Abstract：
:The ability of collapsing (cavitating) bubbles to focus and concentrate energy, forces and stresses is at the root of phenomena such as cavitation damage, sonochemistry or sonoluminescence. In a biomedical context, ultrasound-driven microbubbles have been used to enhance contrast in ultrasonic images. The observation of bubble-enhanced sonoporation--acoustically induced rupture of membranes--has also opened up intriguing possibilities for the therapeutic application of sonoporation as an alternative to cell-wall permeation techniques such as electroporation and particle guns. However, these pioneering experiments have not been able to pinpoint the mechanism by which the violently collapsing bubble opens pores or larger holes in membranes. Here we present an experiment in which gentle (linear) bubble oscillations are sufficient to achieve rupture of lipid membranes. In this regime, the bubble dynamics and the ensuing sonoporation can be accurately controlled. The use of microbubbles as focusing agents makes acoustics on the micrometre scale (microacoustics) a viable tool, with possible applications in cell manipulation and cell-wall permeation as well as in microfluidic devices.
journal_name
Naturejournal_title
Natureauthors
Marmottant P,Hilgenfeldt Sdoi
10.1038/nature01613keywords:
subject
Has Abstractpub_date
2003-05-08 00:00:00pages
153-6issue
6936eissn
0028-0836issn
1476-4687pii
nature01613journal_volume
423pub_type
杂志文章相关文献
NATURE文献大全abstract：:When we reach towards an object that suddenly appears in our peripheral visual field, not only does our arm extend towards the object, but our eyes, head and body also move in such a way that the image of the object falls on the fovea. Popular models of how reaching movements are programmed have argued that while the ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/320748a0
更新日期：1986-04-24 00:00:00
abstract：:Aerobic methanotrophic bacteria consume methane as it diffuses away from methanogenic zones of soil and sediment. They act as a biofilter to reduce methane emissions to the atmosphere, and they are therefore targets in strategies to combat global climate change. No cultured methanotroph grows optimally below pH 5, but...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature06411
更新日期：2007-12-06 00:00:00
abstract：:Repetitive activation of excitatory synapses in the central nervous system results in a long-lasting increase in synaptic transmission called long-term potentiation (LTP). It is generally believed that this synaptic plasticity may underlie certain forms of learning and memory. LTP at most synapses involves the activat...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/41574
更新日期：1997-08-07 00:00:00
abstract：:Relative to the present day, meridional temperature gradients in the Early Eocene age ( approximately 56-53 Myr ago) were unusually low, with slightly warmer equatorial regions but with much warmer subtropical Arctic and mid-latitude climates. By the end of the Eocene epoch ( approximately 34 Myr ago), the first major...
journal_title：Nature
pub_type： 历史文章,杂志文章
doi：10.1038/nature08399
更新日期：2009-10-08 00:00:00
abstract：:In lung diseases such as asthma, expiratory flow becomes limited, airways can collapse and the vital exchange of gases is compromised. Here we model the inflation of collapsed regions of the lung during inspiration in terms of avalanches propagating through a bifurcating network of airways, and find that the accompany...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/417809b
更新日期：2002-06-20 00:00:00
abstract：:Gut microbes supply the human body with energy from dietary polysaccharides through carbohydrate active enzymes, or CAZymes, which are absent in the human genome. These enzymes target polysaccharides from terrestrial plants that dominated diet throughout human evolution. The array of CAZymes in gut microbes is highly ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature08937
更新日期：2010-04-08 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41586-020-2691-0
更新日期：2020-09-01 00:00:00
abstract：: ...
journal_title：Nature
pub_type： 评论,信件
doi：10.1038/d41586-019-00764-z
更新日期：2019-03-01 00:00:00
abstract：:The standard form of back-propagation learning is implausible as a model of perceptual learning because it requires an external teacher to specify the desired output of the network. We show how the external teacher can be replaced by internally derived teaching signals. These signals are generated by using the assumpt...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/355161a0
更新日期：1992-01-09 00:00:00
abstract：:Combined PD-1 and CTLA-4-targeted immunotherapy with nivolumab and ipilimumab is effective against melanoma, renal cell carcinoma and non-small-cell lung cancer1-3. However, this comes at the cost of frequent, serious immune-related adverse events, necessitating a reduction in the recommended dose of ipilimumab that i...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-019-1162-y
更新日期：2019-05-01 00:00:00
abstract：:Mast cells are primary effectors in allergic reactions, and may have important roles in disease by secreting histamine and various inflammatory and immunomodulatory substances. Although they are classically activated by immunoglobulin (Ig)E antibodies, a unique property of mast cells is their antibody-independent resp...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature14022
更新日期：2015-03-12 00:00:00
abstract：:G-protein-coupled receptors comprise the largest family of mammalian transmembrane receptors. They mediate numerous cellular pathways by coupling with downstream signalling transducers, including the hetrotrimeric G proteins Gs (stimulatory) and Gi (inhibitory) and several arrestin proteins. The structural mechanisms ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-018-0215-y
更新日期：2018-06-01 00:00:00
abstract：:Diatremes are carrot-shaped bodies forming the upper parts of very deep magmatic intrusions of kimberlite rock. These unusual, enigmatic and complex features are famous as the source of diamonds. Here we present a new model of kimberlite ascent and eruption, emphasizing the extremely unsteady nature of this process to...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature05692
更新日期：2007-05-03 00:00:00
abstract：:This corrects the article DOI: 10.1038/nature24295. ...
