Abstract:
:The presence of papillomaviruses in epithelial-derived cancers from several animal species has led to the speculation that these viruses may also have a pathogenic role in the development of certain human carcinomas, particularly those associated with the anogenital tract. Recently, human papillomavirus (HPV) DNA has been detected in epithelial-derived cancers, both cutaneous and metastatic, from patients exhibiting the rare, chronic flat wart disease, epidermodysplasia verruciformis (EV). Except for patients exhibiting this chronic wart syndrome, the association of HPV genomes with human epithelial cancers has not been demonstrated. In an attempt to delineate the association and possible involvement of papillomaviruses with human anogenital carcinomas, we have begun an analysis of these cancers for the presence of HPV-specific nucleotide sequences by using highly sensitive hybridization procedures capable of detecting distantly related papillomaviruses at low copy number. Here we demonstrate the presence of HPV DNA in several types of anogenital tumours: Bowenoid papulosis, carcinoma in situ, and verrucous carcinoma. These data indicate that HPV can be detected in several types of premalignant and malignant tumours, supporting the contention that this group of viruses may be involved in the development of certain types of human epithelial-derived cancers.
journal_name
Naturejournal_title
Natureauthors
Zachow KR,Ostrow RS,Bender M,Watts S,Okagaki T,Pass F,Faras AJdoi
10.1038/300771a0subject
Has Abstractpub_date
1982-12-23 00:00:00pages
771-3issue
5894eissn
0028-0836issn
1476-4687journal_volume
300pub_type
杂志文章相关文献
NATURE文献大全abstract::Hyperpolarization-activated cation channels of the HCN gene family contribute to spontaneous rhythmic activity in both heart and brain. All four family members contain both a core transmembrane segment domain, homologous to the S1-S6 regions of voltage-gated K+ channels, and a carboxy-terminal 120 amino-acid cyclic nu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35081088
更新日期:2001-06-14 00:00:00
abstract::The vomeronasal organ (VNO) is a chemoreceptive organ that is thought to transduce pheromones into electrical responses that regulate sexual, hormonal and reproductive function in mammals. The characteristics of pheromone signal detection by vomeronasal neurons remain unclear. Here we use a mouse VNO slice preparation...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35015572
更新日期:2000-06-15 00:00:00
abstract::In their investigation into whether female mate-choice drives male dispersal, Höner et al. argue that female spotted hyaenas (Crocuta crocuta) prefer mates whose tenure in the social group is less than the females' age, to avoid paternal incest, and suggest that male dispersal reflects this preference. However, we are...
journal_title:Nature
pub_type: 评论,杂志文章
doi:10.1038/nature07122
更新日期:2008-07-10 00:00:00
abstract::Bottom trawling is a non-selective commercial fishing technique whereby heavy nets and gear are pulled along the sea floor. The direct impact of this technique on fish populations and benthic communities has received much attention, but trawling can also modify the physical properties of seafloor sediments, water–sedi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11410
更新日期:2012-09-13 00:00:00
abstract::Ferroptosis is a form of regulated cell death that is caused by the iron-dependent peroxidation of lipids1,2. The glutathione-dependent lipid hydroperoxidase glutathione peroxidase 4 (GPX4) prevents ferroptosis by converting lipid hydroperoxides into non-toxic lipid alcohols3,4. Ferroptosis has previously been implica...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1705-2
更新日期:2019-11-01 00:00:00
abstract::The primary function of the adenovirus E1A-region genes is to activate other adenoviral genes during a permissive viral infection by modifying the host cell transcriptional apparatus. Host cell immortalization, or transformation by the whole adenoviral early region, presumably results as a consequence of these modific...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/332553a0
更新日期:1988-04-07 00:00:00
abstract::Type II topoisomerases help regulate DNA topology during transcription, replication and recombination by catalysing DNA strand transfer through transient double-stranded breaks. All type II topoisomerases described so far are members of a single protein family. We have cloned and sequenced the genes encoding the A and...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/386414a0
更新日期:1997-03-27 00:00:00
abstract::Materials showing simultaneous ferroelectric and magnetic ordering are attracting a great deal of interest because of their unusual physics and potential applications. Hemberger et al. have reported relaxor-like dielectric properties and colossal magnetocapacitance (in excess of 500%) for the cubic spinel compound CdC...
