Messenger RNA from human brain induces drug- and voltage-operated channels in Xenopus oocytes.

abstract：:The cartilage and skin of animals, which are made up of more than fifty per cent water, are rather stiff (having elastic moduli of up to 100 megapascals) as well as tough and hard to break (with fracture energies of up to 9,000 joules per square metre). Such features make these biological materials mechanically superi...

journal_title：Nature

authors： Rauner N,Meuris M,Zoric M,Tiller JC

更新日期：2017-03-16 00:00:00

abstract：:The interneuronal messenger nitric oxide (NO) may play a central role in the processing of olfactory information. Several circuit elements in the mammalian olfactory bulb contain NO synthase or its functional equivalent, NADPH diaphorase. The effects of NO on cellular excitability or circuit dynamics in the olfactory ...

journal_title：Nature

authors： Gelperin A

更新日期：1994-05-05 00:00:00

abstract：:Obesity is a disorder of energy balance, indicating a chronic disequilibrium between energy intake and expenditure. Recently, the mouse ob gene, and subsequently its human and rat homologues, have been cloned. The ob gene product, leptin, is expressed exclusively in adipose tissue, and appears to be a signalling facto...

journal_title：Nature

authors： Saladin R,De Vos P,Guerre-Millo M,Leturque A,Girard J,Staels B,Auwerx J

更新日期：1995-10-12 00:00:00

abstract：:Functional studies seem now to confirm, as first suggested by E. Geoffroy Saint-Hilaire in 1822, that there was an inversion of the dorsoventral axis during animal evolution. A conserved system of extracellular signals provides positional information for the allocation of embryonic cells to specific tissue types both ...

journal_title：Nature

authors： De Robertis EM,Sasai Y

更新日期：1996-03-07 00:00:00

abstract：:The cloning of mammals from differentiated donor cells has refuted the old dogma that development is an irreversible process. It has demonstrated that the oocyte can reprogramme an adult nucleus into an embryonic state that can direct development of a new organism. The prospect of deriving patient-specific embryonic s...

journal_title：Nature

authors： Hochedlinger K,Jaenisch R

更新日期：2006-06-29 00:00:00

abstract：:The ability of cells to form cell contacts, adhere to the extracellular matrix, change morphology, and migrate is essential for development, wound healing, metastasis, cell survival and the immune response. These events depend on the binding of integrin to the extracellular matrix, and assembly of focal adhesions, whi...

journal_title：Nature

authors： Ling K,Doughman RL,Firestone AJ,Bunce MW,Anderson RA

更新日期：2002-11-07 00:00:00

abstract：:Vaccines against a variety of infectious diseases represent one of the great triumphs of medicine. The immune correlates of protection induced by most current vaccines seem to be mediated by long-lived humoral immune responses. By contrast, there are no currently available vaccines that are uniformly effective for dis...

journal_title：Nature

authors： Seder RA,Hill AV

更新日期：2000-08-17 00:00:00

abstract：:Fast radio bursts (FRBs) are millisecond-duration radio transients1,2 of unknown origin. Two possible mechanisms that could generate extremely coherent emission from FRBs invoke neutron star magnetospheres3-5 or relativistic shocks far from the central energy source6-8. Detailed polarization observations may help us t...

journal_title：Nature

authors： Luo R,Wang BJ,Men YP,Zhang CF,Jiang JC,Xu H,Wang WY,Lee KJ,Han JL,Zhang B,Caballero RN,Chen MZ,Chen XL,Gan HQ,Guo YJ,Hao LF,Huang YX,Jiang P,Li H,Li J,Li ZX,Luo JT,Pan J,Pei X,Qian L,Sun JH,Wang M,Wa

更新日期：2020-10-01 00:00:00

abstract：:Nutrients, such as amino acids and glucose, signal through the Rag GTPases to activate mTORC1. The GATOR1 protein complex-comprising DEPDC5, NPRL2 and NPRL3-regulates the Rag GTPases as a GTPase-activating protein (GAP) for RAGA; loss of GATOR1 desensitizes mTORC1 signalling to nutrient starvation. GATOR1 components h...

journal_title：Nature

authors： Shen K,Huang RK,Brignole EJ,Condon KJ,Valenstein ML,Chantranupong L,Bomaliyamu A,Choe A,Hong C,Yu Z,Sabatini DM

更新日期：2018-04-05 00:00:00

abstract：:The key behavioural, physiological and anatomical components of a magnetite-based magnetic sense have been demonstrated in rainbow trout (Oncorhynchus mykiss). Candidate receptor cells located within a discrete sub-layer of the olfactory lamellae contained iron-rich crystals that were similar in size and shape to magn...

