Molecular structure of F-actin and location of surface binding sites.

abstract：:Io leaves a magnetic footprint on Jupiter's upper atmosphere that appears as a spot of ultraviolet emission that remains fixed underneath Io as Jupiter rotates. The specific physical mechanisms responsible for generating those emissions are not well understood, but in general the spot seems to arise because of an elec...

journal_title：Nature

authors： Clarke JT,Ajello J,Ballester G,Ben Jaffel L,Connerney J,Gérard JC,Gladstone GR,Grodent D,Pryor W,Trauger J,Waite JH Jr

更新日期：2002-02-28 00:00:00

abstract：:CD95 (also called Fas and APO-1) is a prototypical death receptor that regulates tissue homeostasis mainly in the immune system through the induction of apoptosis. During cancer progression CD95 is frequently downregulated or cells are rendered apoptosis resistant, raising the possibility that loss of CD95 is part of ...

journal_title：Nature

authors： Chen L,Park SM,Tumanov AV,Hau A,Sawada K,Feig C,Turner JR,Fu YX,Romero IL,Lengyel E,Peter ME

更新日期：2010-05-27 00:00:00

abstract：:The circadian clock imposes daily rhythms in cell proliferation, metabolism, inflammation and DNA damage response. Perturbations of these processes are hallmarks of cancer and chronic circadian rhythm disruption predisposes individuals to tumour development. This raises the hypothesis that pharmacological modulation o...

journal_title：Nature

authors： Sulli G,Rommel A,Wang X,Kolar MJ,Puca F,Saghatelian A,Plikus MV,Verma IM,Panda S

更新日期：2018-01-18 00:00:00

abstract：:The architecture of trabecular bone, the porous bone found in the spine and at articulating joints, provides the requirements for optimal load transfer, by pairing suitable strength and stiffness to minimal weight according to rules of mathematical design. But, as it is unlikely that the architecture is fully pre-prog...

journal_title：Nature

authors： Huiskes R,Ruimerman R,van Lenthe GH,Janssen JD

更新日期：2000-06-08 00:00:00

abstract：:One goal of regenerative medicine, to use stem cells to replace cells lost by injury or disease, depends on producing an excess of the relevant cell for study or transplantation. To this end, the stepwise differentiation of stem cells into specialized derivatives has been successful for some cell types, but a major pr...

journal_title：Nature

authors： Sneddon JB,Borowiak M,Melton DA

更新日期：2012-11-29 00:00:00

abstract：:Saturn's largest moon, Titan, remains an enigma, explored only by remote sensing from Earth, and by the Voyager and Cassini spacecraft. The most puzzling aspects include the origin of the molecular nitrogen and methane in its atmosphere, and the mechanism(s) by which methane is maintained in the face of rapid destruct...

journal_title：Nature

authors： Niemann HB,Atreya SK,Bauer SJ,Carignan GR,Demick JE,Frost RL,Gautier D,Haberman JA,Harpold DN,Hunten DM,Israel G,Lunine JI,Kasprzak WT,Owen TC,Paulkovich M,Raulin F,Raaen E,Way SH

更新日期：2005-12-08 00:00:00

abstract：:Subduction zones produce the largest earthquakes. Over the past two decades, space geodesy has revolutionized our view of crustal deformation between consecutive earthquakes. The short time span of modern measurements necessitates comparative studies of subduction zones that are at different stages of the deformation ...

journal_title：Nature

authors： Wang K,Hu Y,He J

更新日期：2012-04-18 00:00:00

abstract：:Relapsed acute lymphoblastic leukaemia (ALL) is a leading cause of death due to disease in young people, but the biological determinants of treatment failure remain poorly understood. Recent genome-wide profiling of structural DNA alterations in ALL have identified multiple submicroscopic somatic mutations targeting k...

