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NATURE文献大全abstract::Many precious, 'iron-loving' metals, such as gold, are surprisingly abundant in the accessible parts of the Earth, given the efficiency with which core formation should have removed them to the planet's deep interior. One explanation of their over-abundance is a 'late veneer'--a flux of meteorites added to the Earth a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10399
更新日期:2011-09-07 00:00:00
abstract::The shape of the human erythrocyte depends on intracellular ATP content and echinocytic erythrocyte ghosts obtained in the presence of Mg-ATP acquire a diskocytic shape after incubation at 37 degrees C; however, agreement is lacking about the molecular basis of the shape changes. The suggestion that phosphorylation of...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/307376a0
更新日期:1984-01-26 00:00:00
abstract::The development of catalyst-controlled stereoselective olefin metathesis processes has been a pivotal recent advance in chemistry. The incorporation of appropriate ligands within complexes based on molybdenum, tungsten and ruthenium has led to reactivity and selectivity levels that were previously inaccessible. Here w...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature21043
更新日期:2017-02-02 00:00:00
abstract::Homeostasis is a biological principle for regulation of essential physiological parameters within a set range. Behavioural responses due to deviation from homeostasis are critical for survival, but motivational processes engaged by physiological need states are incompletely understood. We examined motivational charact...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14416
更新日期:2015-05-14 00:00:00
abstract::A CENTRAL assumption about long-term potentiation in the hippocampus is that the two classes of glutamate-receptor ion channel, the N-methyl-D-aspartate (NMDA) and the kainate/quisqualate (non-NMDA) subtypes, are co-localized at individual excitatory synapses. This assumption is important because of the perceived inte...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/341230a0
更新日期:1989-09-21 00:00:00
abstract::CDKN2A (INK4a/ARF) is frequently disrupted in various types of human cancer, and germline mutations of this locus can confer susceptibility to melanoma and other tumours. However, because CDKN2A encodes two distinct cell cycle inhibitory proteins, p16INK4a and p14ARF (p19Arf in mice), the mechanism of tumour suppressi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35092584
更新日期:2001-09-06 00:00:00
abstract::Many small proteins seem to fold by a simple process explicable by conventional chemical kinetics and transition-state theory. This assumes an instant equilibrium between reactants and a high-energy activated state. In reality, equilibration occurs on timescales dependent on the molecules involved, below which such an...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01609
更新日期:2003-05-08 00:00:00
abstract::The assimilation and mineralization of dissolved organic carbon (DOC) by marine bacterioplankton is a major process in the ocean carbon cycle. However, little information exists on the specific metabolic functions of participating bacteria and on whether individual taxa specialize on particular components of the marin...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06513
更新日期:2008-02-07 00:00:00
abstract::An outstanding question is how cells control the number and size of membrane organelles. The small GTPase Rab5 has been proposed to be a master regulator of endosome biogenesis. Here, to test this hypothesis, we developed a mathematical model of endosome dependency on Rab5 and validated it by titrating down all three ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11133
更新日期:2012-05-23 00:00:00
abstract::Metazoan gene regulation often involves the pausing of RNA polymerase II (Pol II) in the promoter-proximal region. Paused Pol II is stabilized by the protein complexes DRB sensitivity-inducing factor (DSIF) and negative elongation factor (NELF). Here we report the cryo-electron microscopy structure of a paused transcr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0442-2
更新日期:2018-08-01 00:00:00
abstract::Nanoscale electronic devices made from carbon nanotubes, such as transistors and sensors, are much smaller and more versatile than those that rely on conventional microelectronic chips, but their development for mass production has been thwarted by difficulties in aligning and integrating the millions of nanotubes req...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/425036a
更新日期:2003-09-04 00:00:00
abstract::The nucleotide sequence of the RNA polymerase binding site at a promotor on fd RF DNA has been determined in comparison with the starting sequence of RNA initiated at this promoter. The RNA polymerase binding site contained the startpoint of transcription in the centre and a region with twofold symmetry in the non-tra...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/253410a0
更新日期:1975-02-06 00:00:00
abstract::The evolution of snakes involved major changes in vertebrate body plan organization, but the developmental basis of those changes is unknown. The python axial skeleton consists of hundreds of similar vertebrae, forelimbs are absent and hindlimbs are severely reduced. Combined limb loss and trunk elongation is found in...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/20944
更新日期:1999-06-03 00:00:00
abstract::Despite its widespread distribution on both lymphoid and myeloid cells, the biological role of the low-affinity immunoglobulin-G receptor, Fc gamma RII, is not fully understood. Defects in this receptor or its signalling pathway in B cells result in perturbations in immune-complex-mediated feedback inhibition of antib...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/379346a0
更新日期:1996-01-25 00:00:00
abstract::Haematopoiesis, the process of mature blood and immune cell production, is functionally organized as a hierarchy, with self-renewing haematopoietic stem cells and multipotent progenitor cells sitting at the very top. Multiple models have been proposed as to what the earliest lineage choices are in these primitive haem...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature25168
