Similar level of polyteny in bands and interbands of Drosophila giant chromosomes.

abstract：:The expression of immunodeficiency in patients with specific purine enzyme defects indicates a crucial role of the purine salvage pathway in the acquisition and expression of normal immune function. One current hypothesis links the failure of normal lymphocyte development in these diseases to the accumulation of deoxy...

journal_title：Nature

authors： Dosch HM,Mansour A,Cohen A,Shore A,Gelfand EW

更新日期：1980-06-12 00:00:00

abstract：:Ecdysone in Drosophila has been a paradigm for steroid hormones since its ability to induce gene activity directly was demonstrated by its effects on moulting and polytene chromosome puffing. The ecdysone receptor (EcR) was recently confirmed as a member of the nuclear receptor superfamily by cloning and characterizat...

journal_title：Nature

authors： Thomas HE,Stunnenberg HG,Stewart AF

更新日期：1993-04-01 00:00:00

abstract：:The T-cell receptor is a cell surface heterodimer consisting of an alpha and a beta chain that binds foreign antigen in the context of a cell surface molecule encoded by the major histocompatibility complex (MHC), thus restricting the T-cell response to the surface of antigen presenting cells. The variable (V) domain ...

journal_title：Nature

authors： Winoto A,Urban JL,Lan NC,Goverman J,Hood L,Hansburg D

更新日期：1986-12-18 00:00:00

abstract：:In vertebrates the developing hindbrain is organized in segmental units. These units provide the primary grid for differentiation and axonal outgrowth. In the more anterior regions of the brain, however, the subdivisions remain more controversial. Cellular and molecular studies of the embryonic brain in lower vertebra...

journal_title：Nature

authors： Krauss S,Johansen T,Korzh V,Fjose A

更新日期：1991-09-19 00:00:00

abstract：:Protein modification by the conjugation of ubiquitin moieties--ubiquitination--plays a major part in many biological processes, including cell cycle and apoptosis. The enzymes that mediate ubiquitin-conjugation have been well-studied, but much less is known about the ubiquitin-specific proteases that mediate de-ubiqui...

journal_title：Nature

authors： Brummelkamp TR,Nijman SM,Dirac AM,Bernards R

更新日期：2003-08-14 00:00:00

abstract：:Amyloid beta-protein (AP) is a peptide of relative molecular mass (Mr) 42,000 found in the senile plaques, cerebrovascular amyloid deposits, and neurofibrillary tangles of patients with Alzheimer's disease and Down's syndrome (trisomy 21). Recent molecular genetic evidence has indicated that AP is encoded as part of a...

journal_title：Nature

authors： Tanzi RE,St George-Hyslop PH,Haines JL,Polinsky RJ,Nee L,Foncin JF,Neve RL,McClatchey AI,Conneally PM,Gusella JF

更新日期：1987-09-10 00:00:00

abstract：:Observations of cometary nuclei have revealed a very limited amount of surface water ice, which is insufficient to explain the observed water outgassing. This was clearly demonstrated on comet 9P/Tempel 1, where the dust jets (driven by volatiles) were only partially correlated with the exposed ice regions. The observ...

journal_title：Nature

authors： De Sanctis MC,Capaccioni F,Ciarniello M,Filacchione G,Formisano M,Mottola S,Raponi A,Tosi F,Bockelée-Morvan D,Erard S,Leyrat C,Schmitt B,Ammannito E,Arnold G,Barucci MA,Combi M,Capria MT,Cerroni P,Ip WH,Kuehrt E,M

更新日期：2015-09-24 00:00:00

abstract：:The rapid development of the silk glands of Bombyx mori during the last larval instar shows two phases. During the first 4 days, in both the middle and posterior parts of the silk glands, the ribosomal machinery is assembled and the synthesis of housekeeping proteins starts. During the second phase (the last 4 days), ...

journal_title：Nature

authors： Hentzen D,Chevallier A,Garel JP

更新日期：1981-03-19 00:00:00

abstract：:The homeobox is a 183-base-pair DNA sequence originally found in Drosophila segmentation and homeotic genes. In Drosophila, homeotic genes are clustered in the Antennapedia and Bithorax complexes, collectively called the homeotic gene complex (HOM-C). In the mouse genome, about 40 homeobox genes (Hox) are clustered in...

journal_title：Nature

authors： Tomotsune D,Shoji H,Wakamatsu Y,Kondoh H,Takahashi N

更新日期：1993-09-02 00:00:00

abstract：:The colorectal adenoma-carcinoma sequence has provided a paradigmatic framework for understanding the successive somatic genetic changes and consequent clonal expansions that lead to cancer1. However, our understanding of the earliest phases of colorectal neoplastic changes-which may occur in morphologically normal ti...