journal_title:Nature
pub_type: 评论,杂志文章
doi:10.1038/nature06156
更新日期:2007-08-23 00:00:00
abstract::A cholecystokinin (CCK)-inactivating peptidase was purified and identified as a membrane-bound isoform of tripeptidyl peptidase II (EC 3.4.14.10), a cytosolic subtilisin-like peptidase of previously unknown functions. The peptidase was found in neurons responding to cholecystokinin, as well as in non-neuronal cells. B...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/380403a0
更新日期:1996-04-04 00:00:00
abstract::Antifreeze proteins provide fish with protection against the freezing effect of polar environments by binding to ice surfaces and inhibiting growth of ice crystals. We present the X-ray crystal structure at 1.5 A resolution of a lone alpha-helical antifreeze protein from winter flounder, which provides a detailed look...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/375427a0
更新日期:1995-06-01 00:00:00
abstract::Exceptional genomic stability is one of the hallmarks of mouse embryonic stem (ES) cells. However, the genes contributing to this stability remain obscure. We previously identified Zscan4 as a specific marker for two-cell embryo and ES cells. Here we show that Zscan4 is involved in telomere maintenance and long-term g...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08882
更新日期:2010-04-08 00:00:00
abstract::Electromagnetically induced transparency is a quantum interference effect that permits the propagation of light through an otherwise opaque atomic medium; a 'coupling' laser is used to create the interference necessary to allow the transmission of resonant pulses from a 'probe' laser. This technique has been used to s...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35054017
更新日期:2001-01-25 00:00:00
abstract::To ensure cell survival, it is essential that the ubiquitous pro-apoptotic machinery is kept quiescent. As death is irreversible, cells must continually integrate developmental information with regulatory inputs to control the switch between repressing and activating apoptosis. Inappropriate activation or suppression ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01920
更新日期:2003-08-28 00:00:00
abstract::Large panels of comprehensively characterized human cancer models, including the Cancer Cell Line Encyclopedia (CCLE), have provided a rigorous framework with which to study genetic variants, candidate targets, and small-molecule and biological therapeutics and to identify new marker-driven cancer dependencies. To imp...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1186-3
更新日期:2019-05-01 00:00:00
abstract::Using numerical simulation, Holmström et al. proposed a plausible alternative explanation of the observed Lyman-alpha absorption that was seen during the transit of HD 209458b (ref. 2). They conclude that radiation pressure alone cannot explain the observations and that a peculiar stellar wind is needed. Here we show ...
journal_title:Nature
pub_type: 评论,杂志文章
doi:10.1038/nature07402
更新日期:2008-11-13 00:00:00
abstract::Ten eleven translocation (TET) enzymes, including TET1, TET2 and TET3, convert 5-methylcytosine to 5-hydroxymethylcytosine and regulate gene transcription. However, the molecular mechanism by which TET family enzymes regulate gene transcription remains elusive. Using protein affinity purification, here we search for f...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11742
更新日期:2013-01-24 00:00:00
abstract::Osteoclasts are the only somatic cells with bone-resorbing capacity and, as such, they have a critical role not only in normal bone homeostasis (called 'bone remodelling') but also in the pathogenesis of bone destructive disorders such as rheumatoid arthritis and osteoporosis. A major focus of research in the field ha...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07713
更新日期:2009-03-26 00:00:00
abstract::The seemingly endless studies of the ethical connotations of genetics serve a valuable role in general understanding even if the ethical problems involved are often insubstantial. ...
