Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions.

abstract：:Mutations in BRCA1 and BRCA2 predispose individuals to certain cancers1-3, and disease-specific screening and preventative strategies have reduced cancer mortality in affected patients4,5. These classical tumour-suppressor genes have tumorigenic effects associated with somatic biallelic inactivation, although haploins...

journal_title：Nature

authors： Jonsson P,Bandlamudi C,Cheng ML,Srinivasan P,Chavan SS,Friedman ND,Rosen EY,Richards AL,Bouvier N,Selcuklu SD,Bielski CM,Abida W,Mandelker D,Birsoy O,Zhang L,Zehir A,Donoghue MTA,Baselga J,Offit K,Scher HI,O'Reill

更新日期：2019-07-01 00:00:00

abstract：:Apart from the retroviral gag, pol and env the HIV genome contains the F (3' orf) gene which encodes a polypeptide of 206 amino acids which is myristylated at the N-terminal and whose function is unknown. We have expressed the F gene in Escherichia coli and from a recombinant vaccinia virus, VVTGfHIV. The F-protein pr...

journal_title：Nature

authors： Guy B,Kieny MP,Riviere Y,Le Peuch C,Dott K,Girard M,Montagnier L,Lecocq JP

更新日期：1987-11-19 00:00:00

abstract：:The histocompatibility-Y (H-Y) antigen is a minor histocompatibility antigen which has been detected on cell surfaces from the heterogametic sexes of mammalian, bird, amphibian, teleost and invertebrate species. H-Y is thought to be a male-determining substance in mammals because of its almost perfect correlation with...

journal_title：Nature

authors： Shapiro M,Erickson RP

更新日期：1981-04-09 00:00:00

abstract：:Precipitation and atmospheric circulation are the coupled processes through which tropical ocean surface temperatures drive global weather and climate1-5. Local sea surface warming tends to increase precipitation, but this local control is difficult to disentangle from remote effects of conditions elsewhere. As an exa...

journal_title：Nature

authors： Good P,Chadwick R,Holloway CE,Kennedy J,Lowe JA,Roehrig R,Rushley SS

更新日期：2021-01-01 00:00:00

abstract：:Some plasmid DNAs, when maintained in wild-type Escherichia coli strains, form high levels of oligomeric species while others remain primarily monomers. One explanation of this observation is that the plasmids that do not form circular oligomers lack a DNA sequence necessary for the formation or maintenance of circula...

journal_title：Nature

authors： James AA,Morrison PT,Kolodner R

更新日期：1983-05-19 00:00:00

abstract：:A re-analysis of published data on mouse mutation rates induced by X and gamma rays suggests that the kinetics of induction can be analysed by fitting the data to a parabolic curve. We interpret this to mean that a substantial proportion of the induced mutations results from gross chromosomal changes such as deletions...

journal_title：Nature

authors： Abrahamson S,Wolff S

更新日期：1976-12-23 00:00:00

abstract：:Ligand-gated ion channels are multi-subunit complexes where each subunit-type is encoded by several related genes. Heterologous expression of any one of the neuronal nicotinic acetylcholine receptors (nAChR) alpha-type subunits, either alone or with any beta-type subunit, typically yields functional nAChR channels. A ...

journal_title：Nature

authors： Ramirez-Latorre J,Yu CR,Qu X,Perin F,Karlin A,Role L

更新日期：1996-03-28 00:00:00

abstract：:Co-evolution between plants and their natural enemies is generally believed to have generated much of the Earth's biological diversity. A process analogous to co-evolution occurs in agricultural systems, in which natural enemies adapt to crop resistance introduced by breeding or genetic engineering. Because of this si...

journal_title：Nature

authors： Rausher MD

更新日期：2001-06-14 00:00:00

abstract：:Type Ia supernovae have been used empirically as 'standard candles' to demonstrate the acceleration of the expansion of the Universe even though fundamental details, such as the nature of their progenitor systems and how the stars explode, remain a mystery. There is consensus that a white dwarf star explodes after acc...

journal_title：Nature

authors： Nugent PE,Sullivan M,Cenko SB,Thomas RC,Kasen D,Howell DA,Bersier D,Bloom JS,Kulkarni SR,Kandrashoff MT,Filippenko AV,Silverman JM,Marcy GW,Howard AW,Isaacson HT,Maguire K,Suzuki N,Tarlton JE,Pan YC,Bildsten L,Ful

更新日期：2011-12-14 00:00:00

abstract：:Laboratory measurements of sound velocities of high-pressure minerals provide crucial information on the composition and constitution of the deep mantle via comparisons with observed seismic velocities. Calcium silicate (CaSiO3) perovskite (CaPv) is a high-pressure phase that occurs at depths greater than about 560 ki...

