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NATURE文献大全abstract::Epithelial organs undergo steady-state turnover throughout adult life, with old cells being continually replaced by the progeny of stem cell divisions. To avoid hyperplasia or atrophy, organ turnover demands strict equilibration of cell production and loss. However, the mechanistic basis of this equilibrium is unknown...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature23678
更新日期:2017-08-31 00:00:00
abstract::The vertical structure of the recent Arctic warming contains information about the processes governing Arctic climate trends. Graversen et al. argue, on the basis of ERA-40 reanalysis data, that a distinct maximum in 1979-2001 warm-season (April-October) Arctic temperature trends appears around 3 km above ground. Here...
journal_title:Nature
pub_type: 评论,杂志文章
doi:10.1038/nature07257
更新日期:2008-09-11 00:00:00
abstract::Large, actively swimming suspension feeders evolved several times in Earth's history, arising independently from groups as diverse as sharks, rays and stem teleost fishes, and in mysticete whales. However, animals occupying this niche have not been identified from the early Palaeozoic era. Anomalocarids, a group of st...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13010
更新日期:2014-03-27 00:00:00
abstract::A magnetic field penetrates a superconductor through an array of 'vortices', each of which carries one quantum of flux that is surrounded by a circulating supercurrent. In this vortex state, the resistivity is determined by the dynamical properties of the vortex 'matter'. For the high-temperature copper oxide supercon...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35078016
更新日期:2001-05-24 00:00:00
abstract::Regulatory T (T(reg)) cells are a critical sub-population of CD4+ T cells that are essential for maintaining self tolerance and preventing autoimmunity, for limiting chronic inflammatory diseases, such as asthma and inflammatory bowel disease, and for regulating homeostatic lymphocyte expansion. However, they also sup...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06306
更新日期:2007-11-22 00:00:00
abstract::Haptic (touch) perception normally entails an active exploration of object surfaces over time. This is called active touch. When exploring the shape of an object, we experience both geometrical and force cues. For example, when sliding a finger across a surface with a rigid bump on it, the finger moves over the bump w...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35086588
更新日期:2001-07-26 00:00:00
abstract::Schistosoma japonicum is a parasitic flatworm that causes human schistosomiasis, which is a significant cause of morbidity in China and the Philippines. Here we present a draft genomic sequence for the worm. The genome provides a global insight into the molecular architecture and host interaction of this complex metaz...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08140
更新日期:2009-07-16 00:00:00
abstract::Inactivation of APC is a strongly predisposing event in the development of colorectal cancer, prompting the search for vulnerabilities specific to cells that have lost APC function. Signalling through the mTOR pathway is known to be required for epithelial cell proliferation and tumour growth, and the current paradigm...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13896
更新日期:2015-01-22 00:00:00
abstract::Accurate chromosome segregation requires timely dissolution of chromosome cohesion after chromosomes are properly attached to the mitotic spindle. Separase is absolutely essential for cohesion dissolution in organisms from yeast to man. It cleaves the kleisin subunit of cohesin and opens the cohesin ring to allow chro...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature17402
更新日期:2016-04-07 00:00:00
abstract::The enzyme Cu, Zn superoxide dismutase (SOD) protects against oxidative damage by dismuting the superoxide radical O2-. to molecular oxygen and hydrogen peroxide at the active-site Cu ion in a reaction that is rate-limited by diffusion and enhanced by electrostatic guidance. SOD has evolved to be one of the fastest en...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/358347a0
更新日期:1992-07-23 00:00:00
abstract::A rapid decrease in shear velocity in the suboceanic mantle is used to infer the thickness of the lithosphere. It is proposed that new and highly precise group velocity data constrain the solutions and imply a thickness near 70 km. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/226330a0
更新日期:1970-04-25 00:00:00
abstract::In Parkinson's disease, brain dopamine neurons degenerate most prominently in the substantia nigra. Neurotrophic factors promote survival, differentiation and maintenance of neurons in developing and adult vertebrate nervous system. The most potent neurotrophic factor for dopamine neurons described so far is the glial...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05957
更新日期:2007-07-05 00:00:00
abstract::The commitment of non-dividing cells (in G0) to enter division can be studied using primary cultures of lymphocytes. The cells are stable in G0 unless stimulated by mitogen such as concanavalin A (Con A). Commitment to enter the division cycle depends on the expression of gene(s) induced by Con A and the synthesis of ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/310143a0
更新日期:1984-07-12 00:00:00
abstract::Insulin is the primary hormone involved in glucose homeostasis, and impairment of insulin action and/or secretion has a critical role in the pathogenesis of diabetes mellitus. Type-II SH2-domain-containing inositol 5-phosphatase, or 'SHIP2', is a member of the inositol polyphosphate 5-phosphatase family. In vitro stud...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35051094
更新日期:2001-01-04 00:00:00
abstract::Explaining the large-scale diversity of soil organisms that drive biogeochemical processes-and their responses to environmental change-is critical. However, identifying consistent drivers of belowground diversity and abundance for some soil organisms at large spatial scales remains problematic. Here we investigate a m...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0189-9
更新日期:2018-06-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-020-2958-5
更新日期:2020-12-01 00:00:00
abstract::Coordinated cell migration is essential in many fundamental biological processes including embryonic development, organogenesis, wound healing and the immune response. During organogenesis, groups of cells are directed to specific locations within the embryo. Here we show that the zebrafish miles apart (mil) mutation ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35018092
更新日期:2000-07-13 00:00:00
abstract::There are major impediments to finding improved DEET alternatives because the receptors causing olfactory repellency are unknown, and new chemicals require exorbitant costs to determine safety for human use. Here we identify DEET-sensitive neurons in a pit-like structure in the Drosophila melanogaster antenna called t...
