The Caenorhabditis elegans heterochronic gene lin-14 encodes a nuclear protein that forms a temporal developmental switch.

abstract：:Any polarizable body placed in an inhomogeneous electric field experiences a dielectric force. This phenomenon is well known from the macroscopic world: a water jet is deflected when approached by a charged object. This fundamental mechanism is exploited in a variety of contexts-for example, trapping microscopic parti...

journal_title：Nature

authors： Unterreithmeier QP,Weig EM,Kotthaus JP

更新日期：2009-04-23 00:00:00

abstract：:RecBCD enzyme is a processive DNA helicase and nuclease that participates in the repair of chromosomal DNA through homologous recombination. We have visualized directly the movement of individual RecBCD enzymes on single molecules of double-stranded DNA (dsDNA). Detection involves the optical trapping of solitary, flu...

journal_title：Nature

authors： Bianco PR,Brewer LR,Corzett M,Balhorn R,Yeh Y,Kowalczykowski SC,Baskin RJ

更新日期：2001-01-18 00:00:00

abstract：:Seismological studies have revealed that a complex texture or heterogeneity exists in the Earth's inner core and at the boundary between core and mantle. These studies highlight the importance of understanding the properties of iron when modelling the composition and dynamics of the core and the interaction of the cor...

journal_title：Nature

authors： Dubrovinsky L,Annersten H,Dubrovinskaia N,Westman F,Harryson H,Fabrichnaya O,Carlson S

更新日期：2001-08-02 00:00:00

abstract：:Nucleosomes cover most of the genome and are thought to be displaced by transcription factors in regions that direct gene expression. However, the modes of interaction between transcription factors and nucleosomal DNA remain largely unknown. Here we systematically explore interactions between the nucleosome and 220 tr...

journal_title：Nature

authors： Zhu F,Farnung L,Kaasinen E,Sahu B,Yin Y,Wei B,Dodonova SO,Nitta KR,Morgunova E,Taipale M,Cramer P,Taipale J

更新日期：2018-10-01 00:00:00

abstract：:A newly-constructed antibody-like molecule containing the gp120-binding domain of the receptor for human immunodeficiency virus blocks HIV-1 infection of T cells and monocytes. Its long plasma half-life, other antibody-like properties, and potential to block all HIV isolates, make it a good candidate for therapeutic u...

journal_title：Nature

authors： Capon DJ,Chamow SM,Mordenti J,Marsters SA,Gregory T,Mitsuya H,Byrn RA,Lucas C,Wurm FM,Groopman JE

更新日期：1989-02-09 00:00:00

abstract：:The average air temperature at the Earth's surface has increased by 0.06 degrees C per decade during the 20th century, and by 0.19 degrees C per decade from 1979 to 1998. Climate models generally predict amplified warming in polar regions, as observed in Antarctica's peninsula region over the second half of the 20th c...

journal_title：Nature

authors： Doran PT,Priscu JC,Lyons WB,Walsh JE,Fountain AG,McKnight DM,Moorhead DL,Virginia RA,Wall DH,Clow GD,Fritsen CH,McKay CP,Parsons AN

更新日期：2002-01-31 00:00:00

abstract：:Human-mediated translocation of species to areas beyond their natural distribution (which results in 'alien' populations1) is a key signature of the Anthropocene2, and is a primary global driver of biodiversity loss and environmental change3. Stemming the tide of invasions requires understanding why some species fail ...

journal_title：Nature

authors： Redding DW,Pigot AL,Dyer EE,Şekercioğlu ÇH,Kark S,Blackburn TM

更新日期：2019-07-01 00:00:00

abstract：:The IKKalpha and IKKbeta catalytic subunits of IkappaB kinase (IKK) share 51% amino-acid identity and similar biochemical activities: they both phosphorylate IkappaB proteins at serines that trigger their degradation. IKKalpha and IKKbeta differ, however, in their physiological functions. IKKbeta and the IKKgamma/NEMO...

journal_title：Nature

authors： Hu Y,Baud V,Oga T,Kim KI,Yoshida K,Karin M

更新日期：2001-04-05 00:00:00

abstract：:The mechanism whereby eukaryotic pre-messenger RNAs are polyadenylated is unknown. Most models for polyadenylation invoke cleavage of precursor transcripts at the site of poly(A) addition followed by polymerization of A residues by poly(A) polymerase. Analysis of the sequences surrounding poly(A) addition sites has id...