journal_title：Nature

authors： Mullighan CG,Zhang J,Kasper LH,Lerach S,Payne-Turner D,Phillips LA,Heatley SL,Holmfeldt L,Collins-Underwood JR,Ma J,Buetow KH,Pui CH,Baker SD,Brindle PK,Downing JR

更新日期：2011-03-10 00:00:00

abstract：:Mutations in the Schizosaccharomyces pombe cdc8 gene impair cytokinesis. Here we clone cdc8+ and find that it encodes a novel tropomyosin. Gene disruption results in lethal arrest of the cell cycle, but spore germination, cell growth, DNA replication and mitosis are all unaffected. Haploid cdc8 gene disruptants are re...

journal_title：Nature

authors： Balasubramanian MK,Helfman DM,Hemmingsen SM

更新日期：1992-11-05 00:00:00

abstract：:Most patients with cancer either do not respond to immune checkpoint blockade or develop resistance to it, often because of acquired mutations that impair antigen presentation. Here we show that loss of function of the RNA-editing enzyme ADAR1 in tumour cells profoundly sensitizes tumours to immunotherapy and overcome...

journal_title：Nature

authors： Ishizuka JJ,Manguso RT,Cheruiyot CK,Bi K,Panda A,Iracheta-Vellve A,Miller BC,Du PP,Yates KB,Dubrot J,Buchumenski I,Comstock DE,Brown FD,Ayer A,Kohnle IC,Pope HW,Zimmer MD,Sen DR,Lane-Reticker SK,Robitschek EJ,Grif

更新日期：2019-01-01 00:00:00

abstract：:Transition-metal complexes are widely used in the physical and biological sciences. They have essential roles in catalysis, synthesis, materials science, photophysics and bioinorganic chemistry. Our understanding of transition-metal complexes originates from Alfred Werner's realization that their three-dimensional sha...

journal_title：Nature

authors： Garçon M,Bakewell C,Sackman GA,White AJP,Cooper RI,Edwards AJ,Crimmin MR

更新日期：2019-10-01 00:00:00

abstract：:Knowledge of the composition of the Earth's core is important for understanding its melting point and therefore the temperature at the inner-core boundary and the temperature profile of the core and mantle. In addition, the partitioning of light elements between solid and liquid, as the outer core freezes at the inner...

journal_title：Nature

authors： Alfe D,Gillan MJ,Price GD

更新日期：2000-05-11 00:00:00

abstract：:The genetic architecture of autism spectrum disorder involves the interplay of common and rare variants and their impact on hundreds of genes. Using exome sequencing, here we show that analysis of rare coding variation in 3,871 autism cases and 9,937 ancestry-matched or parental controls implicates 22 autosomal genes ...

journal_title：Nature

authors： De Rubeis S,He X,Goldberg AP,Poultney CS,Samocha K,Cicek AE,Kou Y,Liu L,Fromer M,Walker S,Singh T,Klei L,Kosmicki J,Shih-Chen F,Aleksic B,Biscaldi M,Bolton PF,Brownfeld JM,Cai J,Campbell NG,Carracedo A,Chahrour

更新日期：2014-11-13 00:00:00

abstract：:On the basis of fossil and archaeological data it has been hypothesized that the exodus of Homo sapiens out of Africa and into Eurasia between ~50-120 thousand years ago occurred in several orbitally paced migration episodes. Crossing vegetated pluvial corridors from northeastern Africa into the Arabian Peninsula and ...

journal_title：Nature

authors： Timmermann A,Friedrich T

更新日期：2016-10-06 00:00:00

abstract：:At one time the synthetic chemist's last resort, reactions catalysed by transition metals are now the preferred method for synthesizing many types of organic molecule. A recent success in this type of catalysis is the discovery of reactions that form bonds between carbon and heteroatoms (such as nitrogen, oxygen, sulp...

