Natural and anthropogenic variations in methane sources during the past two millennia.

abstract：:The neuronal structure and connectivity underlying receptive field organisation of cells in the cat visual cortex have been investigated. Intracellular recordings were made using a micropipette filled with a histochemical marker, which was injected into the cells after their receptive fields had been characterised. Th...

journal_title：Nature

authors： Gilbert CD,Wiesel TN

更新日期：1979-07-12 00:00:00

abstract：:Differentiation of bone marrow derived precursors into mature T cells takes place in the thymus. During differentiation, T cells develop the receptor repertoire which allows them to recognize antigen in the context of self major histocompatibility complex (MHC) molecules. Mature T helper cells (mostly CD4+ CD8-) recog...

journal_title：Nature

authors： Maruŝić-Galesić S,Stephany DA,Longo DL,Kruisbeek AM

更新日期：1988-05-12 00:00:00

abstract：:Lipid-bilayer membranes supported on solid substrates are widely used as cell-surface models that connect biological and artificial materials. They can be placed either directly on solids or on ultrathin polymer supports that mimic the generic role of the extracellular matrix. The tools of modern genetic engineering a...

journal_title：Nature

authors： Tanaka M,Sackmann E

更新日期：2005-09-29 00:00:00

abstract：:The development of new chemical transformations based on catalytic functionalization of unactivated C-H bonds has the potential to simplify the synthesis of complex molecules dramatically. Transition metal catalysis has emerged as a powerful tool with which to convert these unreactive bonds into carbon-carbon and carb...

journal_title：Nature

authors： McNally A,Haffemayer B,Collins BS,Gaunt MJ

更新日期：2014-06-05 00:00:00

abstract：:The hydrosulphide ion (HS(-)) and its undissociated form, hydrogen sulphide (H(2)S), which are believed to have been critical to the origin of life on Earth, remain important in physiology and cellular signalling. As a major metabolite in anaerobic bacterial growth, hydrogen sulphide is a product of both assimilatory ...

journal_title：Nature

authors： Czyzewski BK,Wang DN

更新日期：2012-03-11 00:00:00

abstract：:The extensive literature on the origin of the ratites focuses mainly on three questions: are the ratites mono- or polyphyletic, did they evolve from flying ancestors, and are they primitive or advanced? Opinion tends to accept a common descent from flying ancestors for the large ratites (for a summary of ideas see ref...

journal_title：Nature

authors： de Boer LE

更新日期：1980-09-04 00:00:00

abstract：:The combination of complementary DNA expression and single-channel current analysis provides a powerful tool for studying the structure-function relationship of the nicotinic acetylcholine receptor (AChR) (refs 1-5). We have previously shown that AChR channels consisting of subunits from different species, expressed i...

journal_title：Nature

authors： Imoto K,Methfessel C,Sakmann B,Mishina M,Mori Y,Konno T,Fukuda K,Kurasaki M,Bujo H,Fujita Y

更新日期：1986-12-18 00:00:00

abstract：:The existence of so great a diversity of species on Earth remains a mystery, the solution to which may also explain why and how biodiversity influences the functioning of ecosystems. The answer may lie in quantifying the trade-offs that organisms face in dealing with the constraints of their environment. Societal resp...

journal_title：Nature

authors： Tilman D

更新日期：2000-05-11 00:00:00

abstract：:The hot streak-loosely defined as 'winning begets more winnings'-highlights a specific period during which an individual's performance is substantially better than his or her typical performance. Although hot streaks have been widely debated in sports1,2, gambling3-5 and financial markets6,7 over the past several deca...

journal_title：Nature

authors： Liu L,Wang Y,Sinatra R,Giles CL,Song C,Wang D

更新日期：2018-07-01 00:00:00

abstract：:The internal organization of eukaryotic cells into functionally specialized, membrane-delimited organelles of unique composition implies a need for active, regulated lipid transport. Phosphatidylserine (PS), for example, is synthesized in the endoplasmic reticulum and then preferentially associates--through mechanisms...

journal_title：Nature

authors： Maeda K,Anand K,Chiapparino A,Kumar A,Poletto M,Kaksonen M,Gavin AC

更新日期：2013-09-12 00:00:00

abstract：:It is common knowledge that our feelings of alertness or drowsiness vary throughout the day. Indeed, this diurnal variation is so widely accepted that it has been used to validate the drowsy/alert component of activation obtained from mood adjective checklists. There is, however, some evidence from sleep deprivation a...

