Endogenous human microRNAs that suppress breast cancer metastasis.

abstract：:Modifications of histone proteins have essential roles in normal development and human disease. Recognition of modified histones by 'reader' proteins is a key mechanism that mediates the function of histone modifications, but how the dysregulation of these readers might contribute to disease remains poorly understood....

journal_title：Nature

authors： Wan L,Chong S,Xuan F,Liang A,Cui X,Gates L,Carroll TS,Li Y,Feng L,Chen G,Wang SP,Ortiz MV,Daley SK,Wang X,Xuan H,Kentsis A,Muir TW,Roeder RG,Li H,Li W,Tjian R,Wen H,Allis CD

更新日期：2020-01-01 00:00:00

abstract：:RNA polymerase II (RNAP II) is responsible for transcribing all messenger RNAs in eukaryotic cells during a highly regulated process that is conserved from yeast to human, and that serves as a central control point for cellular function. Here we investigate the transcription dynamics of single RNAP II molecules from S...

journal_title：Nature

authors： Galburt EA,Grill SW,Wiedmann A,Lubkowska L,Choy J,Nogales E,Kashlev M,Bustamante C

更新日期：2007-04-12 00:00:00

abstract：:Eukaryotic ribosomes consist of a small 40S and a large 60S subunit that are assembled in a highly coordinated manner. More than 200 factors ensure correct modification, processing and folding of ribosomal RNA and the timely incorporation of ribosomal proteins1,2. Small subunit maturation ends in the cytosol, when the...

journal_title：Nature

authors： Ameismeier M,Zemp I,van den Heuvel J,Thoms M,Berninghausen O,Kutay U,Beckmann R

更新日期：2020-11-01 00:00:00

abstract：:Molecular approaches to understanding the functional circuitry of the nervous system promise new insights into the relationship between genes, brain and behaviour. The cellular diversity of the brain necessitates a cellular resolution approach towards understanding the functional genomics of the nervous system. We des...

journal_title：Nature

authors： Lein ES,Hawrylycz MJ,Ao N,Ayres M,Bensinger A,Bernard A,Boe AF,Boguski MS,Brockway KS,Byrnes EJ,Chen L,Chen L,Chen TM,Chin MC,Chong J,Crook BE,Czaplinska A,Dang CN,Datta S,Dee NR,Desaki AL,Desta T,Diep E,Dol

更新日期：2007-01-11 00:00:00

abstract：:Self-incompatibility in flowering plants is often controlled by a single nuclear gene (the S-gene) having several alleles. This gene prevents fertilization by self-pollen or by pollen bearing either of the two S-alleles expressed in the style. Sequence analysis shows that three alleles of the S gene of Nicotiana alata...

journal_title：Nature

authors： McClure BA,Haring V,Ebert PR,Anderson MA,Simpson RJ,Sakiyama F,Clarke AE

更新日期：1989-12-21 00:00:00

abstract：:The "Gardner hypothesis" suggests that an excess of childhood leukaemia near a nuclear reprocessing plant is caused by paternal exposure to ionizing radiation. But the evidence shows that this explanation is wrong. ...

journal_title：Nature

authors： Doll R,Evans HJ,Darby SC

更新日期：1994-02-24 00:00:00

abstract：:Activity-dependent change in the efficacy of transmission is a basic feature of many excitatory synapses in the central nervous system. The best understood postsynaptic modification involves a change in responsiveness of AMPAR (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor)-mediated currents follo...

journal_title：Nature

authors： Liu SQ,Cull-Candy SG

更新日期：2000-05-25 00:00:00

abstract：:Estimates of the total number of bacterial species indicate that existing DNA sequence databases carry only a tiny fraction of the total amount of DNA sequence space represented by this division of life. Indeed, environmental DNA samples have been shown to encode many previously unknown classes of proteins and RNAs. B...

journal_title：Nature

authors： Weinberg Z,Perreault J,Meyer MM,Breaker RR

更新日期：2009-12-03 00:00:00

abstract：:Combined PD-1 and CTLA-4-targeted immunotherapy with nivolumab and ipilimumab is effective against melanoma, renal cell carcinoma and non-small-cell lung cancer1-3. However, this comes at the cost of frequent, serious immune-related adverse events, necessitating a reduction in the recommended dose of ipilimumab that i...

journal_title：Nature

authors： Perez-Ruiz E,Minute L,Otano I,Alvarez M,Ochoa MC,Belsue V,de Andrea C,Rodriguez-Ruiz ME,Perez-Gracia JL,Marquez-Rodas I,Llacer C,Alvarez M,de Luque V,Molina C,Teijeira A,Berraondo P,Melero I

更新日期：2019-05-01 00:00:00

abstract：:Inorganic nanoparticles exhibit size-dependent properties that are of interest for applications ranging from biosensing and catalysis to optics and data storage. They are readily available in a wide variety of discrete compositions and sizes. Shape-selective synthesis strategies now also yield shapes other than nanosp...