journal_title:Nature
pub_type: 杂志文章,收录出版
doi:10.1038/nature12594
更新日期:2013-10-24 00:00:00
abstract::Leks have traditionally been considered as arenas where males compete to attract females and secure matings. Thus, direct fitness benefits mediated through competition between males to fertilize females have been considered to be the primary force driving the evolution of lekking behaviour. Inclusive fitness benefits ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35042562
更新日期:2000-11-16 00:00:00
abstract::Analytical tools that have spatial resolution at the nanometre scale are indispensable for the life and physical sciences. It is desirable that these tools also permit elemental and chemical identification on a scale of 10 nm or less, with large penetration depths. A variety of techniques in X-ray imaging are currentl...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03719
更新日期:2005-06-30 00:00:00
abstract::Alphabeta T lymphocytes are able to detect even a single peptide-major histocompatibility complex (MHC) on the surface of an antigen-presenting cell. This is despite clear evidence, at least with CD4+ T cells, that monomeric ligands are not stimulatory. In an effort to understand how this remarkable sensitivity is ach...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03391
更新日期:2005-03-10 00:00:00
abstract::Recurring outbursts associated with matter flowing onto compact stellar remnants (such as black holes, neutron stars and white dwarfs) in close binary systems provide a way of constraining the poorly understood accretion process. The light curves of these outbursts are shaped by the efficiency of angular-momentum (and...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature25159
更新日期:2018-02-01 00:00:00
abstract::The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mev...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/343425a0
更新日期:1990-02-01 00:00:00
abstract::Cells deficient in the Brca1 and Brca2 genes have reduced capacity to repair DNA double-strand breaks by homologous recombination and consequently are hypersensitive to DNA-damaging agents, including cisplatin and poly(ADP-ribose) polymerase (PARP) inhibitors. Here we show that loss of the MLL3/4 complex protein, PTIP...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature18325
更新日期:2016-07-21 00:00:00
abstract::Historical ecologists working in the Neotropics argue that the present natural environment is an historical product of human intentionality and ingenuity, a creation that is imposed, built, managed and maintained by the collective multigenerational knowledge and experience of Native Americans. In the past 12,000 years...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/35041555
更新日期:2000-11-09 00:00:00
abstract::Structural fluctuations in proteins on the picosecond timescale have been studied in considerable detail by theoretical methods such as molecular dynamics simulation, but there exist very few experimental data with which to test the conclusions. We have used the technique of inelastic neutron scattering to investigate...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/337754a0
更新日期:1989-02-23 00:00:00
abstract::The human B cell-specific alloantigen which is closely linked genetically to HLA contains two non-covalently associated, sialogycoprotein subunits of molecular weight (MW) 29,000 (p29), and 34,000 (p34). Although p29 and p34 have different amino-terminal sequences, their tyrosine peptide maps indicate considerable sim...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/268213a0
更新日期:1977-07-21 00:00:00
abstract::The developmental fate of immature thymocytes is determined by the specificity of their T-cell antigen receptors (TCRs). Immature CD4+8+ thymocytes are positively selected to differentiate into mature T cells by recognition of peptides associated with major histocompatibility complex (MHC) encoded molecules on thymic ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/371067a0
更新日期:1994-09-01 00:00:00
abstract::The initiation of immunoglobulin-E (IgE)-mediated allergic responses requires the binding of IgE antibody to its high-affinity receptor, Fc epsilonRI. Crosslinking of Fc epsilonRI initiates an intracellular signal transduction cascade that triggers the release of mediators of the allergic response. The interaction of ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35018500
更新日期:2000-07-20 00:00:00
abstract::Tracing the transient atomic motions that lie at the heart of chemical reactions requires high-resolution multidimensional structural information on the timescale of molecular vibrations, which commonly range from 10 fs to 1 ps. For simple chemical systems, it has been possible to map out in considerable detail the re...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08527
更新日期:2009-11-12 00:00:00