Abstract:
:Insulin binding to its receptor leads to negatively cooperative interactions among the receptor sites. Studies with 29 insulin analogues (animal insulins and proinsulin, insulin-like growth factor and chemically modified insulins) which vary 1,000-fold in their affinity for the receptor and in their biological potency, suggest that a discrete invariable region on the surface of the insulin monomer is responsible for including the negative cooperativity. This domain comprises some of the eight carboxy-terminal residues of the B-chain and the A21 asparagine. Burying of this 'cooperative site' in the dimerisation of insulin leads to a loss of negative cooperativity. A revised mapping of the insulin molecule is proposed, featuring distinct bioactive and cooperative sites.
journal_name
Naturejournal_title
Natureauthors
De Meyts P,Van Obberghen E,Roth Jdoi
10.1038/273504a0subject
Has Abstractpub_date
1978-06-15 00:00:00pages
504-9issue
5663eissn
0028-0836issn
1476-4687journal_volume
273pub_type
杂志文章相关文献
NATURE文献大全abstract::The purification, renewal and differentiation of native cardiac progenitors would form a mechanistic underpinning for unravelling steps for cardiac cell lineage formation, and their links to forms of congenital and adult cardiac diseases. Until now there has been little evidence for native cardiac precursor cells in t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03215
更新日期:2005-02-10 00:00:00
abstract::The AP-1 family of transcription factors, which includes the proto-oncogene products c-Jun and c-Fos, controls the stimulation of cellular genes by growth factors and the expression of oncogenes, including src and ras. Transcriptional activation by c-Jun is regulated by a cell-type-specific inhibitor that represses th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/352165a0
更新日期:1991-07-11 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-020-2958-5
更新日期:2020-12-01 00:00:00
abstract::In addition to acting as template for protein synthesis, messenger RNA (mRNA) often contains sensory sequence elements that regulate this process. Here we report a new mechanism that limits the number of complete protein molecules that can be synthesized from a single mRNA molecule of the human AMD1 gene encoding aden...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature25174
更新日期:2018-01-18 00:00:00
abstract::Eukaryotic cells seem to use GTP hydrolysis to regulate vesicular traffic in exocytosis and endocytosis. The best evidence for this comes from studies on the yeast Saccharomyces cerevisiae that have identified two small Ras-related GTP-binding proteins, Sec4p and Ypt1p, which control distinct stages of the secretory p...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/345553a0
更新日期:1990-06-07 00:00:00
abstract::Aggregation of amyloid-β peptides into fibrils or other self-assembled states is central to the pathogenesis of Alzheimer's disease. Fibrils formed in vitro by 40- and 42-residue amyloid-β peptides (Aβ40 and Aβ42) are polymorphic, with variations in molecular structure that depend on fibril growth conditions. Recent e...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature20814
更新日期:2017-01-12 00:00:00
abstract::Electrochemical reduction of carbon dioxide (CO2) to carbon monoxide (CO) is the first step in the synthesis of more complex carbon-based fuels and feedstocks using renewable electricity. Unfortunately, the reaction suffers from slow kinetics owing to the low local concentration of CO2 surrounding typical CO2 reductio...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature19060
更新日期:2016-09-15 00:00:00
abstract::The nucleotide sequence of the RNA polymerase binding site at a promotor on fd RF DNA has been determined in comparison with the starting sequence of RNA initiated at this promoter. The RNA polymerase binding site contained the startpoint of transcription in the centre and a region with twofold symmetry in the non-tra...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/253410a0
更新日期:1975-02-06 00:00:00
abstract::Microbes comprise the majority of extant organisms, yet much remains to be learned about the nature and driving forces of microbial diversification. Our understanding of how microorganisms adapt and evolve can be advanced by genome-wide documentation of the patterns of genetic exchange, particularly if analyses target...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05624
更新日期:2007-03-29 00:00:00
abstract::Seismological observations have revealed the existence of low-velocity and high-attenuation zones above the discontinuity at 410 km depth, at the base of the Earth's upper mantle. It has been suggested that a small amount of melt could be responsible for such anomalies. The density of silicate melt under dry condition...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04352
更新日期:2006-01-12 00:00:00
abstract::Any polarizable body placed in an inhomogeneous electric field experiences a dielectric force. This phenomenon is well known from the macroscopic world: a water jet is deflected when approached by a charged object. This fundamental mechanism is exploited in a variety of contexts-for example, trapping microscopic parti...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07932
更新日期:2009-04-23 00:00:00
abstract::Combinatorial binding of transcription factors to regulatory DNA underpins gene regulation in all organisms. Genetic variation in regulatory regions has been connected with diseases and diverse phenotypic traits1, but it remains challenging to distinguish variants that affect regulatory function2. Genomic DNase I foot...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2528-x
更新日期:2020-07-01 00:00:00
abstract::Regular mesoporous oxide materials have been widely studied and have a range of potential applications, such as catalysis, absorption and separation. They are not generally considered for their optical and electronic properties. Elemental semiconductors with nanopores running through them represent a different form of...
