Abstract：
:The antidiuretic effect of arginine vasopressin (AVP) is mediated by renal-type (V2) receptors linked to adenylyl cyclase. We report here the cloning of the rat kidney V2 AVP receptor complementary DNA that encodes a 370-amino-acid protein with a transmembrane topography characteristic of G protein-coupled receptors, and with similarity to the V1a (hepatic) AVP receptor in its seven membrane-spanning domains. Expression of the cloned cDNA in mammalian cells showed specific ligand binding and activity characteristic of the native V2 AVP receptor. The receptor messenger RNA is detected only in the kidney. The human V2 receptor gene has been localized to the long arm of the X chromosome close to the locus for nephrogenic diabetes insipidus, an X-linked recessive disorder characterized by renal resistance to the antidiuretic action of AVP.
journal_name
Naturejournal_title
Natureauthors
Lolait SJ,O'Carroll AM,McBride OW,Konig M,Morel A,Brownstein MJdoi
10.1038/357336a0keywords:
subject
Has Abstractpub_date
1992-05-28 00:00:00pages
336-9issue
6376eissn
0028-0836issn
1476-4687journal_volume
357pub_type
杂志文章相关文献
NATURE文献大全abstract：:Bacterial cell division ends with septation, the constriction of the cell wall and cell membranes that leads to the formation of two daughter cells. During septation, FtsZ, a protein of relative molecular mass 40,000 which is ubiquitous in eubacteria and is also found in archaea and chloroplasts, localizes early at th...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/34472
更新日期：1998-01-08 00:00:00
abstract：:For hundreds of years, scientists have tracked the changing appearance of Mars, first by hand drawings and later by photographs. Because of this historical record, many classical albedo patterns have long been known to shift in appearance over time. Decadal variations of the martian surface albedo are generally attrib...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature05718
更新日期：2007-04-05 00:00:00
abstract：:The assessment of changes in tropical cyclone activity within the context of anthropogenically influenced climate change has been limited by the short temporal resolution of the instrumental tropical cyclone record (less than 50 years). Furthermore, controversy exists regarding the robustness of the observational reco...
journal_title：Nature
pub_type： 历史文章,杂志文章
doi：10.1038/nature12882
更新日期：2014-01-30 00:00:00
abstract：:Climate models with increased levels of carbon dioxide predict that global warming causes heating in the tropics, but investigations of ancient climates based on palaeodata have generally indicated cool tropical temperatures during supposed greenhouse episodes. For example, in the Late Cretaceous and Eocene epochs the...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35097000
更新日期：2001-10-04 00:00:00
abstract：:Cutaneous melanoma is a type of cancer with an inherent potential for lymph node colonization, which is generally preceded by neolymphangiogenesis. However, sentinel lymph node removal does not necessarily extend the overall survival of patients with melanoma. Moreover, lymphatic vessels collapse and become dysfunctio...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature22977
更新日期：2017-06-28 00:00:00
abstract：:Homology-directed DNA repair is essential for genome maintenance through templated DNA synthesis. Alternative lengthening of telomeres (ALT) necessitates homology-directed DNA repair to maintain telomeres in about 10-15% of human cancers. How DNA damage induces assembly and execution of a DNA replication complex (brea...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature20099
更新日期：2016-11-03 00:00:00
abstract：:The gene IL2RG encodes the gamma-chain of the interleukin-2 receptor and is mutated in patients with X-linked severe combined immune deficiency (X-SCID). Woods et al. report the development of thymus tumours in a mouse model of X-SCID after correction by lentiviral overexpression of IL2RG and claim that these were cau...
