Abstract:
:Within the substantia nigra, the dendrites of dopaminergic neurons that project to the striatum appear to play an active and nonclassical role in the physiology of the neuron in that they release transmitter and protein, but little is known of the factors controlling release of substances from these dendrites. In this study, we show that 5-hydroxytryptamine, which is contained in afferent fibres to the substantia nigra, is present in terminals making direct synaptic contact with dopaminergic neurons and also that it has a site-dependent, receptor-mediated, facilitatory effect on a specific dendritic calcium-dependent potential in nigrostriatal neurons in vitro. The ionic and spatial features of this response, which is insensitive to blockade by three different K+-channel antagonists, could correspond to those underlying the dendritic release of dopamine.
journal_name
Naturejournal_title
Natureauthors
Nedergaard S,Bolam JP,Greenfield SAdoi
10.1038/333174a0subject
Has Abstractpub_date
1988-05-12 00:00:00pages
174-7issue
6169eissn
0028-0836issn
1476-4687journal_volume
333pub_type
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