Functional contributions of alpha5 subunit to neuronal acetylcholine receptor channels.

abstract：:High mobility group 1 (HMGB1) protein is both a nuclear factor and a secreted protein. In the cell nucleus it acts as an architectural chromatin-binding factor that bends DNA and promotes protein assembly on specific DNA targets. Outside the cell, it binds with high affinity to RAGE (the receptor for advanced glycatio...

journal_title：Nature

authors： Scaffidi P,Misteli T,Bianchi ME

更新日期：2002-07-11 00:00:00

abstract：:The low concentration of atmospheric CO2 inferred to have been present during glacial periods is thought to have been partly caused by an increased supply of iron-bearing dust to the ocean surface. This is supported by a recent model that attributes half of the CO2 reduction during past glacial stages to iron-stimulat...

journal_title：Nature

authors： Maher BA,Dennis PF

更新日期：2001-05-10 00:00:00

abstract：:Methyl chloride is the largest natural source of ozone-depleting chlorine compounds, and accounts for about 15 per cent of the present atmospheric chlorine content. This contribution was likely to have been relatively greater in pre-industrial times, when additional anthropogenic sources-such as chlorofluorocarbons-we...

journal_title：Nature

authors： Yokouchi Y,Ikeda M,Inuzuka Y,Yukawa T

更新日期：2002-03-14 00:00:00

abstract：:A hybrid gene was constructed between the beta-lactamase gene of plasmid pBR322 and the cloned coding sequence for rat growth hormone. This gene is expressed in bacteria and growth hormone sequences are detectable by immunological methods. ...

journal_title：Nature

authors： Seeburg PH,Shine J,Martial JA,Ivarie RD,Morris JA,Ullrich A,Baxter JD,Goodman HM

更新日期：1978-12-21 00:00:00

abstract：:Initial studies of somatically acquired mutations in immunoglobulin V regions from hybridomas and myelomas that are not derived from joining aberrations, suggested a controlled and specific hypermutation process, because spontaneous mutation rates observed for other genes are extremely low. Some evidence for the idea ...

journal_title：Nature

authors： O'Brien RL,Brinster RL,Storb U

更新日期：1987-03-26 00:00:00

abstract：:The assembly of ribosomes in bacterial cells is a complex process that remains poorly characterized. The in vitro assembly of active ribosomal subunits from purified RNA and protein components indicates that all of the information for proper assembly resides in the primary sequences of these macromolecules. On the oth...

journal_title：Nature

authors： Nishi K,Morel-Deville F,Hershey JW,Leighton T,Schnier J

更新日期：1988-12-01 00:00:00

abstract：: ...

journal_title：Nature

authors： Savage N

更新日期：2018-12-01 00:00:00

abstract：:The neural crest, a source of many different cell types in vertebrate embryos, has not been identified in other chordates. Current opinion therefore holds that neural crest cells were a vertebrate innovation. Here we describe a migratory cell population resembling neural crest cells in the ascidian urochordate Ecteina...

journal_title：Nature

authors： Jeffery WR,Strickler AG,Yamamoto Y

更新日期：2004-10-07 00:00:00

abstract：:At most synapses in the brain, short-term plasticity dynamically modulates synaptic strength. Rapid frequency-dependent changes in synaptic strength have key roles in sensory adaptation, gain control and many other neural computations. However, some auditory, vestibular and cerebellar synapses maintain constant streng...

journal_title：Nature

authors： Turecek J,Jackman SL,Regehr WG

更新日期：2017-11-23 00:00:00

abstract：:Embryonic stem (ES) cells are pluripotent and characterized by open chromatin and high transcription levels, achieved through auto-regulatory and feed-forward transcription factor loops. ES-cell identity is maintained by a core of factors including Oct4 (also known as Pou5f1), Sox2, Klf4, c-Myc (OSKM) and Nanog, and f...

journal_title：Nature

authors： Pijnappel WW,Esch D,Baltissen MP,Wu G,Mischerikow N,Bergsma AJ,van der Wal E,Han DW,Bruch Hv,Moritz S,Lijnzaad P,Altelaar AF,Sameith K,Zaehres H,Heck AJ,Holstege FC,Schöler HR,Timmers HT

更新日期：2013-03-28 00:00:00

abstract：:Relative motion is one of the most salient cues for segmentation of a visual scene into separate objects. This is illustrated by the vivid contours that are perceived when random dot patterns move in different directions. Once motion is halted in such displays the segmentation contours disappear. This makes random dot...

