Abstract:
:The human B cell-specific alloantigen which is closely linked genetically to HLA contains two non-covalently associated, sialogycoprotein subunits of molecular weight (MW) 29,000 (p29), and 34,000 (p34). Although p29 and p34 have different amino-terminal sequences, their tyrosine peptide maps indicate considerable similarity in other portions of their polypeptide chains. Thus the genes for their proteins may have evolved by duplication of a common ancestral gene. Another lymphocyte cell surface protein of MW 16,000 (p16) has also been characterised. Both p16 and p44 (the heavy chain of HLA-A,B antigens) have been compared with p29 and p34.
journal_name
Naturejournal_title
Natureauthors
Springer TA,Kaufman JF,Terhorst C,Strominger JLdoi
10.1038/268213a0subject
Has Abstractpub_date
1977-07-21 00:00:00pages
213-8issue
5617eissn
0028-0836issn
1476-4687journal_volume
268pub_type
杂志文章相关文献
NATURE文献大全abstract::The neurotransmitter dopamine has been demonstrated by biochemical, histochemical and immunocytochemical techniques to be unevenly distributed in the mammalian central nervous system. DARPP-32 (dopamine- and cyclic-AMP-regulated phosphoprotein of molecular weight 32,000) is a neuronal phosphoprotein that displays a re...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/310503a0
更新日期:1984-08-09 00:00:00
abstract::Solitons are large-amplitude, spatially confined wave packets in nonlinear media. They occur in a wide range of physical systems, such as water surfaces, optical fibres, plasmas, Bose-Einstein condensates and magnetically ordered media. A distinguishing feature of soliton behaviour that is common to all systems, is th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02042
更新日期:2003-11-13 00:00:00
abstract::Recent observations have revealed streams of gas and stars in the halo of the Milky Way that are the debris from interactions between our Galaxy and some of its dwarf companion galaxies; the Sagittarius dwarf galaxy and the Magellanic clouds. Analysis of the material has shown that much of the halo is made up of canni...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35083506
更新日期:2001-07-05 00:00:00
abstract::Photoreceptors of the vertebrate retina hyperpolarize in response to light. The hyperpolarization elicited by a brief flash is approximately ten times slower in rods than in cones of the same retina. We have examined the amplification and temporal properties of synaptic transfer of rod and cone signals to a common pos...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/296862a0
更新日期:1982-04-29 00:00:00
abstract::Brosnan and de Waal report that capuchin monkeys show evidence of a sense of fairness or 'inequity aversion' because they rejected a less preferred reward when they saw a partner monkey receive a preferred reward for the same task. However, this does not show that monkeys are averse to inequity, only that they reject ...
journal_title:Nature
pub_type: 评论,杂志文章
doi:10.1038/428140a
更新日期:2004-03-11 00:00:00
abstract::Macrophages are pivotal constituents of the innate immune system, vital for recognition and elimination of microbial pathogens. Macrophages use Toll-like receptors (TLRs) to detect pathogen-associated molecular patterns--including bacterial cell wall components, such as lipopolysaccharide or lipoteichoic acid, and vir...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02405
更新日期:2004-03-18 00:00:00
abstract::The high-resolution seismic imaging of subducted oceanic slabs has become a powerful tool for reconstructing palaeogeography. The images can now be interpreted quantitatively by comparison with models of the general circulation of the Earth's mantle. Here we use a three-dimensional spherical computer model of mantle c...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35012586
更新日期:2000-05-18 00:00:00
abstract::A safe and effective vaccine against COVID-19 is urgently needed in quantities sufficient to immunise large populations. We report the preclinical development of two BNT162b vaccine candidates, which contain lipid-nanoparticle (LNP) formulated nucleoside-modified mRNA encoding SARS-CoV-2 spike glycoprotein-derived imm...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-021-03275-y
更新日期:2021-02-01 00:00:00
abstract::Mycorrhizae, the symbiotic associations of plant roots and fungal hyphae, are classic examples of mutualisms. In these ecologically important associations, the fungi derive photosynthetic sugars from their plant hosts, which in turn benefit from fungus-mediated uptake of mineral nutrients. Early views on the evolution...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35035065
更新日期:2000-09-28 00:00:00
abstract::The major excitatory amino acids, glutamate (Glu) and aspartate (Asp), are thought to act at three receptor subtypes in the mammalian central nervous system (CNS). These are termed quisqualate (QA), N-methyl-D-aspartate (NMDA) and kainate (KA) receptors according to the specific agonist properties of these compounds r...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/317717a0
更新日期:1985-10-24 00:00:00
abstract::While progress in fusion research continues with magnetic and inertial confinement, alternative approaches--such as Coulomb explosions of deuterium clusters and ultrafast laser-plasma interactions--also provide insight into basic processes and technological applications. However, attempts to produce fusion in a room t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03575
更新日期:2005-04-28 00:00:00
abstract::An analysis of 15 protein structures indicates: First, the loss of accessible surface area by monomeric proteins on folding-proportional to hydrophobic energy-is a simple function of molecular weight; second, the proportion of polar groups forming intramolecular hydrogen bonds is constant; and third, protein interiors...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/254304a0
更新日期:1975-03-27 00:00:00
abstract::Since the pioneering work of the Millers it has become clear that most chemical carcinogens require metabolism to reactive electrophiles and then exhibit their carcinogenic potential by reacting chemically with, and modifying, cellular macromolecules. At first modification of proteins was considered most likely to be ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/287244a0
更新日期:1980-09-18 00:00:00
abstract::An Amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-019-1552-1
更新日期:2019-09-01 00:00:00
