Genome-wide atlas of gene expression in the adult mouse brain.

abstract：:In the adult brain, new synapses are formed and pre-existing ones are lost, but the function of this structural plasticity has remained unclear. Learning of new skills is correlated with formation of new synapses. These may directly encode new memories, but they may also have more general roles in memory encoding and ...

journal_title：Nature

authors： Ruediger S,Vittori C,Bednarek E,Genoud C,Strata P,Sacchetti B,Caroni P

更新日期：2011-05-26 00:00:00

abstract：:Practice, with feedback, is a fundamental variable that influences the aquisition of motor skills: with it, everyone improves, but some improve more than others. This simple fact has led to frequent debate over the relative importance of genetic and environmental influences on motor learning. In principle these factor...

journal_title：Nature

authors： Fox PW,Hershberger SL,Bouchard TJ Jr

更新日期：1996-11-28 00:00:00

abstract：:Multiple sclerosis is thought to be an autoimmune disease of the central nervous system mediated by T cells specific for a myelin antigen. Myelin basic protein has been studied as a potential autoantigen in the disease because of its role as an encephalitogen in experimental autoimmune encephalomyelitis and post-viral...

journal_title：Nature

authors： Ota K,Matsui M,Milford EL,Mackin GA,Weiner HL,Hafler DA

更新日期：1990-07-12 00:00:00

abstract：:The mouse genetic revolution has shown repeatedly that most organs have more functions than expected. This has led to the realization that, in addition to a molecular and cellular approach, there is a need for a whole-organism study of physiology. The skeleton is an example of how a whole-organism approach to physiolo...

journal_title：Nature

authors： Karsenty G,Ferron M

更新日期：2012-01-18 00:00:00

abstract：:Scanning probe microscopy is a versatile and powerful method that uses sharp tips to image, measure and manipulate matter at surfaces with atomic resolution. At cryogenic temperatures, scanning probe microscopy can even provide electron tunnelling spectra that serve as fingerprints of the vibrational properties of ads...

journal_title：Nature

authors： Sugimoto Y,Pou P,Abe M,Jelinek P,Pérez R,Morita S,Custance O

更新日期：2007-03-01 00:00:00

abstract：:Theory predicts that sexual behaviour in animals can evolve rapidly, accelerating the rate of species formation. Here we estimate the rate of speciation in Laupala, a group of forest-dwelling Hawaiian crickets that is characterized primarily through differences in male courtship song. We find that Laupala has the high...

journal_title：Nature

authors： Mendelson TC,Shaw KL

更新日期：2005-01-27 00:00:00

abstract：:Using data on the global distribution of mammal, bird and amphibian species, Grenyer et al. conclude that planning based on individual taxa does not provide efficient solutions for the conservation of other taxa. They also report that the performance of existing global conservation strategies-endemic bird areas, biodi...

journal_title：Nature

authors： Rodrigues AS

更新日期：2007-12-06 00:00:00

abstract：:Efforts to ablate soft tissue with conventional lasers have been limited by collateral damage and by concern over potential photochemical effects. Motivated by the thermal-confinement model, past infrared investigations targeted the OH-stretch mode of water with fast pulses from lasers emitting near 3,000 nm (refs 1, ...

journal_title：Nature

authors： Edwards G,Logan R,Copeland M,Reinisch L,Davidson J,Johnson B,Maciunas R,Mendenhall M,Ossoff R,Tribble J

更新日期：1994-09-29 00:00:00

abstract：:Immunoprecipitation and tryptic peptide analysis of newly synthesized proteins from rat islets have identified an 18,000 molecular weight (MW) protein as proglucagon. Conversion of this precursor was kinetically similar to the conversion of proinsulin and resulted in the formation of both pancreatic glucagon and a 10,...

journal_title：Nature

authors： Patzelt C,Tager HS,Carroll RJ,Steiner DF

更新日期：1979-11-15 00:00:00

abstract：:The kinesin superfamily is a class of microtubule-based mechano-enzymes involved in intracellular transport and chromosome movements. Molecules that move towards either the plus end or the minus end of microtubules are represented within the family. The motor domains of these molecules exhibit considerable sequence ho...

journal_title：Nature

authors： Hoenger A,Sablin EP,Vale RD,Fletterick RJ,Milligan RA

更新日期：1995-07-20 00:00:00

abstract：:Because it is so tall, the giraffe, Giraffa camelopardalis, provides an important animal model for investigating adaptive mechanisms to orthostatic (gravitational) pressure changes. Previous physiological studies of the giraffe have concentrated on arterial blood pressures in the heart and neck. Briefly, these investi...

