Characterization and inhibition of a cholecystokinin-inactivating serine peptidase.

abstract：:The steel of Damascus blades, which were first encountered by the Crusaders when fighting against Muslims, had features not found in European steels--a characteristic wavy banding pattern known as damask, extraordinary mechanical properties, and an exceptionally sharp cutting edge. Here we use high-resolution transmis...

journal_title：Nature

authors： Reibold M,Paufler P,Levin AA,Kochmann W,Pätzke N,Meyer DC

更新日期：2006-11-16 00:00:00

abstract：:T lymphocytes are predisposed to recognition of foreign protein fragments bound to cell-surface molecules encoded by the major histocompatibility complex (MHC). There is now compelling evidence that this specificity is a consequence of a selection process operating on developing T lymphocytes in the thymus. As a resul...

journal_title：Nature

authors： Kaye J,Hsu ML,Sauron ME,Jameson SC,Gascoigne NR,Hedrick SM

更新日期：1989-10-26 00:00:00

abstract：:The recent discoveries of RNA interference and related RNA silencing pathways have revolutionized our understanding of gene regulation. RNA interference has been used as a research tool to control the expression of specific genes in numerous experimental organisms and has potential as a therapeutic strategy to reduce ...

journal_title：Nature

authors： Mello CC,Conte D Jr

更新日期：2004-09-16 00:00:00

abstract：:Relapse to cocaine use after prolonged abstinence is an important clinical problem. This relapse is often induced by exposure to cues associated with cocaine use. To account for the persistent propensity for relapse, it has been suggested that cue-induced cocaine craving increases over the first several weeks of absti...

journal_title：Nature

authors： Conrad KL,Tseng KY,Uejima JL,Reimers JM,Heng LJ,Shaham Y,Marinelli M,Wolf ME

更新日期：2008-07-03 00:00:00

abstract：:The germ-cell lineage ensures the continuity of life through the generation of male and female gametes, which unite to form a totipotent zygote. We have previously demonstrated that, by using cytokines, embryonic stem cells and induced pluripotent stem cells can be induced into epiblast-like cells (EpiLCs) and then in...

journal_title：Nature

authors： Nakaki F,Hayashi K,Ohta H,Kurimoto K,Yabuta Y,Saitou M

更新日期：2013-09-12 00:00:00

abstract：:Seasonal influenza epidemics are a major public health concern, causing tens of millions of respiratory illnesses and 250,000 to 500,000 deaths worldwide each year. In addition to seasonal influenza, a new strain of influenza virus against which no previous immunity exists and that demonstrates human-to-human transmis...

journal_title：Nature

authors： Ginsberg J,Mohebbi MH,Patel RS,Brammer L,Smolinski MS,Brilliant L

更新日期：2009-02-19 00:00:00

abstract：:The plasma membrane-bound mammalian ras proteins of relative molecular mass 21,000 (ras p21) share biochemical and structural properties with other guanine nucleotide-binding regulatory proteins (G-proteins). Oncogenic ras p21 variants result from amino acid substitutions at specific positions that cause p21 to occur ...

journal_title：Nature

authors： Vogel US,Dixon RA,Schaber MD,Diehl RE,Marshall MS,Scolnick EM,Sigal IS,Gibbs JB

更新日期：1988-09-01 00:00:00

abstract：:The existence in the ocean of deep western boundary currents, which connect the high-latitude regions where deep water is formed with upwelling regions as part of the global ocean circulation, was postulated more than 40 years ago. These ocean currents have been found adjacent to the continental slopes of all ocean ba...

journal_title：Nature

authors： Dengler M,Schott FA,Eden C,Brandt P,Fischer J,Zantopp RJ

更新日期：2004-12-23 00:00:00

abstract：:The search for the earliest fossil evidence of the human lineage has been concentrated in East Africa. Here we report the discovery of six hominid specimens from Chad, central Africa, 2,500 km from the East African Rift Valley. The fossils include a nearly complete cranium and fragmentary lower jaws. The associated fa...

journal_title：Nature

authors： Brunet M,Guy F,Pilbeam D,Mackaye HT,Likius A,Ahounta D,Beauvilain A,Blondel C,Bocherens H,Boisserie JR,De Bonis L,Coppens Y,Dejax J,Denys C,Duringer P,Eisenmann V,Fanone G,Fronty P,Geraads D,Lehmann T,Lihoreau F,

更新日期：2002-07-11 00:00:00

abstract：:The discovery of a plume of water vapour and ice particles emerging from warm fractures ('tiger stripes') in Saturn's small, icy moon Enceladus raised the question of whether the plume emerges from a subsurface liquid source or from the decomposition of ice. Previous compositional analyses of particles injected by the...