abstract::Stimuli-responsive hydrogels that undergo abrupt changes in volume in response to external stimuli such as pH, temperature and solvent composition have potential applications in biomedicine and the creation of 'intelligent' materials systems, for example as media for drug delivery, separation processes and protein imm...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/21619
更新日期:1999-06-24 00:00:00
abstract::More than twenty types of retinal ganglion cells conduct visual information from the eye to the rest of the brain. Each retinal ganglion cell type tessellates the retina in a regular mosaic, so that every point in visual space is processed for visual primitives such as contrast and motion. This information flows to tw...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14103
更新日期:2015-03-12 00:00:00
abstract::We have shown previously that chromosome VI of Saccharomyces cerevisiae contains nine origins of DNA replication that differ in initiation frequency and replicate sequentially during the S phase of the cell cycle. Here we show that there are links between activation of these multiple origins and regulation of S-phase ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/27007
更新日期:1998-10-08 00:00:00
abstract::Apoptosis is a highly regulated process that is crucial for normal development and homeostasis of multicellular organisms. The p35 protein from baculoviruses effectively prevents apoptosis by its broad-spectrum caspase inhibition. Here we report the crystal structure of p35 in complex with human caspase-8 at 3.0 A res...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35068604
更新日期:2001-03-22 00:00:00
abstract::The discovery of a plume of water vapour and ice particles emerging from warm fractures ('tiger stripes') in Saturn's small, icy moon Enceladus raised the question of whether the plume emerges from a subsurface liquid source or from the decomposition of ice. Previous compositional analyses of particles injected by the...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10175
更新日期:2011-06-22 00:00:00
abstract::Photosynthetic dinoflagellates are important aquatic primary producers and notorious causes of toxic 'red tides'. Typical dinoflagellate chloroplasts differ from all other plastids in having a combination of three envelope membranes and peridinin-chlorophyll a/c light-harvesting pigments. Despite evidence of a dinofla...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/22099
更新日期:1999-07-08 00:00:00
abstract::More than twelve morphologically and physiologically distinct subtypes of primary somatosensory neuron report salient features of our internal and external environments1-4. It is unclear how specialized gene expression programs emerge during development to endow these subtypes with their unique properties. To assess t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1900-1
更新日期:2020-01-01 00:00:00
abstract::Sex and recombination are widespread, but explaining these phenomena has been one of the most difficult problems in evolutionary biology. Recombination is advantageous when different individuals in a population carry different advantageous alleles. By bringing together advantageous alleles onto the same chromosome, re...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05049
更新日期:2006-09-07 00:00:00
abstract::A temperature sensitive mutant has been isolated for the first time from a replication defective acute leukaemia virus, AEV. In vivo, at 41 degrees C, the mutant shows a reduced leukaemogenic potential. In vitro, in erythroblasts transformed at 35 degrees C, haemoglobin synthesis can be induced by a shift to 41 degree...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/275496a0
更新日期:1978-10-12 00:00:00
abstract::Peroxisomes are among the intracellular organelles of eukaryotic cells that contain specialized sets of enzymes with specific functions. Little is known of membranous components involved in assembly of the intracellular compartments. We isolated two peroxisome-deficient and mutually complementary, Chinese hamster ovar...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/350077a0
更新日期:1991-03-07 00:00:00
abstract::The type I interferon response protects cells against invading viral pathogens. The cellular factors that mediate this defence are the products of interferon-stimulated genes (ISGs). Although hundreds of ISGs have been identified since their discovery more than 25 years ago, only a few have been characterized with res...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09907
更新日期:2011-04-28 00:00:00
abstract::Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis, is a major cause of morbidity and mortality worldwide. Efforts to control it are hampered by difficulties with diagnosis, prevention and treatment. Most people infected with M. tuberculosis remain asymptomatic, termed latent TB, with a 10% lifetim...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09247
更新日期:2010-08-19 00:00:00
abstract::Haematopoiesis is a developmental cascade that generates all blood cell lineages in health and disease. This process relies on quiescent haematopoietic stem cells capable of differentiating, self renewing and expanding upon physiological demand. However, the mechanisms that regulate haematopoietic stem cell homeostasi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13498
更新日期:2014-10-02 00:00:00
abstract::The maternal messenger RNA An3 was originally identified localized to the animal hemisphere of Xenopus laevis oocytes, eggs and early embryos. Xenopus embryos depend on mRNA and protein present in the egg before fertilization (maternal molecules) to provide the information needed for early development. Localization of...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/349717a0
更新日期:1991-02-21 00:00:00
abstract::Cancer somatic mutations can generate neoantigens that distinguish malignant from normal cells. However, the personalized identification and validation of neoantigens remains a major challenge. Here we discover neoantigens in human mantle-cell lymphomas by using an integrated genomic and proteomic strategy that interr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature21433
更新日期:2017-03-30 00:00:00
abstract::Erythropoietin is the primary physiological regulator of erythropoiesis; however, in vitro studies have identified another class of mediators which appear to be important in stimulating erythroid progenitors. These factors have generally been referred to as burst-promoting activities (BPA), because they stimulate the ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/315768a0
更新日期:1985-06-27 00:00:00