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NATURE文献大全abstract::The human B cell-specific alloantigen which is closely linked genetically to HLA contains two non-covalently associated, sialogycoprotein subunits of molecular weight (MW) 29,000 (p29), and 34,000 (p34). Although p29 and p34 have different amino-terminal sequences, their tyrosine peptide maps indicate considerable sim...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/268213a0
更新日期:1977-07-21 00:00:00
abstract::Keratinocytes of three different epithelia grown in cell culture express a large number of differentiation markers with either no differences or relatively small differences, depending on the species. Much of the distinctive phenotype of these epithelia in vivo must be due to external modulation and relatively little,...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/269489a0
更新日期:1977-10-06 00:00:00
abstract::Exploring visual illusions reveals fundamental principles of cortical processing. Illusory motion perception of non-moving stimuli was described almost a century ago by Gestalt psychologists. However, the underlying neuronal mechanisms remain unknown. To explore cortical mechanisms underlying the 'line-motion' illusio...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02396
更新日期:2004-03-25 00:00:00
abstract::In the pseudogap state of the high-transition-temperature (high-T(c)) copper oxide superconductors, angle-resolved photoemission (ARPES) measurements have seen Fermi arcs-that is, open-ended gapless sections in the large Fermi surface-rather than a closed loop expected of an ordinary metal. This is all the more puzzli...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08521
更新日期:2009-11-19 00:00:00
abstract::The crystal structure of human H-Ras complexed with the Ras guanine-nucleotide-exchange-factor region of the Son of sevenless (Sos) protein has been determined at 2.8 A resolution. The normally tight interaction of nucleotides with Ras is disrupted by Sos in two ways. First, the insertion into Ras of an alpha-helix fr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/28548
更新日期:1998-07-23 00:00:00
abstract::The Duchenne muscular dystrophy (DMD) locus has been localized to the short arm of the human X chromosome (Xp21) by detection of structural abnormalities and by genetic linkage studies. A library highly enriched for human DNA from Xp21 was constructed using DNA isolated from a male patient who had a visible deletion a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/316842a0
更新日期:1985-08-29 00:00:00
abstract::The neural crest, a source of many different cell types in vertebrate embryos, has not been identified in other chordates. Current opinion therefore holds that neural crest cells were a vertebrate innovation. Here we describe a migratory cell population resembling neural crest cells in the ascidian urochordate Ecteina...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02975
更新日期:2004-10-07 00:00:00
abstract::During wild-type development, a protein product of the Caenorhabditis elegans heterochronic gene lin-14 is localized to nuclei of specific somatic cells in embryos and early larvae, but is absent in late larvae and adult soma. Gain-of-function lin-14 mutations cause the level of lin-14 protein to remain high throughou...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/338313a0
更新日期:1989-03-23 00:00:00
abstract::Cancer genetics has for many years focused on mutational events that have their primary effect within the cancer cell. Recently that focus has widened, with evidence of the importance of epigenetic events and of cellular interactions in cancer development. The role of common genetic variation in determining the range ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/35077207
更新日期:2001-05-17 00:00:00
abstract::The three-dimensional structure of the 66-amino acid cro repressor protein of bacteriophage lambda suggests how it binds to its operator DNA. We propose that a dimer of cro protein is bound to the B-form of DNA with the 2-fold axis of the dimer coincident with the 2-fold axis of DNA. A pair of 2-fold-related alpha-hel...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/290754a0
更新日期:1981-04-30 00:00:00
abstract::The murine cardioviruses, such as the Mengo and encephalomyocarditis viruses, and the bovine aphthoviruses, such as foot-and-mouth disease virus, are distinguished among positive-strand RNA viruses by the presence of long homopolymeric poly(C) tracts within their 5' noncoding sequences. Although the specific lengths (...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/343474a0
更新日期:1990-02-01 00:00:00
abstract::Specific chromosomal deletions sometimes associated with tumours such as retinoblastoma (chromosome 13q14) and Wilm's tumour (chromosome 11p13) have led to the hypothesis that recessive genes may be involved in tumorigenesis. This hypothesis is supported by demonstration of allele loss specific for these regions using...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/329451a0
更新日期:1987-10-01 00:00:00
abstract::Antifreeze proteins provide fish with protection against the freezing effect of polar environments by binding to ice surfaces and inhibiting growth of ice crystals. We present the X-ray crystal structure at 1.5 A resolution of a lone alpha-helical antifreeze protein from winter flounder, which provides a detailed look...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/375427a0
更新日期:1995-06-01 00:00:00
abstract::Thewissen et al. describe new fossils from India that apparently support a phylogeny that places Cetacea (that is, whales, dolphins, porpoises) as the sister group to the extinct family Raoellidae, and Hippopotamidae as more closely related to pigs and peccaries (that is, Suina) than to cetaceans. However, our reanaly...