journal_title：Nature

authors： Gréaux S,Irifune T,Higo Y,Tange Y,Arimoto T,Liu Z,Yamada A

更新日期：2019-01-01 00:00:00

abstract：:The mammalian central nervous system (CNS) contains a remarkable array of neural cells, each with a complex pattern of connections that together generate perceptions and higher brain functions. Here we describe a large-scale screen to create an atlas of CNS gene expression at the cellular level, and to provide a libra...

journal_title：Nature

authors： Gong S,Zheng C,Doughty ML,Losos K,Didkovsky N,Schambra UB,Nowak NJ,Joyner A,Leblanc G,Hatten ME,Heintz N

更新日期：2003-10-30 00:00:00

abstract：:In the frog Xenopus, the somatic-type 5S ribosomal RNA genes are active in all cells; the oocyte-type 5S genes are active in oocytes but not in somatic cells. A new method of native gel electrophoresis resolves the two types of 5S RNA which are of the same length but different sequence. When somatic nuclei were inject...

journal_title：Nature

authors： Korn LJ,Gurdon JB

更新日期：1981-02-05 00:00:00

abstract：:Abyssal-hill-bounding faults that pervade the oceanic crust are the most common tectonic feature on the surface of the Earth. The recognition that these faults form at plate spreading centres came with the plate tectonic revolution. Recent observations reveal a large range of fault sizes and orientations; numerical mo...

journal_title：Nature

authors： Buck WR,Lavier LL,Poliakov AN

更新日期：2005-04-07 00:00:00

abstract：:The genome of Aspergillus oryzae, a fungus important for the production of traditional fermented foods and beverages in Japan, has been sequenced. The ability to secrete large amounts of proteins and the development of a transformation system have facilitated the use of A. oryzae in modern biotechnology. Although both...

journal_title：Nature

authors： Machida M,Asai K,Sano M,Tanaka T,Kumagai T,Terai G,Kusumoto K,Arima T,Akita O,Kashiwagi Y,Abe K,Gomi K,Horiuchi H,Kitamoto K,Kobayashi T,Takeuchi M,Denning DW,Galagan JE,Nierman WC,Yu J,Archer DB,Bennett JW,Bh

更新日期：2005-12-22 00:00:00

abstract：:A variety of observations indicate that mid-ocean ridges produce less crust at spreading rates below 20 mm yr(-1) (refs 1-3), reflecting changes in fundamental ridge processes with decreasing spreading rate. The nature of these changes, however, remains uncertain, with end-member explanations being decreasing shallow ...

journal_title：Nature

authors： Lizarralde D,Gaherty JB,Collins JA,Hirth G,Kim SD

更新日期：2004-12-09 00:00:00

abstract：:A rapid decrease in shear velocity in the suboceanic mantle is used to infer the thickness of the lithosphere. It is proposed that new and highly precise group velocity data constrain the solutions and imply a thickness near 70 km. ...

journal_title：Nature

authors： Kanamori H,Press F

更新日期：1970-04-25 00:00:00

abstract：:In metazoans, the Ras-Raf-MEK (mitogen-activated protein-kinase kinase)-ERK (extracellular signal-regulated kinase) signalling pathway relays extracellular stimuli to elicit changes in cellular function and gene expression. Aberrant activation of this pathway through oncogenic mutations is responsible for a large prop...

journal_title：Nature

authors： Brennan DF,Dar AC,Hertz NT,Chao WC,Burlingame AL,Shokat KM,Barford D

更新日期：2011-04-21 00:00:00

abstract：:Type Ia supernovae are thought to result from thermonuclear explosions of carbon-oxygen white dwarf stars. Existing models generally explain the observed properties, with the exception of the sub-luminous 1991bg-like supernovae. It has long been suspected that the merger of two white dwarfs could give rise to a type I...

journal_title：Nature

authors： Pakmor R,Kromer M,Röpke FK,Sim SA,Ruiter AJ,Hillebrandt W

更新日期：2010-01-07 00:00:00

abstract：:The human nose is often considered something of a luxury, but in the rest of the animal world, from bacteria to mammals, detecting chemicals in the environment has been critical to the successful organism. An indication of the importance of olfactory systems is the significant proportion - as much as 4% - of the genom...

journal_title：Nature

authors： Firestein S

更新日期：2001-09-13 00:00:00

abstract：:Nanomachines of the future will require molecular-scale motors that can perform work and collectively induce controlled motion of much larger objects. We have designed a synthetic, light-driven molecular motor that is embedded in a liquid-crystal film and can rotate objects placed on the film that exceed the size of t...

journal_title：Nature

authors： Eelkema R,Pollard MM,Vicario J,Katsonis N,Ramon BS,Bastiaansen CW,Broer DJ,Feringa BL

