A developmental coordinate of pluripotency among mice, monkeys and humans.

abstract：:It is not yet clear whether humans are able to learn while they are sleeping. Here we show that full-term human newborns can be taught to discriminate between similar vowel sounds when they are fast asleep. It is possible that such sleep training soon after birth could find application in clinical or educational situa...

journal_title：Nature

authors： Cheour M,Martynova O,Näätänen R,Erkkola R,Sillanpää M,Kero P,Raz A,Kaipio ML,Hiltunen J,Aaltonen O,Savela J,Hämäläinen H

更新日期：2002-02-07 00:00:00

abstract：:Observations from cultured cells, animal models and patients raise the possibility that the dependency of tumours on the therapeutic drugs to which they have acquired resistance represents a vulnerability with potential applications in cancer treatment. However, for this drug addiction trait to become of clinical inte...

journal_title：Nature

authors： Kong X,Kuilman T,Shahrabi A,Boshuizen J,Kemper K,Song JY,Niessen HWM,Rozeman EA,Geukes Foppen MH,Blank CU,Peeper DS

更新日期：2017-10-12 00:00:00

abstract：:Angiogenesis, the formation of new capillaries from pre-existing vessels, is essential for tumour progression. Angiostatin, a proteolytic fragment of plasminogen that was first isolated from the serum and urine of tumour-bearing mice, inhibits angiogenesis and thereby growth of primary and metastatic tumours. Radiothe...

journal_title：Nature

authors： Mauceri HJ,Hanna NN,Beckett MA,Gorski DH,Staba MJ,Stellato KA,Bigelow K,Heimann R,Gately S,Dhanabal M,Soff GA,Sukhatme VP,Kufe DW,Weichselbaum RR

更新日期：1998-07-16 00:00:00

abstract：:Although infection by HIV-1 has been implicated as the primary cause of AIDS and related disorders, cofactorial mechanisms may be involved in the pathogenesis of the disease. For example, several viruses commonly detected in AIDS patients and capable of transactivating the long terminal repeat of HIV-1, such as herpes...

journal_title：Nature

authors： Lusso P,Ensoli B,Markham PD,Ablashi DV,Salahuddin SZ,Tschachler E,Wong-Staal F,Gallo RC

更新日期：1989-01-26 00:00:00

abstract：:Microtubules have a central role in eukaryotic cell polarity, in part through interactions between microtubule end-binding proteins and the cell cortex. In the fission yeast Schizosaccharomyces pombe, microtubules and the polarity modulator tea1p maintain cylindrical cell shape and strictly antipodal cell growth. The ...

journal_title：Nature

authors： Snaith HA,Sawin KE

更新日期：2003-06-05 00:00:00

abstract：:The travelling salesman problem is a classical problem in the field of combinatorial optimization, concerned with efficient methods for maximizing or minimizing a function of many independent variables. Given the positions of N cities, which in the simplest case lie in the plane, what is the shortest closed tour in wh...

journal_title：Nature

authors： Durbin R,Willshaw D

更新日期：1987-04-16 00:00:00

abstract：:The axial coupling of the nucleon, gA, is the strength of its coupling to the weak axial current of the standard model of particle physics, in much the same way as the electric charge is the strength of the coupling to the electromagnetic current. This axial coupling dictates the rate at which neutrons decay to proton...

journal_title：Nature

authors： Chang CC,Nicholson AN,Rinaldi E,Berkowitz E,Garron N,Brantley DA,Monge-Camacho H,Monahan CJ,Bouchard C,Clark MA,Joó B,Kurth T,Orginos K,Vranas P,Walker-Loud A

更新日期：2018-06-01 00:00:00

abstract：:First-order difference equations arise in many contexts in the biological, economic and social sciences. Such equations, even though simple and deterministic, can exhibit a surprising array of dynamical behaviour, from stable points, to a bifurcating hiearchy of stable cycles, to apparently random fluctuations. There ...

journal_title：Nature

authors： May RM

更新日期：1976-06-10 00:00:00

abstract：:The halo of the Milky Way provides a laboratory to study the properties of the shocked hot gas that is predicted by models of galaxy formation. There is observational evidence of energy injection into the halo from past activity in the nucleus of the Milky Way1-4; however, the origin of this energy (star formation or ...

journal_title：Nature

authors： Predehl P,Sunyaev RA,Becker W,Brunner H,Burenin R,Bykov A,Cherepashchuk A,Chugai N,Churazov E,Doroshenko V,Eismont N,Freyberg M,Gilfanov M,Haberl F,Khabibullin I,Krivonos R,Maitra C,Medvedev P,Merloni A,Nandra K,N

更新日期：2020-12-01 00:00:00

abstract：:The formation of glasses is normal for substances that remain liquid over a wide temperature range (the 'good glassformers') and can be induced for most liquids if cooling is fast enough to bypass crystallization. During reheating but still below the melting point, good glassformers exhibit glass transitions as they a...

