Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies.

abstract：:The identification of novel metabolites and the characterization of their biological functions are major challenges in biology. X-ray crystallography can reveal unanticipated ligands that persist through purification and crystallization. These adventitious protein-ligand complexes provide insights into new activities,...

journal_title：Nature

authors： Kim J,Xiao H,Bonanno JB,Kalyanaraman C,Brown S,Tang X,Al-Obaidi NF,Patskovsky Y,Babbitt PC,Jacobson MP,Lee YS,Almo SC

更新日期：2013-06-06 00:00:00

abstract：:The success of cisplatin in cancer chemotherapy derives from its ability to crosslink DNA and alter the structure. Most cisplatin-DNA adducts are intrastrand d(GpG) and d(ApG) crosslinks, which unwind and bend the duplex to facilitate the binding of proteins that contain one or more high-mobility group (HMG) domains. ...

journal_title：Nature

authors： Takahara PM,Rosenzweig AC,Frederick CA,Lippard SJ

更新日期：1995-10-19 00:00:00

abstract：:The presence of papillomaviruses in epithelial-derived cancers from several animal species has led to the speculation that these viruses may also have a pathogenic role in the development of certain human carcinomas, particularly those associated with the anogenital tract. Recently, human papillomavirus (HPV) DNA has ...

journal_title：Nature

authors： Zachow KR,Ostrow RS,Bender M,Watts S,Okagaki T,Pass F,Faras AJ

更新日期：1982-12-23 00:00:00

abstract：:Homeostasis is a biological principle for regulation of essential physiological parameters within a set range. Behavioural responses due to deviation from homeostasis are critical for survival, but motivational processes engaged by physiological need states are incompletely understood. We examined motivational charact...

journal_title：Nature

authors： Betley JN,Xu S,Cao ZFH,Gong R,Magnus CJ,Yu Y,Sternson SM

更新日期：2015-05-14 00:00:00

abstract：:The ATM (ataxia-telangiectasia mutated) protein kinase mediates early cellular responses to DNA double-strand breaks (DSBs) generated during metabolic processes or by DNA-damaging agents. ATM deficiency leads to ataxia-telangiectasia, a disease marked by lymphopenia, genomic instability and an increased predisposition...

journal_title：Nature

authors： Bredemeyer AL,Sharma GG,Huang CY,Helmink BA,Walker LM,Khor KC,Nuskey B,Sullivan KE,Pandita TK,Bassing CH,Sleckman BP

更新日期：2006-07-27 00:00:00

abstract：:A 12 amino-acid synthetic peptide (NANP)3 comprising the immunodominant epitope of Plasmodium falciparum circumsporozoite protein was conjugated to tetanus toxoid (TT), adjuvanted with aluminium hydroxide, and administered intramuscularly in three doses at monthly intervals to 35 healthy males as a malaria vaccine. No...

journal_title：Nature

authors： Herrington DA,Clyde DF,Losonsky G,Cortesia M,Murphy JR,Davis J,Baqar S,Felix AM,Heimer EP,Gillessen D

更新日期：1987-07-16 00:00:00

abstract：:Abundant data link hypercholesterolaemia to atherogenesis. However, only recently have we appreciated that inflammatory mechanisms couple dyslipidaemia to atheroma formation. Leukocyte recruitment and expression of pro-inflammatory cytokines characterize early atherogenesis, and malfunction of inflammatory mediators m...

journal_title：Nature

authors： Libby P

更新日期：2002-12-19 00:00:00

abstract：:In mammals, one of the most pronounced consequences of viral infection is the induction of type I interferons, cytokines with potent antiviral activity. Schlafen (Slfn) genes are a subset of interferon-stimulated early response genes (ISGs) that are also induced directly by pathogens via the interferon regulatory fact...

journal_title：Nature

authors： Li M,Kao E,Gao X,Sandig H,Limmer K,Pavon-Eternod M,Jones TE,Landry S,Pan T,Weitzman MD,David M

更新日期：2012-11-01 00:00:00

abstract：:Classically, there is a direct correlation between the lipophilic nature of a molecule and its rate of permeation across a biological membrane, so cell membranes should be more permeable to small, neutral molecules than they are to charged molecular species of similar size. Consequently, the distribution of NH+4 in bi...

