Characterization and inhibition of a cholecystokinin-inactivating serine peptidase.

Abstract:

:A cholecystokinin (CCK)-inactivating peptidase was purified and identified as a membrane-bound isoform of tripeptidyl peptidase II (EC 3.4.14.10), a cytosolic subtilisin-like peptidase of previously unknown functions. The peptidase was found in neurons responding to cholecystokinin, as well as in non-neuronal cells. Butabindide, a potent and specific inhibitor, was designed and shown to protect endogenous cholecystokinin from inactivation and to display pro-satiating effects mediated by the CCKA receptor.

journal_name

Nature

journal_title

Nature

authors

Rose C,Vargas F,Facchinetti P,Bourgeat P,Bambal RB,Bishop PB,Chan SM,Moore AN,Ganellin CR,Schwartz JC

doi

10.1038/380403a0

subject

Has Abstract

pub_date

1996-04-04 00:00:00

pages

403-9

issue

6573

eissn

0028-0836

issn

1476-4687

journal_volume

380

pub_type

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