journal_title：Nature

authors： Yue Y,Angell CA

更新日期：2004-02-19 00:00:00

abstract：:Autism spectrum disorder (ASD) is an early-onset developmental disorder characterized by deficits in communication and social interaction and restrictive or repetitive behaviours1,2. Family studies demonstrate that ASD has a substantial genetic basis with contributions both from inherited and de novo variants3,4. It h...

journal_title：Nature

authors： Mitra I,Huang B,Mousavi N,Ma N,Lamkin M,Yanicky R,Shleizer-Burko S,Lohmueller KE,Gymrek M

更新日期：2021-01-01 00:00:00

abstract：:During the biosynthesis of selenoproteins in both prokaryotes and eukaryotes, selenocysteine is cotranslationally incorporated into the nascent polypeptide chain through a process directed by a UGA codon that normally functions as a stop codon. Recently, four genes have been identified whose products are required for ...

journal_title：Nature

authors： Forchhammer K,Leinfelder W,Böck A

更新日期：1989-11-23 00:00:00

abstract：:The imaginal discs of Drosophila, which give rise to the adult appendages, are patterned during a period of intense cell proliferation. The specification of differing regions occurs in some cases by subdividing the disc epithelium into lineage compartments. However, in most cases precise boundaries are formed between ...

journal_title：Nature

authors： Rulifson EJ,Micchelli CA,Axelrod JD,Perrimon N,Blair SS

更新日期：1996-11-07 00:00:00

abstract：:Clonal deletion in the thymus plays a major part in T-cell tolerance to self antigens. But the mechanism of negative selection, its fine specificity and the threshold of affinity and avidity remains unknown. We have now examined these aspects of negative selection with mice expressing a transgenic T-cell receptor with...

journal_title：Nature

authors： Pircher H,Rohrer UH,Moskophidis D,Zinkernagel RM,Hengartner H

更新日期：1991-06-06 00:00:00

abstract：:Epigenetic pathways can regulate gene expression by controlling and interpreting chromatin modifications. Cancer cells are characterized by altered epigenetic landscapes, and commonly exploit the chromatin regulatory machinery to enforce oncogenic gene expression programs. Although chromatin alterations are, in princi...

journal_title：Nature

authors： Zuber J,Shi J,Wang E,Rappaport AR,Herrmann H,Sison EA,Magoon D,Qi J,Blatt K,Wunderlich M,Taylor MJ,Johns C,Chicas A,Mulloy JC,Kogan SC,Brown P,Valent P,Bradner JE,Lowe SW,Vakoc CR

更新日期：2011-08-03 00:00:00

abstract：:A long-standing problem in managing the behaviour of a collection of solid grains concerns the nature of the grain packing, a property that is typically controlled by how the grains are poured or shaken. Here we show that a systematic and controllable increase in granular packing can be induced by simply raising and t...

journal_title：Nature

authors： Chen K,Cole J,Conger C,Draskovic J,Lohr M,Klein K,Scheidemantel T,Schiffer P

更新日期：2006-07-20 00:00:00

abstract：:Regulation of the rapid compensatory growth seen in the remaining adrenal gland of rats following unilateral adrenalectomy is poorly understood. The role of adrenocorticotropic hormone (ACTH) is obscure as immunoneutralization of circulating ACTH does not affect the observed compensatory growth or hyperplasia. This fi...

journal_title：Nature

authors： Lowry PJ,Silas L,McLean C,Linton EA,Estivariz FE

更新日期：1983-11-03 00:00:00

abstract：:Appropriate repair of DNA lesions and the inhibition of DNA repair activities at telomeres are crucial to prevent genomic instability. By fuelling the generation of genetic alterations and by compromising cell viability, genomic instability is a driving force in cancer and ageing. Here we identify MAD2L2 (also known a...

journal_title：Nature

authors： Boersma V,Moatti N,Segura-Bayona S,Peuscher MH,van der Torre J,Wevers BA,Orthwein A,Durocher D,Jacobs JJL

更新日期：2015-05-28 00:00:00

abstract：:Osteoclasts are multinucleated giant cells that resorb bone, ensuring development and continuous remodelling of the skeleton and the bone marrow haematopoietic niche. Defective osteoclast activity leads to osteopetrosis and bone marrow failure1-9, whereas excess activity can contribute to bone loss and osteoporosis10....

journal_title：Nature

authors： Jacome-Galarza CE,Percin GI,Muller JT,Mass E,Lazarov T,Eitler J,Rauner M,Yadav VK,Crozet L,Bohm M,Loyher PL,Karsenty G,Waskow C,Geissmann F

更新日期：2019-04-01 00:00:00

abstract：:Hyperpolarization-activated cation channels of the HCN gene family contribute to spontaneous rhythmic activity in both heart and brain. All four family members contain both a core transmembrane segment domain, homologous to the S1-S6 regions of voltage-gated K+ channels, and a carboxy-terminal 120 amino-acid cyclic nu...