journal_title:Nature
pub_type: 信件
doi:10.1038/nature04833
更新日期:2006-06-29 00:00:00
abstract::Braunwald, a professor at Harvard Medical School, responds to a paper by Walter W. Stewart and Ned Feder ("The integrity of the scientific literature," Nature 1987 Jan 15; 325(6101): 207-214) concerning their findings of errors, discrepancies, and other lapses in publications coauthored by John Darsee, a biomedical re...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/325215a0
更新日期:1987-01-15 00:00:00
abstract::The planet in the system HD209458 is the first one for which repeated transits across the stellar disk have been observed. Together with radial velocity measurements, this has led to a determination of the planet's radius and mass, confirming it to be a gas giant. But despite numerous searches for an atmospheric signa...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01448
更新日期:2003-03-13 00:00:00
abstract::In the ocean, the chemical forms of nitrogen that are readily available for biological use (known collectively as 'fixed' nitrogen) fuel the global phytoplankton productivity that exports carbon to the deep ocean. Accordingly, variation in the oceanic fixed nitrogen reservoir has been proposed as a cause of glacial-in...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature12397
更新日期:2013-09-12 00:00:00
abstract::Phelan-McDermid syndrome (PMDS) is a complex neurodevelopmental disorder characterized by global developmental delay, severely impaired speech, intellectual disability, and an increased risk of autism spectrum disorders (ASDs). PMDS is caused by heterozygous deletions of chromosome 22q13.3. Among the genes in the dele...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12618
更新日期:2013-11-14 00:00:00
abstract::Do biological motors move with regular steps? To address this question, we constructed instrumentation with the spatial and temporal sensitivity to resolve movement on a molecular scale. We deposited silica beads carrying single molecules of the motor protein kinesin on microtubules using optical tweezers and analysed...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/365721a0
更新日期:1993-10-21 00:00:00
abstract::How long does it take a random walker to reach a given target point? This quantity, known as a first-passage time (FPT), has led to a growing number of theoretical investigations over the past decade. The importance of FPTs originates from the crucial role played by first encounter properties in various real situation...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06201
更新日期:2007-11-01 00:00:00
abstract::The interplay of evolution and development has been at the heart of evolutionary theory for more than a century. Heterochrony—change in the timing or rate of developmental events—has been implicated in the evolution of major vertebrate lineages such as mammals, including humans. Birds are the most speciose land verteb...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11146
更新日期:2012-07-12 00:00:00
abstract::In this Letter, the statement 'I.I. and A.B. performed computations at the NCI Australia' was missing from the Acknowledgements section. This has been corrected online. ...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-019-1123-5
更新日期:2019-05-01 00:00:00
abstract::Substrates of the proteasome are recognized and unfolded by the regulatory particle, and then translocated into the core particle (CP) to be degraded. A hetero-hexameric ATPase ring, containing subunits Rpt1-6, is situated within the base subassembly of the regulatory particle. The ATPase ring sits atop the CP, with t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08065
更新日期:2009-06-11 00:00:00
abstract::Learning through trial-and-error interactions allows animals to adapt innate behavioural ‘rules of thumb’ to the local environment, improving their prospects for survival and reproduction. Naive Drosophila melanogaster males, for example, court both virgin and mated females, but learn through experience to selectively...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11345
更新日期:2012-09-06 00:00:00
abstract::Elucidation of the molecular contacts between actin and myosin is central to understanding the force-generating process in muscle and other cells. Actin, a highly conserved globular protein found in all eukaryotes, polymerizes into filaments (F-actin) for most of its biological functions. Myosins, which are more diver...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/364171a0
更新日期:1993-07-08 00:00:00
abstract::Endocytosis has long been thought of as simply a way for cells to internalize nutrients and membrane-associated molecules. But an explosive growth in knowledge has given a new dimension to our understanding of this process. It now seems that endocytosis is a master organizer of signalling circuits, with one of its mai...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature08910
更新日期:2010-01-28 00:00:00
abstract::Tumour necrosis factor is a trimeric molecule, each subunit of which consists of an antiparallel beta-sandwich. Individual subunits from the trimer by a novel edge-to-face packing of beta-sheets. A comparison of the subunit fold with that of other proteins reveals a remarkable similarity to the 'jelly-roll' structural...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/338225a0
更新日期:1989-03-16 00:00:00
abstract::Ants travelling to and fro between their nest and a foraging area may follow stereotyped foodward and homeward routes that are guided by different visual and directional memory sequences. Honeybees are known to fly a feeder-to-hive or hive-to-feeder vector according to whether or not they have recently fed--their feed...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/438302a
更新日期:2005-11-17 00:00:00
abstract::Surgical sectioning of the corpus callosum in epileptic patients has provided a unique opportunity to study separately the competence and processing capacities of the two cerebral hemispheres, each of which is able to perceive, think, memorize and learn independently and essentially outside the realm of awareness of t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/305800a0
更新日期:1983-10-27 00:00:00
abstract::In yeast and somatic cells, mechanisms ensure cell-cycle events are initiated only when preceding events have been completed. In contrast, interruption of specific cell-cycle processes in early embryonic cells of many organisms does not affect the timing of subsequent events, indicating that cell-cycle events are trig...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/43927
更新日期:1999-09-23 00:00:00
abstract::Molecular self-assembly offers a 'bottom-up' route to fabrication with subnanometre precision of complex structures from simple components. DNA has proved to be a versatile building block for programmable construction of such objects, including two-dimensional crystals, nanotubes, and three-dimensional wireframe nanop...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08016
更新日期:2009-05-21 00:00:00