Zscan4 regulates telomere elongation and genomic stability in ES cells.

abstract：:Activated T lymphocytes differentiate into effector cells tailored to meet disparate challenges to host integrity. For example, type 1 and type 2 helper (T(H)1 and T(H)2) cells secrete cytokines that enhance cell-mediated and humoral immunity, respectively. The chemokine monocyte chemoattractant protein-1 (MCP-1) can ...

journal_title：Nature

authors： Gu L,Tseng S,Horner RM,Tam C,Loda M,Rollins BJ

更新日期：2000-03-23 00:00:00

abstract：:Leprosy is a spectral disease in which immune responses to Mycobacterium leprae correlate with the clinical, bacteriological and histopathological manifestations of disease, so study of its pathology provides insights into immunoregulatory mechanisms in man. At the tuberculoid pole, patients have few lesions in the sk...

journal_title：Nature

authors： Modlin RL,Kato H,Mehra V,Nelson EE,Fan XD,Rea TH,Pattengale PK,Bloom BR

更新日期：1986-07-31 00:00:00

abstract：:The partial amino-acid sequence of purified human transforming growth factor-beta (TGF-beta) was used to identify a series of cDNA clones encoding the protein. The cDNA sequence indicates that the 112-amino acid monomeric form of the natural TGF-beta homodimer is derived proteolytically from a much longer precursor po...

journal_title：Nature

authors： Derynck R,Jarrett JA,Chen EY,Eaton DH,Bell JR,Assoian RK,Roberts AB,Sporn MB,Goeddel DV

更新日期：1985-08-22 00:00:00

abstract：:Mitochondrial cytochrome oxidase is a functionally complex, membrane-bound respiratory enzyme which catalyses both the reduction of O2 to water and proton-pumping. During respiration, an exogenous donor, cytochrome c, donates four electrons to O2 bound at the bimetallic haem alpha 3 Fe-Cu centre within the enzyme. The...

journal_title：Nature

authors： Wikström M

更新日期：1989-04-27 00:00:00

abstract：:Several hormones and neurotransmitters raise the cytosolic free Ca2+ concentration by stimulating the influx of Ca2+ and/or by mobilizing stored Ca2+. However, the link between the agonist receptor on the cell surface and the organelle(s) from which Ca2+ is mobilized is unknown. One feature of the agonists that increa...

journal_title：Nature

authors： Prentki M,Biden TJ,Janjic D,Irvine RF,Berridge MJ,Wollheim CB

更新日期：1984-06-07 00:00:00

abstract：:The terminal differentiation of myogenic cells initiates in the proximal portion of the limb bud whereas the distal region remains undifferentiated and proliferative. The apical ectodermal ridge maintains the progress zone in an undifferentiated state and induces proliferation of limb mesenchymal cells. Hox-7.1, a hom...

journal_title：Nature

authors： Song K,Wang Y,Sassoon D

更新日期：1992-12-03 00:00:00

abstract：:Polymer electrolyte membrane fuel cells (PEMFCs) running on hydrogen are attractive alternative power supplies for a range of applications, with in situ release of the required hydrogen from a stable liquid offering one way of ensuring its safe storage and transportation before use. The use of methanol is particularly...

journal_title：Nature

authors： Lin L,Zhou W,Gao R,Yao S,Zhang X,Xu W,Zheng S,Jiang Z,Yu Q,Li YW,Shi C,Wen XD,Ma D

更新日期：2017-04-06 00:00:00

abstract：:The methylation of vertebrate DNA at the 5-position of approximately 3-10% of its cytosine residues occurs in a sequence-specific and tissue-specific manner and has been implicated in the control of transcription. How these differences are established and how they mediate the initiation or maintenance of transcription...

journal_title：Nature

authors： Huang LH,Wang R,Gama-Sosa MA,Shenoy S,Ehrlich M

更新日期：1984-03-15 00:00:00

abstract：:Sensory systems can adapt to the conditions imposed on them. In the visual system, adapting to a pattern increases the threshold of the ability to see that pattern, and reduces the perceived contrast of the pattern above threshold. Most neurons of the striate cortex reduce their responsiveness after being stimulated f...

journal_title：Nature

authors： Snowden RJ,Hammett ST

更新日期：1992-01-16 00:00:00

abstract：:Humans are able to classify novel items correctly by category; some other animals have also been shown to do this. During category learning, humans group perceptual stimuli by abstracting qualities from similarity relationships of their physical properties. Forming categories is fundamental to cognition and can be ind...