journal_title：Nature

authors： Lamme VA,van Dijk BW,Spekreijse H

更新日期：1993-06-10 00:00:00

abstract：:The manner in which phase transformations occur in solids determines important structural and physical properties of many materials. The main problem in characterizing the kinetic processes that occur during phase transformations is the difficulty of observing directly, in real time, the growth of one phase at the exp...

journal_title：Nature

authors： Hannon JB,Hibino H,Bartelt NC,Swartzentruber BS,Ogino T,Kellogg GL

更新日期：2000-06-01 00:00:00

abstract：:Therapies for patients with cancer have changed gradually over the past decade, moving away from the administration of broadly acting cytotoxic drugs towards the use of more-specific therapies that are targeted to each tumour. To facilitate this shift, tests need to be developed to identify those individuals who requi...

journal_title：Nature

authors： van't Veer LJ,Bernards R

更新日期：2008-04-03 00:00:00

abstract：:Aberrant neovascularization contributes to diseases such as cancer, blindness and atherosclerosis, and is the consequence of inappropriate angiogenic signalling. Although many regulators of pathogenic angiogenesis have been identified, our understanding of this process is incomplete. Here we explore the transcriptome ...

journal_title：Nature

authors： Wang X,Abraham S,McKenzie JAG,Jeffs N,Swire M,Tripathi VB,Luhmann UFO,Lange CAK,Zhai Z,Arthur HM,Bainbridge J,Moss SE,Greenwood J

更新日期：2013-07-18 00:00:00

abstract：:The study of language origin and divergence is important for understanding the history of human populations and their cultures. The Sino-Tibetan language family is the second largest in the world after Indo-European, and there is a long-running debate about its phylogeny and the time depth of its original divergence1....

journal_title：Nature

authors： Zhang M,Yan S,Pan W,Jin L

更新日期：2019-05-01 00:00:00

abstract：:Most of the 470-million-year history of plants on land belongs to bryophytes, pteridophytes and gymnosperms, which eventually yielded to the ecological dominance by angiosperms 90 Myr ago. Our knowledge of angiosperm phylogeny, particularly the branching order of the earliest lineages, has recently been increased by t...

journal_title：Nature

authors： Pryer KM,Schneider H,Smith AR,Cranfill R,Wolf PG,Hunt JS,Sipes SD

更新日期：2001-02-01 00:00:00

abstract：:During endocytosis, clathrin and the clathrin adaptor protein AP-2, assisted by a variety of accessory factors, help to generate an invaginated bud at the cell membrane. One of these factors is Eps15, a clathrin-coat-associated protein that binds the alpha-adaptin subunit of AP-2. Here we investigate the function of E...

journal_title：Nature

authors： Chen H,Fre S,Slepnev VI,Capua MR,Takei K,Butler MH,Di Fiore PP,De Camilli P

更新日期：1998-08-20 00:00:00

abstract：:Double-stranded DNA copies of the RNA gene coding for the haemagglutinin glycoproteins from human H2 and H3 pandemic strains of influenza virus have been cloned. DNA sequence analysis provides the first reported complete nucleotide sequence of an H2 haemagglutinin gene and a partial sequence (45%) of the H3 gene. The ...

journal_title：Nature

authors： Gething MJ,Bye J,Skehel J,Waterfield M

更新日期：1980-09-25 00:00:00

abstract：:High-energy cosmic-ray electrons and positrons (CREs), which lose energy quickly during their propagation, provide a probe of Galactic high-energy processes and may enable the observation of phenomena such as dark-matter particle annihilation or decay. The CRE spectrum has been measured directly up to approximately 2 ...

journal_title：Nature

authors： DAMPE Collaboration.

