Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine.

abstract：:More than 50 copies of a phi X174 DNA template can be made in 60 min in an in vitro DNA replication system consisting of seven purfied replication proteins isolated from T4 bacteriophage-infected cells. By transfecting with the DNA products and assaying for the reversion of specific amber mutants, the high degree of b...

journal_title：Nature

authors： Hibner U,Alberts BM

更新日期：1980-05-29 00:00:00

abstract：:Novel biochemical processes using magnetic particles have been automated to provide a robotic system to perform processes for large-scale shotgun sequencing. ...

journal_title：Nature

authors： Watson A,Smaldon N,Lucke R,Hawkins T

更新日期：1993-04-08 00:00:00

abstract：:Formation of electron pairs is essential to superconductivity. For conventional superconductors, tunnelling spectroscopy has established that pairing is mediated by bosonic modes (phonons); a peak in the second derivative of tunnel current d2I/dV2 corresponds to each phonon mode. For high-transition-temperature (high-...

journal_title：Nature

authors： Lee J,Fujita K,McElroy K,Slezak JA,Wang M,Aiura Y,Bando H,Ishikado M,Masui T,Zhu JX,Balatsky AV,Eisaki H,Uchida S,Davis JC

更新日期：2006-08-03 00:00:00

abstract：:Recent work demonstrates that stochastic fluctuations in molecular populations have consequences for gene regulation. Previous experiments focused on noise sources or noise propagation through gene networks by measuring noise magnitudes. However, in theoretical analysis, we showed that noise frequency content is deter...

journal_title：Nature

authors： Austin DW,Allen MS,McCollum JM,Dar RD,Wilgus JR,Sayler GS,Samatova NF,Cox CD,Simpson ML

更新日期：2006-02-02 00:00:00

abstract：:The actin cytoskeleton is regulated by GTP-hydrolysing proteins, the Rho GTPases, which act as molecular switches in diverse signal-transduction processes. Various bacterial toxins can inactivate Rho GTPases by ADP-ribosylation or glucosylation. Previous research has identified Rho proteins as putative targets for Esc...

journal_title：Nature

authors： Schmidt G,Sehr P,Wilm M,Selzer J,Mann M,Aktories K

更新日期：1997-06-12 00:00:00

abstract：:Defining the functional relationships between proteins is critical for understanding virtually all aspects of cell biology. Large-scale identification of protein complexes has provided one important step towards this goal; however, even knowledge of the stoichiometry, affinity and lifetime of every protein-protein int...

journal_title：Nature

authors： Collins SR,Miller KM,Maas NL,Roguev A,Fillingham J,Chu CS,Schuldiner M,Gebbia M,Recht J,Shales M,Ding H,Xu H,Han J,Ingvarsdottir K,Cheng B,Andrews B,Boone C,Berger SL,Hieter P,Zhang Z,Brown GW,Ingles CJ,Emili

更新日期：2007-04-12 00:00:00

abstract：:Living organisms rely on simultaneous reactions catalysed by mutually compatible and selective enzymes to synthesize complex natural products and other metabolites. To combine the advantages of these biological systems with the reactivity of artificial chemical catalysts, chemists have devised sequential, concurrent, ...

journal_title：Nature

authors： Litman ZC,Wang Y,Zhao H,Hartwig JF

更新日期：2018-08-01 00:00:00

abstract：:Defects in insulin signalling are among the most common and earliest defects that predispose an individual to the development of type 2 diabetes. MicroRNAs have been identified as a new class of regulatory molecules that influence many biological functions, including metabolism. However, the direct regulation of insul...

journal_title：Nature

authors： Trajkovski M,Hausser J,Soutschek J,Bhat B,Akin A,Zavolan M,Heim MH,Stoffel M

更新日期：2011-06-08 00:00:00

abstract：:The contractile proteins of adult skeletal and cardiac muscle tissue are very similar. Some of these proteins are identical in amino acid sequence or differ only slightly. Various structural studies have shown that the heavy and light chains of myosin are also homologous in skeletal and cardiac muscles. In developing ...

journal_title：Nature

authors： Whalen RG,Sell SM

更新日期：1980-08-14 00:00:00

abstract：:The identical structure of two racially distinct alpha 1-globin alleles and the high degree of homology between the alpha 1- and alpha 2-globin loci indicate that mechanisms exist for suppression of allelic polymorphisms and for exchange of genetic information within the alpha-globin gene complex. ...

journal_title：Nature

authors： Liebhaber SA,Goossens M,Kan YW

更新日期：1981-03-05 00:00:00

abstract：:Only 17% of 111 reef-building coral genera and none of the 18 coral families with reef-builders are considered endemic to the Atlantic, whereas the corresponding percentages for the Indo-west Pacific are 76% and 39%. These figures depend on the assumption that genera and families spanning the two provinces belong to t...