journal_title：Nature

authors： Diebel CE,Proksch R,Green CR,Neilson P,Walker MM

更新日期：2000-07-20 00:00:00

abstract：:The ability of collapsing (cavitating) bubbles to focus and concentrate energy, forces and stresses is at the root of phenomena such as cavitation damage, sonochemistry or sonoluminescence. In a biomedical context, ultrasound-driven microbubbles have been used to enhance contrast in ultrasonic images. The observation ...

journal_title：Nature

authors： Marmottant P,Hilgenfeldt S

更新日期：2003-05-08 00:00:00

abstract：:Subduction zones produce the largest earthquakes. Over the past two decades, space geodesy has revolutionized our view of crustal deformation between consecutive earthquakes. The short time span of modern measurements necessitates comparative studies of subduction zones that are at different stages of the deformation ...

journal_title：Nature

authors： Wang K,Hu Y,He J

更新日期：2012-04-18 00:00:00

abstract：:More than 99 per cent of the roughly 58,000 living vertebrate species have jaws. This major clade, whose members are collectively known as gnathostomes ('jawed mouths'), made its earliest definitive appearance in the Silurian period, 444-416 million years (Myr) ago, with both the origin of the modern (crown-group) rad...

journal_title：Nature

authors： Anderson PS,Friedman M,Brazeau MD,Rayfield EJ

更新日期：2011-07-06 00:00:00

abstract：:The Gram-negative bacterium Yersinia pestis is the causative agent of the systemic invasive infectious disease classically referred to as plague, and has been responsible for three human pandemics: the Justinian plague (sixth to eighth centuries), the Black Death (fourteenth to nineteenth centuries) and modern plague ...

journal_title：Nature

authors： Parkhill J,Wren BW,Thomson NR,Titball RW,Holden MT,Prentice MB,Sebaihia M,James KD,Churcher C,Mungall KL,Baker S,Basham D,Bentley SD,Brooks K,Cerdeño-Tárraga AM,Chillingworth T,Cronin A,Davies RM,Davis P,Dougan G,

更新日期：2001-10-04 00:00:00

abstract：:An unusual feature of the cerebellar cortex is that its output neurons, Purkinje cells, release GABA (γ-aminobutyric acid). Their high intrinsic firing rates (50 Hz) and extensive convergence predict that their target neurons in the cerebellar nuclei would be largely inhibited unless Purkinje cells pause their spiking...

journal_title：Nature

authors： Person AL,Raman IM

更新日期：2011-12-25 00:00:00

abstract：:The main function of postural nervous mechanisms in different species, from mollusc to man, is to counteract the force of gravity and stabilize body orientation in space. Here we investigate the basic principles of postural control in a simple animal model, the marine mollusc Clione limacina. When swimming, C. limacin...

journal_title：Nature

authors： Deliagina TG,Arshavsky YI,Orlovsky GN

更新日期：1998-05-14 00:00:00

abstract：: ...

journal_title：Nature

authors： Reardon S

更新日期：2018-12-01 00:00:00

abstract：:A hallmark of RNA silencing is a class of approximately 22-nucleotide RNAs that are processed from double-stranded RNA precursors by Dicer. Accurate processing by Dicer is crucial for the functionality of microRNAs (miRNAs). The current model posits that Dicer selects cleavage sites by measuring a set distance from th...

journal_title：Nature

authors： Park JE,Heo I,Tian Y,Simanshu DK,Chang H,Jee D,Patel DJ,Kim VN

更新日期：2011-07-13 00:00:00

abstract：:Despite the introduction of antiproliferative drug-eluting stents, coronary heart disease remains the leading cause of death in the United States. In-stent restenosis and bypass graft failure are characterized by excessive smooth muscle cell (SMC) proliferation and concomitant myointima formation with luminal oblitera...

journal_title：Nature

authors： Deuse T,Hua X,Wang D,Maegdefessel L,Heeren J,Scheja L,Bolaños JP,Rakovic A,Spin JM,Stubbendorff M,Ikeno F,Länger F,Zeller T,Schulte-Uentrop L,Stoehr A,Itagaki R,Haddad F,Eschenhagen T,Blankenberg S,Kiefmann R,Reic

更新日期：2014-05-29 00:00:00

abstract：:The brightness of type Ia supernovae, and their homogeneity as a class, makes them powerful tools in cosmology, yet little is known about the progenitor systems of these explosions. They are thought to arise when a white dwarf accretes matter from a companion star, is compressed and undergoes a thermonuclear explosion...

