Abstract:
:Cancer genetics has for many years focused on mutational events that have their primary effect within the cancer cell. Recently that focus has widened, with evidence of the importance of epigenetic events and of cellular interactions in cancer development. The role of common genetic variation in determining the range of individual susceptibility within the population is increasingly recognized, and will be addressed using information from the Human Genome Project. These new research directions will highlight determinants of cancer that lie outside the cancer cell, suggest new targets for intervention, and inform the design of strategies for prevention in groups at increased risk.
journal_name
Naturejournal_title
Natureauthors
Ponder BAdoi
10.1038/35077207keywords:
subject
Has Abstractpub_date
2001-05-17 00:00:00pages
336-41issue
6835eissn
0028-0836issn
1476-4687pii
35077207journal_volume
411pub_type
杂志文章,评审相关文献
NATURE文献大全abstract::Gravitational lensing is a powerful tool for the study of the distribution of dark matter in the Universe. The cold-dark-matter model of the formation of large-scale structures (that is, clusters of galaxies and even larger assemblies) predicts the existence of quasars gravitationally lensed by concentrations of dark ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02153
更新日期:2003-12-18 00:00:00
abstract::The nuclear bulge is a region with a radius of about 200 parsecs around the centre of the Milky Way. It contains stars with ages ranging from a few million years to over a billion years, yet its star-formation history and the triggering process for star formation remain to be resolved. Recently, episodic star formatio...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10359
更新日期:2011-08-24 00:00:00
abstract::During cell division, sister chromosomes segregate from each other on a microtubule-based structure called the mitotic spindle. Proteins bind to the centromere, a region of chromosomal DNA, to form the kinetochore, which mediates chromosome attachment to the mitotic spindle microtubules. In the budding yeast Saccharom...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/359533a0
更新日期:1992-10-08 00:00:00
abstract::Experimental and simulation studies show that small monomeric proteins fold in one kinetic step, which entails overcoming the free-energy barrier between the unfolded and the native protein through a transition state. Two models of transition state formation have been proposed: a 'nonspecific' one in which it depends ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/379096a0
更新日期:1996-01-04 00:00:00
abstract::With the current shortage in fetal bovine serum, researchers are turning to a variety of options for cell and tissue culture. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/334547a0
更新日期:1988-08-11 00:00:00
abstract::Lung epithelial cells can influence immune responses to airway allergens. Airway epithelial cells also undergo apoptosis after encountering environmental allergens; yet, relatively little is known about how these are cleared, and their effect on airway inflammation. Here we show that airway epithelial cells efficientl...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11714
更新日期:2013-01-24 00:00:00
abstract::A long-sought goal in structural biology has been the imaging of membrane proteins in their membrane environments. This goal has been achieved with electron crystallography in those special cases where a protein forms highly ordered arrays in lipid bilayers. It has also been achieved by NMR methods in proteins up to 5...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08291
更新日期:2009-09-10 00:00:00
abstract::The inhibitory activity associated with myelin is a major obstacle for successful axon regeneration in the adult mammalian central nervous system (CNS). In addition to myelin-associated glycoprotein (MAG) and Nogo-A, available evidence suggests the existence of additional inhibitors in CNS myelin. We show here that a ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature00867
更新日期:2002-06-27 00:00:00
abstract::The skin of mice contains dendritic epidermal cells carrying the Thy-1 antigen (Thy-1+ dEC) which express antigen receptors composed of the T-cell antigen receptor (TCR) gamma- and delta-chains. Although the role of the thymus in the generation of most T cells is well established, the involvement of the thymus in the ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/344068a0
更新日期:1990-03-01 00:00:00
abstract::Post-transcriptional gene regulation frequently occurs through elements in mRNA 3' untranslated regions (UTRs). Although crucial roles for 3'UTR-mediated gene regulation have been found in Caenorhabditis elegans, most C. elegans genes have lacked annotated 3'UTRs. Here we describe a high-throughput method for reliable...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09616
更新日期:2011-01-06 00:00:00
abstract::Time is divided by geologists according to marked shifts in Earth's state. Recent global environmental changes suggest that Earth may have entered a new human-dominated geological epoch, the Anthropocene. Here we review the historical genesis of the idea and assess anthropogenic signatures in the geological record aga...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature14258
更新日期:2015-03-12 00:00:00
abstract::Most normal mammalian cells have a finite lifespan, thought to constitute a protective mechanism against unlimited proliferation. This phenomenon, called senescence, is driven by telomere attrition, which triggers the induction of tumour suppressors including p16(INK4a) (ref. 5). In cultured cells, senescence can be e...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03890
更新日期:2005-08-04 00:00:00
abstract::B lymphocytes re-circulate between B-cell-rich compartments (follicles or B zones) in secondary lymphoid organs, surveying for antigen. After antigen binding, B cells move to the boundary of B and T zones to interact with T-helper cells. Despite the importance of B--T-cell interactions for the induction of antibody re...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/416094a
更新日期:2002-03-07 00:00:00
abstract::Pheromone-based behaviours are crucial in animals from insects to mammals, and reproductive isolation is often based on pheromone differences. However, the genetic mechanisms by which pheromone signals change during the evolution of new species are largely unknown. In the sexual communication system of moths (Insecta:...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09058
更新日期:2010-07-22 00:00:00
abstract::During serial structure analysis of cobaloxime derivatives, aimed at interpreting the catalytic capability of the asymmetric hydrogenation, we have found that the crystal of R-alpha-cyanoethyl (S-alpha-methylbenzylamine)-cobaloxime changes its unit cell dimensions by X-ray exposure without degradation of a single crys...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/267142a0
更新日期:1977-05-12 00:00:00
abstract::In Drosophila, a large group of structural genes exhibit coordinate regulation, not because they function in a common developmental pathway but because they happen to reside on the X chromosome. These genes are subjected to the regulatory mechanism of dosage compensation which insures that their phenotypic products ar...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/285573a0
更新日期:1980-06-19 00:00:00
abstract::Many physiological events require transient increases in cytosolic Ca(2+) concentrations. Ryanodine receptors (RyRs) are ion channels that govern the release of Ca(2+) from the endoplasmic and sarcoplasmic reticulum. Mutations in RyRs can lead to severe genetic conditions that affect both cardiac and skeletal muscle, ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09471
更新日期:2010-11-25 00:00:00
abstract::In this Letter, errors in Supplementary Table 1 have been corrected. ...
