Detection of deletions spanning the Duchenne muscular dystrophy locus using a tightly linked DNA segment.

abstract：:The immunophilins cyclophilin and FK506 binding protein (FKBP) are small, predominantly soluble proteins that bind the immunosuppressant drugs cyclosporin A and FK506, respectively, with high affinity, and which seem to mediate their pharmacological actions. The Ca(2+)-dependent protein phosphatase, calcineurin, binds...

journal_title：Nature

authors： Steiner JP,Dawson TM,Fotuhi M,Glatt CE,Snowman AM,Cohen N,Snyder SH

更新日期：1992-08-13 00:00:00

abstract：:The RIG-like helicase (RLH) family of intracellular receptors detect viral nucleic acid and signal through the mitochondrial antiviral signalling adaptor MAVS (also known as Cardif, VISA and IPS-1) during a viral infection. MAVS activation leads to the rapid production of antiviral cytokines, including type 1 interfer...

journal_title：Nature

authors： Moore CB,Bergstralh DT,Duncan JA,Lei Y,Morrison TE,Zimmermann AG,Accavitti-Loper MA,Madden VJ,Sun L,Ye Z,Lich JD,Heise MT,Chen Z,Ting JP

更新日期：2008-01-31 00:00:00

abstract：:Cells operate in dynamic environments using extraordinary communication capabilities that emerge from the interactions of genetic circuitry. The mammalian immune response is a striking example of the coordination of different cell types. Cell-to-cell communication is primarily mediated by signalling molecules that for...

journal_title：Nature

authors： Tay S,Hughey JJ,Lee TK,Lipniacki T,Quake SR,Covert MW

更新日期：2010-07-08 00:00:00

abstract：:In songbirds, the remarkable temporal precision of song is generated by a sparse sequence of bursts in the premotor nucleus HVC. To distinguish between two possible classes of models of neural sequence generation, we carried out intracellular recordings of HVC neurons in singing zebra finches (Taeniopygia guttata). We...

journal_title：Nature

authors： Long MA,Jin DZ,Fee MS

更新日期：2010-11-18 00:00:00

abstract：:During serial structure analysis of cobaloxime derivatives, aimed at interpreting the catalytic capability of the asymmetric hydrogenation, we have found that the crystal of R-alpha-cyanoethyl (S-alpha-methylbenzylamine)-cobaloxime changes its unit cell dimensions by X-ray exposure without degradation of a single crys...

journal_title：Nature

authors： Ohashi Y,Sasada Y

更新日期：1977-05-12 00:00:00

abstract：:The mammalian microbiome has many important roles in health and disease, and genetic engineering is enabling the development of microbial therapeutics and diagnostics. A key determinant of the activity of both natural and engineered microorganisms in vivo is their location within the host organism. However, existing m...

journal_title：Nature

authors： Bourdeau RW,Lee-Gosselin A,Lakshmanan A,Farhadi A,Kumar SR,Nety SP,Shapiro MG

更新日期：2018-01-03 00:00:00

abstract：:The 26S proteasome is the chief site of regulatory protein turnover in eukaryotic cells. It comprises one 20S catalytic complex (composed of four stacked rings of seven members) and two axially positioned 19S regulatory complexes (each containing about 18 subunits) that control substrate access to the catalytic chambe...

journal_title：Nature

authors： Lam YA,Lawson TG,Velayutham M,Zweier JL,Pickart CM

更新日期：2002-04-18 00:00:00

abstract：:Long-term potentiation (LTP) in the hippocampus is widely studied as the mechanisms involved in its induction and maintenance are believed to underlie fundamental properties of learning and memory in vertebrates. Most synapses that exhibit LTP use an excitatory amino-acid neurotransmitter that acts on two types of rec...

journal_title：Nature

authors： Davies SN,Lester RA,Reymann KG,Collingridge GL

更新日期：1989-04-06 00:00:00

abstract：:When a force deforms an elastic object, practical experience suggests that the resulting displacement will be in the same direction as the force. This property is known as positive stiffness. Less familiar is the concept of negative stiffness, where the deforming force and the resulting displacement are in opposite di...

journal_title：Nature

authors： Lakes RS,Lee T,Bersie A,Wang YC

更新日期：2001-03-29 00:00:00

abstract：:After an earthquake, numerous smaller shocks are triggered over distances comparable to the dimensions of the mainshock fault rupture, although they are rare at larger distances. Here we analyse the scaling of dynamic deformations (the stresses and strains associated with seismic waves) with distance from, and magnitu...