journal_title：Nature

authors： Jin R,Cao YC,Hao E,Métraux GS,Schatz GC,Mirkin CA

更新日期：2003-10-02 00:00:00

abstract：:The U6 small nuclear (sn)RNA gene (SNR6) from the yeast Saccharomyces cerevisiae is transcribed by RNA polymerase III in vivo. This gene is unusual in having a TATA box at position -30, and an essential B-block element located downstream of the T-rich termination signal. The B block is one of the two intragenic promot...

journal_title：Nature

authors： Burnol AF,Margottin F,Huet J,Almouzni G,Prioleau MN,Méchali M,Sentenac A

更新日期：1993-04-01 00:00:00

abstract：:Substitutions of single glycine residues of alpha 1(I) collagen have previously been associated with the inherited disease osteogenesis imperfecta type II. Transgenic mice bearing a mutant alpha 1(I) collagen gene into which specific glycine substitutions have been engineered show a dominant lethal phenotype character...

journal_title：Nature

authors： Stacey A,Bateman J,Choi T,Mascara T,Cole W,Jaenisch R

更新日期：1988-03-10 00:00:00

abstract：:Complexity in male sexual displays is widely appreciated but diversity in female mate choice has received little attention. Males of many species have sexual displays composed of multiple display traits, and females are thought to use these different traits in mate choice. Models of multiple display trait evolution su...

journal_title：Nature

authors： Coleman SW,Patricelli GL,Borgia G

更新日期：2004-04-15 00:00:00

abstract：:A large number of cis-regulatory sequences have been annotated in the human genome, but defining their target genes remains a challenge. One strategy is to identify the long-range looping interactions at these elements with the use of chromosome conformation capture (3C)-based techniques. However, previous studies lac...

journal_title：Nature

authors： Jin F,Li Y,Dixon JR,Selvaraj S,Ye Z,Lee AY,Yen CA,Schmitt AD,Espinoza CA,Ren B

更新日期：2013-11-14 00:00:00

abstract：:Organisms use endogenous clocks to anticipate regular environmental cycles, such as days and tides. Natural variants resulting in differently timed behaviour or physiology, known as chronotypes in humans, have not been well characterized at the molecular level. We sequenced the genome of Clunio marinus, a marine midge...

journal_title：Nature

authors： Kaiser TS,Poehn B,Szkiba D,Preussner M,Sedlazeck FJ,Zrim A,Neumann T,Nguyen LT,Betancourt AJ,Hummel T,Vogel H,Dorner S,Heyd F,von Haeseler A,Tessmar-Raible K

更新日期：2016-12-01 00:00:00

abstract：:Type Ia supernovae have been used empirically as 'standard candles' to demonstrate the acceleration of the expansion of the Universe even though fundamental details, such as the nature of their progenitor systems and how the stars explode, remain a mystery. There is consensus that a white dwarf star explodes after acc...

journal_title：Nature

authors： Nugent PE,Sullivan M,Cenko SB,Thomas RC,Kasen D,Howell DA,Bersier D,Bloom JS,Kulkarni SR,Kandrashoff MT,Filippenko AV,Silverman JM,Marcy GW,Howard AW,Isaacson HT,Maguire K,Suzuki N,Tarlton JE,Pan YC,Bildsten L,Ful

更新日期：2011-12-14 00:00:00

abstract：:The rod and cone transducins are specific G proteins originally thought to be present only in photoreceptor cells of the vertebrate retina. Transducins convert light stimulation of photoreceptor opsins into activation of cyclic GMP phosphodiesterase (reviewed in refs. 5-7). A transducin-like G protein, gustducin, has ...

journal_title：Nature

authors： Ruiz-Avila L,McLaughlin SK,Wildman D,McKinnon PJ,Robichon A,Spickofsky N,Margolskee RF

更新日期：1995-07-06 00:00:00

abstract：:The peptide GsMTx4, isolated from the venom of the tarantula Grammostola spatulata, is a selective inhibitor of stretch-activated cation channels (SACs). The mechanism of inhibition remains unknown; but both GsMTx4 and its enantiomer, enGsMTx4, modify the gating of SACs, thus violating a trademark of the traditional l...

journal_title：Nature

authors： Suchyna TM,Tape SE,Koeppe RE 2nd,Andersen OS,Sachs F,Gottlieb PA

更新日期：2004-07-08 00:00:00

abstract：:In plants, the small GTP-binding proteins called Rops work as signalling switches that control growth, development and plant responses to various environmental stimuli. Rop proteins (Rho of plants, Rac-like and AtRac in Arabidopsis thaliana) belong to the Rho family of Ras-related GTP-binding proteins that turn on sig...

journal_title：Nature

authors： Berken A,Thomas C,Wittinghofer A

更新日期：2005-08-25 00:00:00

abstract：:Considerable attention has centered recently on the changes in neuron excitability and synaptic efficacy caused by certain biogenic amines and neuropeptides. These neuromodulators act at a wide variety of both central and peripheral targets, and bring about diverse biological results. In sensory pathways, modulation o...