journal_title：Nature

authors： Lee-Six H,Olafsson S,Ellis P,Osborne RJ,Sanders MA,Moore L,Georgakopoulos N,Torrente F,Noorani A,Goddard M,Robinson P,Coorens THH,O'Neill L,Alder C,Wang J,Fitzgerald RC,Zilbauer M,Coleman N,Saeb-Parsy K,Martincorena

更新日期：2019-10-01 00:00:00

abstract：:The Borrmann effect-a dramatic increase in transparency to X-ray beams-is observed when X-rays satisfying Bragg's law diffract through a perfect crystal. The minimization of absorption seen in the Borrmann effect has been explained by noting that the electric field of the X-ray beam approaches zero amplitude at the cr...

journal_title：Nature

authors： Pettifer RF,Collins SP,Laundy D

更新日期：2008-07-10 00:00:00

abstract：:When integral membrane proteins are visualized in detergents or other artificial systems, an important layer of information is lost regarding lipid interactions and their effects on protein structure. This is especially relevant to proteins for which lipids have both structural and regulatory roles. Here we demonstrat...

journal_title：Nature

authors： Gao Y,Cao E,Julius D,Cheng Y

更新日期：2016-06-16 00:00:00

abstract：:Tau is one of the diverse group of microtubule-associated proteins that bind to microtubules and may thereby influence their structure and function. It occurs in the mammalian brain, mainly in axons, and is a component of the neurofibrillary tangles of Alzheimer's disease. Tau was recently sequenced, but there remains...

journal_title：Nature

authors： Lichtenberg B,Mandelkow EM,Hagestedt T,Mandelkow E

更新日期：1988-07-28 00:00:00

abstract：:Anti-cancer agents that have been made selective for tumour cells by exploiting the known differences in the availability of oxygen between normal and transformed cells are a promising development in cancer chemotherapy. We have recently suggested a new type of bioreductive activity which would depend on a two-electro...

journal_title：Nature

authors： Reynolds CA,King PM,Richards WG

更新日期：1988-07-07 00:00:00

abstract：:Acetylcholine (ACh) released on vagal stimulation reduces the heart rate by increasing K+ conductance of pacemaker cells in the sinoatrial (S-A) node. Fluctuation analysis of ACh-activated currents in pacemaker tissue showed this to be due to opening of a separate class of K+ channels gated by muscarinic ACh receptors...

journal_title：Nature

authors： Sakmann B,Noma A,Trautwein W

更新日期：1983-05-19 00:00:00

abstract：:Mutations of the presenilin-1 gene are a major cause of familial early-onset Alzheimer's disease. Presenilin-1 can associate with members of the catenin family of signalling proteins, but the significance of this association is unknown. Here we show that presenilin-1 forms a complex with beta-catenin in vivo that incr...

journal_title：Nature

authors： Zhang Z,Hartmann H,Do VM,Abramowski D,Sturchler-Pierrat C,Staufenbiel M,Sommer B,van de Wetering M,Clevers H,Saftig P,De Strooper B,He X,Yankner BA

更新日期：1998-10-15 00:00:00

abstract：:High mobility group 1 (HMGB1) protein is both a nuclear factor and a secreted protein. In the cell nucleus it acts as an architectural chromatin-binding factor that bends DNA and promotes protein assembly on specific DNA targets. Outside the cell, it binds with high affinity to RAGE (the receptor for advanced glycatio...

journal_title：Nature

authors： Scaffidi P,Misteli T,Bianchi ME

更新日期：2002-07-11 00:00:00

abstract：:Many homeobox genes are clustered in a linear array along a chromosome, reflecting their ordered expression along the anterior-posterior axis of the embryo. Expression patterns as well as grafting, ectopic expression and loss-of-function experiments suggest that the Hox genes encode a combinatorial system of positiona...

journal_title：Nature

authors： Roberts CW,Shutter JR,Korsmeyer SJ

更新日期：1994-04-21 00:00:00

abstract：:Initial studies of somatically acquired mutations in immunoglobulin V regions from hybridomas and myelomas that are not derived from joining aberrations, suggested a controlled and specific hypermutation process, because spontaneous mutation rates observed for other genes are extremely low. Some evidence for the idea ...

journal_title：Nature

authors： O'Brien RL,Brinster RL,Storb U

更新日期：1987-03-26 00:00:00

abstract：:Citrullination is the post-translational conversion of an arginine residue within a protein to the non-coded amino acid citrulline. This modification leads to the loss of a positive charge and reduction in hydrogen-bonding ability. It is carried out by a small family of tissue-specific vertebrate enzymes called peptid...

journal_title：Nature

authors： Christophorou MA,Castelo-Branco G,Halley-Stott RP,Oliveira CS,Loos R,Radzisheuskaya A,Mowen KA,Bertone P,Silva JC,Zernicka-Goetz M,Nielsen ML,Gurdon JB,Kouzarides T

