Abstract:
:The use of chemotherapy to suppress replication of the human immunodeficiency virus (HIV) has transformed the face of AIDS in the developed world. Pronounced reductions in illness and death have been achieved and healthcare utilization has diminished. HIV therapy has also provided many new insights into the pathogenesis and the viral and cellular dynamics of HIV infection. But challenges remain. Treatment does not suppress HIV replication in all patients, and the emergence of drug-resistant virus hinders subsequent treatment. Chronic therapy can also result in toxicity. These challenges prompt the search for new drugs and new therapeutic strategies to control chronic viral replication.
journal_name
Naturejournal_title
Natureauthors
Richman DDdoi
10.1038/35073673keywords:
subject
Has Abstractpub_date
2001-04-19 00:00:00pages
995-1001issue
6831eissn
0028-0836issn
1476-4687pii
35073673journal_volume
410pub_type
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