Summits that matter.

abstract：:Melanoma is a tumour of transformed melanocytes, which are originally derived from the embryonic neural crest. It is unknown to what extent the programs that regulate neural crest development interact with mutations in the BRAF oncogene, which is the most commonly mutated gene in human melanoma. We have used zebrafish...

journal_title：Nature

authors： White RM,Cech J,Ratanasirintrawoot S,Lin CY,Rahl PB,Burke CJ,Langdon E,Tomlinson ML,Mosher J,Kaufman C,Chen F,Long HK,Kramer M,Datta S,Neuberg D,Granter S,Young RA,Morrison S,Wheeler GN,Zon LI

更新日期：2011-03-24 00:00:00

abstract：:Interfacing a single photon with another quantum system is a key capability in modern quantum information science. It allows quantum states of matter, such as spin states of atoms, atomic ensembles or solids, to be prepared and manipulated by photon counting and, in particular, to be distributed over long distances. S...

journal_title：Nature

authors： Riedinger R,Hong S,Norte RA,Slater JA,Shang J,Krause AG,Anant V,Aspelmeyer M,Gröblacher S

更新日期：2016-02-18 00:00:00

abstract：:Organ-specific metastasis is governed, in part, by interactions between chemokine receptors on cancer cells and matching chemokines in target organs. For example, malignant breast cancer cells express the chemokine receptor CXCR4 and commonly metastasize to organs that are an abundant source of the CXCR4-specific liga...

journal_title：Nature

authors： Staller P,Sulitkova J,Lisztwan J,Moch H,Oakeley EJ,Krek W

更新日期：2003-09-18 00:00:00

abstract：:A key event in the domestication and breeding of the oil palm Elaeis guineensis was loss of the thick coconut-like shell surrounding the kernel. Modern E. guineensis has three fruit forms, dura (thick-shelled), pisifera (shell-less) and tenera (thin-shelled), a hybrid between dura and pisifera. The pisifera palm is us...

journal_title：Nature

authors： Singh R,Low ET,Ooi LC,Ong-Abdullah M,Ting NC,Nagappan J,Nookiah R,Amiruddin MD,Rosli R,Manaf MA,Chan KL,Halim MA,Azizi N,Lakey N,Smith SW,Budiman MA,Hogan M,Bacher B,Van Brunt A,Wang C,Ordway JM,Sambanthamurthi

更新日期：2013-08-15 00:00:00

abstract：:Transgenic mice bearing the cellular myc oncogene coupled to the immunoglobulin mu or kappa enhancer frequently develop a fatal lymphoma within a few months of birth. Since the tumours represent represent both immature and mature B lymphocytes, constitutive c-myc expression appears to be highly leukaemogenic at severa...

journal_title：Nature

authors： Adams JM,Harris AW,Pinkert CA,Corcoran LM,Alexander WS,Cory S,Palmiter RD,Brinster RL

更新日期：1985-12-12 00:00:00

abstract：:Archaeal and eukaryotic translation elongation factor 2 contain a unique post-translationally modified histidine residue called diphthamide, which is the target of diphtheria toxin. The biosynthesis of diphthamide was proposed to involve three steps, with the first being the formation of a C-C bond between the histidi...

journal_title：Nature

authors： Zhang Y,Zhu X,Torelli AT,Lee M,Dzikovski B,Koralewski RM,Wang E,Freed J,Krebs C,Ealick SE,Lin H

更新日期：2010-06-17 00:00:00

abstract：: ...

journal_title：Nature

authors： Bietz A

更新日期：2018-11-01 00:00:00

abstract：:The Pacific oyster Crassostrea gigas belongs to one of the most species-rich but genomically poorly explored phyla, the Mollusca. Here we report the sequencing and assembly of the oyster genome using short reads and a fosmid-pooling strategy, along with transcriptomes of development and stress response and the proteom...

journal_title：Nature

authors： Zhang G,Fang X,Guo X,Li L,Luo R,Xu F,Yang P,Zhang L,Wang X,Qi H,Xiong Z,Que H,Xie Y,Holland PW,Paps J,Zhu Y,Wu F,Chen Y,Wang J,Peng C,Meng J,Yang L,Liu J,Wen B,Zhang N,Huang Z,Zhu Q,Feng Y,Mount A

更新日期：2012-10-04 00:00:00

abstract：:The domestication of dogs was an important episode in the development of human civilization. The precise timing and location of this event is debated and little is known about the genetic changes that accompanied the transformation of ancient wolves into domestic dogs. Here we conduct whole-genome resequencing of dogs...