更新日期：2017-12-07 00:00:00

abstract：:Endocytosis of the major histocompatibility complex (MHC)-encoded class I and class II molecules has been the subject of recent investigations. Class I molecules, which are key elements in T cell-mediated cytotoxicity, are differentially endocytosed by different cell types. Fibroblasts internalize their class I molecu...

journal_title：Nature

authors： Machy P,Truneh A,Gennaro D,Hoffstein S

更新日期：1987-08-20 00:00:00

abstract：:Bacterial cell division ends with septation, the constriction of the cell wall and cell membranes that leads to the formation of two daughter cells. During septation, FtsZ, a protein of relative molecular mass 40,000 which is ubiquitous in eubacteria and is also found in archaea and chloroplasts, localizes early at th...

journal_title：Nature

authors： Löwe J,Amos LA

更新日期：1998-01-08 00:00:00

abstract：:The guanine nucleotide-binding stimulatory protein (Gs) couples hormone-receptor interaction to the activation of adenylate cyclase and the generation of cyclic AMP. Studies using frog neuroepithelium indicate that the sense of smell is mediated by a Gs-adenylate cyclase system, and this prompted us to test olfaction ...

journal_title：Nature

authors： Weinstock RS,Wright HN,Spiegel AM,Levine MA,Moses AM

更新日期：1986-08-14 00:00:00

abstract：:Guard cells are located in the epidermis of plant leaves, and in pairs surround stomatal pores. These control both the influx of CO2 as a raw material for photosynthesis and water loss from plants through transpiration to the atmosphere. Guard cells have become a highly developed system for dissecting early signal tra...

journal_title：Nature

authors： Schroeder JI,Kwak JM,Allen GJ

更新日期：2001-03-15 00:00:00

abstract：:Formation of electron pairs is essential to superconductivity. For conventional superconductors, tunnelling spectroscopy has established that pairing is mediated by bosonic modes (phonons); a peak in the second derivative of tunnel current d2I/dV2 corresponds to each phonon mode. For high-transition-temperature (high-...

journal_title：Nature

authors： Lee J,Fujita K,McElroy K,Slezak JA,Wang M,Aiura Y,Bando H,Ishikado M,Masui T,Zhu JX,Balatsky AV,Eisaki H,Uchida S,Davis JC

更新日期：2006-08-03 00:00:00

abstract：:CYCLINS are proteins synthesized during each cell cycle and abruptly destroyed in each mitosis. Cyclins have been implicated in the induction of mitosis and are associated with the serine-threonine protein kinase p34cdc2 as components of mitosis promoting factor (MPF). On the basis of conserved sequence motifs cyclins...

journal_title：Nature

authors： Pines J,Hunter T

更新日期：1990-08-23 00:00:00

abstract：:Several organisms have evolved the ability to measure daylength, or photoperiod, allowing them to adjust their development in anticipation of annual seasonal changes. Daylength measurement requires the integration of temporal information, provided by the circadian system, with light/dark discrimination, initiated by s...

journal_title：Nature

authors： Yanovsky MJ,Kay SA

更新日期：2002-09-19 00:00:00

abstract：:Comprehensive identification of polymorphisms among individuals within a species is essential both for studying the genetic basis of phenotypic differences and for elucidating the evolutionary history of the species. Large-scale polymorphism surveys have recently been reported for human, mouse and Arabidopsis thaliana...

journal_title：Nature

authors： Schacherer J,Shapiro JA,Ruderfer DM,Kruglyak L

更新日期：2009-03-19 00:00:00

abstract：:A type Ia supernova is thought to be a thermonuclear explosion of either a single carbon-oxygen white dwarf or a pair of merging white dwarfs. The explosion fuses a large amount of radioactive (56)Ni (refs 1-3). After the explosion, the decay chain from (56)Ni to (56)Co to (56)Fe generates γ-ray photons, which are rep...

journal_title：Nature

authors： Churazov E,Sunyaev R,Isern J,Knödlseder J,Jean P,Lebrun F,Chugai N,Grebenev S,Bravo E,Sazonov S,Renaud M

更新日期：2014-08-28 00:00:00

abstract：:It is generally accepted that the specific function of a gene depends on its coding sequence. The three paired-box and homeobox genes paired (prd), gooseberry (gsb) and gooseberry neuro (gsbn) have distinct developmental functions in Drosophila embryogenesis. During the syncytial blastoderm stage, the pair-rule gene p...

journal_title：Nature

authors： Li X,Noll M

更新日期：1994-01-06 00:00:00

abstract：:Intracellular responses recorded in vitro from the cochleas of anaesthetized mammals have shown that the mechanoreceptive inner and outer hair cells are sharply tuned, accounting for many of the properties of the afferent fibres in the auditory nerve. However, in vivo it has not been possible to measure directly the e...

journal_title：Nature

authors： Russell IJ,Richardson GP,Cody AR

更新日期：1986-05-29 00:00:00