journal_title：Nature

authors： Hartwig JF

更新日期：2008-09-18 00:00:00

abstract：:Activation of RIPK1 controls TNF-mediated apoptosis, necroptosis and inflammatory pathways1. Cleavage of human and mouse RIPK1 after residues D324 and D325, respectively, by caspase-8 separates the RIPK1 kinase domain from the intermediate and death domains. The D325A mutation in mouse RIPK1 leads to embryonic lethali...

journal_title：Nature

authors： Tao P,Sun J,Wu Z,Wang S,Wang J,Li W,Pan H,Bai R,Zhang J,Wang Y,Lee PY,Ying W,Zhou Q,Hou J,Wang W,Sun B,Yang M,Liu D,Fang R,Han H,Yang Z,Huang X,Li H,Deuitch N,Zhang Y,Dissanayake D,Haude K,McWalter K

更新日期：2020-01-01 00:00:00

abstract：:In the adult brain, new synapses are formed and pre-existing ones are lost, but the function of this structural plasticity has remained unclear. Learning of new skills is correlated with formation of new synapses. These may directly encode new memories, but they may also have more general roles in memory encoding and ...

journal_title：Nature

authors： Ruediger S,Vittori C,Bednarek E,Genoud C,Strata P,Sacchetti B,Caroni P

更新日期：2011-05-26 00:00:00

abstract：:Dysfunction in prosocial interactions is a core symptom of autism spectrum disorder. However, the neural mechanisms that underlie sociability are poorly understood, limiting the rational development of therapies to treat social deficits. Here we show in mice that bidirectional modulation of the release of serotonin (5...

journal_title：Nature

authors： Walsh JJ,Christoffel DJ,Heifets BD,Ben-Dor GA,Selimbeyoglu A,Hung LW,Deisseroth K,Malenka RC

更新日期：2018-08-01 00:00:00

abstract：:Lyman-alpha emitters are thought to be young, low-mass galaxies with ages of approximately 10(8) yr (refs 1, 2). An overdensity of them in one region of the sky (the SSA 22 field) traces out a filamentary structure in the early Universe at a redshift of z approximately 3.1 (equivalent to 15 per cent of the age of the ...

journal_title：Nature

authors： Tamura Y,Kohno K,Nakanishi K,Hatsukade B,Iono D,Wilson GW,Yun MS,Takata T,Matsuda Y,Tosaki T,Ezawa H,Perera TA,Scott KS,Austermann JE,Hughes DH,Aretxaga I,Chung A,Oshima T,Yamaguchi N,Tanaka K,Kawabe R

更新日期：2009-05-07 00:00:00

abstract：:Inhibin is a hypophysiotropic hormone which selectively suppresses the secretion of pituitary follicle-stimulating hormone. It has been isolated from gonadal fluids and characterized as a protein heterodimer consisting of an alpha subunit and one of two beta subunits (beta A or beta B). FSH-releasing protein (FRP), al...

journal_title：Nature

authors： Yu J,Shao LE,Lemas V,Yu AL,Vaughan J,Rivier J,Vale W

更新日期：1987-12-24 00:00:00

abstract：:Electrons in a single sheet of graphene behave quite differently from those in traditional two-dimensional electron systems. Like massless relativistic particles, they have linear dispersion and chiral eigenstates. Furthermore, two sets of electrons centred at different points in reciprocal space ('valleys') have this...

journal_title：Nature

authors： Song YJ,Otte AF,Kuk Y,Hu Y,Torrance DB,First PN,de Heer WA,Min H,Adam S,Stiles MD,MacDonald AH,Stroscio JA

更新日期：2010-09-09 00:00:00

abstract：:Reorganizations of the Atlantic meridional overturning circulation were associated with large and abrupt climatic changes in the North Atlantic region during the last glacial period. Projections with climate models suggest that similar reorganizations may also occur in response to anthropogenic global warming. Here I ...

journal_title：Nature

authors： Schmittner A

更新日期：2005-03-31 00:00:00

abstract：:Hereditary nonpolyposis colorectal cancer (HNPCC) is one of man's commonest hereditary diseases. Several studies have implicated a defect in DNA mismatch repair in the pathogenesis of this disease. In particular, hMSH2 and hMLH1 homologues of the bacterial DNA mismatch repair genes mutS and mutL, respectively, were sh...