journal_title：Nature

authors： Hargens AR,Millard RW,Pettersson K,Johansen K

更新日期：1987-09-03 00:00:00

abstract：:Growing populations and agricultural intensification have led to raised riverine nitrogen (N) loads, widespread oxygen depletion in coastal zones (coastal hypoxia)1 and increases in the incidence of algal blooms.Although recent work has suggested that individual wetlands have the potential to improve water quality2-9,...

journal_title：Nature

authors： Cheng FY,Van Meter KJ,Byrnes DK,Basu NB

更新日期：2020-12-01 00:00:00

abstract：:The commitment of non-dividing cells (in G0) to enter division can be studied using primary cultures of lymphocytes. The cells are stable in G0 unless stimulated by mitogen such as concanavalin A (Con A). Commitment to enter the division cycle depends on the expression of gene(s) induced by Con A and the synthesis of ...

journal_title：Nature

authors： Milner J

更新日期：1984-07-12 00:00:00

abstract：:With the current shortage in fetal bovine serum, researchers are turning to a variety of options for cell and tissue culture. ...

journal_title：Nature

authors： Jayme DW,Epstein DA,Conrad DR

更新日期：1988-08-11 00:00:00

abstract：:Most species live in species-rich food webs; yet, for a century, most mathematical models for population dynamics have included only one or two species. We ask whether such models are relevant to the real world. Two-species population models of an interacting consumer and resource collapse to one-species dynamics when...

journal_title：Nature

authors： Murdoch WW,Kendall BE,Nisbet RM,Briggs CJ,McCauley E,Bolser R

更新日期：2002-05-30 00:00:00

abstract：:Contraction of cardiac muscle depends on a transient rise of intracellular calcium concentration ([Ca2+]i) which is initiated by the action potential. It has, however, also been suggested that [Ca2+]i can fluctuate in the absence of changes in membrane potential. The evidence for this is indirect and comes from observ...

journal_title：Nature

authors： Orchard CH,Eisner DA,Allen DG

更新日期：1983-08-25 00:00:00

abstract：:A continuous array of overlapping clones covering the entire human chromosome 21q was constructed from human yeast artificial chromosome libraries using sequence-tagged sites as landmarks specifically detected by polymerase chain reaction. The yeast artificial chromosome contiguous unit starts with pericentromeric and...

journal_title：Nature

authors： Chumakov I,Rigault P,Guillou S,Ougen P,Billaut A,Guasconi G,Gervy P,LeGall I,Soularue P,Grinas L

更新日期：1992-10-01 00:00:00

abstract：:The ability to grow properly sized and good quality crystals is one of the cornerstones of single-crystal diffraction, is advantageous in many industrial-scale chemical processes1-3, and is important for obtaining institutional approvals of new drugs for which high-quality crystallographic data are required4-7. Typica...

journal_title：Nature

authors： Sun JK,Sobolev YI,Zhang W,Zhuang Q,Grzybowski BA

更新日期：2020-03-01 00:00:00

abstract：:Bioluminescent symbioses range from facultative associations to highly adapted, apparently obligate ones. The family Anomalopidae (flashlight fishes) encompasses five genera of tropical reef fishes that have large suborbital light organs. The suborder Ceratioidei (deep-sea anglerfishes) contains 11 families. In nine o...

journal_title：Nature

authors： Haygood MG,Distel DL

更新日期：1993-05-13 00:00:00

abstract：:The distribution of fitness effects of protein mutations is still unknown. Of particular interest is whether accumulating deleterious mutations interact, and how the resulting epistatic effects shape the protein's fitness landscape. Here we apply a model system in which bacterial fitness correlates with the enzymatic ...

journal_title：Nature

authors： Bershtein S,Segal M,Bekerman R,Tokuriki N,Tawfik DS

更新日期：2006-12-14 00:00:00

abstract：:The CD4 subset of cells displays helper/inducer activity and recognizes class II antigens of the major histocompatibility complex (MHC), while the CD8 subset recognizes class I MHC antigens and exhibits cytotoxic or suppressor function. Considerable functional as well as corresponding phenotypic heterogeneity exists w...

journal_title：Nature

authors： Morimoto C,Rudd CE,Letvin NL,Schlossman SF

更新日期：1987-12-03 00:00:00

abstract：:The spindle checkpoint prevents chromosome mis-segregation by delaying sister chromatid separation until all chromosomes have achieved bipolar attachment to the mitotic spindle. Its operation is essential for accurate chromosome segregation, whereas its dysregulation can contribute to birth defects and tumorigenesis. ...