journal_title：Nature

authors： Gomberg J,Johnson P

更新日期：2005-10-06 00:00:00

abstract：:Laboratory measurements of sound velocities of high-pressure minerals provide crucial information on the composition and constitution of the deep mantle via comparisons with observed seismic velocities. Calcium silicate (CaSiO3) perovskite (CaPv) is a high-pressure phase that occurs at depths greater than about 560 ki...

journal_title：Nature

authors： Gréaux S,Irifune T,Higo Y,Tange Y,Arimoto T,Liu Z,Yamada A

更新日期：2019-01-01 00:00:00

abstract：:The biogenic amine transporters (BATs) regulate endogenous neurotransmitter concentrations and are targets for a broad range of therapeutic agents including selective serotonin reuptake inhibitors (SSRIs), serotonin-noradrenaline reuptake inhibitors (SNRIs) and tricyclic antidepressants (TCAs). Because eukaryotic BATs...

journal_title：Nature

authors： Wang H,Goehring A,Wang KH,Penmatsa A,Ressler R,Gouaux E

更新日期：2013-11-07 00:00:00

abstract：:Protein aggregates are the hallmark of stressed and ageing cells, and characterize several pathophysiological states. Healthy metazoan cells effectively eliminate intracellular protein aggregates, indicating that efficient disaggregation and/or degradation mechanisms exist. However, metazoans lack the key heat-shock p...

journal_title：Nature

authors： Nillegoda NB,Kirstein J,Szlachcic A,Berynskyy M,Stank A,Stengel F,Arnsburg K,Gao X,Scior A,Aebersold R,Guilbride DL,Wade RC,Morimoto RI,Mayer MP,Bukau B

更新日期：2015-08-13 00:00:00

abstract：:The main function of postural nervous mechanisms in different species, from mollusc to man, is to counteract the force of gravity and stabilize body orientation in space. Here we investigate the basic principles of postural control in a simple animal model, the marine mollusc Clione limacina. When swimming, C. limacin...

journal_title：Nature

authors： Deliagina TG,Arshavsky YI,Orlovsky GN

更新日期：1998-05-14 00:00:00

abstract：:Critical issues in the cognitive neuroscience of language are whether there are multiple systems for the representation of meaning, perhaps organized by processing system (such as vision or language), and whether further subsystems are distinguishable within these larger ones. We describe here a patient (K.R.) with ce...

journal_title：Nature

authors： Hart J Jr,Gordon B

更新日期：1992-09-03 00:00:00

abstract：:The recent discovery of more than a thousand planets outside our Solar System, together with the significant push to achieve inertially confined fusion in the laboratory, has prompted a renewed interest in how dense matter behaves at millions to billions of atmospheres of pressure. The theoretical description of such ...

journal_title：Nature

authors： Smith RF,Eggert JH,Jeanloz R,Duffy TS,Braun DG,Patterson JR,Rudd RE,Biener J,Lazicki AE,Hamza AV,Wang J,Braun T,Benedict LX,Celliers PM,Collins GW

更新日期：2014-07-17 00:00:00

abstract：:Leukaemia inhibitory factor (LIF) has a variety of effects on different cell types in vitro, inhibiting the differentiation of embryonic stem cells and promoting the survival and/or proliferation of primitive haematopoietic precursors and primordial germ cells. Here we show that LIF-deficient mice derived by gene targ...

journal_title：Nature

authors： Escary JL,Perreau J,Duménil D,Ezine S,Brûlet P

更新日期：1993-05-27 00:00:00

abstract：:Data collected at approximately 60 Global Positioning System (GPS) sites in southeast Asia show the crustal deformation caused by the 26 December 2004 Sumatra-Andaman earthquake at an unprecedented large scale. Small but significant co-seismic jumps are clearly detected more than 3,000 km from the earthquake epicentre...

journal_title：Nature

authors： Vigny C,Simons WJ,Abu S,Bamphenyu R,Satirapod C,Choosakul N,Subarya C,Socquet A,Omar K,Abidin HZ,Ambrosius BA

更新日期：2005-07-14 00:00:00

abstract：:The innate immune system is critical for the early detection of invading pathogens and for initiating cellular host defence countermeasures, which include the production of type I interferon (IFN). However, little is known about how the innate immune system is galvanized to respond to DNA-based microbes. Here we show ...

journal_title：Nature

authors： Ishikawa H,Ma Z,Barber GN

更新日期：2009-10-08 00:00:00

abstract：:The metabolic basis of the autosomal recessive disease cystic fibrosis (CF) remains unidentified. Elevated levels of a serum protein in CF homozygotes and obligate heterozygotes have been described. As heterozygotes are clinically unaffected, any consistently observed abnormality in these individuals is a likely point...