journal_title：Nature

authors： Berget SM

更新日期：1984-05-10 00:00:00

abstract：:Few intergalactic, plausibly primordial clouds of neutral atomic hydrogen (H(i)) have been found in the local Universe, suggesting that such structures have either dispersed, become ionized or produced a stellar population on gigayear timescales. The Leo ring, a massive (M(H(i)) approximately 1.8 x 10(9)M[symbol: see ...

journal_title：Nature

authors： Thilker DA,Donovan J,Schiminovich D,Bianchi L,Boissier S,de Paz AG,Madore BF,Martin DC,Seibert M

更新日期：2009-02-19 00:00:00

abstract：:Life implies movement. Most forms of movement in the living world are powered by tiny protein machines known as molecular motors. Among the best known are motors that use sophisticated intramolecular amplification mechanisms to take nanometre steps along protein tracks in the cytoplasm. These motors transport a wide v...

journal_title：Nature

authors： Schliwa M,Woehlke G

更新日期：2003-04-17 00:00:00

abstract：:The retinoblastoma tumour-suppressor protein Rb inhibits cell proliferation by repressing a subset of genes that are controlled by the E2F family of transcription factors and which are involved in progression from the G1 to the S phase of the cell cycle. Rb, which is recruited to target promoters by E2F1, represses tr...

journal_title：Nature

authors： Magnaghi-Jaulin L,Groisman R,Naguibneva I,Robin P,Lorain S,Le Villain JP,Troalen F,Trouche D,Harel-Bellan A

更新日期：1998-02-05 00:00:00

abstract：:Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation. The Cancer Genome Atlas (TCGA) pilot project aims to assess the value of large-scale multi-dimensional analysis of these molecular characteristics in human c...

journal_title：Nature

authors： Cancer Genome Atlas Research Network.

更新日期：2008-10-23 00:00:00

abstract：:Heterotrimeric G-proteins bind to cell-surface receptors and are integral in transmission of signals from outside the cell. Upon activation of the Galpha subunit by binding of GTP, the Galpha and Gbetagamma subunits dissociate and interact with effector proteins for signal transduction. Regulatory proteins with the 19...

journal_title：Nature

authors： Kimple RJ,Kimple ME,Betts L,Sondek J,Siderovski DP

更新日期：2002-04-25 00:00:00

abstract：:Quantum simulation--the use of one quantum system to simulate a less controllable one--may provide an understanding of the many quantum systems which cannot be modelled using classical computers. Considerable progress in control and manipulation has been achieved for various quantum systems, but one of the remaining c...

journal_title：Nature

authors： Wilson AC,Colombe Y,Brown KR,Knill E,Leibfried D,Wineland DJ

更新日期：2014-08-07 00:00:00

abstract：:Fireflies communicate with each other by emitting yellow-green to yellow-orange brilliant light. The bioluminescence reaction, which uses luciferin, Mg-ATP and molecular oxygen to yield an electronically excited oxyluciferin species, is carried out by the enzyme luciferase. Visible light is emitted during relaxation o...

journal_title：Nature

authors： Nakatsu T,Ichiyama S,Hiratake J,Saldanha A,Kobashi N,Sakata K,Kato H

更新日期：2006-03-16 00:00:00

abstract：:Estimates of the total number of bacterial species indicate that existing DNA sequence databases carry only a tiny fraction of the total amount of DNA sequence space represented by this division of life. Indeed, environmental DNA samples have been shown to encode many previously unknown classes of proteins and RNAs. B...

journal_title：Nature

authors： Weinberg Z,Perreault J,Meyer MM,Breaker RR

更新日期：2009-12-03 00:00:00

abstract：:'Pioneer' transcription factors are required for stem-cell pluripotency, cell differentiation and cell reprogramming1,2. Pioneer factors can bind nucleosomal DNA to enable gene expression from regions of the genome with closed chromatin. SOX2 is a prominent pioneer factor that is essential for pluripotency and self-re...

journal_title：Nature

authors： Dodonova SO,Zhu F,Dienemann C,Taipale J,Cramer P

更新日期：2020-04-01 00:00:00

abstract：:Two principals in the once-raging debate over forensic DNA typing conclude that the scientific issues have all been resolved. ...

journal_title：Nature

authors： Lander ES,Budowle B

更新日期：1994-10-27 00:00:00

abstract：:53BP1 governs a specialized, context-specific branch of the classical non-homologous end joining DNA double-strand break repair pathway. Mice lacking 53bp1 (also known as Trp53bp1) are immunodeficient owing to a complete loss of immunoglobulin class-switch recombination1,2, and reduced fidelity of long-range V(D)J rec...

