Structure of the UmuD' protein and its regulation in response to DNA damage.

abstract：:About one-third of the carbon dioxide (CO(2)) released into the atmosphere as a result of human activity has been absorbed by the oceans, where it partitions into the constituent ions of carbonic acid. This leads to ocean acidification, one of the major threats to marine ecosystems and particularly to calcifying organ...

journal_title：Nature

authors： Beaufort L,Probert I,de Garidel-Thoron T,Bendif EM,Ruiz-Pino D,Metzl N,Goyet C,Buchet N,Coupel P,Grelaud M,Rost B,Rickaby RE,de Vargas C

更新日期：2011-08-03 00:00:00

abstract：:Temperature is a key factor in controlling the distribution of marine organisms and is particularly important at hydrothermal vents, where steep thermal gradients are present over a scale of centimetres. The thermophilic worm Alvinella pompejana, which is found at the vents of the East Pacific Rise (2,500-m depth), ha...

journal_title：Nature

authors： Pradillon F,Shillito B,Young CM,Gaill F

更新日期：2001-10-18 00:00:00

abstract：:The origin and growth of magnetic fields in galaxies is still something of an enigma. It is generally assumed that seed fields are amplified over time through the dynamo effect, but there are few constraints on the timescale. It was recently demonstrated that field strengths as traced by rotation measures of distant (...

journal_title：Nature

authors： Bernet ML,Miniati F,Lilly SJ,Kronberg PP,Dessauges-Zavadsky M

更新日期：2008-07-17 00:00:00

abstract：:Hypermethylation is associated with the silencing of tumour susceptibility genes in several forms of cancer; however, the mechanisms responsible for this aberrant methylation are poorly understood. The prototypic DNA methyltransferase, DNMT1, has been widely assumed to be responsible for most of the methylation of the...

journal_title：Nature

authors： Rhee I,Jair KW,Yen RW,Lengauer C,Herman JG,Kinzler KW,Vogelstein B,Baylin SB,Schuebel KE

更新日期：2000-04-27 00:00:00

abstract：:The erosion of mountain belts controls their topographic and structural evolution and is the main source of sediment delivered to the oceans. Mountain erosion rates have been estimated from current relief and precipitation, but a more complete evaluation of the controls on erosion rates requires detailed measurements ...

journal_title：Nature

authors： Dadson SJ,Hovius N,Chen H,Dade WB,Hsieh ML,Willett SD,Hu JC,Horng MJ,Chen MC,Stark CP,Lague D,Lin JC

更新日期：2003-12-11 00:00:00

abstract：:Traditionally, entanglement was considered to be a quirk of microscopic objects that defied a common-sense explanation. Now, however, entanglement is recognized to be ubiquitous and robust. With the realization that entanglement can occur in macroscopic systems - and with the development of experiments aimed at exploi...

journal_title：Nature

authors： Vedral V

更新日期：2008-06-19 00:00:00

abstract：:Studies of galaxy surveys in the context of the cold dark matter paradigm have shown that the mass of the dark matter halo and the total stellar mass are coupled through a function that varies smoothly with mass. Their average ratio Mhalo/Mstars has a minimum of about 30 for galaxies with stellar masses near that of t...

journal_title：Nature

authors： van Dokkum P,Danieli S,Cohen Y,Merritt A,Romanowsky AJ,Abraham R,Brodie J,Conroy C,Lokhorst D,Mowla L,O'Sullivan E,Zhang J

更新日期：2018-03-28 00:00:00

abstract：:Many homeobox genes are clustered in a linear array along a chromosome, reflecting their ordered expression along the anterior-posterior axis of the embryo. Expression patterns as well as grafting, ectopic expression and loss-of-function experiments suggest that the Hox genes encode a combinatorial system of positiona...

journal_title：Nature

authors： Roberts CW,Shutter JR,Korsmeyer SJ

更新日期：1994-04-21 00:00:00

abstract：:A long-standing hypothesis on tumorigenesis is that cell division failure, generating genetically unstable tetraploid cells, facilitates the development of aneuploid malignancies. Here we test this idea by transiently blocking cytokinesis in p53-null (p53-/-) mouse mammary epithelial cells (MMECs), enabling the isolat...