journal_title：Nature

authors： Folkard S,Hume KI,Minors DS,Waterhouse JM,Watson FL

更新日期：1985-02-21 00:00:00

abstract：:'Long' gamma-ray bursts (GRBs) are commonly accepted to originate in the explosion of particularly massive stars, which give rise to highly relativistic jets. Inhomogeneities in the expanding flow result in internal shock waves that are believed to produce the gamma-rays we see. As the jet travels further outward into...

journal_title：Nature

authors： Tagliaferri G,Goad M,Chincarini G,Moretti A,Campana S,Burrows DN,Perri M,Barthelmy SD,Gehrels N,Krimm H,Sakamoto T,Kumar P,Mészáros PI,Kobayashi S,Zhang B,Angelini L,Banat P,Beardmore AP,Capalbi M,Covino S,Cusuman

更新日期：2005-08-18 00:00:00

abstract：: ...

journal_title：Nature

authors： Beekes M,Mielke M,Thomzig A

更新日期：2019-01-01 00:00:00

abstract：:An Amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature

authors： Segel M,Neumann B,Hill MFE,Weber IP,Viscomi C,Zhao C,Young A,Agley CC,Thompson AJ,Gonzalez GA,Sharma A,Holmqvist S,Rowitch DH,Franze K,Franklin RJM,Chalut KJ

更新日期：2019-09-01 00:00:00

abstract：:Nanoscale electronic devices made from carbon nanotubes, such as transistors and sensors, are much smaller and more versatile than those that rely on conventional microelectronic chips, but their development for mass production has been thwarted by difficulties in aligning and integrating the millions of nanotubes req...

journal_title：Nature

authors： Rao SG,Huang L,Setyawan W,Hong S

更新日期：2003-09-04 00:00:00

abstract：:The mechanism of transformation of the overtly similar cells of the neural plate into the numerous and diverse cell types of the mature vertebrate central nervous system (CNS) can better be understood by studying the clonal development of isolated CNS precursor cells. Here I describe a culture system in which blast ce...

journal_title：Nature

authors： Temple S

更新日期：1989-08-10 00:00:00

abstract：:One reason for the failure of chemotherapy in the treatment of advanced cancers may be the outgrowth of multidrug-resistant tumour cells. Multidrug resistance has been modelled in numerous mammalian cell lines in which the phenotype is characterized by a pleiotropic cross-resistance to unrelated drugs. In the study re...

journal_title：Nature

authors： Kartner N,Evernden-Porelle D,Bradley G,Ling V

更新日期：1985-08-29 00:00:00

abstract：:c-Abl, a non-receptor tyrosine kinase, is activated by agents that damage DNA. This activation results in either arrest of the cell cycle in phase G1 or apoptotic cell death, both of which are dependent on the kinase activity of c-Abl. p73, a member of the p53 family of tumour-suppressor proteins, can also induce apop...

journal_title：Nature

authors： Agami R,Blandino G,Oren M,Shaul Y

更新日期：1999-06-24 00:00:00

abstract：:PIWI-interacting RNAs (piRNAs) silence transposons to maintain genome integrity in animal germ lines. piRNAs are classified as primary and secondary piRNAs, depending on their biogenesis machinery. Primary piRNAs are processed from long non-coding RNA precursors transcribed from piRNA clusters in the genome through th...

journal_title：Nature

authors： Nishimasu H,Ishizu H,Saito K,Fukuhara S,Kamatani MK,Bonnefond L,Matsumoto N,Nishizawa T,Nakanaga K,Aoki J,Ishitani R,Siomi H,Siomi MC,Nureki O

更新日期：2012-11-08 00:00:00

abstract：:How left/right functional asymmetry is layered on top of an anatomically symmetrical nervous system is poorly understood. In the nematode Caenorhabditis elegans, two morphologically bilateral taste receptor neurons, ASE left (ASEL) and ASE right (ASER), display a left/right asymmetrical expression pattern of putative ...

journal_title：Nature

authors： Johnston RJ,Hobert O

更新日期：2003-12-18 00:00:00

abstract：:The import of nuclear proteins proceeds through the nuclear pore complex and requires nuclear localization signals (NLSs), energy and soluble factors, namely importin-alpha (M(r) 60K), importin-beta (90K) and Ran. Importin-alpha is primarily responsible for NLS recognition and is a member of a protein family that incl...

