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Gewin V





2019-02-01 00:00:00
















  • Curare can open and block ionic channels associated with cholinergic receptors.

    abstract::Curare has long been regarded as a typical competitive antagonist of acetylcholine (ACh) at the vertebrate neuromuscular junction. Recently, however, it has been shown that curare can also block the channels opened by ACh at the frog neuromuscular junction as well as on rat and Aplysia neurones; moreover, curare is ab...


    pub_type: 杂志文章


    authors: Trautmann A

    更新日期:1982-07-15 00:00:00

  • Magnetic phase control by an electric field.

    abstract::The quest for higher data density in information storage is motivating investigations into approaches for manipulating magnetization by means other than magnetic fields. This is evidenced by the recent boom in magnetoelectronics and 'spintronics', where phenomena such as carrier effects in magnetic semiconductors and ...


    pub_type: 杂志文章


    authors: Lottermoser T,Lonkai T,Amann U,Hohlwein D,Ihringer J,Fiebig M

    更新日期:2004-07-29 00:00:00

  • Communications: quantum teleportation across the Danube.

    abstract::Efficient long-distance quantum teleportation is crucial for quantum communication and quantum networking schemes. Here we describe the high-fidelity teleportation of photons over a distance of 600 metres across the River Danube in Vienna, with the optimal efficiency that can be achieved using linear optics. Our resul...


    pub_type: 杂志文章


    authors: Ursin R,Jennewein T,Aspelmeyer M,Kaltenbaek R,Lindenthal M,Walther P,Zeilinger A

    更新日期:2004-08-19 00:00:00

  • Do 'lipidic particles' represent intermembrane attachment sites?

    abstract::Although freeze-fracture electron microscopy is normally analysed with the presumption that particles represent proteins embedded within the membrane, particles which appeared to represent inverted lipid micelles within membranes have been reported. I have now confirmed the occurrence of particles in protein-free lipo...


    pub_type: 杂志文章


    authors: Miller RG

    更新日期:1980-09-11 00:00:00

  • Hippocampal synaptic transmission enhanced by low concentrations of nicotine.

    abstract::Nicotine obtained from tobacco can improve learning and memory on various tasks and has been linked to arousal, attention, rapid information processing, working memory, and long-term memories that can cause craving years after someone has stopped smoking. One likely target for these effects is the hippocampus, a centr...


    pub_type: 杂志文章


    authors: Gray R,Rajan AS,Radcliffe KA,Yakehiro M,Dani JA

    更新日期:1996-10-24 00:00:00

  • Martian dust storm impact on atmospheric H2O and D/H observed by ExoMars Trace Gas Orbiter.

    abstract::Global dust storms on Mars are rare1,2 but can affect the Martian atmosphere for several months. They can cause changes in atmospheric dynamics and inflation of the atmosphere3, primarily owing to solar heating of the dust3. In turn, changes in atmospheric dynamics can affect the distribution of atmospheric water vapo...


    pub_type: 杂志文章


    authors: Vandaele AC,Korablev O,Daerden F,Aoki S,Thomas IR,Altieri F,López-Valverde M,Villanueva G,Liuzzi G,Smith MD,Erwin JT,Trompet L,Fedorova AA,Montmessin F,Trokhimovskiy A,Belyaev DA,Ignatiev NI,Luginin M,Olsen KS,Baggi

    更新日期:2019-04-01 00:00:00

  • Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a.

    abstract::The cyclin-dependent kinases 4 and 6 (Cdk4/6) that control the G1 phase of the cell cycle and their inhibitor, the p16INK4a tumour suppressor, have a central role in cell proliferation and in tumorigenesis. The structures of Cdk6 bound to p16INK4a and to the related p19INK4d reveal that the INK4 inhibitors bind next t...


    pub_type: 杂志文章


    authors: Russo AA,Tong L,Lee JO,Jeffrey PD,Pavletich NP

    更新日期:1998-09-17 00:00:00

  • Evolutionary instability of ectomycorrhizal symbioses in basidiomycetes.