journal_title：Nature
pub_type： 杂志文章,已发布勘误
doi：10.1038/nature25017
更新日期：2018-01-25 00:00:00
abstract：:Cocaine is believed to work by blocking the dopamine transporter (DAT) and thereby increasing the availability of free dopamine within the brain. Although this concept is central to current cocaine research and to treatment development, a direct relationship between DAT blockade and the subjective effects of cocaine h...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/386827a0
更新日期：1997-04-24 00:00:00
abstract：:A decade ago, Lovelock and Whitfield raised the question of how much longer the biosphere can survive on Earth. They pointed out that, despite the current fossil-fuel induced increase in the atmospheric CO2 concentration, the long-term trend should be in the opposite direction: as increased solar luminosity warms th...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/360721a0
更新日期：1992-12-24 00:00:00
abstract：:The holotype of Deinocheirus mirificus was collected by the 1965 Polish-Mongolian Palaeontological Expedition at Altan Uul III in the southern Gobi of Mongolia. Because the holotype consists mostly of giant forelimbs (2.4 m in length) with scapulocoracoids, for almost 50 years Deinocheirus has remained one of the most...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature13874
更新日期：2014-11-13 00:00:00
abstract：:Bcl-2 was isolated from the t(14;18) chromosomal breakpoint in follicular B-cell lymphoma. Bcl-2 has the unique oncogenic role of extending cell survival by inhibiting a variety of apoptotic deaths. An emerging family of Bcl-2-related proteins share two highly conserved regions referred to here as Bcl-2 homology 1 and...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/369321a0
更新日期：1994-05-26 00:00:00
abstract：:Ice sheets are currently ignored in global methane budgets1,2. Although ice sheets have been proposed to contain large reserves of methane that may contribute to a rise in atmospheric methane concentration if released during periods of rapid ice retreat3,4, no data exist on the current methane footprint of ice sheets....
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-018-0800-0
更新日期：2019-01-01 00:00:00
abstract：:Planetary formation theories suggest that the giant planets formed on circular and coplanar orbits. The eccentricities of Jupiter, Saturn and Uranus, however, reach values of 6 per cent, 9 per cent and 8 per cent, respectively. In addition, the inclinations of the orbital planes of Saturn, Uranus and Neptune take maxi...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature03539
更新日期：2005-05-26 00:00:00
abstract：:Parkinson's disease is characterized by loss of dopamine neurons in the substantia nigra1. Similar to other major neurodegenerative disorders, there are no disease-modifying treatments for Parkinson's disease. While most treatment strategies aim to prevent neuronal loss or protect vulnerable neuronal circuits, a poten...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-020-2388-4
更新日期：2020-06-01 00:00:00
abstract：:There is increasing evidence for the process of sympatric speciation, in which reproductive isolation of species occurs without physical isolation. Theoretical models have focused on disruptive natural selection as the crucial pressure for splitting a species. Here we report the theoretical finding that sympatric spec...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/990087
更新日期：1999-12-02 00:00:00
abstract：:The analysis of mutations affecting flower structure has led to the identification of some of the genes that direct flower development. Cloning of these genes has allowed the formulation of molecular models of how floral meristem and organ identity may be specified, and has shown that the distantly related flowering p...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/353031a0
更新日期：1991-09-05 00:00:00
abstract：:Antigenic variation in the haemagglutinin (HA) glycoprotein of influenza virus is associated with recurrent epidemics of respiratory disease in man (for review see ref. 1). We have examined the size of structural changes necessary to alter the antigenicity of HA by determining the three-dimensional structure of the HA...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/311678a0
更新日期：1984-10-18 00:00:00
abstract：:Measuring the completeness of the fossil record is essential to understanding evolution over long timescales, particularly when comparing evolutionary patterns among biological groups with different preservational properties. Completeness measures have been presented for various groups based on gaps in the stratigraph...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/18872
更新日期：1999-04-01 00:00:00
abstract：: ...
journal_title：Nature
pub_type： 新闻
doi：10.1038/d41586-018-07413-x
更新日期：2018-11-01 00:00:00
abstract：:Water masers are found in dense molecular clouds closely associated with supermassive black holes at the centres of active galaxies. On the basis of the understanding of the local water-maser luminosity function, it was expected that masers at intermediate and high redshifts would be extremely rare. However, galaxies ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature07544
更新日期：2008-12-18 00:00:00
abstract：:For a system at a temperature of absolute zero, all thermal fluctuations are frozen out, while quantum fluctuations prevail. These microscopic quantum fluctuations can induce a macroscopic phase transition in the ground state of a many-body system when the relative strength of two competing energy terms is varied acro...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/415039a
更新日期：2002-01-03 00:00:00
abstract：:Zika virus (ZIKV) is a flavivirus that is responsible for the current epidemic in Brazil and the Americas. ZIKV has been causally associated with fetal microcephaly, intrauterine growth restriction, and other birth defects in both humans and mice. The rapid development of a safe and effective ZIKV vaccine is a global ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature18952
更新日期：2016-08-25 00:00:00
abstract：:Data collected at approximately 60 Global Positioning System (GPS) sites in southeast Asia show the crustal deformation caused by the 26 December 2004 Sumatra-Andaman earthquake at an unprecedented large scale. Small but significant co-seismic jumps are clearly detected more than 3,000 km from the earthquake epicentre...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature03937
更新日期：2005-07-14 00:00:00