journal_title：Nature

authors： Görlich D,Vogel F,Mills AD,Hartmann E,Laskey RA

更新日期：1995-09-21 00:00:00

abstract：:Spin dynamics in antiferromagnets has much shorter timescales than in ferromagnets, offering attractive properties for potential applications in ultrafast devices1-3. However, spin-current generation via antiferromagnetic resonance and simultaneous electrical detection by the inverse spin Hall effect in heavy metals h...

journal_title：Nature

authors： Li J,Wilson CB,Cheng R,Lohmann M,Kavand M,Yuan W,Aldosary M,Agladze N,Wei P,Sherwin MS,Shi J

更新日期：2020-02-01 00:00:00

abstract：:H-2 class I antigens appear to direct the recognition of virus-infected and neoplastic transformed cells by cytotoxic T lymphocytes (CTLs). Here, to identify the regions of class I antigens involved in CTL recognition, four hybrid class I genes were constructed in which exons were exchanged between the H-2Kb and H-2Db...

journal_title：Nature

authors： Allen H,Wraith D,Pala P,Askonas B,Flavell RA

更新日期：1984-05-17 00:00:00

abstract：: ...

journal_title：Nature

authors： Reardon S

更新日期：2018-12-01 00:00:00

abstract：:Sensory transduction in taste and olfaction, the principal chemical senses, seems to be mediated by membrane-associated proteins on the apical surfaces of the respective receptor cells. The recent isolation and characterization of soluble 'odorant-binding proteins' secreted from the nasal glands of rat, cow and frog, ...

journal_title：Nature

authors： Schmale H,Holtgreve-Grez H,Christiansen H

更新日期：1990-01-25 00:00:00

abstract：:RNA is involved in many biological functions, ranging from information storage and transfer to the catalysis of reactions involving both nucleic acids and proteins. Previous crystallographic studies on RNA oligomeric chains provide only averaged structures or information limited in resolution. The oligomer [U(U-A)6A]2...

journal_title：Nature

authors： Dock-Bregeon AC,Chevrier B,Podjarny A,Moras D,deBear JS,Gough GR,Gilham PT,Johnson JE

更新日期：1988-09-22 00:00:00

abstract：:Volatile anaesthetics have historically been considered to act in a nonspecific manner on the central nervous system. More recent studies, however, have revealed that the receptors for inhibitory neurotransmitters such as gamma-aminobutyric acid (GABA) and glycine are sensitive to clinically relevant concentrations of...

journal_title：Nature

authors： Mihic SJ,Ye Q,Wick MJ,Koltchine VV,Krasowski MD,Finn SE,Mascia MP,Valenzuela CF,Hanson KK,Greenblatt EP,Harris RA,Harrison NL

更新日期：1997-09-25 00:00:00

abstract：:Pairs of asteroids sharing similar heliocentric orbits, but not bound together, were found recently. Backward integrations of their orbits indicated that they separated gently with low relative velocities, but did not provide additional insight into their formation mechanism. A previously hypothesized rotational fissi...

journal_title：Nature

authors： Pravec P,Vokrouhlický D,Polishook D,Scheeres DJ,Harris AW,Galád A,Vaduvescu O,Pozo F,Barr A,Longa P,Vachier F,Colas F,Pray DP,Pollock J,Reichart D,Ivarsen K,Haislip J,Lacluyze A,Kusnirák P,Henych T,Marchis F,Mac

更新日期：2010-08-26 00:00:00

abstract：:The epiblast (EPI) is the origin of all somatic and germ cells in mammals, and of pluripotent stem cells in vitro. To explore the ontogeny of human and primate pluripotency, here we perform comprehensive single-cell RNA sequencing for pre- and post-implantation EPI development in cynomolgus monkeys (Macaca fasciculari...

journal_title：Nature

authors： Nakamura T,Okamoto I,Sasaki K,Yabuta Y,Iwatani C,Tsuchiya H,Seita Y,Nakamura S,Yamamoto T,Saitou M

更新日期：2016-09-01 00:00:00

abstract：:The nuclear bulge is a region with a radius of about 200 parsecs around the centre of the Milky Way. It contains stars with ages ranging from a few million years to over a billion years, yet its star-formation history and the triggering process for star formation remain to be resolved. Recently, episodic star formatio...

journal_title：Nature

authors： Matsunaga N,Kawadu T,Nishiyama S,Nagayama T,Kobayashi N,Tamura M,Bono G,Feast MW,Nagata T

更新日期：2011-08-24 00:00:00