更新日期：2006-03-09 00:00:00

abstract：:Self-replication has been demonstrated in synthetic chemical systems based on oligonucleotides, peptides and complementary molecules without natural analogues. However, within a living cell virtually no molecule catalyses its own formation, and the search for chemical systems in which both auto- and cross-catalysis ca...

journal_title：Nature

authors： Yao S,Ghosh I,Zutshi R,Chmielewski J

更新日期：1998-12-03 00:00:00

abstract：:Metallothioneins are small cysteine-rich proteins that bind heavy metals such as zinc, cadmium, copper and mercury. Recent interest in these proteins has focused on the part they play in zinc metabolism and heavy metal detoxification. Our interest in metallothionein genes stems largely from the observations that these...

journal_title：Nature

authors： Glanville N,Durnam DM,Palmiter RD

更新日期：1981-07-16 00:00:00

abstract：:The formation of glasses is normal for substances that remain liquid over a wide temperature range (the 'good glassformers') and can be induced for most liquids if cooling is fast enough to bypass crystallization. During reheating but still below the melting point, good glassformers exhibit glass transitions as they a...

journal_title：Nature

authors： Yue Y,Angell CA

更新日期：2004-02-19 00:00:00

abstract：:Genetic manipulations of insect populations for pest control have been advocated for some time, but there are few cases where manipulated individuals have been released in the field and no cases where they have successfully invaded target populations. Population transformation using the intracellular bacterium Wolbach...

journal_title：Nature

authors： Hoffmann AA,Montgomery BL,Popovici J,Iturbe-Ormaetxe I,Johnson PH,Muzzi F,Greenfield M,Durkan M,Leong YS,Dong Y,Cook H,Axford J,Callahan AG,Kenny N,Omodei C,McGraw EA,Ryan PA,Ritchie SA,Turelli M,O'Neill SL

更新日期：2011-08-24 00:00:00

abstract：:About one-third of the carbon dioxide (CO(2)) released into the atmosphere as a result of human activity has been absorbed by the oceans, where it partitions into the constituent ions of carbonic acid. This leads to ocean acidification, one of the major threats to marine ecosystems and particularly to calcifying organ...

journal_title：Nature

authors： Beaufort L,Probert I,de Garidel-Thoron T,Bendif EM,Ruiz-Pino D,Metzl N,Goyet C,Buchet N,Coupel P,Grelaud M,Rost B,Rickaby RE,de Vargas C

更新日期：2011-08-03 00:00:00

abstract：:Mutants of cdc2+ can disrupt the dependency of S phase on completion of the previous mitosis. By changing the state of p34cdc2 it is possible to reprogramme a cell from entering mitosis to undergoing S phase. This leads to the proposal that the cell cycle can be considered a p34cdc2 cycle, and has implications for the...

journal_title：Nature

authors： Broek D,Bartlett R,Crawford K,Nurse P

更新日期：1991-01-31 00:00:00

abstract：:RNA polymerase II (RNAP II) is responsible for transcribing all messenger RNAs in eukaryotic cells during a highly regulated process that is conserved from yeast to human, and that serves as a central control point for cellular function. Here we investigate the transcription dynamics of single RNAP II molecules from S...

journal_title：Nature

authors： Galburt EA,Grill SW,Wiedmann A,Lubkowska L,Choy J,Nogales E,Kashlev M,Bustamante C

更新日期：2007-04-12 00:00:00

abstract：:Electrophoretic studies suggest that bacterial populations consist of a number of independent clones and that genetic recombination is rare in nature. But DNA sequencing reveals that individual bacterial genes have a mosaic structure that could have arisen only by recombination. How can these observations be reconcile...

journal_title：Nature

authors： Smith JM,Dowson CG,Spratt BG

更新日期：1991-01-03 00:00:00

abstract：:The ability of cells to form cell contacts, adhere to the extracellular matrix, change morphology, and migrate is essential for development, wound healing, metastasis, cell survival and the immune response. These events depend on the binding of integrin to the extracellular matrix, and assembly of focal adhesions, whi...

journal_title：Nature

authors： Ling K,Doughman RL,Firestone AJ,Bunce MW,Anderson RA

更新日期：2002-11-07 00:00:00

abstract：:Chromatin is traditionally viewed as a nuclear entity that regulates gene expression and silencing. However, we recently discovered the presence of cytoplasmic chromatin fragments that pinch off from intact nuclei of primary cells during senescence, a form of terminal cell-cycle arrest associated with pro-inflammatory...

journal_title：Nature

authors： Dou Z,Ghosh K,Vizioli MG,Zhu J,Sen P,Wangensteen KJ,Simithy J,Lan Y,Lin Y,Zhou Z,Capell BC,Xu C,Xu M,Kieckhaefer JE,Jiang T,Shoshkes-Carmel M,Tanim KMAA,Barber GN,Seykora JT,Millar SE,Kaestner KH,Garcia BA,Ada

更新日期：2017-10-19 00:00:00