journal_title：Nature

authors： Kikeri D,Sun A,Zeidel ML,Hebert SC

更新日期：1989-06-08 00:00:00

abstract：:Combined analyses of gene networks and DNA sequence variation can provide new insights into the aetiology of common diseases that may not be apparent from genome-wide association studies alone. Recent advances in rat genomics are facilitating systems-genetics approaches. Here we report the use of integrated genome-wid...

journal_title：Nature

authors： Heinig M,Petretto E,Wallace C,Bottolo L,Rotival M,Lu H,Li Y,Sarwar R,Langley SR,Bauerfeind A,Hummel O,Lee YA,Paskas S,Rintisch C,Saar K,Cooper J,Buchan R,Gray EE,Cyster JG,Cardiogenics Consortium.,Erdmann J,Heng

更新日期：2010-09-23 00:00:00

abstract：:As countries in Europe gradually relaxed lockdown restrictions after the first wave, test-trace-isolate strategies became critical to maintain the incidence of coronavirus disease 2019 (COVID-19) at low levels1,2. Reviewing their shortcomings can provide elements to consider in light of the second wave that is current...

journal_title：Nature

authors： Pullano G,Di Domenico L,Sabbatini CE,Valdano E,Turbelin C,Debin M,Guerrisi C,Kengne-Kuetche C,Souty C,Hanslik T,Blanchon T,Boëlle PY,Figoni J,Vaux S,Campèse C,Bernard-Stoecklin S,Colizza V

更新日期：2020-12-21 00:00:00

abstract：:Several functionally important genetic elements (such as the TATA box, mRNA splice sequences, poly(A) addition signal) were first detected as short segments of unexplained sequence homology within non-coding regions of different genes. A short region of unknown sequence in the intron between the human J kappa and C ka...

journal_title：Nature

authors： Emorine L,Kuehl M,Weir L,Leder P,Max EE

更新日期：1983-08-04 00:00:00

abstract：: ...

journal_title：Nature

authors： Wight AJ

更新日期：2019-01-01 00:00:00

abstract：:Antisense oligodeoxynucleotides (ODNs) have great promise as agents for the specific manipulation of gene expression. Until recently, nonspecific effects of ODNs often confounded the interpretation of antisense studies. Improvements in ODN chemistry and cellular delivery techniques now allow for more potent and specif...

journal_title：Nature

authors： Wagner RW

更新日期：1994-11-24 00:00:00

abstract：:DNA fragments of chemically transformed and normal avian and murine cells induce transformation of NIH 3T3 mouse cells with low efficiencies. High molecular weight DNAs of cells transformed by DNA fragments induce transformation with high efficiencies in secondary transfection assays. It thus seems that endogenous tra...

journal_title：Nature

authors： Cooper GM,Okenquist S,Silverman L

更新日期：1980-04-03 00:00:00

abstract：:Guanine-nucleotide exchange factors on ADP-ribosylation factor GTPases (ARF-GEFs) regulate vesicle formation in time and space by activating ARF substrates on distinct donor membranes. Mammalian GBF1 (ref. 2) and yeast Gea1/2 (ref. 3) ARF-GEFs act at Golgi membranes, regulating COPI-coated vesicle formation. In contra...

journal_title：Nature

authors： Richter S,Geldner N,Schrader J,Wolters H,Stierhof YD,Rios G,Koncz C,Robinson DG,Jürgens G

更新日期：2007-07-26 00:00:00

abstract：:The global burden of malaria has been substantially reduced over the past two decades. Future efforts to reduce malaria further will require moving beyond the treatment of clinical infections to targeting malaria transmission more broadly in the community. As such, the accurate identification of asymptomatic human inf...

journal_title：Nature

authors： Wu L,van den Hoogen LL,Slater H,Walker PG,Ghani AC,Drakeley CJ,Okell LC

更新日期：2015-12-03 00:00:00

abstract：:SEVERAL dioecious marine brown algae have been valuable in studying chemical communication during sexual reproduction. For example, female gametes of Ectocarpus siliculosus, Cutleria multifida and Fucus serratus secrete olefinic hydrocarbons into the seawater to attract male gametes(1-3). A more complex system is foun...

journal_title：Nature

authors： Müller DG,Gassmann G,Lüning K

更新日期：1979-05-31 00:00:00

abstract：:Schizophrenia is a severe mental illness with a typically chronic course affecting nearly 1% of the human population. It is generally accepted that genetic factors have an important pathogenic role in a substantial portion of schizophrenia cases; however, despite decades of family studies, there is no agreed-upon mode...