journal_title：Nature

authors： Fujiwara T,Bandi M,Nitta M,Ivanova EV,Bronson RT,Pellman D

更新日期：2005-10-13 00:00:00

abstract：:Decision making in an uncertain environment poses a conflict between the opposing demands of gathering and exploiting information. In a classic illustration of this 'exploration-exploitation' dilemma, a gambler choosing between multiple slot machines balances the desire to select what seems, on the basis of accumulate...

journal_title：Nature

authors： Daw ND,O'Doherty JP,Dayan P,Seymour B,Dolan RJ

更新日期：2006-06-15 00:00:00

abstract：:The assessment of uncertainties in global warming projections is often based on expert judgement, because a number of key variables in climate change are poorly quantified. In particular, the sensitivity of climate to changing greenhouse-gas concentrations in the atmosphere and the radiative forcing effects by aerosol...

journal_title：Nature

authors： Knutti R,Stocker TF,Joos F,Plattner GK

更新日期：2002-04-18 00:00:00

abstract：:The identical structure of two racially distinct alpha 1-globin alleles and the high degree of homology between the alpha 1- and alpha 2-globin loci indicate that mechanisms exist for suppression of allelic polymorphisms and for exchange of genetic information within the alpha-globin gene complex. ...

journal_title：Nature

authors： Liebhaber SA,Goossens M,Kan YW

更新日期：1981-03-05 00:00:00

abstract：:The two-dimensional electron system is a powerful laboratory for investigating the physics of interacting particles. Application of a large magnetic field produces massively degenerate quantum levels known as Landau levels; within a Landau level the kinetic energy of the electrons is suppressed, and electron-electron ...

journal_title：Nature

authors： Dial OE,Ashoori RC,Pfeiffer LN,West KW

更新日期：2010-03-25 00:00:00

abstract：:Sex-determination genes are among the most fluid features of the genome in many groups of animals. In some taxa the master sex-determining gene moves frequently between chromosomes, whereas in other taxa different genes have been recruited to determine the sex of the zygotes. There is a well developed theory for the o...

journal_title：Nature

authors： van Doorn GS,Kirkpatrick M

更新日期：2007-10-18 00:00:00

abstract：:There are major impediments to finding improved DEET alternatives because the receptors causing olfactory repellency are unknown, and new chemicals require exorbitant costs to determine safety for human use. Here we identify DEET-sensitive neurons in a pit-like structure in the Drosophila melanogaster antenna called t...

journal_title：Nature

authors： Kain P,Boyle SM,Tharadra SK,Guda T,Pham C,Dahanukar A,Ray A

更新日期：2013-10-24 00:00:00

abstract：:A central aspect of neuronal function is how each nerve cell translated synaptic input into a sequence of action potentials that carry information along the axon, coded as spike frequency. When transduction from a graded depolarizing input to spikes is studied by injecting a depolarizing current, there is often a rema...

journal_title：Nature

authors： Storm JF

更新日期：1988-11-24 00:00:00

abstract：:Alzheimer's disease is a progressive loss of memory and cognition, for which there is no cure. Although genetic studies initially suggested a primary role for amyloid-in Alzheimer's disease, treatment strategies targeted at reducing amyloid-have failed to reverse cognitive symptoms. These clinical findings suggest tha...

journal_title：Nature

authors： Canter RG,Penney J,Tsai LH

更新日期：2016-11-10 00:00:00

abstract：:ELLIPTICAL galaxies acting as gravitational lenses occasionally produce spectacular images-Einstein rings-of distant objects. Giant arcs(1) and radio rings(2) have been observed. A wide variety of image morphologies is possible, the generation of which is qualitatively understood in terms of large magnifications at ca...

journal_title：Nature

authors： Langston GI,Conner SR,Lehar J,Burke BF,Weiler KW

更新日期：1990-03-01 00:00:00

abstract：:The subsidence history of the Bahamian Platform points to a non-uniform rate of sea-floor spreading since the beginning of the Cretaceous. Lower Cretaceous rates of perhaps 5 cm/yr led to an active trench system at the boundary between the American and Caribbean lithosphere plates, and the rapid subsidence of the cont...

journal_title：Nature

authors： Lynts GW

更新日期：1970-03-28 00:00:00

abstract：:Why sex prevails in nature remains one of the great puzzles of evolution. Sexual reproduction has an immediate cost relative to asexual reproduction, as males only express their contribution to population growth through females. With no males to sustain, an asexual mutant can double its relative representation in the ...