journal_title：Nature

authors： Ohl FW,Scheich H,Freeman WJ

更新日期：2001-08-16 00:00:00

abstract：:A DNA probe from a human Y chromosome-derived cosmid detects a single-copy genomic DNA fragment which can appear in different allelic forms shared by both sex chromosomes. Variants at this DNA locus show an autosomal pattern of inheritance, undergo recombination with sexual phenotype and can therefore be described as ...

journal_title：Nature

authors： Simmler MC,Rouyer F,Vergnaud G,Nyström-Lahti M,Ngo KY,de la Chapelle A,Weissenbach J

更新日期：1985-10-24 00:00:00

abstract：:Corticosteroids as well as non-steroid anti-inflammatory drugs inhibit the prostaglandin-mediated vasodilatation accompanying lipolysis in subcutaneous fat. Whereas the non-steroids produce their effect by inhibition of prostaglandin synthesis, however, corticosteroids inhibit their release. This mechanism may be the ...

journal_title：Nature

authors： Lewis GP,Piper PJ

更新日期：1975-03-27 00:00:00

abstract：:A fundamental tenet of classical mendelian genetics is that allelic information is stably inherited from one generation to the next, resulting in predictable segregation patterns of differing alleles. Although several exceptions to this principle are known, all represent specialized cases that are mechanistically rest...

journal_title：Nature

authors： Lolle SJ,Victor JL,Young JM,Pruitt RE

更新日期：2005-03-24 00:00:00

abstract：:Processes such as the scattering of alpha particles ((4)He), the triple-alpha reaction, and alpha capture play a major role in stellar nucleosynthesis. In particular, alpha capture on carbon determines the ratio of carbon to oxygen during helium burning, and affects subsequent carbon, neon, oxygen, and silicon burning...

journal_title：Nature

authors： Elhatisari S,Lee D,Rupak G,Epelbaum E,Krebs H,Lähde TA,Luu T,Meißner UG

更新日期：2015-12-03 00:00:00

abstract：:The brightness of type Ia supernovae, and their homogeneity as a class, makes them powerful tools in cosmology, yet little is known about the progenitor systems of these explosions. They are thought to arise when a white dwarf accretes matter from a companion star, is compressed and undergoes a thermonuclear explosion...

journal_title：Nature

authors： Ruiz-Lapuente P,Comeron F,Méndez J,Canal R,Smartt SJ,Filippenko AV,Kurucz RL,Chornock R,Foley RJ,Stanishev V,Ibata R

更新日期：2004-10-28 00:00:00

abstract：:Double-stranded RNAs (dsRNAs) induce post-transcriptional gene silencing in several species of animal and plant. In plants, dsRNAs targeted to CpG islands within a promoter can also induce RNA-directed DNA methylation; however, it remains unclear whether gene silencing mediated by DNA methylation can be induced by dsR...

journal_title：Nature

authors： Kawasaki H,Taira K

更新日期：2004-09-09 00:00:00

abstract：:The colonization of a new habitat is a fundamental process in metapopulation biology, but it is difficult to study. The emigration of colonists from established populations might be induced by resource competition owing to high local population density. Migration distances are also important because they determine the...

journal_title：Nature

authors： Gaggiotti OE,Jones F,Lee WM,Amos W,Harwood J,Nichols RA

更新日期：2002-03-28 00:00:00

abstract：:The making and breaking of atomic bonds are essential processes in chemical reactions. Although the ultrafast dynamics of bond breaking have been studied intensively using time-resolved techniques, it is very difficult to study the structural dynamics of bond making, mainly because of its bimolecular nature. It is esp...

journal_title：Nature

authors： Kim KH,Kim JG,Nozawa S,Sato T,Oang KY,Kim TW,Ki H,Jo J,Park S,Song C,Sato T,Ogawa K,Togashi T,Tono K,Yabashi M,Ishikawa T,Kim J,Ryoo R,Kim J,Ihee H,Adachi S

更新日期：2015-02-19 00:00:00

abstract：:Alkaloids, secondary metabolites that contain basic nitrogen atoms, are some of the most well-known biologically active natural products in chemistry and medicine. Although efficient laboratory synthesis of alkaloids would enable the study and optimization of their biological properties, their preparation is often com...

journal_title：Nature

authors： Parr BT,Economou C,Herzon SB

更新日期：2015-09-24 00:00:00

abstract：:Anomalies in temperature and precipitation in northern Russia over the past few years have been viewed as manifestations of anthropogenic climate change, prompting suggestions that this may also account for exceptional forest fires in the region. Here we examine the number of forest-fire events across the boreal Russi...

journal_title：Nature

authors： Mollicone D,Eva HD,Achard F

更新日期：2006-03-23 00:00:00

abstract：:The creation of neural circuits depends on the formation of synapses between specific sets of neurons. Little is known, however, of the molecular mechanisms governing synaptic choice. A mutation in the unc-4 gene alters the pattern of synaptic input to one class of motor neurons in the Caenorhabditis elegans ventral n...

