Hexameric assembly of the proteasomal ATPases is templated through their C termini.

abstract：:The plasma membrane-bound mammalian ras proteins of relative molecular mass 21,000 (ras p21) share biochemical and structural properties with other guanine nucleotide-binding regulatory proteins (G-proteins). Oncogenic ras p21 variants result from amino acid substitutions at specific positions that cause p21 to occur ...

journal_title：Nature

authors： Vogel US,Dixon RA,Schaber MD,Diehl RE,Marshall MS,Scolnick EM,Sigal IS,Gibbs JB

更新日期：1988-09-01 00:00:00

abstract：:In vertebrates, unfertilized eggs (or mature oocytes) are arrested at metaphase of meiosis II by a cytoplasmic activity called cytostatic factor (CSF). The classical Mos-MAPK pathway has long been implicated in CSF arrest of vertebrate eggs, but exactly how it exerts CSF activity remains unclear. Recently, Erp1 (also ...

journal_title：Nature

authors： Inoue D,Ohe M,Kanemori Y,Nobui T,Sagata N

更新日期：2007-04-26 00:00:00

abstract：:Males and females share many traits that have a common genetic basis; however, selection on these traits often differs between the sexes, leading to sexual conflict. Under such sexual antagonism, theory predicts the evolution of genetic architectures that resolve this sexual conflict. Yet, despite intense theoretical ...

journal_title：Nature

authors： Barson NJ,Aykanat T,Hindar K,Baranski M,Bolstad GH,Fiske P,Jacq C,Jensen AJ,Johnston SE,Karlsson S,Kent M,Moen T,Niemelä E,Nome T,Næsje TF,Orell P,Romakkaniemi A,Sægrov H,Urdal K,Erkinaro J,Lien S,Primmer CR

更新日期：2015-12-17 00:00:00

abstract：:The Gram-negative bacterium Yersinia pestis is the causative agent of the systemic invasive infectious disease classically referred to as plague, and has been responsible for three human pandemics: the Justinian plague (sixth to eighth centuries), the Black Death (fourteenth to nineteenth centuries) and modern plague ...

journal_title：Nature

authors： Parkhill J,Wren BW,Thomson NR,Titball RW,Holden MT,Prentice MB,Sebaihia M,James KD,Churcher C,Mungall KL,Baker S,Basham D,Bentley SD,Brooks K,Cerdeño-Tárraga AM,Chillingworth T,Cronin A,Davies RM,Davis P,Dougan G,

更新日期：2001-10-04 00:00:00

abstract：:Gross chromosome rearrangements (GCRs), such as translocations, deletion of a chromosome arm, interstitial deletions and inversions, are often observed in cancer cells. Spontaneous GCRs are rare in Saccharomyces cerevisiae; however, the existence of mutator mutants with increased genome instability suggests that GCRs ...

journal_title：Nature

authors： Myung K,Chen C,Kolodner RD

更新日期：2001-06-28 00:00:00

abstract：:A long-standing hypothesis posits that natural selection can favour two female strategies when density cycles. At low density, females producing many smaller progeny are favoured when the intrinsic rate of increase, r, governs population growth. At peak density, females producing fewer, high-quality, progeny are favou...

journal_title：Nature

authors： Sinervo B,Svensson E,Comendant T

更新日期：2000-08-31 00:00:00

abstract：:Activation of many T-cell functions depends on their interaction with antigen-presenting accessory cells which express I region associated (Ia) products. Cells expressing accessory cell function include those of the monocyte/macrophage lineage and dendritic cells. More recently, B cells and a number of tumour cell lin...

journal_title：Nature

authors： Ramila G,Erb P

更新日期：1983-08-04 00:00:00

abstract：:Hydrothermal vents are ephemeral because of frequent volcanic and tectonic activities associated with crust formation. Although the larvae of hydrothermal vent fauna can rapidly colonize new vent sites separated by tens to hundreds of kilometres, the mechanisms by which these larvae disperse and recruit are not unders...

journal_title：Nature

authors： Marsh AG,Mullineaux LS,Young CM,Manahan DT

更新日期：2001-05-03 00:00:00

abstract：:Inositol-1,4,5-trisphosphate receptors (InsP(3)Rs) and ryanodine receptors (RyRs) are tetrameric intracellular Ca(2+) channels. In each of these receptor families, the pore, which is formed by carboxy-terminal transmembrane domains, is regulated by signals that are detected by large cytosolic structures. InsP(3)R gati...

journal_title：Nature

authors： Seo MD,Velamakanni S,Ishiyama N,Stathopulos PB,Rossi AM,Khan SA,Dale P,Li C,Ames JB,Ikura M,Taylor CW