    abstract::Mycorrhizae, the symbiotic associations of plant roots and fungal hyphae, are classic examples of mutualisms. In these ecologically important associations, the fungi derive photosynthetic sugars from their plant hosts, which in turn benefit from fungus-mediated uptake of mineral nutrients. Early views on the evolution...


    pub_type: 杂志文章


    authors: Hibbett DS,Gilbert LB,Donoghue MJ

    更新日期:2000-09-28 00:00:00

  • The tungsten isotopic composition of the Earth's mantle before the terminal bombardment.

    abstract::Many precious, 'iron-loving' metals, such as gold, are surprisingly abundant in the accessible parts of the Earth, given the efficiency with which core formation should have removed them to the planet's deep interior. One explanation of their over-abundance is a 'late veneer'--a flux of meteorites added to the Earth a...


    pub_type: 杂志文章


    authors: Willbold M,Elliott T,Moorbath S

    更新日期:2011-09-07 00:00:00

  • Association between GTPase activators for Rho and Ras families.

    abstract::The ras-related low-molecular-mass GTPases participate in signal transduction involving a variety of cellular functions, including cell-cycle progression, cellular differentiation, cytoskeletal organization, protein transport and secretion. The cycling of these proteins between GTP-bound and GDP-bound states is partia...


    pub_type: 杂志文章


    authors: Settleman J,Albright CF,Foster LC,Weinberg RA

    更新日期:1992-09-10 00:00:00

  • A hexagonal planar transition-metal complex.

    abstract::Transition-metal complexes are widely used in the physical and biological sciences. They have essential roles in catalysis, synthesis, materials science, photophysics and bioinorganic chemistry. Our understanding of transition-metal complexes originates from Alfred Werner's realization that their three-dimensional sha...


    pub_type: 杂志文章


    authors: Garçon M,Bakewell C,Sackman GA,White AJP,Cooper RI,Edwards AJ,Crimmin MR

    更新日期:2019-10-01 00:00:00

  • Widespread changes in protein synthesis induced by microRNAs.

    abstract::Animal microRNAs (miRNAs) regulate gene expression by inhibiting translation and/or by inducing degradation of target messenger RNAs. It is unknown how much translational control is exerted by miRNAs on a genome-wide scale. We used a new proteomic approach to measure changes in synthesis of several thousand proteins i...


    pub_type: 杂志文章


    authors: Selbach M,Schwanhäusser B,Thierfelder N,Fang Z,Khanin R,Rajewsky N

    更新日期:2008-09-04 00:00:00

  • The Mg-chelatase H subunit is an abscisic acid receptor.

    abstract::Abscisic acid (ABA) is a vital phytohormone that regulates mainly stomatal aperture and seed development, but ABA receptors involved in these processes have yet to be determined. We previously identified from broad bean an ABA-binding protein (ABAR) potentially involved in stomatal signalling, the gene for which encod...


    pub_type: 杂志文章


    authors: Shen YY,Wang XF,Wu FQ,Du SY,Cao Z,Shang Y,Wang XL,Peng CC,Yu XC,Zhu SY,Fan RC,Xu YH,Zhang DP

    更新日期:2006-10-19 00:00:00

  • Conserved residues and the mechanism of protein folding.

    abstract::Experimental and simulation studies show that small monomeric proteins fold in one kinetic step, which entails overcoming the free-energy barrier between the unfolded and the native protein through a transition state. Two models of transition state formation have been proposed: a 'nonspecific' one in which it depends ...


    pub_type: 杂志文章


    authors: Shakhnovich E,Abkevich V,Ptitsyn O

    更新日期:1996-01-04 00:00:00

  • Control of spatial orientation in a mollusc.

    abstract::The main function of postural nervous mechanisms in different species, from mollusc to man, is to counteract the force of gravity and stabilize body orientation in space. Here we investigate the basic principles of postural control in a simple animal model, the marine mollusc Clione limacina. When swimming, C. limacin...