journal_title：Nature

authors： Ruiz-Lapuente P,Comeron F,Méndez J,Canal R,Smartt SJ,Filippenko AV,Kurucz RL,Chornock R,Foley RJ,Stanishev V,Ibata R

更新日期：2004-10-28 00:00:00

abstract：:The human alpha-interferon (IFN-alpha) gene family consists of at least 14 potentially functional non-allelic members; the amino acid sequences they encode differ from each other by up to approximately 20% of their residues. Human IFN-beta, which is encoded by a single gene, is distantly related to the IFN-alpha famil...

journal_title：Nature

authors： Valenzuela D,Weber H,Weissmann C

更新日期：1985-02-21 00:00:00

abstract：:The ras-related low-molecular-mass GTPases participate in signal transduction involving a variety of cellular functions, including cell-cycle progression, cellular differentiation, cytoskeletal organization, protein transport and secretion. The cycling of these proteins between GTP-bound and GDP-bound states is partia...

journal_title：Nature

authors： Settleman J,Albright CF,Foster LC,Weinberg RA

更新日期：1992-09-10 00:00:00

abstract：:Protein ubiquitination is a common form of post-translational modification that regulates a broad spectrum of protein substrates in diverse cellular pathways. Through a three-enzyme (E1-E2-E3) cascade, the attachment of ubiquitin to proteins is catalysed by the E3 ubiquitin ligase, which is best represented by the sup...

journal_title：Nature

authors： Angers S,Li T,Yi X,MacCoss MJ,Moon RT,Zheng N

更新日期：2006-10-05 00:00:00

abstract：:Pressure is mounting to relax the regulations on importation of chimpanzees for research. Such a policy is unnecessary and would deepen the plight of an already endangered species. ...

journal_title：Nature

authors： Prince AM,Moor-Jankowski J,Eichberg JW,Schellekens H,Mauler RF,Girard M,Goodall J

更新日期：1988-06-09 00:00:00

abstract：:Changes in redox status are a conspicuous feature of immune responses in a variety of eukaryotes, but the associated signalling mechanisms are not well understood. In plants, attempted microbial infection triggers the rapid synthesis of nitric oxide and a parallel accumulation of reactive oxygen intermediates, the lat...

journal_title：Nature

authors： Yun BW,Feechan A,Yin M,Saidi NB,Le Bihan T,Yu M,Moore JW,Kang JG,Kwon E,Spoel SH,Pallas JA,Loake GJ

更新日期：2011-10-13 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) have been generated by enforced expression of defined sets of transcription factors in somatic cells. It remains controversial whether iPSCs are molecularly and functionally equivalent to blastocyst-derived embryonic stem (ES) cells. By comparing genetically identical mouse ES ce...

journal_title：Nature

authors： Stadtfeld M,Apostolou E,Akutsu H,Fukuda A,Follett P,Natesan S,Kono T,Shioda T,Hochedlinger K

更新日期：2010-05-13 00:00:00

abstract：:Recent advances in understanding the molecular basis of human X-linked muscular dystrophies have come from the identification of dystrophin, a cytoskeletal protein associated with the surface membrane. Although there is little or virtually no dystrophin in affected individuals, it is not known how this causes muscle d...

journal_title：Nature

authors： Franco A Jr,Lansman JB

更新日期：1990-04-12 00:00:00

abstract：:Quantum electrodynamics describes the interactions of electrons and photons. Electric charge (the gauge coupling constant) is energy dependent, and there is a previous claim that charge is affected by gravity (described by general relativity) with the implication that the charge is reduced at high energies. However, t...

journal_title：Nature

authors： Toms DJ

更新日期：2010-11-04 00:00:00

abstract：:High-energy cosmic-ray electrons and positrons (CREs), which lose energy quickly during their propagation, provide a probe of Galactic high-energy processes and may enable the observation of phenomena such as dark-matter particle annihilation or decay. The CRE spectrum has been measured directly up to approximately 2 ...

journal_title：Nature

authors： DAMPE Collaboration.

更新日期：2017-12-07 00:00:00

abstract：:Many receptors for neuropeptides and hormones are coupled with the heterotrimeric G(i) protein, which activates the p42/44 mitogen-activated protein kinase (ERK/MAPK) cascade through both the alpha- and betagamma-subunits of G(i). The betagamma-subunit activates the ERK/MAPK cascade through tyrosine kinase. Constituti...

journal_title：Nature

authors： Mochizuki N,Ohba Y,Kiyokawa E,Kurata T,Murakami T,Ozaki T,Kitabatake A,Nagashima K,Matsuda M

更新日期：1999-08-26 00:00:00