Abstract：
:Metallothioneins are small cysteine-rich proteins that bind heavy metals such as zinc, cadmium, copper and mercury. Recent interest in these proteins has focused on the part they play in zinc metabolism and heavy metal detoxification. Our interest in metallothionein genes stems largely from the observations that these proteins are inducible by both heavy metals and glucocorticoid hormones. To explore the regulation of these genes, we have isolated cDNA and genomic clones corresponding to mouse metallothionein-I (MT-I), and have used them to show that both inducers act at the transcriptional level in vivo and in a wide variety of cell lines. We have also shown that the MT-I gene is amplified during selection for cadmium resistance. To investigate the mechanisms of gene regulation, knowledge of the primary DNA sequence is necessary. Here we present the entire sequence of mouse MT-I gene along with approximately 300 bases of 5' flanking region that presumably includes promoter and regulatory sites. The 5' mRNA sequence, defined by S1 nuclease mapping, was combined with sequences of the coding and 3' untranslated regions obtained previously to allow a computer prediction of the most stable secondary structure of MT-I mRNA.
journal_name
Naturejournal_title
Natureauthors
Glanville N,Durnam DM,Palmiter RDdoi
10.1038/292267a0subject
Has Abstractpub_date
1981-07-16 00:00:00pages
267-9issue
5820eissn
0028-0836issn
1476-4687journal_volume
292pub_type
杂志文章相关文献
NATURE文献大全abstract：:High-coverage whole-genome sequence studies have so far focused on a limited number of geographically restricted populations, or been targeted at specific diseases, such as cancer. Nevertheless, the availability of high-resolution genomic data has led to the development of new methodologies for inferring population hi...
journal_title：Nature
pub_type： 历史文章,杂志文章
doi：10.1038/nature19792
更新日期：2016-10-13 00:00:00
abstract：:Human T-cell receptors for antigen and major histocompatibility complex (MHC) determinants have now been defined on inducer, suppressor, and class 1 and class 2 MHC-specific cytotoxic T lymphocytes as T3-associated clonotypic molecules (Ti) of relative molecular mass 90,000 (90K) composed of one 49-54K alpha- and one ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/312269a0
更新日期：1984-11-15 00:00:00
abstract：:The medial entorhinal cortex (MEC) is part of the brain's circuit for dynamic representation of self-location. The metric of this representation is provided by grid cells, cells with spatial firing fields that tile environments in a periodic hexagonal pattern. Limited anatomical sampling has obscured whether the grid ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature11649
更新日期：2012-12-06 00:00:00
abstract：:The three-dimensional structure of intact human rhinovirus 14 (HRV-14) complexed with Fab fragments (Fab17-IA) from a strongly neutralizing antibody that binds bivalently to the virion has been determined to 4.0 angstrom resolution by a combination of X-ray crystallography and cryo-electron microscopy. In contradictio...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/383350a0
更新日期：1996-09-26 00:00:00
abstract：:Protoplanetary disks are known to possess a variety of substructures in the distribution of their millimetre-sized grains, predominantly seen as rings and gaps1, which are frequently interpreted as arising from the shepherding of large grains by either hidden, still-forming planets within the disk2 or (magneto-)hydrod...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-019-1642-0
更新日期：2019-10-01 00:00:00
abstract：:THE mouse H19 gene encodes one of the most abundant RNAs in the developing mouse embryo. It is expressed at the blastocyst stage of development, and accumulates to high levels in tissues of endodermal and mesodermal origin (H. Kim, unpublished result). After birth the gene is expressed in all tissues except skeletal m...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/351153a0
更新日期：1991-05-09 00:00:00
abstract：:Protein-tyrosine phosphatases (PTPs) are vital for regulating tryosine phosphorylation in many processes, including growth and differentiation. The regulation of receptor-like PTP (RPTP) activity remains poorly understood, but based on the crystal structure of RPTPalpha domain 1 we have proposed that dimerization can ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/44170
更新日期：1999-10-07 00:00:00
abstract：:From drug delivery to chemical and biological catalysis and cosmetics, the need for efficient fabrication pathways for particles over a wide range of sizes, from a variety of materials, and in many different structures has been well established. Here we harness the inherent scalability of fibre production and an in-fi...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature11215
更新日期：2012-07-26 00:00:00
abstract：:The detection of electron spins associated with single defects in solids is a critical operation for a range of quantum information and measurement applications under development. So far, it has been accomplished for only two defect centres in crystalline solids: phosphorus dopants in silicon, for which electrical rea...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature12081
更新日期：2013-05-02 00:00:00
abstract：:Haematopoiesis is a developmental cascade that generates all blood cell lineages in health and disease. This process relies on quiescent haematopoietic stem cells capable of differentiating, self renewing and expanding upon physiological demand. However, the mechanisms that regulate haematopoietic stem cell homeostasi...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature13498
更新日期：2014-10-02 00:00:00
abstract：:Although the influence of electrical activity on neural development has been studied extensively, experiments have only recently focused on the role of activity in the development of the mammalian central nervous system (CNS). Using tetrodotoxin (TTX) to abolish sodium-mediated action potentials, studies on the visual...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/323156a0
更新日期：1986-09-11 00:00:00
abstract：:For life to be sustained, mistakes in DNA repair must be tolerated when damage obscures the genetic information. In bacteria such as Escherichia coli, DNA damage elicits the well regulated 'SOS response'. For the extreme case of damage that cannot be repaired by conventional enzymes, there are proteins that allow the ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/380727a0
更新日期：1996-04-25 00:00:00
abstract：:How the brain selects appropriate sensory inputs and suppresses distractors is unknown. Given the well-established role of the prefrontal cortex (PFC) in executive function, its interactions with sensory cortical areas during attention have been hypothesized to control sensory selection. To test this idea and, more ge...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature15398
更新日期：2015-10-29 00:00:00
abstract：:The cartilage and skin of animals, which are made up of more than fifty per cent water, are rather stiff (having elastic moduli of up to 100 megapascals) as well as tough and hard to break (with fracture energies of up to 9,000 joules per square metre). Such features make these biological materials mechanically superi...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature21392
更新日期：2017-03-16 00:00:00
abstract：:Valuable information about proto-oncogenes and their physiological function has been obtained by studying their expression in normal cells. However, expression of the c-mos gene, the cellular homologue of the transforming gene of Moloney murine sarcoma virus, has not been detected in normal mouse cells or tissues. The...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/315516a0
更新日期：1985-06-06 00:00:00
abstract：:Retinoic-acid-inducible gene-I (RIG-I; also called DDX58) is a cytosolic viral RNA receptor that interacts with MAVS (also called VISA, IPS-1 or Cardif) to induce type I interferon-mediated host protective innate immunity against viral infection. Furthermore, members of the tripartite motif (TRIM) protein family, whic...