journal_title：Nature
pub_type： 评论,杂志文章
doi：10.1038/nature05218
更新日期：2006-09-21 00:00:00
abstract：:Sodium channels and receptors to serotonin and kainate were 'transplanted' from human brain into frog oocytes, by isolating messenger RNA from a fetal brain, and injecting it into Xenopus laevis oocytes. The mRNA was translated by the oocyte and induced the appearance of functional receptors and channels in its membra...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/308421a0
更新日期：1984-03-29 00:00:00
abstract：:Transport of calcium ions across membranes and against a thermodynamic gradient is essential to many biological processes, including muscle contraction, the citric acid cycle, glycogen metabolism, release of neurotransmitters, vision, biological signal transduction and immune response. Synthetic systems that transport...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature01209
更新日期：2002-11-28 00:00:00
abstract：:The crown-of-thorns starfish (COTS, the Acanthaster planci species group) is a highly fecund predator of reef-building corals throughout the Indo-Pacific region. COTS population outbreaks cause substantial loss of coral cover, diminishing the integrity and resilience of reef ecosystems. Here we sequenced genomes of CO...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature22033
更新日期：2017-04-05 00:00:00
abstract：:Recognition of modified histone species by distinct structural domains within 'reader' proteins plays a critical role in the regulation of gene expression. Readers that simultaneously recognize histones with multiple marks allow transduction of complex chromatin modification patterns into specific biological outcomes....
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature09542
更新日期：2010-12-16 00:00:00
abstract：:At most synapses in the brain, short-term plasticity dynamically modulates synaptic strength. Rapid frequency-dependent changes in synaptic strength have key roles in sensory adaptation, gain control and many other neural computations. However, some auditory, vestibular and cerebellar synapses maintain constant streng...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature24474
更新日期：2017-11-23 00:00:00
abstract：:To cause diseases in plants, pathogenic microorganisms have evolved mechanisms to deliver proteins directly into plant cells, where they suppress plant defences and facilitate tissue invasion. How plant pathogenic fungi, which cause many of the world's most serious plant diseases, deliver proteins during plant infecti...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature04567
更新日期：2006-03-23 00:00:00
abstract：:Among the ten subtypes of mammalian voltage-gated calcium (Cav) channels, Cav3.1-Cav3.3 constitute the T-type, or the low-voltage-activated, subfamily, the abnormal activities of which are associated with epilepsy, psychiatric disorders and pain1-5. Here we report the cryo-electron microscopy structures of human Cav3....
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-019-1801-3
更新日期：2019-12-01 00:00:00
abstract：:Biological dinitrogen fixation provides the largest input of nitrogen to the oceans, therefore exerting important control on the ocean's nitrogen inventory and primary productivity. Nitrogen-isotope data from ocean sediments suggest that the marine-nitrogen inventory has been balanced for the past 3,000 years (ref. 4)...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature11338
更新日期：2012-08-16 00:00:00
abstract：:The mitotic recombination behaviour of a duplication of the his4 region on chromosome III in the yeast Saccharomyces cerevisiae was studied. The major recombination event between the duplicated segments is gene conversion unassociated with reciprocal recombination. The rad52-1 mutation preferentially decreases mitotic...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/292306a0
更新日期：1981-07-23 00:00:00
abstract：:The planet in the system HD209458 is the first one for which repeated transits across the stellar disk have been observed. Together with radial velocity measurements, this has led to a determination of the planet's radius and mass, confirming it to be a gas giant. But despite numerous searches for an atmospheric signa...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature01448
更新日期：2003-03-13 00:00:00
abstract：:Microbes comprise the majority of extant organisms, yet much remains to be learned about the nature and driving forces of microbial diversification. Our understanding of how microorganisms adapt and evolve can be advanced by genome-wide documentation of the patterns of genetic exchange, particularly if analyses target...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature05624
更新日期：2007-03-29 00:00:00
abstract：:Wilms' tumour (WT), a paediatric renal neoplasm, affect approximately 1 in 10,000 children. One or both kidneys can be affected and 5-10% of tumours are bilateral. Most tumours occur sporadically; however, around 1% of the cases are familial, with siblings or cousins most often being affected. Familial cases are more ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/336377a0
更新日期：1988-11-24 00:00:00
abstract：:The use of chemotherapy to suppress replication of the human immunodeficiency virus (HIV) has transformed the face of AIDS in the developed world. Pronounced reductions in illness and death have been achieved and healthcare utilization has diminished. HIV therapy has also provided many new insights into the pathogenes...