更新日期：2012-01-29 00:00:00

abstract：:Many corals bleach as a result of increased seawater temperature, which causes them to lose their vital symbiotic algae (Symbiodinium spp.) - unless these symbioses are able to adapt to global warming, bleaching threatens coral reefs worldwide. Here I show that some corals have adapted to higher temperatures, at least...

journal_title：Nature

authors： Rowan R

更新日期：2004-08-12 00:00:00

abstract：:Actin is one of the most ubiquitous, abundant and well-conserved proteins of eukaryotes, participating in many crucial cellular processes including the maintenance of cell shape, motility and cell division. Actins from the most divergent sources still share amino-acid identities in excess of 70% (ref. 3). This may wel...

journal_title：Nature

authors： Clark SW,Meyer DI

更新日期：1992-09-17 00:00:00

abstract：:Transgenic mice bearing the cellular myc oncogene coupled to the immunoglobulin mu or kappa enhancer frequently develop a fatal lymphoma within a few months of birth. Since the tumours represent represent both immature and mature B lymphocytes, constitutive c-myc expression appears to be highly leukaemogenic at severa...

journal_title：Nature

authors： Adams JM,Harris AW,Pinkert CA,Corcoran LM,Alexander WS,Cory S,Palmiter RD,Brinster RL

更新日期：1985-12-12 00:00:00

abstract：:Of the vertebrate senses, touch is the least understood at the molecular level The ion channels that form the core of the mechanosensory complex and confer touch sensitivity remain unknown. However, the similarity of the brain sodium channel 1 (BNC1) to nematode proteins involved in mechanotransduction indicated that ...

journal_title：Nature

authors： Price MP,Lewin GR,McIlwrath SL,Cheng C,Xie J,Heppenstall PA,Stucky CL,Mannsfeldt AG,Brennan TJ,Drummond HA,Qiao J,Benson CJ,Tarr DE,Hrstka RF,Yang B,Williamson RA,Welsh MJ

更新日期：2000-10-26 00:00:00

abstract：:The growth of plants depends on continuous function of the meristems. Shoot meristems are responsible for all the post-embryonic aerial organs, such as leaves, stems and flowers. It has been assumed that the phytohormone cytokinin has a positive role in shoot meristem function. A severe reduction in the size of merist...

journal_title：Nature

authors： Kurakawa T,Ueda N,Maekawa M,Kobayashi K,Kojima M,Nagato Y,Sakakibara H,Kyozuka J

更新日期：2007-02-08 00:00:00

abstract：:Observations from cultured cells, animal models and patients raise the possibility that the dependency of tumours on the therapeutic drugs to which they have acquired resistance represents a vulnerability with potential applications in cancer treatment. However, for this drug addiction trait to become of clinical inte...

journal_title：Nature

authors： Kong X,Kuilman T,Shahrabi A,Boshuizen J,Kemper K,Song JY,Niessen HWM,Rozeman EA,Geukes Foppen MH,Blank CU,Peeper DS

更新日期：2017-10-12 00:00:00

abstract：:The advent of endothermy, which is achieved through the continuous homeostatic regulation of body temperature and metabolism1,2, is a defining feature of mammalian and avian evolution. However, when challenged by food deprivation or harsh environmental conditions, many mammalian species initiate adaptive energy-conser...

journal_title：Nature

authors： Hrvatin S,Sun S,Wilcox OF,Yao H,Lavin-Peter AJ,Cicconet M,Assad EG,Palmer ME,Aronson S,Banks AS,Griffith EC,Greenberg ME

更新日期：2020-07-01 00:00:00

abstract：:In the chick embryo, left-right asymmetric patterns of gene expression in the lateral plate mesoderm are initiated by signals located in and around Hensen's node. Here we show that Caronte (Car), a secreted protein encoded by a member of the Cerberus/Dan gene family, mediates the Sonic hedgehog (Shh)-dependent inducti...

journal_title：Nature

authors： Rodríguez Esteban C,Capdevila J,Economides AN,Pascual J,Ortiz A,Izpisúa Belmonte JC

更新日期：1999-09-16 00:00:00

abstract：:The atmospheric partial pressure of carbon dioxide (p(CO(2))) will almost certainly be double that of pre-industrial levels by 2100 and will be considerably higher than at any time during the past few million years. The oceans are a principal sink for anthropogenic CO(2) where it is estimated to have caused a 30% incr...

journal_title：Nature

authors： Hall-Spencer JM,Rodolfo-Metalpa R,Martin S,Ransome E,Fine M,Turner SM,Rowley SJ,Tedesco D,Buia MC

更新日期：2008-07-03 00:00:00

abstract：:Polymeric matrices can be used to grow new tissues and organs, and the delivery of growth factors from these matrices is one method to regenerate tissues. A problem with engineering tissues that exist in a mechanically dynamic environment, such as bone, muscle and blood vessels, is that most drug delivery systems have...

