk factor is ultraviolet (UV) solar radiation, with the highest risk associated with intermittent burning doses, especi...

journal_title：Nature

authors： Zaidi MR,Davis S,Noonan FP,Graff-Cherry C,Hawley TS,Walker RL,Feigenbaum L,Fuchs E,Lyakh L,Young HA,Hornyak TJ,Arnheiter H,Trinchieri G,Meltzer PS,De Fabo EC,Merlino G

更新日期：2011-01-27 00:00:00

abstract：:Tracing the transient atomic motions that lie at the heart of chemical reactions requires high-resolution multidimensional structural information on the timescale of molecular vibrations, which commonly range from 10 fs to 1 ps. For simple chemical systems, it has been possible to map out in considerable detail the re...

journal_title：Nature

authors： Fang C,Frontiera RR,Tran R,Mathies RA

更新日期：2009-11-12 00:00:00

abstract：:The additional author support information was erroneously omitted from the Supplementary Information. This has been corrected online. ...

journal_title：Nature

authors： Hilf N,Kuttruff-Coqui S,Frenzel K,Bukur V,Stevanović S,Gouttefangeas C,Platten M,Tabatabai G,Dutoit V,van der Burg SH,Straten PT,Martinez-Ricarte F,Ponsati B,Okada H,Lassen U,Admon A,Ottensmeier CH,Ulges A,Kreiter S,

更新日期：2019-02-01 00:00:00

abstract：:The North Atlantic Oscillation (NAO) is the major source of variability in winter atmospheric circulation in the Northern Hemisphere, with large impacts on temperature, precipitation and storm tracks, and therefore also on strategic sectors such as insurance, renewable energy production, crop yields and water manageme...

journal_title：Nature

authors： Ortega P,Lehner F,Swingedouw D,Masson-Delmotte V,Raible CC,Casado M,Yiou P

更新日期：2015-07-02 00:00:00

abstract：:A single U leads to G transversion in the 3' consensus sequence AAUAAA of the adenovirus early region 1A gene was constructed and the effect of this mutation on processing of the 3' end of the nuclear early region 1A RNAs was analysed. The results demonstrate that the intact AAUAAA is not required for RNA polyadenylat...

journal_title：Nature

authors： Montell C,Fisher EF,Caruthers MH,Berk AJ

更新日期：1983-10-13 00:00:00

abstract：:Slower recovery from perturbations near a tipping point and its indirect signatures in fluctuation patterns have been suggested to foreshadow catastrophes in a wide variety of systems. Recent studies of populations in the field and in the laboratory have used time-series data to confirm some of the theoretically predi...

journal_title：Nature

authors： Dai L,Korolev KS,Gore J

更新日期：2013-04-18 00:00:00

abstract：:The idea that natural selection on genes might be detected using only a single genome has been put forward by Plotkin and colleagues, who present a method that they claim can detect selection without the need for comparative data and which, if correct, would confer greater power of analysis with less information. Here...

journal_title：Nature

authors： Hahn MW,Mezey JG,Begun DJ,Gillespie JH,Kern AD,Langley CH,Moyle LC

更新日期：2005-01-20 00:00:00

abstract：:The giant polytene chromosomes of Drosophila melanogaster have long been of interest to the geneticist because of the visible map of the genome provided by their characteristic banding patterns. An issue in the understanding of the molecular basis of chromosome banding has been whether the chromosomal DNA is replicate...

journal_title：Nature

authors： Spierer A,Spierer P

更新日期：1984-01-12 00:00:00