journal_title：Nature

authors： Postberg F,Schmidt J,Hillier J,Kempf S,Srama R

更新日期：2011-06-22 00:00:00

abstract：:Recent studies in which cloned immunoglobulin genes were introduced into cultured cells have produced two significant findings. First, the genes are expressed after transfection into lymphoid cells but not non-lymphoid cells. Second, transcription of an immunoglobulin gene requires, in addition to the promoter region,...

journal_title：Nature

authors： Foster J,Stafford J,Queen C

更新日期：1985-05-30 00:00:00

abstract：:The hydroxyl radical (OH) is a key oxidant involved in the removal of air pollutants and greenhouse gases from the atmosphere. The ratio of Northern Hemispheric to Southern Hemispheric (NH/SH) OH concentration is important for our understanding of emission estimates of atmospheric species such as nitrogen oxides and m...

journal_title：Nature

authors： Patra PK,Krol MC,Montzka SA,Arnold T,Atlas EL,Lintner BR,Stephens BB,Xiang B,Elkins JW,Fraser PJ,Ghosh A,Hintsa EJ,Hurst DF,Ishijima K,Krummel PB,Miller BR,Miyazaki K,Moore FL,Mühle J,O'Doherty S,Prinn RG,Steele

更新日期：2014-09-11 00:00:00

abstract：:Apoptosis is a highly regulated process that is crucial for normal development and homeostasis of multicellular organisms. The p35 protein from baculoviruses effectively prevents apoptosis by its broad-spectrum caspase inhibition. Here we report the crystal structure of p35 in complex with human caspase-8 at 3.0 A res...

journal_title：Nature

authors： Xu G,Cirilli M,Huang Y,Rich RL,Myszka DG,Wu H

更新日期：2001-03-22 00:00:00

abstract：:The flow of terrestrial groundwater to the sea is an important natural component of the hydrological cycle. This process, however, does not explain the large volumes of low-salinity groundwater that are found below continental shelves. There is mounting evidence for the global occurrence of offshore fresh and brackish...

journal_title：Nature

authors： Post VE,Groen J,Kooi H,Person M,Ge S,Edmunds WM

更新日期：2013-12-05 00:00:00

abstract：:Many natural habitats exist on privately owned land outside protected areas, but few governments can afford to enforce or subsidize conservation of this biodiversity. Even in some developed countries, conservation subsidy schemes have only achieved limited success. Fortunately, some landowners may be willing to accept...

journal_title：Nature

authors： Oldfield TE,Smith RJ,Harrop SR,Leader-Williams N

更新日期：2003-05-29 00:00:00

abstract：:Genome instability is central to ageing, cancer and other diseases. It is not only proteins involved in DNA replication or the DNA damage response (DDR) that are important for maintaining genome integrity: from yeast to higher eukaryotes, mutations in genes involved in pre-mRNA splicing and in the biogenesis and expor...

journal_title：Nature

authors： Bhatia V,Barroso SI,García-Rubio ML,Tumini E,Herrera-Moyano E,Aguilera A

更新日期：2014-07-17 00:00:00

abstract：:The inhibitory activity associated with myelin is a major obstacle for successful axon regeneration in the adult mammalian central nervous system (CNS). In addition to myelin-associated glycoprotein (MAG) and Nogo-A, available evidence suggests the existence of additional inhibitors in CNS myelin. We show here that a ...

journal_title：Nature

authors： Wang KC,Koprivica V,Kim JA,Sivasankaran R,Guo Y,Neve RL,He Z

更新日期：2002-06-27 00:00:00

abstract：:Seafloor spreading is largely unobserved because 98 per cent of the global mid-ocean-ridge system is below the ocean surface. Our understanding of the dynamic processes that control seafloor spreading is thus inferred largely from geophysical observations of spreading events on land at Afar in East Africa and Iceland....

journal_title：Nature

authors： Tan YJ,Tolstoy M,Waldhauser F,Wilcock WS

更新日期：2016-12-08 00:00:00

abstract：:Organisms use endogenous clocks to anticipate regular environmental cycles, such as days and tides. Natural variants resulting in differently timed behaviour or physiology, known as chronotypes in humans, have not been well characterized at the molecular level. We sequenced the genome of Clunio marinus, a marine midge...

journal_title：Nature

authors： Kaiser TS,Poehn B,Szkiba D,Preussner M,Sedlazeck FJ,Zrim A,Neumann T,Nguyen LT,Betancourt AJ,Hummel T,Vogel H,Dorner S,Heyd F,von Haeseler A,Tessmar-Raible K

更新日期：2016-12-01 00:00:00

abstract：:An ageing world population has fuelled interest in regenerative remedies that may stem declining organ function and maintain fitness. Unanswered is whether elimination of intrinsic instigators driving age-associated degeneration can reverse, as opposed to simply arrest, various afflictions of the aged. Such instigator...

journal_title：Nature

authors： Jaskelioff M,Muller FL,Paik JH,Thomas E,Jiang S,Adams AC,Sahin E,Kost-Alimova M,Protopopov A,Cadiñanos J,Horner JW,Maratos-Flier E,Depinho RA