    pub_type: 杂志文章


    authors: Deliagina TG,Arshavsky YI,Orlovsky GN

    更新日期:1998-05-14 00:00:00

  • HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C.

    abstract::The protein HLA-E is a non-classical major histocompatibility complex (MHC) molecule of limited sequence variability. Its expression on the cell surface is regulated by the binding of peptides derived from the signal sequence of some other MHC class I molecules. Here we report the identification of ligands for HLA-E. ...


    pub_type: 杂志文章


    authors: Braud VM,Allan DS,O'Callaghan CA,Söderström K,D'Andrea A,Ogg GS,Lazetic S,Young NT,Bell JI,Phillips JH,Lanier LL,McMichael AJ

    更新日期:1998-02-19 00:00:00

  • Low-temperature hydrogen production from water and methanol using Pt/α-MoC catalysts.

    abstract::Polymer electrolyte membrane fuel cells (PEMFCs) running on hydrogen are attractive alternative power supplies for a range of applications, with in situ release of the required hydrogen from a stable liquid offering one way of ensuring its safe storage and transportation before use. The use of methanol is particularly...


    pub_type: 杂志文章


    authors: Lin L,Zhou W,Gao R,Yao S,Zhang X,Xu W,Zheng S,Jiang Z,Yu Q,Li YW,Shi C,Wen XD,Ma D

    更新日期:2017-04-06 00:00:00

  • Mechanism of differential control of NMDA receptor activity by NR2 subunits.

    abstract::N-methyl-d-aspartate (NMDA) receptors (NMDARs) are a major class of excitatory neurotransmitter receptors in the central nervous system. They form glutamate-gated ion channels that are highly permeable to calcium and mediate activity-dependent synaptic plasticity. NMDAR dysfunction is implicated in multiple brain diso...


    pub_type: 杂志文章


    authors: Gielen M,Siegler Retchless B,Mony L,Johnson JW,Paoletti P

    更新日期:2009-06-04 00:00:00

  • Female mating bias results in conflicting sex-specific offspring fitness.

    abstract::Indirect-benefit models of sexual selection assert that females gain heritable offspring advantages through a mating bias for males of superior genetic quality. This has generally been tested by associating a simple morphological quality indicator (for example, bird tail length) with offspring viability. However, sele...


    pub_type: 杂志文章


    authors: Fedorka KM,Mousseau TA

    更新日期:2004-05-06 00:00:00

  • Kin selection and cooperative courtship in wild turkeys.

    abstract::In the few species of birds in which males form display partnerships to attract females, one male secures most or all of the copulations. This leads to the question of why subordinate males help in the absence of observable reproductive benefits. Hamilton's concept of kin selection, whereby individuals can benefit ind...


    pub_type: 杂志文章


    authors: Krakauer AH

    更新日期:2005-03-03 00:00:00

  • Decarboxylative alkenylation.

    abstract::Olefin chemistry, through pericyclic reactions, polymerizations, oxidations, or reductions, has an essential role in the manipulation of organic matter. Despite its importance, olefin synthesis still relies largely on chemistry introduced more than three decades ago, with metathesis being the most recent addition. Her...


    pub_type: 杂志文章


    authors: Edwards JT,Merchant RR,McClymont KS,Knouse KW,Qin T,Malins LR,Vokits B,Shaw SA,Bao DH,Wei FL,Zhou T,Eastgate MD,Baran PS

    更新日期:2017-05-11 00:00:00

  • DNA sequence for a low-level promoter of the lac repressor gene and an 'up' promoter mutation.

    abstract::The promoter for a weakly expressed constitutive gene, the lactose repressor gene (lacI), has been sequenced, along with an 'up' promoter mutation Iq. The 10-fold enhancement in I expression found in Iq is the result of a single base change at position -35. To facilitate the sequencing, the lacI gene was cloned in a s...


    pub_type: 杂志文章


    authors: Calos MP

    更新日期:1978-08-24 00:00:00

  • Clonal analysis of lineage fate in native haematopoiesis.