journal_title：Nature

authors： Miller DM,Shen MM,Shamu CE,Bürglin TR,Ruvkun G,Dubois ML,Ghee M,Wilson L

更新日期：1992-02-27 00:00:00

abstract：:Amino-acid radicals play key roles in many enzymatic reactions. Catalysis often involves transfer of a radical character within the protein, as in class I ribonucleotide reductase where radical transfer occurs over 35 A, from a tyrosyl radical to a cysteine. It is currently debated whether this kind of long-range tran...

journal_title：Nature

authors： Aubert C,Vos MH,Mathis P,Eker AP,Brettel K

更新日期：2000-06-01 00:00:00

abstract：:De novo-designed proteins1-3 hold great promise as building blocks for synthetic circuits, and can complement the use of engineered variants of natural proteins4-7. One such designer protein-degronLOCKR, which is based on 'latching orthogonal cage-key proteins' (LOCKR) technology8-is a switch that degrades a protein o...

journal_title：Nature

authors： Ng AH,Nguyen TH,Gómez-Schiavon M,Dods G,Langan RA,Boyken SE,Samson JA,Waldburger LM,Dueber JE,Baker D,El-Samad H

更新日期：2019-08-01 00:00:00

abstract：:Mutations in PIK3CA, which encodes the p110α subunit of the insulin-activated phosphatidylinositol-3 kinase (PI3K), and loss of function mutations in PTEN, which encodes a phosphatase that degrades the phosphoinositide lipids generated by PI3K, are among the most frequent events in human cancers1,2. However, pharmacol...

journal_title：Nature

authors： Hopkins BD,Pauli C,Du X,Wang DG,Li X,Wu D,Amadiume SC,Goncalves MD,Hodakoski C,Lundquist MR,Bareja R,Ma Y,Harris EM,Sboner A,Beltran H,Rubin MA,Mukherjee S,Cantley LC

更新日期：2018-08-01 00:00:00

abstract：:Understanding the fluctuations in marine fish stocks is important for the management of fisheries, and attempts have been made to demonstrate links with oceanographic and climatic variability, including the North Atlantic Oscillation (NAO). The NAO has been correlated with a range of long-term ecological measures, inc...

journal_title：Nature

authors： Attrill MJ,Power M

更新日期：2002-05-16 00:00:00

abstract：:Climate models with increased levels of carbon dioxide predict that global warming causes heating in the tropics, but investigations of ancient climates based on palaeodata have generally indicated cool tropical temperatures during supposed greenhouse episodes. For example, in the Late Cretaceous and Eocene epochs the...

journal_title：Nature

authors： Pearson PN,Ditchfield PW,Singano J,Harcourt-Brown KG,Nicholas CJ,Olsson RK,Shackleton NJ,Hall MA

更新日期：2001-10-04 00:00:00

abstract：:Carbon chemistry exhibits a rich variety in bonding patterns, with homo- or heteronuclear multiple bonds involving sp-hybridized carbon atoms as found in molecules such as acetylenes, nitriles, allenes and carbon dioxide. Carbon's heavier homologues in group 14 of the periodic table--including silicon, germanium and t...

journal_title：Nature

authors： Ishida S,Iwamoto T,Kabuto C,Kira M

更新日期：2003-02-13 00:00:00

abstract：:Although it is well established that family members resemble each other in intelligence , the extent to which this results from either shared genes or a shared environment remains controversial, perhaps especially since the relevant evidence presented by Burt has been shown probably to have been fabricated. The influe...

journal_title：Nature

authors： Teasdale TW,Owen DR

更新日期：1984-06-14 00:00:00

abstract：:How bacteria regulate cell cycle progression at a molecular level is a fundamental but poorly understood problem. In Caulobacter crescentus, two-component signal transduction proteins are crucial for cell cycle regulation, but the connectivity of regulators involved has remained elusive and key factors are unidentifie...

journal_title：Nature

authors： Biondi EG,Reisinger SJ,Skerker JM,Arif M,Perchuk BS,Ryan KR,Laub MT

更新日期：2006-12-14 00:00:00

abstract：:Precipitation and atmospheric circulation are the coupled processes through which tropical ocean surface temperatures drive global weather and climate1-5. Local sea surface warming tends to increase precipitation, but this local control is difficult to disentangle from remote effects of conditions elsewhere. As an exa...

journal_title：Nature

authors： Good P,Chadwick R,Holloway CE,Kennedy J,Lowe JA,Roehrig R,Rushley SS

更新日期：2021-01-01 00:00:00