journal_title:Nature
pub_type: 评论,杂志文章
doi:10.1038/nature07776
更新日期:2009-03-19 00:00:00
abstract::Recent studies have shown that short chemically synthesized peptides very often induce antibodies which react with the cognate sequence in the intact folded protein. Since such antibodies react with known regions of proteins, they are of predetermined specificity and offer a precision not previously possible with immu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/306697a0
更新日期:1983-12-15 00:00:00
abstract::The lysis of murine sarcoma virus-murine leukaemia virus (MSV-MuLV)-induced tumour cells by cytotoxic T lymphocytes (CTL) appears to require that an antigen specified by MSV-MuLV, or induced by the infection, be presented in association with class I major histocompatibility complex antigens. The viral proteins of the ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/305815a0
更新日期:1983-10-27 00:00:00
abstract::Excitatory amino acids (EAAs) are important neurotransmitters in the vertebrate central nervous system. Electrophysiological and ligand-binding studies indicate that at least three different receptor subtypes for EAAs exist--N-methyl-D-aspartate, kainate and quisqualate receptor subtypes--on the basis of the preferred...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/342684a0
更新日期:1989-12-07 00:00:00
abstract::In Fig. 1b of this Article, a U was inadvertently inserted after G15 in the D loop. The original Article has not been corrected. ...
journal_title:Nature
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41586-018-0760-4
更新日期:2018-12-01 00:00:00
abstract::Peptidoglycan is the major structural constituent of the bacterial cell wall, forming a meshwork outside the cytoplasmic membrane that maintains cell shape and prevents lysis. In Gram-negative bacteria, peptidoglycan is located in the periplasm, where it is protected from exogenous lytic enzymes by the outer membrane....
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10244
更新日期:2011-07-20 00:00:00
abstract::The folding of newly synthesized proteins to the native state is a major challenge within the crowded cellular environment, as non-productive interactions can lead to misfolding, aggregation and degradation1. Cells cope with this challenge by coupling synthesis with polypeptide folding and by using molecular chaperone...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0462-y
更新日期:2018-09-01 00:00:00
abstract::The transcription factor NF-kappaB is composed of homodimeric and heterodimeric complexes of Rel/NF-kappaB-family polypeptides, which include Rel-A, c-Rel, Rel-B, NF-kappaB/p50 and NF-kappaB2/p52 . The NF-kappaB1 gene encodes a larger precursor protein, p105, from which p50 is produced constitutively by proteasome-med...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/16946
更新日期:1999-01-28 00:00:00
abstract::Endochondral ossification, an important process in vertebrate bone formation, is highly dependent on correct functioning of growth plate chondrocytes1. Proliferation of these cells determines longitudinal bone growth and the matrix deposited provides a scaffold for future bone formation. However, these two energy-depe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-0874-3
更新日期:2019-01-01 00:00:00
abstract::Lipoprotein(a) is an LDL-like lipoprotein whose concentration in plasma is correlated with atherosclerosis. The characteristic protein component of lipoprotein(a) is apolipoprotein(a) which is disulphide-linked to apolipoprotein B-100. Sequencing of cloned human apolipoprotein(a) complementary DNA shows that it is ver...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/330132a0
更新日期:1987-11-12 00:00:00
abstract::The restriction of intermingling between specific cell populations is crucial for the maintenance of organized patterns during development. A striking example is the restriction of cell mixing between segments in the insect epidermis and the vertebrate hindbrain that may enable each segment to maintain a distinct iden...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/20452
更新日期:1999-05-20 00:00:00
abstract::Mast cells are primary effectors in allergic reactions, and may have important roles in disease by secreting histamine and various inflammatory and immunomodulatory substances. Although they are classically activated by immunoglobulin (Ig)E antibodies, a unique property of mast cells is their antibody-independent resp...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14022
更新日期:2015-03-12 00:00:00
abstract::The biological importance of DNA methylation for gene expression in eukaryotes is becoming increasingly evident, and a direct role of methylation in gene expression has been suggested by an analysis of the infectivity of integrated retroviral genomes in a transfection assay. These studies, however, did not address whe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/304275a0
更新日期:1983-07-21 00:00:00
abstract::A safe and effective vaccine against COVID-19 is urgently needed in quantities sufficient to immunise large populations. We report the preclinical development of two BNT162b vaccine candidates, which contain lipid-nanoparticle (LNP) formulated nucleoside-modified mRNA encoding SARS-CoV-2 spike glycoprotein-derived imm...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-021-03275-y
更新日期:2021-02-01 00:00:00
abstract::The mineral olivine dominates the composition of the Earth's upper mantle and hence controls its mechanical behaviour and seismic anisotropy. Experiments at high temperature and moderate pressure, and extensive data on naturally deformed mantle rocks, have led to the conclusion that olivine at upper-mantle conditions ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03266
更新日期:2005-02-17 00:00:00
abstract::Inorganic nanoparticles exhibit size-dependent properties that are of interest for applications ranging from biosensing and catalysis to optics and data storage. They are readily available in a wide variety of discrete compositions and sizes. Shape-selective synthesis strategies now also yield shapes other than nanosp...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02020
更新日期:2003-10-02 00:00:00
abstract::Scanning probe microscopy is a versatile and powerful method that uses sharp tips to image, measure and manipulate matter at surfaces with atomic resolution. At cryogenic temperatures, scanning probe microscopy can even provide electron tunnelling spectra that serve as fingerprints of the vibrational properties of ads...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05530
更新日期:2007-03-01 00:00:00