Abstract:
:The crystal structure of a soluble form of the T lymphocyte antigen CD2 provides the first complete view of the extracellular region of a cell adhesion molecule. The topology of the molecule, which comprises two immunoglobulin-like domains, is the same as that of the first two domains of CD4 but the relative domain orientation is altered by a fairly flexible linker region. The putative ligand-binding beta-sheet forms a flat surface towards the top of the molecule. Crystal contacts between these surfaces suggest a plausible model for the adhesive interaction.
journal_name
Naturejournal_title
Natureauthors
Jones EY,Davis SJ,Williams AF,Harlos K,Stuart DIdoi
10.1038/360232a0keywords:
subject
Has Abstractpub_date
1992-11-19 00:00:00pages
232-9issue
6401eissn
0028-0836issn
1476-4687journal_volume
360pub_type
杂志文章相关文献
NATURE文献大全abstract::Cellular ras genes encode a family of membrane-associated proteins (p21ras) that bind guanine nucleotide and possess a low intrinsic GTPase activity. The p21ras proteins are ubiquitously expressed in mammalian cells and are thought to be involved in a growth-promoting signal transduction pathway; their mode of action,...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/347396a0
更新日期:1990-09-27 00:00:00
abstract::Genomic imprinting is an allele-specific gene expression system that is important for mammalian development and function. The molecular basis of genomic imprinting is allele-specific DNA methylation. Although it is well known that the de novo DNA methyltransferases Dnmt3a and Dnmt3b are responsible for the establishme...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12805
更新日期:2013-12-19 00:00:00
abstract::The carotid body type I cell contains amines and has features, both morphological and cytochemical, which indicate that it may also produce a peptide. Many regulatory peptides are now known to be present in both central and peripheral tissues. In the periphery these neuropeptides occur in both classical endocrine (APU...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/284269a0
更新日期:1980-03-20 00:00:00
abstract::The antidiuretic effect of arginine vasopressin (AVP) is mediated by renal-type (V2) receptors linked to adenylyl cyclase. We report here the cloning of the rat kidney V2 AVP receptor complementary DNA that encodes a 370-amino-acid protein with a transmembrane topography characteristic of G protein-coupled receptors, ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/357336a0
更新日期:1992-05-28 00:00:00
abstract::Increased levels of brain amyloid-beta, a secreted peptide cleavage product of amyloid precursor protein (APP), is believed to be critical in the aetiology of Alzheimer's disease. Increased amyloid-beta can cause synaptic depression, reduce the number of spine protrusions (that is, sites of synaptic contacts) and bloc...
journal_title:Nature
pub_type: 评论,杂志文章
doi:10.1038/nature09217
更新日期:2010-08-12 00:00:00
abstract::Memory formation is a multi-stage process that initially requires cellular consolidation in the hippocampus, after which memories are downloaded to the cortex for maintenance, in a process termed systems consolidation. Epigenetic mechanisms regulate both types of consolidation, but histone variant exchange, in which c...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13707
更新日期:2014-11-27 00:00:00
abstract::The response of tropical cyclone activity to global warming is widely debated. It is often assumed that warmer sea surface temperatures provide a more favourable environment for the development and intensification of tropical cyclones, but cyclone genesis and intensity are also affected by the vertical thermodynamic p...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06423
更新日期:2007-12-13 00:00:00
abstract::Poly(dA).poly(dT) has unusual properties in that it cannot associate into nucleosomes and short, phased runs of it cause DNA bending. The crystal structure of a B-type DNA dodecamer containing a homopolymeric run of six A.T base pairs shows that this region possesses special structural features, including a system of ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/330221a0
更新日期:1987-11-19 00:00:00
abstract::Mitochondria take up and extrude various inorganic and organic ions, as well as larger substances such as proteins. The technique of patch clamping should provide real-time information on such transport and on energy transduction in oxidative phosphorylation. It has been applied to detect microscopic currents from mit...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/352244a0
更新日期:1991-07-18 00:00:00
abstract::Three Hipparion trails, two from adults and one from a juvenile dating from about 3.5 Myr ago, have now been found in Laetoli. Comparison of the Hipparion footprints with a variety of imprints made by domestic horses showed that the animals moved with a running walk over the soft and slippery soil of Laetoli: in the a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/308179a0
更新日期:1984-03-08 00:00:00
abstract::The E6 oncoprotein derived from tumour-associated human papillomaviruses (HPVs) binds to and induces the degradation of the cellular tumour-suppressor protein p53. A common polymorphism that occurs in the p53 amino-acid sequence results in the presence of either a proline or an arginine at position 72. The effect of t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/30400
更新日期:1998-05-21 00:00:00
abstract::The optimal water transport system in plants should maximize hydraulic conductance (which is proportional to photosynthesis) for a given investment in transport tissue. To investigate how this optimum may be achieved, we have performed computer simulations of the hydraulic conductance of a branched transport system. H...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01444
更新日期:2003-02-27 00:00:00
abstract::Neutralizing antibody function provides a foundation for the efficacy of vaccines and therapies1-3. Here, using a robust in vitro Ebola virus (EBOV) pseudo-particle infection assay and a well-defined set of solid-phase assays, we describe a wide spectrum of antibody responses in a cohort of healthy survivors of the Si...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-03146-y
更新日期:2021-01-27 00:00:00