journal_title：Nature

authors： Stegmeier F,Rape M,Draviam VM,Nalepa G,Sowa ME,Ang XL,McDonald ER 3rd,Li MZ,Hannon GJ,Sorger PK,Kirschner MW,Harper JW,Elledge SJ

更新日期：2007-04-19 00:00:00

abstract：:Patterns in natural systems abound, from the stripes on a zebra to ripples in a riverbed. In many of these systems, the appearance of an ordered state is not unexpected as the outcome of an underlying ordered process. Thus crystal growth, honeycomb manufacture and floret evolution generate regular and predictable patt...

journal_title：Nature

authors： Shinbrot T,Muzzio FJ

更新日期：2001-03-08 00:00:00

abstract：:Of the vertebrate senses, touch is the least understood at the molecular level The ion channels that form the core of the mechanosensory complex and confer touch sensitivity remain unknown. However, the similarity of the brain sodium channel 1 (BNC1) to nematode proteins involved in mechanotransduction indicated that ...

journal_title：Nature

authors： Price MP,Lewin GR,McIlwrath SL,Cheng C,Xie J,Heppenstall PA,Stucky CL,Mannsfeldt AG,Brennan TJ,Drummond HA,Qiao J,Benson CJ,Tarr DE,Hrstka RF,Yang B,Williamson RA,Welsh MJ

更新日期：2000-10-26 00:00:00

abstract：:T-cell differentiation in the thymus is thought to involve a progression from the CD4-CD8- phenotype through CD4+CD8+ intermediates to mature CD4+ or CD8+ cells. There is evidence that during this process T cells bearing receptors potentially reactive to 'self' are deleted by a process termed 'negative selection' One ...

journal_title：Nature

authors： Berg LJ,Fazekas de St Groth B,Pullen AM,Davis MM

更新日期：1989-08-17 00:00:00

abstract：:In this Article, owing to an error during the production process, in Fig. 1a, the dark blue and light blue wedges were incorrectly labelled as 'G•C → T•A' and 'G•C → A•T', instead of 'C•G → T•A' and 'C•G → A•T', respectively. Fig. 1 has been corrected online. ...

journal_title：Nature

authors： Gaudelli NM,Komor AC,Rees HA,Packer MS,Badran AH,Bryson DI,Liu DR

更新日期：2018-07-01 00:00:00

abstract：:Cell-free DNA in the blood provides a non-invasive diagnostic avenue for patients with cancer1. However, characteristics of the origins and molecular features of cell-free DNA are poorly understood. Here we developed an approach to evaluate fragmentation patterns of cell-free DNA across the genome, and found that prof...

journal_title：Nature

authors： Cristiano S,Leal A,Phallen J,Fiksel J,Adleff V,Bruhm DC,Jensen SØ,Medina JE,Hruban C,White JR,Palsgrove DN,Niknafs N,Anagnostou V,Forde P,Naidoo J,Marrone K,Brahmer J,Woodward BD,Husain H,van Rooijen KL,Ørntoft MW

更新日期：2019-06-01 00:00:00

abstract：:The most unique feature of Earth is the existence of life, and the most extraordinary feature of life is its diversity. Approximately 9 million types of plants, animals, protists and fungi inhabit the Earth. So, too, do 7 billion people. Two decades ago, at the first Earth Summit, the vast majority of the world's nati...

journal_title：Nature

authors： Cardinale BJ,Duffy JE,Gonzalez A,Hooper DU,Perrings C,Venail P,Narwani A,Mace GM,Tilman D,Wardle DA,Kinzig AP,Daily GC,Loreau M,Grace JB,Larigauderie A,Srivastava DS,Naeem S

更新日期：2012-06-06 00:00:00

abstract：:Assembly of multi-component supramolecular machines is fundamental to biology, yet in most cases, assembly pathways and their control are poorly understood. An example is the type III secretion machine, which mediates the transfer of bacterial virulence proteins into host cells. A central component of this nanomachine...

journal_title：Nature

authors： Marlovits TC,Kubori T,Lara-Tejero M,Thomas D,Unger VM,Galán JE

更新日期：2006-06-01 00:00:00

abstract：:Somatic sexual differentiation in Drosophila melanogaster involves a cascade of regulated splicing events and provides an attractive model system for the analysis of alternative splicing mechanisms. The protein Sex-lethal (Sxl) activates a female-specific 3' splice site in the first intron of transformer (tra) pre-mRN...

journal_title：Nature

authors： Valcárcel J,Singh R,Zamore PD,Green MR

更新日期：1993-03-11 00:00:00