Abstract:
:Corticosteroids as well as non-steroid anti-inflammatory drugs inhibit the prostaglandin-mediated vasodilatation accompanying lipolysis in subcutaneous fat. Whereas the non-steroids produce their effect by inhibition of prostaglandin synthesis, however, corticosteroids inhibit their release. This mechanism may be the basis of some actions of corticosteroids in inflammation, in the gastric mucosa and in the CNS.
journal_name
Naturejournal_title
Natureauthors
Lewis GP,Piper PJdoi
10.1038/254308a0keywords:
subject
Has Abstractpub_date
1975-03-27 00:00:00pages
308-11issue
5498eissn
0028-0836issn
1476-4687journal_volume
254pub_type
杂志文章相关文献
NATURE文献大全abstract::The unusual helium-rich (type Ib) supernova SN 2005E is distinguished from all supernovae hitherto observed by its faint and rapidly fading light curve, prominent calcium lines in late-phase spectra and lack of any mark of recent star formation near the supernova location. These properties are claimed to be explained ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09055
更新日期:2010-05-20 00:00:00
abstract::Appropriate repair of DNA lesions and the inhibition of DNA repair activities at telomeres are crucial to prevent genomic instability. By fuelling the generation of genetic alterations and by compromising cell viability, genomic instability is a driving force in cancer and ageing. Here we identify MAD2L2 (also known a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14216
更新日期:2015-05-28 00:00:00
abstract::Four-residue beta-turns and larger loop structures represent a significant fraction of globular protein surfaces and play an important role in determining the conformation and specificity of enzyme active sites and antibody-combining sites. Turns are an attractive starting point to develop protein design methods, as t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/339073a0
更新日期:1989-05-04 00:00:00
abstract::Cytochrome c oxidase is a member of the haem copper oxidase superfamily (HCO). HCOs function as the terminal enzymes in the respiratory chain of mitochondria and aerobic prokaryotes, coupling molecular oxygen reduction to transmembrane proton pumping. Integral to the enzyme's function is the transfer of electrons from...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11182
更新日期:2012-07-26 00:00:00
abstract::Shiga toxin and some other protein toxins that act on targets in the cytosol have previously been shown to enter the trans-Golgi network. Transport by this route may be necessary for translocation of the toxin to the cytosol and for intoxication, but it is not known whether the enzymatically active part of the toxins ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/358510a0
更新日期:1992-08-06 00:00:00
abstract::Insulin binding to its receptor leads to negatively cooperative interactions among the receptor sites. Studies with 29 insulin analogues (animal insulins and proinsulin, insulin-like growth factor and chemically modified insulins) which vary 1,000-fold in their affinity for the receptor and in their biological potency...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/273504a0
更新日期:1978-06-15 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 评论,新闻
doi:10.1038/d41586-019-00450-0
更新日期:2019-02-01 00:00:00
abstract::T200, a major cell-surface glycoprotein on lymphoid cells, exists in several forms with different electrophoretic mobilities. These forms have been correlated with different classes of lymphoid cell. The smaller forms, with molecular weights (MWs) of congruent to 170,000 and 180,000 are found predominantly on T cells ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/289681a0
更新日期:1981-02-19 00:00:00
abstract::Oligodendrocytes and astrocytes are macroglial cells of the vertebrate central nervous system. These cells have diverse roles in the maintenance of neurological function. In the embryo, the genetic mechanisms that underlie the specification of macroglial precursors in vivo appear strikingly similar to those that regul...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature09611
更新日期:2010-11-11 00:00:00
abstract::Metallothioneins are small cysteine-rich proteins that bind heavy metals such as zinc, cadmium, copper and mercury. Recent interest in these proteins has focused on the part they play in zinc metabolism and heavy metal detoxification. Our interest in metallothionein genes stems largely from the observations that these...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/292267a0
更新日期:1981-07-16 00:00:00
abstract::The cranial morphology of the earliest known hominins in the genus Australopithecus remains unclear. The oldest species in this genus (Australopithecus anamensis, specimens of which have been dated to 4.2-3.9 million years ago) is known primarily from jaws and teeth, whereas younger species (dated to 3.5-2.0 million y...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1513-8
更新日期:2019-09-01 00:00:00
abstract::Lung diseases such as chronic obstructive pulmonary disease and pulmonary fibrosis involve the progressive and inexorable destruction of oxygen exchange surfaces and airways, and have emerged as a leading cause of death worldwide. Mitigating therapies, aside from impractical organ transplantation, remain limited and t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13903
更新日期:2015-01-29 00:00:00
abstract::Although directed migration is a feature of both individual cells and cell groups, guided migration has been studied most extensively for single cells in simple environments. Collective guidance of cell groups remains poorly understood, despite its relevance for development and metastasis. Neural crest cells and neuro...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05965
更新日期:2007-07-19 00:00:00
abstract::Considerable attention has centered recently on the changes in neuron excitability and synaptic efficacy caused by certain biogenic amines and neuropeptides. These neuromodulators act at a wide variety of both central and peripheral targets, and bring about diverse biological results. In sensory pathways, modulation o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/326793a0
更新日期:1987-04-23 00:00:00
abstract::Most sensory information destined for the neocortex is relayed through the thalamus, where considerable transformation occurs1,2. One means of transformation involves interactions between excitatory thalamocortical neurons that carry data to the cortex and inhibitory neurons of the thalamic reticular nucleus (TRN) tha...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2512-5