journal_title：Nature

authors： Kennedy JL,Giuffra LA,Moises HW,Cavalli-Sforza LL,Pakstis AJ,Kidd JR,Castiglione CM,Sjogren B,Wetterberg L,Kidd KK

更新日期：1988-11-10 00:00:00

abstract：:The mechanical environment crucially influences many cell functions. However, it remains largely mysterious how mechanical stimuli are transmitted into biochemical signals. Src is known to regulate the integrin-cytoskeleton interaction, which is essential for the transduction of mechanical stimuli. Using fluorescent r...

journal_title：Nature

authors： Wang Y,Botvinick EL,Zhao Y,Berns MW,Usami S,Tsien RY,Chien S

更新日期：2005-04-21 00:00:00

abstract：:Haptic (touch) perception normally entails an active exploration of object surfaces over time. This is called active touch. When exploring the shape of an object, we experience both geometrical and force cues. For example, when sliding a finger across a surface with a rigid bump on it, the finger moves over the bump w...

journal_title：Nature

authors： Robles-De-La-Torre G,Hayward V

更新日期：2001-07-26 00:00:00

abstract：:Connectivity in the cortex is organized at multiple scales, suggesting that scale-dependent correlated activity is particularly important for understanding the behaviour of sensory cortices and their function in stimulus encoding. We analysed the scale-dependent structure of cortical interactions by using maximum entr...

journal_title：Nature

authors： Ohiorhenuan IE,Mechler F,Purpura KP,Schmid AM,Hu Q,Victor JD

更新日期：2010-07-29 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-11-01 00:00:00

abstract：:Cells subjected to a heat shock, or a variety of other stresses increase the synthesis of a set of proteins, known as heat shock proteins. This response is apparently universal, occurring in the entire range from bacterial to mammalian cells. In Escherichia coli heat shock protein synthesis transiently increases follo...

journal_title：Nature

authors： Straus DB,Walter WA,Gross CA

更新日期：1987-09-24 00:00:00

abstract：:Since its discovery in 1989, efforts to grow clinical isolates of the hepatitis C virus (HCV) in cell culture have met with limited success. Only the JFH-1 isolate has the capacity to replicate efficiently in cultured hepatoma cells without cell culture-adaptive mutations. We hypothesized that cultured cells lack one ...

journal_title：Nature

authors： Saeed M,Andreo U,Chung HY,Espiritu C,Branch AD,Silva JM,Rice CM

更新日期：2015-08-27 00:00:00

abstract：:The yeast [PSI+] element represents a new type of genetic inheritance, in which changes in phenotype are transmitted by a 'protein only' mechanism reminiscent of the 'protein-only' transmission of mammalian prion diseases. The underlying molecular mechanisms for both are poorly understood and it is not clear how simil...

journal_title：Nature

authors： Liu JJ,Lindquist S

更新日期：1999-08-05 00:00:00

abstract：:Visual transduction in vertebrate photoreceptors is thought to involve a diffusible internal transmitter which links photon absorption in disk membranes to the conductance decrease in the plasma membrane of the outer segment. The desensitisation of the photoresponse which occurs during and after illumination may also ...

journal_title：Nature

authors： McNaughton PA,Yau KW,Lamb TD

更新日期：1980-01-03 00:00:00

abstract：:In yeast and somatic cells, mechanisms ensure cell-cycle events are initiated only when preceding events have been completed. In contrast, interruption of specific cell-cycle processes in early embryonic cells of many organisms does not affect the timing of subsequent events, indicating that cell-cycle events are trig...

journal_title：Nature

authors： Haase SB,Reed SI

更新日期：1999-09-23 00:00:00

abstract：:Large seasonal and hemispheric asymmetries in the martian climate system are generally ascribed to variations in solar heating associated with orbital eccentricity. As the orbital elements slowly change (over a period of >104 years), characteristics of the climate such as dustiness and the vigour of atmospheric circul...

journal_title：Nature

authors： Richardson MI,Wilson RJ

更新日期：2002-03-21 00:00:00

abstract：:Non-coding apurinic/apyrimidinic (AP) sites in DNA are continually created in cells both spontaneously and by damage-specific DNA glycosylases. The biologically critical human base excision repair enzyme APE1 cleaves the DNA sugar-phosphate backbone at a position 5' of AP sites to prime DNA repair synthesis. Here we r...

journal_title：Nature

authors： Mol CD,Izumi T,Mitra S,Tainer JA

更新日期：2000-01-27 00:00:00