更新日期：2014-03-06 00:00:00

abstract：: ...

journal_title：Nature

authors： Jia H

更新日期：2018-11-01 00:00:00

abstract：:Increasing population and consumption are placing unprecedented demands on agriculture and natural resources. Today, approximately a billion people are chronically malnourished while our agricultural systems are concurrently degrading land, water, biodiversity and climate on a global scale. To meet the world's future ...

journal_title：Nature

authors： Foley JA,Ramankutty N,Brauman KA,Cassidy ES,Gerber JS,Johnston M,Mueller ND,O'Connell C,Ray DK,West PC,Balzer C,Bennett EM,Carpenter SR,Hill J,Monfreda C,Polasky S,Rockström J,Sheehan J,Siebert S,Tilman D,Zaks DP

更新日期：2011-10-12 00:00:00

abstract：:Models and simulations of the epoch of reionization predict that spectra of the 21-centimetre transition of atomic hydrogen will show a clear fluctuation peak, at a redshift and scale, respectively, that mark the central stage of reionization and the characteristic size of ionized bubbles. This is based on the assumpt...

journal_title：Nature

authors： Fialkov A,Barkana R,Visbal E

更新日期：2014-02-13 00:00:00

abstract：:Type III collagen is often found in the same tissues as type I collagen, yet the function and nature of the fibrils formed by the two collagens differ markedly. To understand the evolutionary history of the collagen gene family in more detail, we isolated the gene for type III collagen and compared its structure with ...

journal_title：Nature

authors： Yamada Y,Liau G,Mudryj M,Obici S,de Crombrugghe B

更新日期：1984-07-26 00:00:00

abstract：:Joining dissimilar materials such as plastics and metals in engineered structures remains a challenge1. Mechanical fastening, conventional welding and adhesive bonding are examples of techniques currently used for this purpose, but each of these methods presents its own set of problems2 such as formation of stress con...

journal_title：Nature

authors： Rivera J,Hosseini MS,Restrepo D,Murata S,Vasile D,Parkinson DY,Barnard HS,Arakaki A,Zavattieri P,Kisailus D

更新日期：2020-10-01 00:00:00

abstract：:Topoisomerases relieve the torsional strain in DNA that is built up during replication and transcription. They are vital for cell proliferation and are a target for poisoning by anti-cancer drugs. Type IB topoisomerase (TopIB) forms a protein clamp around the DNA duplex and creates a transient nick that permits remova...

journal_title：Nature

authors： Koster DA,Croquette V,Dekker C,Shuman S,Dekker NH

更新日期：2005-03-31 00:00:00

abstract：:Mammal-like reptiles of the order Therapsida document the emergence of mammals from more primitive synapsids and are of unique zoological and palaeontological interest on that account. Therapsids, first appearing in the Early Permian, were thought to become extinct in the Middle Jurassic, soon after the Late Triassic ...

journal_title：Nature

authors： Fox RC,Youzwyshyn GP,Krause DW

更新日期：1992-07-16 00:00:00

abstract：:Keratinocytes of three different epithelia grown in cell culture express a large number of differentiation markers with either no differences or relatively small differences, depending on the species. Much of the distinctive phenotype of these epithelia in vivo must be due to external modulation and relatively little,...

journal_title：Nature

authors： Sun TT,Green H

更新日期：1977-10-06 00:00:00

abstract：:The potential use of smallpox as a biological weapon has led to the production and stockpiling of smallpox vaccine and the immunization of some healthcare workers. Another public health goal is the licensing of a safer vaccine that could benefit the millions of people advised not to take the current one because they o...

journal_title：Nature

authors： Earl PL,Americo JL,Wyatt LS,Eller LA,Whitbeck JC,Cohen GH,Eisenberg RJ,Hartmann CJ,Jackson DL,Kulesh DA,Martinez MJ,Miller DM,Mucker EM,Shamblin JD,Zwiers SH,Huggins JW,Jahrling PB,Moss B

更新日期：2004-03-11 00:00:00

abstract：:Zygotic genome activation (ZGA) is the first transcription event in life1. However, it is unclear how RNA polymerase is engaged in initiating ZGA in mammals. Here, by developing small-scale Tn5-assisted chromatin cleavage with sequencing (Stacc-seq), we investigated the landscapes of RNA polymerase II (Pol II) binding...

journal_title：Nature

authors： Liu B,Xu Q,Wang Q,Feng S,Lai F,Wang P,Zheng F,Xiang Y,Wu J,Nie J,Qiu C,Xia W,Li L,Yu G,Lin Z,Xu K,Xiong Z,Kong F,Liu L,Huang C,Yu Y,Na J,Xie W

更新日期：2020-11-01 00:00:00