journal_title：Nature
pub_type： 杂志文章,评审
doi：10.1038/35073673
更新日期：2001-04-19 00:00:00
abstract：:The degradation of cytosolic proteins is carried out predominantly by the proteasome, which generates peptides of 7-9 amino acids long. These products need further processing. Recently, a proteolytic system was identified in the model organism Thermoplasma acidophilum that performs this processing. The hexameric core ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35106609
更新日期：2001-11-22 00:00:00
abstract：:Antiviral T cells are thought to regulate whether hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infections result in viral control, asymptomatic persistence or severe disease, although the reasons for these different outcomes remain unclear. Recent genetic evidence, however, has indicated a correlatio...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature10624
更新日期：2011-11-20 00:00:00
abstract：:Hutchinson-Gilford progeria syndrome (HGPS) is a rare and fatal human premature ageing disease, characterized by premature arteriosclerosis and degeneration of vascular smooth muscle cells (SMCs). HGPS is caused by a single point mutation in the lamin A (LMNA) gene, resulting in the generation of progerin, a truncated...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature09879
更新日期：2011-04-14 00:00:00
abstract：:Atmospheric carbon dioxide concentrations seem to have been several times modern levels during much of the Palaeozoic era (543-248 million years ago), but decreased during the Carboniferous period to concentrations similar to that of today. Given that carbon dioxide is a greenhouse gas, it has been proposed that surfa...
journal_title：Nature
pub_type： 历史文章,杂志文章
doi：10.1038/nature06085
更新日期：2007-09-13 00:00:00
abstract：:Mineralocorticoid secretion is predominantly controlled by the octapeptide angiotensin II, which exerts trophic actions on the adrenal glomerulosa and acute regulatory effects on aldosterone biosynthesis. The trophic actions include stimulation of angiotensin II receptors and enzymes of the aldosterone biosynthetic pa...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/289507a0
更新日期：1981-02-05 00:00:00
abstract：:Ordinarily, photons do not interact with one another. However, atoms can be used to mediate photonic interactions1,2, raising the prospect of forming synthetic materials3 and quantum information systems4-7 from photons. One promising approach combines highly excited Rydberg atoms8-12 with the enhanced light-matter cou...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-019-1354-5
更新日期：2019-07-01 00:00:00
abstract：:The yeast [PSI+] element represents a new type of genetic inheritance, in which changes in phenotype are transmitted by a 'protein only' mechanism reminiscent of the 'protein-only' transmission of mammalian prion diseases. The underlying molecular mechanisms for both are poorly understood and it is not clear how simil...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/23048
更新日期：1999-08-05 00:00:00
abstract：:The three-dimensional structures of macromolecules and their complexes are mainly elucidated by X-ray protein crystallography. A major limitation of this method is access to high-quality crystals, which is necessary to ensure X-ray diffraction extends to sufficiently large scattering angles and hence yields informatio...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature16949
更新日期：2016-02-11 00:00:00
abstract：:Interleukin (IL)-17-producing T helper cells (T(H)17) are a recently identified CD4(+) T cell subset distinct from T helper type 1 (T(H)1) and T helper type 2 (T(H)2) cells. T(H)17 cells can drive antigen-specific autoimmune diseases and are considered the main population of pathogenic T cells driving experimental aut...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature10228
更新日期：2011-07-17 00:00:00
abstract：:The extent of allelic variation has been estimated at 46 structural gene loci within three major colonies of Swiss mice and between inbred derivative strains. The colonies have retained nearly the same amount and type of variation found in natural murine or human populations despite laboratory propagation for more tha...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/283157a0
更新日期：1980-01-10 00:00:00