abstract::To cause diseases in plants, pathogenic microorganisms have evolved mechanisms to deliver proteins directly into plant cells, where they suppress plant defences and facilitate tissue invasion. How plant pathogenic fungi, which cause many of the world's most serious plant diseases, deliver proteins during plant infecti...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04567
更新日期:2006-03-23 00:00:00
abstract::Tumour necrosis factor is a trimeric molecule, each subunit of which consists of an antiparallel beta-sandwich. Individual subunits from the trimer by a novel edge-to-face packing of beta-sheets. A comparison of the subunit fold with that of other proteins reveals a remarkable similarity to the 'jelly-roll' structural...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/338225a0
更新日期:1989-03-16 00:00:00
abstract::Early-life dietary transitions reflect fundamental aspects of primate evolution and are important determinants of health in contemporary human populations. Weaning is critical to developmental and reproductive rates; early weaning can have detrimental health effects but enables shorter inter-birth intervals, which inf...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature12169
更新日期:2013-06-13 00:00:00
abstract::The internal organization of eukaryotic cells into functionally specialized, membrane-delimited organelles of unique composition implies a need for active, regulated lipid transport. Phosphatidylserine (PS), for example, is synthesized in the endoplasmic reticulum and then preferentially associates--through mechanisms...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12430
更新日期:2013-09-12 00:00:00
abstract::Three environmental groups have filed suit against the National Institutes of Health in an attempt to block an experiment approved in April by the NIH Recombinant DNA Advisory Committee. The experiment, designed by researchers at the University of California, Berkeley, to enhance the frost resistance of crops, would ...
journal_title:Nature
pub_type: 新闻
doi:10.1038/305262a0
更新日期:1983-09-22 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 评论,信件
doi:10.1038/d41586-019-00232-8
更新日期:2019-01-01 00:00:00
abstract::The evolution of self-fertilization in hermaphrodites is opposed by costs that decrease the value of self progeny relative to that of outcross progeny. However, self-fertilization is common in plants; 20% are highly selfing and 33% are intermediate between selfing and outcrossing. Darwin proposed an adaptive benefit o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02776
更新日期:2004-08-19 00:00:00
abstract::The immunophilins cyclophilin and FK506 binding protein (FKBP) are small, predominantly soluble proteins that bind the immunosuppressant drugs cyclosporin A and FK506, respectively, with high affinity, and which seem to mediate their pharmacological actions. The Ca(2+)-dependent protein phosphatase, calcineurin, binds...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/358584a0
更新日期:1992-08-13 00:00:00
abstract::Quantum simulation--the use of one quantum system to simulate a less controllable one--may provide an understanding of the many quantum systems which cannot be modelled using classical computers. Considerable progress in control and manipulation has been achieved for various quantum systems, but one of the remaining c...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13565
更新日期:2014-08-07 00:00:00
abstract::Fireflies communicate with each other by emitting yellow-green to yellow-orange brilliant light. The bioluminescence reaction, which uses luciferin, Mg-ATP and molecular oxygen to yield an electronically excited oxyluciferin species, is carried out by the enzyme luciferase. Visible light is emitted during relaxation o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04542
更新日期:2006-03-16 00:00:00
abstract::An Amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41586-019-1890-z
更新日期:2020-01-01 00:00:00
abstract::The separation of cells into populations that do not intermix, termed compartments, is a fundamental organizing principle during development. Dorsal-ventral compartmentalization of the Drosophila wing is regulated downstream of the apterous (ap) gene, which encodes a transcription factor that specifies dorsal wing fat...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/46786
更新日期:1999-09-30 00:00:00
abstract::Regular mesoporous oxide materials have been widely studied and have a range of potential applications, such as catalysis, absorption and separation. They are not generally considered for their optical and electronic properties. Elemental semiconductors with nanopores running through them represent a different form of...
journal_title:Nature
pub_type: 信件
doi:10.1038/nature04833
更新日期:2006-06-29 00:00:00
abstract::Growing populations and agricultural intensification have led to raised riverine nitrogen (N) loads, widespread oxygen depletion in coastal zones (coastal hypoxia)1 and increases in the incidence of algal blooms.Although recent work has suggested that individual wetlands have the potential to improve water quality2-9,...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-03042-5
更新日期:2020-12-01 00:00:00
abstract::'Pioneer' transcription factors are required for stem-cell pluripotency, cell differentiation and cell reprogramming1,2. Pioneer factors can bind nucleosomal DNA to enable gene expression from regions of the genome with closed chromatin. SOX2 is a prominent pioneer factor that is essential for pluripotency and self-re...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2195-y
更新日期:2020-04-01 00:00:00
abstract::Measuring the completeness of the fossil record is essential to understanding evolution over long timescales, particularly when comparing evolutionary patterns among biological groups with different preservational properties. Completeness measures have been presented for various groups based on gaps in the stratigraph...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/18872
更新日期:1999-04-01 00:00:00
abstract::Lung diseases such as chronic obstructive pulmonary disease and pulmonary fibrosis involve the progressive and inexorable destruction of oxygen exchange surfaces and airways, and have emerged as a leading cause of death worldwide. Mitigating therapies, aside from impractical organ transplantation, remain limited and t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13903
更新日期:2015-01-29 00:00:00