journal_title：Nature
pub_type： 信件
doi：10.1038/nature05732
更新日期：2007-04-19 00:00:00
abstract：:Brosnan and de Waal report that capuchin monkeys show evidence of a sense of fairness or 'inequity aversion' because they rejected a less preferred reward when they saw a partner monkey receive a preferred reward for the same task. However, this does not show that monkeys are averse to inequity, only that they reject ...
journal_title：Nature
pub_type： 评论,杂志文章
doi：10.1038/428140a
更新日期：2004-03-11 00:00:00
abstract：:Brain-derived neurotrophic factor (BDNF) and other neurotrophins have a vital role in the development of the rat and mouse nervous system by influencing the expression of many specific genes that promote differentiation, cell survival, synapse formation and, later, synaptic plasticity. Although nitric oxide (NO) is kn...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature07238
更新日期：2008-09-18 00:00:00
abstract：:Cyclosporin A (CSA) is a fungal metabolite which exerts profound effects on the immune system and has potential as a selective immuno-suppressive agent. Clinical trials with human renal allograft recipients have confirmed this potential but there have been disturbing reports of lymphoma in a significant number of pati...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/289300a0
更新日期：1981-01-22 00:00:00
abstract：:Scientific fraud, much in the news recently, is not a new phenomenon. What follows is a personal account of a particular case. ...
journal_title：Nature
pub_type： 传,历史文章,杂志文章
doi：10.1038/357434a0
更新日期：1992-06-11 00:00:00
abstract：:Optical laser fields have been widely used to achieve quantum control over the motional and internal degrees of freedom of atoms and ions, molecules and atomic gases. A route to controlling the quantum states of macroscopic mechanical oscillators in a similar fashion is to exploit the parametric coupling between optic...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature10787
更新日期：2012-02-01 00:00:00
abstract：:Behavioural studies and field observations demonstrate that echolocating bats simultaneously perceive range, direction and shape of multiple objects in the environment as acoustic images derived from echoes. Cortical echo delay-tuned neurons contribute to the perception of object range, because focal inactivation of t...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/364620a0
更新日期：1993-08-12 00:00:00
abstract：:It is commonly assumed that certain features are so elementary to the visual system that they require no attentional resources to be perceived. Such 'preattentive' features are traditionally identified by visual search performance, in which the reaction time for detecting a feature difference against a set of distract...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/42940
更新日期：1997-06-19 00:00:00
abstract：:The primary function of the nerve cell is to process electrical signals. Over the past fifteen years there has been renewed interest in the detailed spatial analysis of signalling in individual neurons owing to experimental evidence that the regional electrical properties of neurons are complex. Thus the behaviour of ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/381322a0
更新日期：1996-05-23 00:00:00
abstract：: ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/551S40a
更新日期：2017-11-08 00:00:00
abstract：:Human apolipoprotein E has three isoforms: APOE2, APOE3 and APOE4. APOE4 is a major genetic risk factor for Alzheimer's disease and is associated with Down's syndrome dementia and poor neurological outcome after traumatic brain injury and haemorrhage. Neurovascular dysfunction is present in normal APOE4 carriers and i...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature11087
更新日期：2012-05-16 00:00:00
abstract：:The spider mite Tetranychus urticae is a cosmopolitan agricultural pest with an extensive host plant range and an extreme record of pesticide resistance. Here we present the completely sequenced and annotated spider mite genome, representing the first complete chelicerate genome. At 90 megabases T. urticae has the sma...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature10640
更新日期：2011-11-23 00:00:00
abstract：:The inner ear is capable of highly selective frequency discrimination. This is achieved not only by the travelling wave of the basilar membrane in the cochlear partition, but also by the active participation of nonlinear and vulnerable elements that enhance frequency selectivity. It has been shown that isolated mammal...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/342814a0
更新日期：1989-12-14 00:00:00
abstract：:Single-stranded RNA viruses encompass broad classes of infectious agents and cause the common cold, cancer, AIDS and other serious health threats. Viral replication is regulated at many levels, including the use of conserved genomic RNA structures. Most potential regulatory elements in viral RNA genomes are uncharacte...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature08237
更新日期：2009-08-06 00:00:00
abstract：:The c-myc gene product is a nuclear protein expressed in a wide variety of cell types. It has been implicated in the control of normal cell growth as well as transformation, but its exact function is unknown. When the human promyelocytic leukaemia cell line HL60 is treated with retinoic acid, the cells differentiate i...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/321702a0
更新日期：1986-06-12 00:00:00