journal_title：Nature

authors： Ghezraoui H,Oliveira C,Becker JR,Bilham K,Moralli D,Anzilotti C,Fischer R,Deobagkar-Lele M,Sanchiz-Calvo M,Fueyo-Marcos E,Bonham S,Kessler BM,Rottenberg S,Cornall RJ,Green CM,Chapman JR

更新日期：2018-08-01 00:00:00

abstract：:The recent discoveries of RNA interference and related RNA silencing pathways have revolutionized our understanding of gene regulation. RNA interference has been used as a research tool to control the expression of specific genes in numerous experimental organisms and has potential as a therapeutic strategy to reduce ...

journal_title：Nature

authors： Mello CC,Conte D Jr

更新日期：2004-09-16 00:00:00

abstract：:Mitochondria take up and extrude various inorganic and organic ions, as well as larger substances such as proteins. The technique of patch clamping should provide real-time information on such transport and on energy transduction in oxidative phosphorylation. It has been applied to detect microscopic currents from mit...

journal_title：Nature

authors： Inoue I,Nagase H,Kishi K,Higuti T

更新日期：1991-07-18 00:00:00

abstract：:During cellular translation of messenger RNAs by ribosomes, the translation apparatus sometimes pauses or stalls at the elongation and termination steps. With the exception of programmed stalling, which is usually used by cells for regulatory purposes, ribosomes stalled on mRNAs need to be terminated and recycled to m...

journal_title：Nature

authors： Ma C,Kurita D,Li N,Chen Y,Himeno H,Gao N

更新日期：2017-01-26 00:00:00

abstract：:A mutant form of the alpha-isoform of protein kinase C (PKC) was recently isolated from an ultraviolet radiation-induced murine fibrosarcoma cell line and reported to transform mouse BALB/c 3T3 fibroblasts on transfection. Four point mutations in the regulatory domain were assumed to be responsible for its oncogenicit...

journal_title：Nature

authors： Borner C,Filipuzzi I,Weinstein IB,Imber R

更新日期：1991-09-05 00:00:00

abstract：:The formation of condensed (compacted) protein phases is associated with a wide range of human disorders, such as eye cataracts, amyotrophic lateral sclerosis, sickle cell anaemia and Alzheimer's disease. However, condensed protein phases have their uses: as crystals, they are harnessed by structural biologists to elu...

journal_title：Nature

authors： Van Driessche AES,Van Gerven N,Bomans PHH,Joosten RRM,Friedrich H,Gil-Carton D,Sommerdijk NAJM,Sleutel M

更新日期：2018-04-04 00:00:00

abstract：:Recent studies have shown that developing nerve fibres grow directly to their targets and are guided by specific cues, but the nature of these cues and the mechanism of guidance remain unknown. The growth of sympathetic axons towards an artificial source of nerve growth factor (NGF) in vivo and of sensory neurites up ...

journal_title：Nature

authors： Lumsden AG,Davies AM

更新日期：1983-12-22 00:00:00

abstract：:Plants encounter a myriad of microorganisms, particularly at the root-soil interface, that can invade with detrimental or beneficial outcomes. Prevalent beneficial associations between plants and microorganisms include those that promote plant growth by facilitating the acquisition of limiting nutrients such as nitrog...

journal_title：Nature

authors： Zipfel C,Oldroyd GE

更新日期：2017-03-15 00:00:00

abstract：:The subsidence history of the Bahamian Platform points to a non-uniform rate of sea-floor spreading since the beginning of the Cretaceous. Lower Cretaceous rates of perhaps 5 cm/yr led to an active trench system at the boundary between the American and Caribbean lithosphere plates, and the rapid subsidence of the cont...

journal_title：Nature

authors： Lynts GW

更新日期：1970-03-28 00:00:00

abstract：:CD95 (also called Fas and APO-1) is a prototypical death receptor that regulates tissue homeostasis mainly in the immune system through the induction of apoptosis. During cancer progression CD95 is frequently downregulated or cells are rendered apoptosis resistant, raising the possibility that loss of CD95 is part of ...

journal_title：Nature

authors： Chen L,Park SM,Tumanov AV,Hau A,Sawada K,Feig C,Turner JR,Fu YX,Romero IL,Lengyel E,Peter ME

更新日期：2010-05-27 00:00:00

abstract：:The travelling salesman problem is a classical problem in the field of combinatorial optimization, concerned with efficient methods for maximizing or minimizing a function of many independent variables. Given the positions of N cities, which in the simplest case lie in the plane, what is the shortest closed tour in wh...

journal_title：Nature

authors： Durbin R,Willshaw D

更新日期：1987-04-16 00:00:00