journal_title：Nature

authors： Wainger BJ,DeGennaro M,Santoro B,Siegelbaum SA,Tibbs GR

更新日期：2001-06-14 00:00:00

abstract：:The Ca2+ + Mg2+-activated ATPase of the sarcoplasmic reticulum is responsible for the active Ca2+ transport of this membrane system, the key feature of which is the formation of an energy-rich phosphorylated transport enzyme (EP) and its conversion. To understand the Ca2+-transport mechanism, it is essential to clarif...

journal_title：Nature

authors： Takisawa H,Makinose M

更新日期：1981-03-19 00:00:00

abstract：:Temperature is a primary driver of the distribution of biodiversity as well as of ecosystem boundaries. Declining temperature with increasing elevation in montane systems has long been recognized as a major factor shaping plant community biodiversity, metabolic processes, and ecosystem dynamics. Elevational gradients,...

journal_title：Nature

authors： Mayor JR,Sanders NJ,Classen AT,Bardgett RD,Clément JC,Fajardo A,Lavorel S,Sundqvist MK,Bahn M,Chisholm C,Cieraad E,Gedalof Z,Grigulis K,Kudo G,Oberski DL,Wardle DA

更新日期：2017-02-02 00:00:00

abstract：:Many eukaryotic cellular and viral proteins have a covalently attached myristoyl group at the amino terminus. One such protein is recoverin, a calcium sensor in retinal rod cells, which controls the lifetime of photoexcited rhodopsin by inhibiting rhodopsin kinase. Recoverin has a relative molecular mass of 23,000 (M[...

journal_title：Nature

authors： Ames JB,Ishima R,Tanaka T,Gordon JI,Stryer L,Ikura M

更新日期：1997-09-11 00:00:00

abstract：:The presence of large Northern Hemisphere ice sheets and reduced greenhouse gas concentrations during the Last Glacial Maximum fundamentally altered global ocean-atmosphere climate dynamics. Model simulations and palaeoclimate records suggest that glacial boundary conditions affected the El Niño-Southern Oscillation, ...

journal_title：Nature

authors： Jones TR,Roberts WHG,Steig EJ,Cuffey KM,Markle BR,White JWC

更新日期：2018-02-15 00:00:00

abstract：:The protein coding sequences of most eukaryotic messenger RNA precursors (pre-mRNAs) are interrupted by non-coding sequences called introns. Pre-mRNA splicing is the process by which introns are removed and the protein coding elements assembled into mature mRNAs. Alternative pre-mRNA splicing selectively joins differe...

journal_title：Nature

authors： Maniatis T,Tasic B

更新日期：2002-07-11 00:00:00

abstract：:The P2Y12 receptor (P2Y12R), one of eight members of the P2YR family expressed in humans, is one of the most prominent clinical drug targets for inhibition of platelet aggregation. Although mutagenesis and modelling studies of the P2Y12R provided useful insights into ligand binding, the agonist and antagonist recognit...

journal_title：Nature

authors： Zhang J,Zhang K,Gao ZG,Paoletta S,Zhang D,Han GW,Li T,Ma L,Zhang W,Müller CE,Yang H,Jiang H,Cherezov V,Katritch V,Jacobson KA,Stevens RC,Wu B,Zhao Q

更新日期：2014-05-01 00:00:00

abstract：:Protein-tyrosine phosphatases (PTPs) are vital for regulating tryosine phosphorylation in many processes, including growth and differentiation. The regulation of receptor-like PTP (RPTP) activity remains poorly understood, but based on the crystal structure of RPTPalpha domain 1 we have proposed that dimerization can ...

journal_title：Nature

authors： Jiang G,den Hertog J,Su J,Noel J,Sap J,Hunter T

更新日期：1999-10-07 00:00:00

abstract：:Transparent electronic devices formed on flexible substrates are expected to meet emerging technological demands where silicon-based electronics cannot provide a solution. Examples of active flexible applications include paper displays and wearable computers. So far, mainly flexible devices based on hydrogenated amorp...

journal_title：Nature

authors： Nomura K,Ohta H,Takagi A,Kamiya T,Hirano M,Hosono H

更新日期：2004-11-25 00:00:00

abstract：:A major component of the large genomes of higher plants and vertebrates comprises transposable elements and their derivatives, which potentially reduce the stability of the genome. It has been proposed that methylation of cytosine residues may suppress transposition, but experimental evidence for this has been limited...

journal_title：Nature

authors： Miura A,Yonebayashi S,Watanabe K,Toyama T,Shimada H,Kakutani T

更新日期：2001-05-10 00:00:00

abstract：:Cosmological models in which dark matter consists of cold elementary particles predict that the dark halo population should extend to masses many orders of magnitude below those at which galaxies can form1-3. Here we report a cosmological simulation of the formation of present-day haloes over the full range of observe...

journal_title：Nature

authors： Wang J,Bose S,Frenk CS,Gao L,Jenkins A,Springel V,White SDM

更新日期：2020-09-01 00:00:00