更新日期：2011-01-06 00:00:00

abstract：:Protein G is a cell-surface protein from Streptococcus which binds to IgG molecules from a wide range of species with an affinity comparable to that of antigen. The high affinity of protein G for the Fab portion of IgG poses a particular challenge in molecular recognition, given the variability of heavy chain subclass...

journal_title：Nature

authors： Derrick JP,Wigley DB

更新日期：1992-10-22 00:00:00

abstract：:Excitatory amino acids mediate fast synaptic transmission in the central nervous system through the activation of at least three distinct ionotropic receptors: N-methyl-D-aspartate (NMDA), the alpha-amino-3-hydroxy-5-methyl-isoxasole-4-propionate (AMPA)/quisqualate (QUIS) and the kainate subtypes (for reviews, see ref...

journal_title：Nature

authors： Charpak S,Gähwiler BH,Do KQ,Knöpfel T

更新日期：1990-10-25 00:00:00

abstract：:Men who develop metastatic castration-resistant prostate cancer (CRPC) invariably succumb to the disease. Progression to CRPC after androgen ablation therapy is predominantly driven by deregulated androgen receptor (AR) signalling. Despite the success of recently approved therapies targeting AR signalling, such as abi...

journal_title：Nature

authors： Asangani IA,Dommeti VL,Wang X,Malik R,Cieslik M,Yang R,Escara-Wilke J,Wilder-Romans K,Dhanireddy S,Engelke C,Iyer MK,Jing X,Wu YM,Cao X,Qin ZS,Wang S,Feng FY,Chinnaiyan AM

更新日期：2014-06-12 00:00:00

abstract：:Imperfect knowledge of the times at which 'snapshots' of a system are recorded degrades our ability to recover dynamical information, and can scramble the sequence of events. In X-ray free-electron lasers, for example, the uncertainty--the so-called timing jitter--between the arrival of an optical trigger ('pump') pul...

journal_title：Nature

authors： Fung R,Hanna AM,Vendrell O,Ramakrishna S,Seideman T,Santra R,Ourmazd A,Ourmazd A

更新日期：2016-04-28 00:00:00

abstract：: ...

journal_title：Nature

authors： Holmes J

更新日期：2018-10-01 00:00:00

abstract：:The aspergilli comprise a diverse group of filamentous fungi spanning over 200 million years of evolution. Here we report the genome sequence of the model organism Aspergillus nidulans, and a comparative study with Aspergillus fumigatus, a serious human pathogen, and Aspergillus oryzae, used in the production of sake,...

journal_title：Nature

authors： Galagan JE,Calvo SE,Cuomo C,Ma LJ,Wortman JR,Batzoglou S,Lee SI,Baştürkmen M,Spevak CC,Clutterbuck J,Kapitonov V,Jurka J,Scazzocchio C,Farman M,Butler J,Purcell S,Harris S,Braus GH,Draht O,Busch S,D'Enfert C,Bou

更新日期：2005-12-22 00:00:00

abstract：:In Drosophila, a large group of structural genes exhibit coordinate regulation, not because they function in a common developmental pathway but because they happen to reside on the X chromosome. These genes are subjected to the regulatory mechanism of dosage compensation which insures that their phenotypic products ar...

journal_title：Nature

authors： Belote JM,Lucchesi JC

更新日期：1980-06-19 00:00:00

abstract：:The Gakkel ridge, which extends under the Arctic ice cap for approximately 1,800 km, is the slowest spreading ocean ridge on Earth. Its spreading created the Eurasian basin, which is isolated from the rest of the oceanic mantle by North America, Eurasia and the Lomonosov ridge. The Gakkel ridge thus provides unique op...

journal_title：Nature

authors： Goldstein SL,Soffer G,Langmuir CH,Lehnert KA,Graham DW,Michael PJ

更新日期：2008-05-01 00:00:00

abstract：:The Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8) is a gamma-2 herpesvirus that is implicated in the pathogenesis of Kaposi's sarcoma and of primary effusion B-cell lymphomas (PELs). KSHV infects malignant and progenitor cells of Kaposi's sarcoma and PEL, it encodes putative oncogenes and genes that may cause Ka...

journal_title：Nature

authors： Bais C,Santomasso B,Coso O,Arvanitakis L,Raaka EG,Gutkind JS,Asch AS,Cesarman E,Gershengorn MC,Mesri EA

更新日期：1998-01-01 00:00:00

abstract：:Despite the continued increase in atmospheric greenhouse gas concentrations, the annual-mean global temperature has not risen in the twenty-first century, challenging the prevailing view that anthropogenic forcing causes climate warming. Various mechanisms have been proposed for this hiatus in global warming, but thei...

journal_title：Nature

authors： Kosaka Y,Xie SP

更新日期：2013-09-19 00:00:00