journal_title：Nature

authors： Nicolaides NC,Papadopoulos N,Liu B,Wei YF,Carter KC,Ruben SM,Rosen CA,Haseltine WA,Fleischmann RD,Fraser CM

更新日期：1994-09-01 00:00:00

abstract：:Type Ia supernovae are thought to result from thermonuclear explosions of carbon-oxygen white dwarf stars. Existing models generally explain the observed properties, with the exception of the sub-luminous 1991bg-like supernovae. It has long been suspected that the merger of two white dwarfs could give rise to a type I...

journal_title：Nature

authors： Pakmor R,Kromer M,Röpke FK,Sim SA,Ruiter AJ,Hillebrandt W

更新日期：2010-01-07 00:00:00

abstract：:Multicomponent reactions are relied on in both academic and industrial synthetic organic chemistry owing to their step- and atom-economy advantages over traditional synthetic sequences1. Recently, bicyclo[1.1.1]pentane (BCP) motifs have become valuable as pharmaceutical bioisosteres of benzene rings, and in particular...

journal_title：Nature

authors： Zhang X,Smith RT,Le C,McCarver SJ,Shireman BT,Carruthers NI,MacMillan DWC

更新日期：2020-04-01 00:00:00

abstract：:Disruption of the normal regulation of cell-cycle progression and division lies at the heart of the events leading to cancer. Complex networks of regulatory factors, the tumour microenvironment and stress signals, such as those resulting from damaged DNA, dictate whether cancer cells proliferate or die. Recent progres...

journal_title：Nature

authors： Sawyers C

更新日期：2004-11-18 00:00:00

abstract：:Despite antiretroviral therapy (ART), human immunodeficiency virus (HIV)-1 persists in a stable latent reservoir, primarily in resting memory CD4(+) T cells. This reservoir presents a major barrier to the cure of HIV-1 infection. To purge the reservoir, pharmacological reactivation of latent HIV-1 has been proposed an...

journal_title：Nature

authors： Deng K,Pertea M,Rongvaux A,Wang L,Durand CM,Ghiaur G,Lai J,McHugh HL,Hao H,Zhang H,Margolick JB,Gurer C,Murphy AJ,Valenzuela DM,Yancopoulos GD,Deeks SG,Strowig T,Kumar P,Siliciano JD,Salzberg SL,Flavell RA,Shan

更新日期：2015-01-15 00:00:00

abstract：:Deposits of beta-amyloid are one of the main pathological characteristics of Alzheimer's disease. The beta-amyloid peptide constituent (relative molecular mass 4,200) of the deposits is derived from the beta-amyloid precursor protein (beta-APP) which is expressed in several different isoforms. The two most prevalent b...

journal_title：Nature

authors： Quon D,Wang Y,Catalano R,Scardina JM,Murakami K,Cordell B

更新日期：1991-07-18 00:00:00

abstract：:RNA polymerase II (RNAP II) is responsible for transcribing all messenger RNAs in eukaryotic cells during a highly regulated process that is conserved from yeast to human, and that serves as a central control point for cellular function. Here we investigate the transcription dynamics of single RNAP II molecules from S...

journal_title：Nature

authors： Galburt EA,Grill SW,Wiedmann A,Lubkowska L,Choy J,Nogales E,Kashlev M,Bustamante C

更新日期：2007-04-12 00:00:00

abstract：:Life implies movement. Most forms of movement in the living world are powered by tiny protein machines known as molecular motors. Among the best known are motors that use sophisticated intramolecular amplification mechanisms to take nanometre steps along protein tracks in the cytoplasm. These motors transport a wide v...

journal_title：Nature

authors： Schliwa M,Woehlke G

更新日期：2003-04-17 00:00:00