journal_title:Nature
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41586-018-0573-5
更新日期:2018-11-01 00:00:00
abstract::Abscisic acid (ABA) is a vital phytohormone that regulates mainly stomatal aperture and seed development, but ABA receptors involved in these processes have yet to be determined. We previously identified from broad bean an ABA-binding protein (ABAR) potentially involved in stomatal signalling, the gene for which encod...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05176
更新日期:2006-10-19 00:00:00
abstract::Myosin, a major contractile protein, characteristically possesses a long coiled-coil alpha-helical tail and two heads. Each head contains both an actin binding site and an ATPase site and is formed from the NH2-terminal half of one of the two heavy chains (relative molecular mass, Mr, 200,000) and a pair of light chai...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/324078a0
更新日期:1986-11-06 00:00:00
abstract::Activation of a visual pigment molecule to initiate phototransduction requires a minimum energy, Ea, that need not be wholly derived from a photon, but may be supplemented by heat. Theory predicts that absorbance at very long wavelengths declines with the fraction of molecules that have a sufficient complement of ther...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35003242
更新日期:2000-01-13 00:00:00
abstract::The Hubbard model, formulated by physicist John Hubbard in the 1960s1, is a simple theoretical model of interacting quantum particles in a lattice. The model is thought to capture the essential physics of high-temperature superconductors, magnetic insulators and other complex quantum many-body ground states2,3. Althou...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2085-3
更新日期:2020-03-01 00:00:00
abstract::Occupancy of the T-cell antigen receptor is insufficient to induce T-cell activation optimally; a second co-stimulatory signal is required. Exposure of T-cell clones to complexes of antigen with major histocompatibility complex molecules in the absence of the co-stimulatory signal induces a state of clonal anergy. Thi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/356607a0
更新日期:1992-04-16 00:00:00
abstract::Nerve growth factor (NGF) is involved in a variety of processes involving signalling, such as cell differentiation and survival, growth cessation and apoptosis of neurons. These events are mediated by NGF as a result of binding to its two cell-surface receptors, TrkA and p75. TrkA is a receptor with tyrosine kinase ac...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/43705
更新日期:1999-09-09 00:00:00
abstract::The guanine nucleotide-binding stimulatory protein (Gs) couples hormone-receptor interaction to the activation of adenylate cyclase and the generation of cyclic AMP. Studies using frog neuroepithelium indicate that the sense of smell is mediated by a Gs-adenylate cyclase system, and this prompted us to test olfaction ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/322635a0
更新日期:1986-08-14 00:00:00
abstract::In this Article, in Fig. 1a, the 5' and 3' labels were reversed in the DNA sequence, and Fig. 4 was missing panel labels a-e. These errors have been corrected online. ...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-019-1343-8
更新日期:2019-07-01 00:00:00
abstract::Histamine secretion from mast cells may be inhibited by elevated intracellular levels of cyclic AMP and by several anti-allergic drugs. These compounds are claimed to act directly on the calcium-gating mechanism activated by the anaphylactic reaction, preventing influx of Ca2+ from the external environment and so bloc...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/289186a0
更新日期:1981-01-15 00:00:00
abstract::Microtubules have a central role in eukaryotic cell polarity, in part through interactions between microtubule end-binding proteins and the cell cortex. In the fission yeast Schizosaccharomyces pombe, microtubules and the polarity modulator tea1p maintain cylindrical cell shape and strictly antipodal cell growth. The ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01672
更新日期:2003-06-05 00:00:00
abstract::Applications are emerging that require the creation of fine-scale structures in three dimensions--examples include scaffolds for tissue engineering, micro-fluidic devices and photonic materials that control light propagation over a range of frequencies. But writing methods such as dip-pen nanolithography and ink-jet p...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/428386a
更新日期:2004-03-25 00:00:00
abstract::Breast cancer patients with the same stage of disease can have markedly different treatment responses and overall outcome. The strongest predictors for metastases (for example, lymph node status and histological grade) fail to classify accurately breast tumours according to their clinical behaviour. Chemotherapy or ho...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/415530a
更新日期:2002-01-31 00:00:00