journal_title：Nature

authors： Pasztor VM,Bush BM

更新日期：1987-04-23 00:00:00

abstract：:Unicellular organisms such as yeasts require a single cyclin-dependent kinase, Cdk1, to drive cell division. In contrast, mammalian cells are thought to require the sequential activation of at least four different cyclin-dependent kinases, Cdk2, Cdk3, Cdk4 and Cdk6, to drive cells through interphase, as well as Cdk1 t...

journal_title：Nature

authors： Santamaría D,Barrière C,Cerqueira A,Hunt S,Tardy C,Newton K,Cáceres JF,Dubus P,Malumbres M,Barbacid M

更新日期：2007-08-16 00:00:00

abstract：:A mouse major histocompatibility antigen (H-2) gene, encoding a novel H-2Ld molecule lacking its intracytoplasmic domain, has been constructed and introduced into mouse L-cells. The novel H-2 molecule is found on the surface of the transfected cells at the same level as L-cells transfected with the native H-2Ld gene. ...

journal_title：Nature

authors： Murre C,Reiss CS,Bernabeu C,Chen LB,Burakoff SJ,Seidman JG

更新日期：1984-02-02 00:00:00

abstract：:For more than three-quarters of a century it has been assumed that basal metabolic rate increases as body mass raised to some power p. However, there is no broad consensus regarding the value of p: whereas many studies have asserted that p is 3/4 (refs 1-4; 'Kleiber's law'), some have argued that it is 2/3 (refs 5-7),...

journal_title：Nature

authors： Kolokotrones T,Van Savage,Deeds EJ,Fontana W

更新日期：2010-04-01 00:00:00

abstract：:The difficulty of working with the intact brain in vivo has led to the increasing use of nerve cell cultures in neurobiology. However, dissociated cells cannot be unambiguously identified by morphological criteria before the third week in culture, for it is not until then that the basic morphology and size of neurones...

journal_title：Nature

authors： Hooghe-Peters EL,Fowlkes BJ,Hooghe RJ

更新日期：1979-10-04 00:00:00

abstract：:Therapies for patients with cancer have changed gradually over the past decade, moving away from the administration of broadly acting cytotoxic drugs towards the use of more-specific therapies that are targeted to each tumour. To facilitate this shift, tests need to be developed to identify those individuals who requi...

journal_title：Nature

authors： van't Veer LJ,Bernards R

更新日期：2008-04-03 00:00:00

abstract：:Abyssal-hill-bounding faults that pervade the oceanic crust are the most common tectonic feature on the surface of the Earth. The recognition that these faults form at plate spreading centres came with the plate tectonic revolution. Recent observations reveal a large range of fault sizes and orientations; numerical mo...

journal_title：Nature

authors： Buck WR,Lavier LL,Poliakov AN

更新日期：2005-04-07 00:00:00

abstract：:Climate change is predicted to increase both drought frequency and duration, and when coupled with substantial warming, will establish a new hydroclimatological model for many regions. Large-scale, warm droughts have recently occurred in North America, Africa, Europe, Amazonia and Australia, resulting in major effects...

journal_title：Nature

authors： Ponce Campos GE,Moran MS,Huete A,Zhang Y,Bresloff C,Huxman TE,Eamus D,Bosch DD,Buda AR,Gunter SA,Scalley TH,Kitchen SG,McClaran MP,McNab WH,Montoya DS,Morgan JA,Peters DP,Sadler EJ,Seyfried MS,Starks PJ

更新日期：2013-02-21 00:00:00

abstract：:In their investigation into whether female mate-choice drives male dispersal, Höner et al. argue that female spotted hyaenas (Crocuta crocuta) prefer mates whose tenure in the social group is less than the females' age, to avoid paternal incest, and suggest that male dispersal reflects this preference. However, we are...

journal_title：Nature

authors： Van Horn RC,Watts HE,Holekamp KE

更新日期：2008-07-10 00:00:00

abstract：:A wide range of receptors are located at the blood sinusoidal aspect of the hepatocyte plasma membrane. Many circulating ligands that bind to receptors on the cell surfaces are interiorized along two pathways. Asialoglycoproteins are transferred from the plasma membrane to lysosomes and degraded, whereas immunoglobuli...

journal_title：Nature

authors： Debanne MT,Evans WH,Flint N,Regoeczi E

更新日期：1982-07-22 00:00:00

abstract：:N-glycosylation of proteins in the endoplasmic reticulum (ER) has a central role in protein quality control. Here we report that N-glycan serves as a signal for degradation by the Skp1-Cullin1-Fbx2-Roc1 (SCF(Fbx2)) ubiquitin ligase complex. The F-box protein Fbx2 (ref. 4) binds specifically to proteins attached to N-l...

journal_title：Nature

authors： Yoshida Y,Chiba T,Tokunaga F,Kawasaki H,Iwai K,Suzuki T,Ito Y,Matsuoka K,Yoshida M,Tanaka K,Tai T

更新日期：2002-07-25 00:00:00