journal_title：Nature

authors： Axelsson E,Ratnakumar A,Arendt ML,Maqbool K,Webster MT,Perloski M,Liberg O,Arnemo JM,Hedhammar A,Lindblad-Toh K

更新日期：2013-03-21 00:00:00

abstract：:Mitochondria take up and extrude various inorganic and organic ions, as well as larger substances such as proteins. The technique of patch clamping should provide real-time information on such transport and on energy transduction in oxidative phosphorylation. It has been applied to detect microscopic currents from mit...

journal_title：Nature

authors： Inoue I,Nagase H,Kishi K,Higuti T

更新日期：1991-07-18 00:00:00

abstract：:Polycomb group proteins have an essential role in the epigenetic maintenance of repressive chromatin states. The gene-silencing activity of the Polycomb repressive complex 2 (PRC2) depends on its ability to trimethylate lysine 27 of histone H3 (H3K27) by the catalytic SET domain of the EZH2 subunit, and at least two o...

journal_title：Nature

authors： Margueron R,Justin N,Ohno K,Sharpe ML,Son J,Drury WJ 3rd,Voigt P,Martin SR,Taylor WR,De Marco V,Pirrotta V,Reinberg D,Gamblin SJ

更新日期：2009-10-08 00:00:00

abstract：:Neurons in the visual cortex respond preferentially to edge-like stimuli of a particular orientation. It is a long-standing hypothesis that orientation selectivity arises during development through the activity-dependent refinement of cortical circuitry. Unambiguous evidence for such a process has, however, remained e...

journal_title：Nature

authors： Wolf F,Geisel T

更新日期：1998-09-03 00:00:00

abstract：:The T-cell specific, rearranging gamma-chain genes bear striking resemblance to T-cell receptor and immunoglobulin genes, but the role of gamma remains unknown. A central problem is to understand the conditions under which gamma RNA is expressed in cells. The transcription of gamma is abundant in T cells of fetal thym...

journal_title：Nature

authors： Jones B,Mjolsness S,Janeway C Jr,Hayday AC

更新日期：1986-10-16 00:00:00

abstract：:Relative motion is one of the most salient cues for segmentation of a visual scene into separate objects. This is illustrated by the vivid contours that are perceived when random dot patterns move in different directions. Once motion is halted in such displays the segmentation contours disappear. This makes random dot...

journal_title：Nature

authors： Lamme VA,van Dijk BW,Spekreijse H

更新日期：1993-06-10 00:00:00

abstract：:Transcriptional activator proteins (activators) function, at least in part, by increasing preinitiation complex assembly (for reviews see refs 1-4). Previous studies have shown that an acidic activator forms a contact with the general transcription factor TFIIB (refs 5-7) and recruits it into the preinitiation complex...

journal_title：Nature

authors： Roberts SG,Green MR

更新日期：1994-10-20 00:00:00

abstract：:A family of G-protein-coupled chemoattractant receptors is known to mediate the transport and activation of neutrophils and macrophages This family includes receptors for chemokines, such as interleukin-8, bacterial formylated peptides, platelet-activating factor, leukotriene B4, and the complement anaphylatoxins. The...

journal_title：Nature

authors： Höpken UE,Lu B,Gerard NP,Gerard C

更新日期：1996-09-05 00:00:00

abstract：:In fission yeast, meiosis is initiated by transcriptional activation of the mei3+ gene, under the combined influence of the four mating-type genes. The product of the mei3+ gene acts as a critical meiotic inducer by binding non-covalently to a newly identified protein kinase encoded by the ran1+ gene and inhibiting it...

journal_title：Nature

authors： McLeod M,Beach D

更新日期：1988-04-07 00:00:00

abstract：:The mouse genetic revolution has shown repeatedly that most organs have more functions than expected. This has led to the realization that, in addition to a molecular and cellular approach, there is a need for a whole-organism study of physiology. The skeleton is an example of how a whole-organism approach to physiolo...

journal_title：Nature

authors： Karsenty G,Ferron M

更新日期：2012-01-18 00:00:00

abstract：:Neuroectoderm cells in the cortical ventricular zone generate many diverse cell types, maintain the ventricular zone during embryonic life and create another germinal layer, the subventricular zone, which persists into adulthood. In other vertebrate tissues, including skin, intestine, blood and neural crest, stem cell...

journal_title：Nature

authors： Davis AA,Temple S

更新日期：1994-11-17 00:00:00

abstract：:Citrullination is the post-translational conversion of an arginine residue within a protein to the non-coded amino acid citrulline. This modification leads to the loss of a positive charge and reduction in hydrogen-bonding ability. It is carried out by a small family of tissue-specific vertebrate enzymes called peptid...