    abstract::Haematopoiesis, the process of mature blood and immune cell production, is functionally organized as a hierarchy, with self-renewing haematopoietic stem cells and multipotent progenitor cells sitting at the very top. Multiple models have been proposed as to what the earliest lineage choices are in these primitive haem...


    pub_type: 杂志文章


    authors: Rodriguez-Fraticelli AE,Wolock SL,Weinreb CS,Panero R,Patel SH,Jankovic M,Sun J,Calogero RA,Klein AM,Camargo FD

    更新日期:2018-01-11 00:00:00

  • Genetic information and life insurance.

    abstract::Genetic testing will become the future standard of medical care. Life insurers will also need access to genetic information if the insurance industry is to survive intact and if cover is to remain affordable. ...


    pub_type: 杂志文章


    authors: Pokorski RJ

    更新日期:1995-07-06 00:00:00

  • Generation of an antibody with enhanced affinity and specificity for its antigen by protein engineering.

    abstract::A detailed description of the interactions between an antibody and its epitope is necessary to allow an understanding of the way in which antibodies bind to antigenic surfaces presented by foreign molecules. Ideally this should be done by analysis of crystal structures of antibody-antigen complexes, but so far only tw...


    pub_type: 杂志文章


    authors: Roberts S,Cheetham JC,Rees AR

    更新日期:1987-08-20 00:00:00

  • Ultrafast terahertz probes of transient conducting and insulating phases in an electron-hole gas.

    abstract::Many-body systems in nature exhibit complexity and self-organization arising from seemingly simple laws. For example, the long-range Coulomb interaction between electrical charges has a simple form, yet is responsible for a plethora of bound states in matter, ranging from the hydrogen atom to complex biochemical struc...


    pub_type: 杂志文章


    authors: Kaindl RA,Carnahan MA,Hägele D,Lövenich R,Chemla DS

    更新日期:2003-06-12 00:00:00

  • Primary sequence of a dimeric bacterial haemoglobin from Vitreoscilla.

    abstract::Vitreoscilla, a filamentous bacterium in the Beggiatoa family, synthesizes a soluble haem-protein which has two identical subunits of relative molecular mass 15,775 and two b haems per molecule. It is synthesized in relatively large quantities when the organism, a strict aerobe, is grown under hypoxic conditions. It f...


    pub_type: 杂志文章


    authors: Wakabayashi S,Matsubara H,Webster DA

    更新日期:1986-07-31 00:00:00

  • The motor side of depth vision.

    abstract::To achieve stereoscopic vision, the brain must search for corresponding image features on the two retinas. As long as the eyes stay still, corresponding features are confined to narrow bands called epipolar lines. But when the eyes change position, the epipolar lines migrate on the retinas. To find the matching featur...


    pub_type: 杂志文章


    authors: Schreiber K,Crawford JD,Fetter M,Tweed D

    更新日期:2001-04-12 00:00:00

  • Carbon isotope composition of individual amino acids in the Murchison meteorite.

    abstract::A significant portion of prebiotic organic matter on the early Earth may have been introduced by carbonaceous asteroids and comets. The distribution and stable-isotope composition of individual organic compounds in carbonaceous meteorites, which are thought to be derived from asteroidal parent bodies, may therefore pr...


    pub_type: 杂志文章


    authors: Engel MH,Macko SA,Silfer JA

    更新日期:1990-11-01 00:00:00

  • Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.

    abstract::Adipocyte fatty-acid-binding protein, aP2 (FABP4) is expressed in adipocytes and macrophages, and integrates inflammatory and metabolic responses. Studies in aP2-deficient mice have shown that this lipid chaperone has a significant role in several aspects of metabolic syndrome, including type 2 diabetes and atheroscle...


    pub_type: 杂志文章


    authors: Furuhashi M,Tuncman G,Görgün CZ,Makowski L,Atsumi G,Vaillancourt E,Kono K,Babaev VR,Fazio S,Linton MF,Sulsky R,Robl JA,Parker RA,Hotamisligil GS

    更新日期:2007-06-21 00:00:00