journal_title：Nature

authors： Lee KY,Peters MC,Anderson KW,Mooney DJ

更新日期：2000-12-21 00:00:00

abstract：:Acetylation within the globular core domain of histone H3 on lysine 56 (H3K56) has recently been shown to have a critical role in packaging DNA into chromatin following DNA replication and repair in budding yeast. However, the function or occurrence of this specific histone mark has not been studied in multicellular e...

journal_title：Nature

authors： Das C,Lucia MS,Hansen KC,Tyler JK

更新日期：2009-05-07 00:00:00

abstract：:The hypothesis that certain RNA molecules may be able to catalyse RNA replication is central to current theories of the early evolution of life. In support of this idea, we describe here an RNA that synthesizes RNA using the same reaction as that employed by protein enzymes that catalyse RNA polymerization. In the pre...

journal_title：Nature

authors： Ekland EH,Bartel DP

更新日期：1996-07-25 00:00:00

abstract：:The inner ear is capable of highly selective frequency discrimination. This is achieved not only by the travelling wave of the basilar membrane in the cochlear partition, but also by the active participation of nonlinear and vulnerable elements that enhance frequency selectivity. It has been shown that isolated mammal...

journal_title：Nature

authors： Brundin L,Flock A,Canlon B

更新日期：1989-12-14 00:00:00

abstract：:Epithelial organs undergo steady-state turnover throughout adult life, with old cells being continually replaced by the progeny of stem cell divisions. To avoid hyperplasia or atrophy, organ turnover demands strict equilibration of cell production and loss. However, the mechanistic basis of this equilibrium is unknown...

journal_title：Nature

authors： Liang J,Balachandra S,Ngo S,O'Brien LE

更新日期：2017-08-31 00:00:00

abstract：:Cell-cell interactions are thought to play a crucial part in determining the developmental fate of vertebrate cells and regulating their subsequent differentiation. In the peripheral nervous system, for example, signals from neuronal axons determine whether or not some Schwann cells wrap their plasma membrane concentr...

journal_title：Nature

authors： Mudge AW

更新日期：1984-05-24 00:00:00

abstract：:A central aspect of neuronal function is how each nerve cell translated synaptic input into a sequence of action potentials that carry information along the axon, coded as spike frequency. When transduction from a graded depolarizing input to spikes is studied by injecting a depolarizing current, there is often a rema...

journal_title：Nature

authors： Storm JF

更新日期：1988-11-24 00:00:00

abstract：:The majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, HIV, Ebola and SARS). Understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals f...

journal_title：Nature

authors： Olival KJ,Hosseini PR,Zambrana-Torrelio C,Ross N,Bogich TL,Daszak P

更新日期：2017-06-29 00:00:00

abstract：:A popular metaphor for the representation of numbers in the brain is the 'mental number line', in which numbers are represented in a continuous, quantity-based analogical format. Here we show that patients with hemispatial neglect misplace the midpoint of a numerical interval when asked to bisect it (for example, stat...

journal_title：Nature

authors： Zorzi M,Priftis K,Umiltà C

更新日期：2002-05-09 00:00:00

abstract：:The proto-oncogene c-jun is the cellular homologue of v-jun, the transforming oncogene of the avian sarcoma virus 17 (ref. 1). c-jun encodes one major component of the AP-1 transcription factor complex and is expressed in many organs during mouse development and in the adult. Because of its rapid induction in cells fo...

journal_title：Nature

authors： Hilberg F,Aguzzi A,Howells N,Wagner EF

更新日期：1993-09-09 00:00:00

abstract：:Large-scale systematic sequencing has generally depended on the availability of an ordered library of large-insert bacterial or viral genomic clones for the organism under study. The generation of these large insert libraries, and the location of each clone on a genome map, is a laborious and time-consuming process. I...

journal_title：Nature

authors： Churcher C,Bowman S,Badcock K,Bankier A,Brown D,Chillingworth T,Connor R,Devlin K,Gentles S,Hamlin N,Harris D,Horsnell T,Hunt S,Jagels K,Jones M,Lye G,Moule S,Odell C,Pearson D,Rajandream M,Rice P,Rowley N,Ske

更新日期：1997-05-29 00:00:00

abstract：:A fundamental tenet of classical mendelian genetics is that allelic information is stably inherited from one generation to the next, resulting in predictable segregation patterns of differing alleles. Although several exceptions to this principle are known, all represent specialized cases that are mechanistically rest...

journal_title：Nature

authors： Lolle SJ,Victor JL,Young JM,Pruitt RE

更新日期：2005-03-24 00:00:00