journal_title：Nature

authors： Christophorou MA,Castelo-Branco G,Halley-Stott RP,Oliveira CS,Loos R,Radzisheuskaya A,Mowen KA,Bertone P,Silva JC,Zernicka-Goetz M,Nielsen ML,Gurdon JB,Kouzarides T

更新日期：2014-03-06 00:00:00

abstract：:Drosophila mutants transformed with a chimaeric gene that expresses the ocellar visual pigment in the major class of photoreceptor cells of the retina were used to investigate the properties of this minor pigment. The photoreceptor cells in which this opsin was misexpressed showed new spectral characteristics and phys...

journal_title：Nature

authors： Feiler R,Harris WA,Kirschfeld K,Wehrhahn C,Zuker CS

更新日期：1988-06-23 00:00:00

abstract：:Insect eyes have an anti-reflective coating, owing to nanostructures on the corneal surface creating a gradient of refractive index between that of air and that of the lens material1,2. These nanocoatings have also been shown to provide anti-adhesive functionality3. The morphology of corneal nanocoatings are very dive...

journal_title：Nature

authors： Kryuchkov M,Bilousov O,Lehmann J,Fiebig M,Katanaev VL

更新日期：2020-09-01 00:00:00

abstract：:Visual stimuli can acquire positive or negative value through their association with rewards and punishments, a process called reinforcement learning. Although we now know a great deal about how the brain analyses visual information, we know little about how visual representations become linked with values. To study t...

journal_title：Nature

authors： Paton JJ,Belova MA,Morrison SE,Salzman CD

更新日期：2006-02-16 00:00:00

abstract：:Contamination of ground waters with water-soluble aromatic hydrocarbons, common components of petroleum pollution, often produces anoxic conditions under which microbial degradation of the aromatics is slow. Oxygen is often added to contaminated ground water to stimulate biodegradation, but this can be technically dif...

journal_title：Nature

authors： Lovley DR,Woodward JC,Chapelle FH

更新日期：1994-07-14 00:00:00

abstract：:During development, cells interpret complex and often conflicting signals to make optimal decisions. Plant stomata, the cellular interface between a plant and the atmosphere, develop according to positional cues, which include a family of secreted peptides called epidermal patterning factors (EPFs). How these signalli...

journal_title：Nature

authors： Lee JS,Hnilova M,Maes M,Lin YC,Putarjunan A,Han SK,Avila J,Torii KU

更新日期：2015-06-25 00:00:00

abstract：:Chromatin is traditionally viewed as a nuclear entity that regulates gene expression and silencing. However, we recently discovered the presence of cytoplasmic chromatin fragments that pinch off from intact nuclei of primary cells during senescence, a form of terminal cell-cycle arrest associated with pro-inflammatory...

journal_title：Nature

authors： Dou Z,Ghosh K,Vizioli MG,Zhu J,Sen P,Wangensteen KJ,Simithy J,Lan Y,Lin Y,Zhou Z,Capell BC,Xu C,Xu M,Kieckhaefer JE,Jiang T,Shoshkes-Carmel M,Tanim KMAA,Barber GN,Seykora JT,Millar SE,Kaestner KH,Garcia BA,Ada

更新日期：2017-10-19 00:00:00

abstract：: ...

journal_title：Nature

authors： Kelly S,Carrington M

更新日期：2018-11-01 00:00:00

abstract：:RNA is involved in many biological functions, ranging from information storage and transfer to the catalysis of reactions involving both nucleic acids and proteins. Previous crystallographic studies on RNA oligomeric chains provide only averaged structures or information limited in resolution. The oligomer [U(U-A)6A]2...

journal_title：Nature

authors： Dock-Bregeon AC,Chevrier B,Podjarny A,Moras D,deBear JS,Gough GR,Gilham PT,Johnson JE

更新日期：1988-09-22 00:00:00

abstract：: ...

journal_title：Nature

authors： Savage N

更新日期：2018-12-01 00:00:00

abstract：:The separation of ON and OFF channels and the development of an antagonistic surround occur at the first synapse in the vertebrate retina. This functional differentiation is mediated by the action of the photoreceptor neurotransmitter on the ON bipolar, OFF bipolar and horizontal cells, respectively. Glutamate mimics ...

journal_title：Nature

authors： Slaughter MM,Miller RF

更新日期：1985-03-07 00:00:00