更新日期:2018-01-11 00:00:00
abstract::Tumour cells become addicted to the expression of initiating oncogenes like Ras, such that loss of oncogene expression in established tumours leads to tumour regression. HRas, NRas or KRas are mutated to remain in the active GTP-bound oncogenic state in many cancers. Although Ras activates several proteins to initiate...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06778
更新日期:2008-04-03 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/d41586-018-07501-y
更新日期:2018-11-01 00:00:00
abstract::Nicotine obtained from tobacco can improve learning and memory on various tasks and has been linked to arousal, attention, rapid information processing, working memory, and long-term memories that can cause craving years after someone has stopped smoking. One likely target for these effects is the hippocampus, a centr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/383713a0
更新日期:1996-10-24 00:00:00
abstract::Several species related to Drosophila melanogaster have two loci containing sequences which code for the major heat-shock protein of molecular weight 70,000 (hsp70). These sequences are arranged as two pairs of inverted repeats. The structure of the 87C locus in D. melanogaster seems to have arisen through DNA inserti...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/290677a0
更新日期:1981-04-23 00:00:00
abstract::When mountains form through the collision of lithospheric plates, uplift of the Earth's surface is accompanied by thickening of the crust, and the buoyancy of these deep crustal roots (relative to the surrounding mantle) is thought to contribute to the support of mountain topography. Once active tectonism ceases, cont...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature00855
更新日期:2002-06-27 00:00:00
abstract::The enzyme cytochrome c nitrite reductase catalyses the six-electron reduction of nitrite to ammonia as one of the key steps in the biological nitrogen cycle, where it participates in the anaerobic energy metabolism of dissimilatory nitrate ammonification. Here we report on the crystal structure of this enzyme from th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/22802
更新日期:1999-07-29 00:00:00
abstract::The structure of poly(dA).poly(dT) currently arouses great interest, mainly because dAn.dTn stretches are associated with considerable DNA bending. Until recently the heteronomous DNA described by Arnott et al., with the poly(dA) and poly(dT) chains in A and B conformations respectively, was the only detailed model of...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/325821a0
更新日期:1987-02-26 00:00:00
abstract::Tumour suppressor genes (TSGs) inhibiting normal cellular growth are frequently silenced epigenetically in cancer. DNA methylation is commonly associated with TSG silencing, yet mutations in the DNA methylation initiation and recognition machinery in carcinogenesis are unknown. An intriguing possible mechanism for gen...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06468
更新日期:2008-01-10 00:00:00
abstract::A combination of biochemistry in animal cell-free systems and genetics in yeast is revealing the molecular machinery of the secretory pathway of eukaryotes. Transporting vesicles have a simple coat structure and employ a general mechanism for fusion that is conserved in evolution. ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/355409a0
更新日期:1992-01-30 00:00:00
abstract::The biochemical response to food intake must be precisely regulated. Because ingested sugars and fats can feed into many anabolic and catabolic pathways1, how our bodies handle nutrients depends on strategically positioned metabolic sensors that link the intrinsic nutritional value of a meal with intermediary metaboli...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0849-9
更新日期:2019-02-01 00:00:00
abstract::T cells become dysfunctional when they encounter self antigens or are exposed to chronic infection or to the tumour microenvironment1. The function of T cells is tightly regulated by a combinational co-stimulatory signal, and dominance of negative co-stimulation results in T cell dysfunction2. However, the molecular m...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-0979-8
更新日期:2019-03-01 00:00:00
abstract::The lysis of murine sarcoma virus-murine leukaemia virus (MSV-MuLV)-induced tumour cells by cytotoxic T lymphocytes (CTL) appears to require that an antigen specified by MSV-MuLV, or induced by the infection, be presented in association with class I major histocompatibility complex antigens. The viral proteins of the ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/305815a0
更新日期:1983-10-27 00:00:00
abstract::Methane is an important greenhouse gas that is emitted from multiple natural and anthropogenic sources. Atmospheric methane concentrations have varied on a number of timescales in the past, but what has caused these variations is not always well understood. The different sources and sinks of methane have specific isot...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature11461
更新日期:2012-10-04 00:00:00
abstract::Histones package DNA, and post-translational modifications of histones can regulate access to DNA. Until recently, histone methylation-unlike all other histone modifications-was considered a permanent mark. The discovery of enzymes that reverse the methylation of lysines and arginines challenges our current thinking o...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature04048
更新日期:2005-08-25 00:00:00
abstract::Neurotransmitters modulate the activity of ion channels through a variety of second messengers, including cyclic AMP, cyclic GMP and the products of phosphatidylinositol breakdown. Little is known about how different transmitters acting through different second-messenger systems interact within a cell to regulate sing...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/325153a0
更新日期:1987-01-08 00:00:00