journal_title：Nature

authors： Dorin JR,Novak M,Hill RE,Brock DJ,Secher DS,van Heyningen V

更新日期：1987-04-09 00:00:00

abstract：:The recurrent patterns in the commonness and rarity of species in ecological communities--the relative species abundance--have puzzled ecologists for more than half a century. Here we show that the framework of the current neutral theory in ecology can easily be generalized to incorporate symmetric density dependence....

journal_title：Nature

authors： Volkov I,Banavar JR,He F,Hubbell SP,Maritan A

更新日期：2005-12-01 00:00:00

abstract：:The verification of nuclear warheads for arms control involves a paradox: international inspectors will have to gain high confidence in the authenticity of submitted items while learning nothing about them. Proposed inspection systems featuring 'information barriers', designed to hide measurements stored in electronic...

journal_title：Nature

authors： Glaser A,Barak B,Goldston RJ

更新日期：2014-06-26 00:00:00

abstract：:Double-stranded RNAs (dsRNAs) induce post-transcriptional gene silencing in several species of animal and plant. In plants, dsRNAs targeted to CpG islands within a promoter can also induce RNA-directed DNA methylation; however, it remains unclear whether gene silencing mediated by DNA methylation can be induced by dsR...

journal_title：Nature

authors： Kawasaki H,Taira K

更新日期：2004-09-09 00:00:00

abstract：:A non-discriminatory base analogue, or universal base, would be an invaluable component of oligonucleotide probes and primers for solving the design problems that arise as a result of the degeneracy of the genetic code, or when only fragmentary peptide sequence data are available. We have designed an alternative to pr...

journal_title：Nature

authors： Nichols R,Andrews PC,Zhang P,Bergstrom DE

更新日期：1994-06-09 00:00:00

abstract：:The first event in the initiation of an immune response is the capture and presentation of antigen to T cells. Such presentation involves two distinct steps: (1) display of the antigen, which requires uptake, processing and re-expression of the antigen in association with MHC molecules on the presenting cell surface; ...

journal_title：Nature

authors： Lassila O,Vainio O,Matzinger P

更新日期：1988-07-21 00:00:00

abstract：:Elongation factor Tu is present in a fourfold excess over the amount seemingly involved in protein synthesis. It is identical to a major protein which we have found associated with the plasma membrane. The possibility of a specific role in that location is considered. ...

journal_title：Nature

authors： Jacobson GR,Rosenbusch JP

更新日期：1976-05-06 00:00:00

abstract：:The formation of glasses is normal for substances that remain liquid over a wide temperature range (the 'good glassformers') and can be induced for most liquids if cooling is fast enough to bypass crystallization. During reheating but still below the melting point, good glassformers exhibit glass transitions as they a...

journal_title：Nature

authors： Yue Y,Angell CA

更新日期：2004-02-19 00:00:00

abstract：:RNAs that contain specific high-affinity binding sites for small molecule ligands immobilized on a solid support are present at a frequency of roughly one in 10(10)-10(11) in pools of random sequence RNA molecules. Here we describe a new in vitro selection procedure designed to ensure the isolation of RNAs that bind t...

journal_title：Nature

authors： Sassanfar M,Szostak JW

更新日期：1993-08-05 00:00:00

abstract：:Astrophysical observations indicate that there is roughly five times more dark matter in the Universe than ordinary baryonic matter1, and an even larger amount of the Universe's energy content is attributed to dark energy2. However, the microscopic properties of these dark components remain unknown. Moreover, even ord...

journal_title：Nature

authors： Smorra C,Stadnik YV,Blessing PE,Bohman M,Borchert MJ,Devlin JA,Erlewein S,Harrington JA,Higuchi T,Mooser A,Schneider G,Wiesinger M,Wursten E,Blaum K,Matsuda Y,Ospelkaus C,Quint W,Walz J,Yamazaki Y,Budker D,Ulmer S

更新日期：2019-11-01 00:00:00

abstract：:Autosomal recessive juvenile parkinsonism (AR-JP) is an early-onset form of Parkinson's disease characterized by motor disturbances and dopaminergic neurodegeneration. To address its underlying molecular pathogenesis, we generated and characterized loss-of-function mutants of Drosophila PTEN-induced putative kinase 1 ...

journal_title：Nature

authors： Park J,Lee SB,Lee S,Kim Y,Song S,Kim S,Bae E,Kim J,Shong M,Kim JM,Chung J

更新日期：2006-06-29 00:00:00