journal_title：Nature

authors： Doncaster CP,Pound GE,Cox SJ

更新日期：2000-03-16 00:00:00

abstract：:B LYMPHOCYTES are key participants in the immune response because of their specificity, their ability to take up and present antigens to T cells, and their capacity to differentiate into antibody-secreting cells. To limit reactivity to self antigens, autospecific B cells can be functionally inactivated or deleted. Dev...

journal_title：Nature

authors： Russell DM,Dembić Z,Morahan G,Miller JF,Bürki K,Nemazee D

更新日期：1991-11-28 00:00:00

abstract：:One approach to the controlled release of drugs involves incorporation of the drug molecules into the matrix of microscopic polymer spheres or capsules. Existing methods for preparing such microparticles do not, however, always guarantee a constant release rate, for example because drug molecules may be trapped prefer...

journal_title：Nature

authors： Pekarek KJ,Jacob JS,Mathiowitz E

更新日期：1994-01-20 00:00:00

abstract：:In developed societies, chronic diseases such as diabetes, obesity, atherosclerosis and cancer are responsible for most deaths. These ailments have complex causes involving genetic, environmental and nutritional factors. There is evidence that a group of closely related nuclear receptors, called peroxisome proliferato...

journal_title：Nature

authors： Kersten S,Desvergne B,Wahli W

更新日期：2000-05-25 00:00:00

abstract：:Within the substantia nigra, the dendrites of dopaminergic neurons that project to the striatum appear to play an active and nonclassical role in the physiology of the neuron in that they release transmitter and protein, but little is known of the factors controlling release of substances from these dendrites. In this...

journal_title：Nature

authors： Nedergaard S,Bolam JP,Greenfield SA

更新日期：1988-05-12 00:00:00

abstract：:In the chick embryo, left-right asymmetric patterns of gene expression in the lateral plate mesoderm are initiated by signals located in and around Hensen's node. Here we show that Caronte (Car), a secreted protein encoded by a member of the Cerberus/Dan gene family, mediates the Sonic hedgehog (Shh)-dependent inducti...

journal_title：Nature

authors： Rodríguez Esteban C,Capdevila J,Economides AN,Pascual J,Ortiz A,Izpisúa Belmonte JC

更新日期：1999-09-16 00:00:00

abstract：:It is well established that muscle contraction results from the relative sliding of actin and myosin filaments. Both filaments have definite polarities and well-ordered structures. Thick filaments, however, are not vital for supporting movement in vitro. Previously we have demonstrated that actin filaments can move co...

journal_title：Nature

authors： Toyoshima YY,Toyoshima C,Spudich JA

更新日期：1989-09-14 00:00:00

abstract：:Mutations in BRCA1 and BRCA2 predispose individuals to certain cancers1-3, and disease-specific screening and preventative strategies have reduced cancer mortality in affected patients4,5. These classical tumour-suppressor genes have tumorigenic effects associated with somatic biallelic inactivation, although haploins...

journal_title：Nature

authors： Jonsson P,Bandlamudi C,Cheng ML,Srinivasan P,Chavan SS,Friedman ND,Rosen EY,Richards AL,Bouvier N,Selcuklu SD,Bielski CM,Abida W,Mandelker D,Birsoy O,Zhang L,Zehir A,Donoghue MTA,Baselga J,Offit K,Scher HI,O'Reill

更新日期：2019-07-01 00:00:00

abstract：:Understanding brain circuits begins with an appreciation of their component parts - the cells. Although GABAergic interneurons are a minority population within the brain, they are crucial for the control of inhibition. Determining the diversity of these interneurons has been a central goal of neurobiologists, but this...

journal_title：Nature

authors： Kepecs A,Fishell G

更新日期：2014-01-16 00:00:00

abstract：: ...

journal_title：Nature

authors： Greulich H,Cherniack AD

更新日期：2019-02-01 00:00:00

abstract：:The dopa analogue 6-fluorodopa (6-FD) used with positron emission tomography (PET) allows in vivo visualization of dopamine and its metabolites in nigrostriatal nerve endings. We have now found abnormal 6-FD scans in four subjects exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). None had parkinsonism. T...

journal_title：Nature

authors： Calne DB,Langston JW,Martin WR,Stoessl AJ,Ruth TJ,Adam MJ,Pate BD,Schulzer M

更新日期：1985-09-19 00:00:00