journal_title：Nature

authors： Fukami H,Budd AF,Paulay G,Solé-Cava A,Allen Chen C,Iwao K,Knowlton N

更新日期：2004-02-26 00:00:00

abstract：:Long-term potentiation of chemical synapses is closely related to memory and learning. Studies of this process have concentrated on chemically mediated excitatory synapses. By contrast, activity-dependent modification of gap junctions, which also widely exist in higher structures such as hippocampus and neocortex, has...

journal_title：Nature

authors： Yang XD,Korn H,Faber DS

更新日期：1990-12-06 00:00:00

abstract：:The global land and ocean carbon sinks have increased proportionally with increasing carbon dioxide emissions during the past decades1. It is thought that Northern Hemisphere lands make a dominant contribution to the global land carbon sink2-7; however, the long-term trend of the northern land sink remains uncertain. ...

journal_title：Nature

authors： Ciais P,Tan J,Wang X,Roedenbeck C,Chevallier F,Piao SL,Moriarty R,Broquet G,Le Quéré C,Canadell JG,Peng S,Poulter B,Liu Z,Tans P

更新日期：2019-04-01 00:00:00

abstract：:The North Atlantic Oscillation (NAO) is the major source of variability in winter atmospheric circulation in the Northern Hemisphere, with large impacts on temperature, precipitation and storm tracks, and therefore also on strategic sectors such as insurance, renewable energy production, crop yields and water manageme...

journal_title：Nature

authors： Ortega P,Lehner F,Swingedouw D,Masson-Delmotte V,Raible CC,Casado M,Yiou P

更新日期：2015-07-02 00:00:00

abstract：:Schizophrenia is a severe mental illness with a typically chronic course affecting nearly 1% of the human population. It is generally accepted that genetic factors have an important pathogenic role in a substantial portion of schizophrenia cases; however, despite decades of family studies, there is no agreed-upon mode...

journal_title：Nature

authors： Kennedy JL,Giuffra LA,Moises HW,Cavalli-Sforza LL,Pakstis AJ,Kidd JR,Castiglione CM,Sjogren B,Wetterberg L,Kidd KK

更新日期：1988-11-10 00:00:00

abstract：:The conventional treatment of dental caries involves mechanical removal of the affected part and filling of the hole with a resin or metal alloy. But this method is not ideal for tiny early lesions because a disproportionate amount of healthy tooth must be removed to make the alloy or resin stick. Here we describe a d...

journal_title：Nature

authors： Yamagishi K,Onuma K,Suzuki T,Okada F,Tagami J,Otsuki M,Senawangse P

更新日期：2005-02-24 00:00:00

abstract：:Mycobacterium tuberculosis (Mtb) is the leading cause of death from infection worldwide1. The only available vaccine, BCG (Bacillus Calmette-Guérin), is given intradermally and has variable efficacy against pulmonary tuberculosis, the major cause of mortality and disease transmission1,2. Here we show that intravenous ...

journal_title：Nature

authors： Darrah PA,Zeppa JJ,Maiello P,Hackney JA,Wadsworth MH 2nd,Hughes TK,Pokkali S,Swanson PA 2nd,Grant NL,Rodgers MA,Kamath M,Causgrove CM,Laddy DJ,Bonavia A,Casimiro D,Lin PL,Klein E,White AG,Scanga CA,Shalek AK,Roede

更新日期：2020-01-01 00:00:00

abstract：:The X-ray crystal structure of the transcription factor IIA (TFIIA) in complex with the TATA-box-binding protein (TBP) and TATA-element DNA is presented at 2.5 A resolution. TFIIA is composed of a beta-barrel and a four-helix bundle motif that together have a boot-like appearance. The beta-barrel extends the TBP beta-...

journal_title：Nature

authors： Tan S,Hunziker Y,Sargent DF,Richmond TJ

更新日期：1996-05-09 00:00:00

abstract：:Body size is intrinsically linked to metabolic rate and life-history traits, and is a crucial determinant of food webs and community dynamics1,2. The increased temperatures associated with the urban-heat-island effect result in increased metabolic costs and are expected to drive shifts to smaller body sizes 3 . Urban ...

journal_title：Nature

authors： Merckx T,Souffreau C,Kaiser A,Baardsen LF,Backeljau T,Bonte D,Brans KI,Cours M,Dahirel M,Debortoli N,De Wolf K,Engelen JMT,Fontaneto D,Gianuca AT,Govaert L,Hendrickx F,Higuti J,Lens L,Martens K,Matheve H,Matthysen

更新日期：2018-06-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature

authors： Aveline DC,Williams JR,Elliott ER,Dutenhoffer C,Kellogg JR,Kohel JM,Lay NE,Oudrhiri K,Shotwell RF,Yu N,Thompson RJ

更新日期：2020-08-01 00:00:00

abstract：:Angiosperms developed floral nectaries that reward pollinating insects. Although nectar function and composition have been characterized, the mechanism of nectar secretion has remained unclear. Here we identify SWEET9 as a nectary-specific sugar transporter in three eudicot species: Arabidopsis thaliana, Brassica rapa...

journal_title：Nature

authors： Lin IW,Sosso D,Chen LQ,Gase K,Kim SG,Kessler D,Klinkenberg PM,Gorder MK,Hou BH,Qu XQ,Carter CJ,Baldwin IT,Frommer WB