更新日期:2020-07-01 00:00:00
abstract::Comparative mapping, which compares the location of homologous genes in different species, is a powerful tool for studying genome evolution. Comparative maps suggest that rates of chromosomal change in mammals can vary from one to ten rearrangements per million years. On the basis of these rates we would expect 84 to ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/46555
更新日期:1999-11-25 00:00:00
abstract::Human lymphocytes have been shown to lyse in vitro a large variety of target cells derived from tumour as well as normal tissues. The effector cells involved in this spontaneous cell-mediated cytotoxicity (SCMC) have generally been characterised as lymphocytes which lack surface membrane immunoglobulin (sIg) and lack ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/283574a0
更新日期:1980-02-07 00:00:00
abstract::Cryo-electron microscopy (cryo-EM) has the capacity to capture molecular machines in action1-3. ATP-binding cassette (ABC) exporters are highly dynamic membrane proteins that extrude a wide range of substances from the cytosol4-6 and thereby contribute to essential cellular processes, adaptive immunity and multidrug r...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1391-0
更新日期:2019-07-01 00:00:00
abstract::Several organisms have evolved the ability to measure daylength, or photoperiod, allowing them to adjust their development in anticipation of annual seasonal changes. Daylength measurement requires the integration of temporal information, provided by the circadian system, with light/dark discrimination, initiated by s...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature00996
更新日期:2002-09-19 00:00:00
abstract::A report adopted by the Council of Europe lists eight recommendations on the legal, ethical, and social issues raised by recombinant DNA research. The legislators stressed that the right to a "genetic inheritance free from any form of engineering" should be included in the European Human Rights Convention, and that s...
journal_title:Nature
pub_type: 新闻
doi:10.1038/295545a0
更新日期:1982-02-18 00:00:00
abstract::That animals and humans can accomplish the same goal using different effectors and different goals using the same effectors attests to the remarkable flexibility of the central nervous system. This phenomenon has been termed 'motor equivalence', an example being the writing of a name with a pencil held between the toe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/33922
更新日期:1998-04-23 00:00:00
abstract::Mammalian neurons contain at least three types of excitatory amino-acid receptors, selectively activated by N-methyl-D-aspartate (NMDA) or aspartate, (S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionate ((S)-AMPA) and kainate. An important aspect of NMDA receptors is their regulation by a variety of factors such...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/345347a0
更新日期:1990-05-24 00:00:00
abstract::Circulating tumour cells in women with advanced oestrogen-receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancer acquire a HER2-positive subpopulation after multiple courses of therapy. In contrast to HER2-amplified primary breast cancer, which is highly sensitive to HER2-targete...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature19328
更新日期:2016-09-01 00:00:00
abstract::The human B cell-specific alloantigen which is closely linked genetically to HLA contains two non-covalently associated, sialogycoprotein subunits of molecular weight (MW) 29,000 (p29), and 34,000 (p34). Although p29 and p34 have different amino-terminal sequences, their tyrosine peptide maps indicate considerable sim...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/268213a0
更新日期:1977-07-21 00:00:00
abstract::To trigger class II-restricted T cells, antigen presenting cells have to capture antigens, process them and display their fragments in association with class II molecules. In most species, activated T cells express class II molecules; however, no evidence has been found that these cells can present soluble antigens. T...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/334530a0
更新日期:1988-08-11 00:00:00
abstract::Cancer control by adaptive immunity involves a number of defined death and clearance mechanisms. However, efficient inhibition of exponential cancer growth by T cells and interferon-γ (IFN-γ) requires additional undefined mechanisms that arrest cancer cell proliferation. Here we show that the combined action of the T-...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11824
更新日期:2013-02-21 00:00:00
abstract::Satellite observations have transformed our understanding of the Antarctic cryosphere. The continent holds the vast majority of Earth's fresh water, and blankets swathes of the Southern Hemisphere in ice. Reductions in the thickness and extent of floating ice shelves have disturbed inland ice, triggering retreat, acce...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/s41586-018-0171-6
更新日期:2018-06-01 00:00:00
abstract::The sequencing of ancient DNA has enabled the reconstruction of speciation, migration and admixture events for extinct taxa1. However, the irreversible post-mortem degradation2 of ancient DNA has so far limited its recovery-outside permafrost areas-to specimens that are not older than approximately 0.5 million years (...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/s41586-019-1555-y
更新日期:2019-10-01 00:00:00
abstract::During an immune response, hypermutation of immunoglobulin genes in B cells proliferating within germinal centres (GCs) generates variant antibodies that react with higher affinity against either foreign or self antigens. Several experiments suggest that self-reactive B cells may be censored at this stage of the immun...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/375334a0
更新日期:1995-05-25 00:00:00
abstract::Co-evolution between plants and their natural enemies is generally believed to have generated much of the Earth's biological diversity. A process analogous to co-evolution occurs in agricultural systems, in which natural enemies adapt to crop resistance introduced by breeding or genetic engineering. Because of this si...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35081193
更新日期:2001-06-14 00:00:00