journal_title:Nature
pub_type: 社论
doi:10.1038/356365a0
更新日期:1992-04-02 00:00:00
abstract::A multitude of heptahelical receptors use heterotrimeric G proteins to transduce signals to specific effector target molecules. The G protein transducin, Gt, couples photon-activated rhodopsin with the effector cyclic GMP phosophodiesterase (PDE) in the vertebrate phototransduction cascade. The interactions of the Gt ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35059138
更新日期:2001-02-22 00:00:00
abstract::The distribution of fitness effects of protein mutations is still unknown. Of particular interest is whether accumulating deleterious mutations interact, and how the resulting epistatic effects shape the protein's fitness landscape. Here we apply a model system in which bacterial fitness correlates with the enzymatic ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05385
更新日期:2006-12-14 00:00:00
abstract::A continuous array of overlapping clones covering the entire human chromosome 21q was constructed from human yeast artificial chromosome libraries using sequence-tagged sites as landmarks specifically detected by polymerase chain reaction. The yeast artificial chromosome contiguous unit starts with pericentromeric and...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/359380a0
更新日期:1992-10-01 00:00:00
abstract::The perception of yellow has played a central role in distinguishing two main theories of colour vision. Hering proposed that yellow results from the activation of a distinct retinal-neural mechanism, whereas according to the Young-Helmholtz-Maxwell view, yellow results from the combined activation of red and green co...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/386066a0
更新日期:1997-03-06 00:00:00
abstract::The debate over human origins has focused on two competing theories. The single African origin model holds that anatomically modern Homo sapiens evolved in Africa 100,000-200,000 years ago. Members of this population migrated out of Africa, replacing archaic human groups through Asia and Europe, with racial differenti...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/368452a0
更新日期:1994-03-31 00:00:00
abstract::L-glutamate, the neurotransmitter of the majority of excitatory synapses in the brain, acts on three classes of ionotropic receptors: NMDA (N-methyl-D-aspartate), AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) and kainate receptors. Little is known about the physiological role of kainate receptors be...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/33408
更新日期:1998-04-09 00:00:00
abstract::The hope that hybridoma antibodies would reveal unique cell surface antigens during embryogenesis, differentiation and oncogenesis has been replaced by the realization that such antigens are mainly carbohydrate structures of glycoproteins and glycolipids occurring in many cell types. These findings either may reflect ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/314053a0
更新日期:1985-03-07 00:00:00
abstract::Mice of the AKR strain are characterised by a high incidence of spontaneous thymic lymphomas. AKR chromosomes contain the genomes of ecotropic murine leukaemia virus (MuLV) at two loci, termed Akv-1 and Akv-2 (refs 2-6). Shortly after birth, the normal tissues of AKR mice begin to produce high levels of this XC-positi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/282753a0
更新日期:1979-12-13 00:00:00
abstract::In contrast to double-stranded DNA, there has so far been little evidence that double-stranded RNA can undergo major conformational transitions. We have investigated the conformation in different conditions of the double-stranded RNA molecule poly(G-C).poly(G-C), by NMR, circular dichroism and absorbance spectroscopy....
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/311584a0
更新日期:1984-10-11 00:00:00
abstract::Quantum electrodynamics describes the interactions of electrons and photons. Electric charge (the gauge coupling constant) is energy dependent, and there is a previous claim that charge is affected by gravity (described by general relativity) with the implication that the charge is reduced at high energies. However, t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09506
更新日期:2010-11-04 00:00:00
abstract::All of the DNA synthesis genes of budding yeast examined so far are periodically expressed and hence under cell-cycle control (Table 1). Expression occurs near the G1/S phase boundary and the genes seem to be coordinately regulated (reviewed in ref. 4). The upstream promoter sequences of these genes have only a hexame...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/350247a0
更新日期:1991-03-21 00:00:00
abstract::Overfishing of large-bodied benthic fishes and their subsequent population collapses on the Scotian Shelf of Canada's east coast and elsewhere resulted in restructuring of entire food webs now dominated by planktivorous, forage fish species and macroinvertebrates. Despite the imposition of strict management measures i...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10285
更新日期:2011-07-27 00:00:00