更新日期：2014-04-24 00:00:00

abstract：:Plasmacytoid dendritic cells (pDCs) sense viral and microbial DNA through endosomal Toll-like receptors to produce type 1 interferons. pDCs do not normally respond to self-DNA, but this restriction seems to break down in human autoimmune disease by an as yet poorly understood mechanism. Here we identify the antimicrob...

journal_title：Nature

authors： Lande R,Gregorio J,Facchinetti V,Chatterjee B,Wang YH,Homey B,Cao W,Wang YH,Su B,Nestle FO,Zal T,Mellman I,Schröder JM,Liu YJ,Gilliet M

更新日期：2007-10-04 00:00:00

abstract：:Lymphocyte-specific tyrosine protein kinase p56lck is physically associated with CD4 and CD8 T-cell surface molecules, suggesting that it may transduce CD4/CD8-triggered tyrosine phosphorylation signals during antigen stimulation. Indeed, antibody-mediated aggregation of CD4 (to mimic interaction with its ligand, majo...

journal_title：Nature

authors： Abraham N,Miceli MC,Parnes JR,Veillette A

更新日期：1991-03-07 00:00:00

abstract：:Some observations suggest that very massive stars experience extreme mass-loss episodes shortly before they explode as supernovae, as do several models. Establishing a causal connection between these mass-loss episodes and the final explosion would provide a novel way to study pre-supernova massive-star evolution. Her...

journal_title：Nature

authors： Ofek EO,Sullivan M,Cenko SB,Kasliwal MM,Gal-Yam A,Kulkarni SR,Arcavi I,Bildsten L,Bloom JS,Horesh A,Howell DA,Filippenko AV,Laher R,Murray D,Nakar E,Nugent PE,Silverman JM,Shaviv NJ,Surace J,Yaron O

更新日期：2013-02-07 00:00:00

abstract：:A key event in the domestication and breeding of the oil palm Elaeis guineensis was loss of the thick coconut-like shell surrounding the kernel. Modern E. guineensis has three fruit forms, dura (thick-shelled), pisifera (shell-less) and tenera (thin-shelled), a hybrid between dura and pisifera. The pisifera palm is us...

journal_title：Nature

authors： Singh R,Low ET,Ooi LC,Ong-Abdullah M,Ting NC,Nagappan J,Nookiah R,Amiruddin MD,Rosli R,Manaf MA,Chan KL,Halim MA,Azizi N,Lakey N,Smith SW,Budiman MA,Hogan M,Bacher B,Van Brunt A,Wang C,Ordway JM,Sambanthamurthi

更新日期：2013-08-15 00:00:00

abstract：:Magnetic compass information has a key role in bird orientation, but the physiological mechanisms enabling birds to sense the Earth's magnetic field remain one of the unresolved mysteries in biology. Two biophysical mechanisms have become established as the most promising magnetodetection candidates. The iron-mineral-...

journal_title：Nature

authors： Zapka M,Heyers D,Hein CM,Engels S,Schneider NL,Hans J,Weiler S,Dreyer D,Kishkinev D,Wild JM,Mouritsen H

更新日期：2009-10-29 00:00:00

abstract：:GTPase-activating proteins (GAPs) increase the rate of GTP hydrolysis on guanine nucleotide-binding proteins by many orders of magnitude. Studies with Ras and Rho have elucidated the mechanism of GAP action by showing that their catalytic machinery is both stabilized by GAP binding and complemented by the insertion of...

journal_title：Nature

authors： Seewald MJ,Körner C,Wittinghofer A,Vetter IR

更新日期：2002-02-07 00:00:00

abstract：:The DNA sequences of the alcohol dehydrogenase (Adh) genes of four very closely related species of Drosophila show that the rates of nucleotide change vary greatly in different functional domains of this gene. A phylogeny of these species based on the Adh sequence data is consistent with that based on polytene chromos...

journal_title：Nature

authors： Bodmer M,Ashburner M

更新日期：1984-05-31 00:00:00

abstract：:Obesity is now so common within the world's population that it is beginning to replace undernutrition and infectious diseases as the most significant contributor to ill health. In particular, obesity is associated with diabetes mellitus, coronary heart disease, certain forms of cancer, and sleep-breathing disorders. O...

journal_title：Nature

authors： Kopelman PG

更新日期：2000-04-06 00:00:00

abstract：:Although the sex-determining gene Sry has been identified in mammals, no comparable genes have been found in non-mammalian vertebrates. Here, we used recombinant breakpoint analysis to restrict the sex-determining region in medaka fish (Oryzias latipes) to a 530-kilobase (kb) stretch of the Y chromosome. Deletion anal...

journal_title：Nature

authors： Matsuda M,Nagahama Y,Shinomiya A,Sato T,Matsuda C,Kobayashi T,Morrey CE,Shibata N,Asakawa S,Shimizu N,Hori H,Hamaguchi S,Sakaizumi M

更新日期：2002-05-30 00:00:00