当前位置： SCI文献检索 > NATURE期刊下所有文献 > Molecular characterization and expression of the gene encoding human erythroid-potentiating activity.

Molecular characterization and expression of the gene encoding human erythroid-potentiating activity.

Abstract：

:Erythropoietin is the primary physiological regulator of erythropoiesis; however, in vitro studies have identified another class of mediators which appear to be important in stimulating erythroid progenitors. These factors have generally been referred to as burst-promoting activities (BPA), because they stimulate the growth of early erythroid progenitors referred to as burst-forming units-erythroid (BFU-E) which give rise to colonies of up to thousands of haemoglobinized cells. We recently reported purification of a burst-promoting activity from medium conditioned by the Mo T-lymphoblast cell line infected with human T-cell lymphotropic virus type II (HTLV-II). This purified glycoprotein of relative molecular mass (Mr) 28,000 also stimulates colony formation by more mature erythroid precursors (CFU-E) and is therefore referred to as erythroid-potentiating activity (EPA). Purified EPA specifically stimulates human and murine cells of the erythroid lineage, unlike murine interleukin-3 (IL-3) which stimulates precursor cells from all haematopoietic lineages. We report here the isolation of a complementary DNA molecular clone encoding EPA and its use in producing EPA in COS (monkey) cells and CHO (Chinese hamster ovary) cells. We also define the organization of the EPA gene in human DNA.

journal_name

Nature

journal_title

Nature

authors

Gasson JC,Golde DW,Kaufman SE,Westbrook CA,Hewick RM,Kaufman RJ,Wong GG,Temple PA,Leary AC,Brown EL

doi

10.1038/315768a0

subject

Has Abstract,Author List Incomplete

pub_date

1985-06-27 00:00:00

pages

768-71

issue

6022

eissn

0028-0836

issn

1476-4687

journal_volume

315

pub_type

杂志文章

相关文献

NATURE文献大全
  • Noise to order.

    abstract：:Patterns in natural systems abound, from the stripes on a zebra to ripples in a riverbed. In many of these systems, the appearance of an ordered state is not unexpected as the outcome of an underlying ordered process. Thus crystal growth, honeycomb manufacture and floret evolution generate regular and predictable patt...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/35065689

    authors： Shinbrot T,Muzzio FJ

    更新日期：2001-03-08 00:00:00

  • Mastering the game of Go without human knowledge.

    abstract：:A long-standing goal of artificial intelligence is an algorithm that learns, tabula rasa, superhuman proficiency in challenging domains. Recently, AlphaGo became the first program to defeat a world champion in the game of Go. The tree search in AlphaGo evaluated positions and selected moves using deep neural networks....

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature24270

    authors： Silver D,Schrittwieser J,Simonyan K,Antonoglou I,Huang A,Guez A,Hubert T,Baker L,Lai M,Bolton A,Chen Y,Lillicrap T,Hui F,Sifre L,van den Driessche G,Graepel T,Hassabis D

    更新日期：2017-10-18 00:00:00

  • A language-specific comprehension strategy.

    abstract：:Infants acquire whatever language is spoken in the environment into which they are born. The mental capability of the newborn child is not biased in any way towards the acquisition of one human language rather than another. Because psychologists who attempt to model the process of language comprehension are interested...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/304159a0

    authors： Cutler A,Mehler J,Norris D,Segui J

    更新日期：1983-07-14 00:00:00

  • Contour from motion processing occurs in primary visual cortex.

    abstract：:Relative motion is one of the most salient cues for segmentation of a visual scene into separate objects. This is illustrated by the vivid contours that are perceived when random dot patterns move in different directions. Once motion is halted in such displays the segmentation contours disappear. This makes random dot...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/363541a0

    authors： Lamme VA,van Dijk BW,Spekreijse H

    更新日期：1993-06-10 00:00:00

  • Molecular machines: nanomotor rotates microscale objects.

    abstract：:Nanomachines of the future will require molecular-scale motors that can perform work and collectively induce controlled motion of much larger objects. We have designed a synthetic, light-driven molecular motor that is embedded in a liquid-crystal film and can rotate objects placed on the film that exceed the size of t...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/440163a

    authors： Eelkema R,Pollard MM,Vicario J,Katsonis N,Ramon BS,Bastiaansen CW,Broer DJ,Feringa BL

    更新日期：2006-03-09 00:00:00

  • The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1.

    abstract：:Many tyrosine kinases, including the receptors for hormones such as epidermal growth factor (EGF), nerve growth factor and insulin, transmit intracellular signals through Ras proteins. Ligand binding to such receptors stimulates Ras guanine-nucleotide-exchange activity and increases the level of GTP-bound Ras, suggest...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/363083a0

    authors： Rozakis-Adcock M,Fernley R,Wade J,Pawson T,Bowtell D

    更新日期：1993-05-06 00:00:00

  • Chiral selection in poly(C)-directed synthesis of oligo(G).

    abstract：:Theories of the origin of optical asymmetry in living systems place fundamental importance on the amplification of optical asymmetry by an autocatalytic process. The replication of a polynucleotide is one obvious choice for such an autocatalytic growth mechanism. If an optically homogeneous polynucleotide could replic...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/310602a0

    authors： Joyce GF,Visser GM,van Boeckel CA,van Boom JH,Orgel LE,van Westrenen J

    更新日期：1984-08-16 00:00:00

  • Functional contributions of alpha5 subunit to neuronal acetylcholine receptor channels.

    abstract：:Ligand-gated ion channels are multi-subunit complexes where each subunit-type is encoded by several related genes. Heterologous expression of any one of the neuronal nicotinic acetylcholine receptors (nAChR) alpha-type subunits, either alone or with any beta-type subunit, typically yields functional nAChR channels. A ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/380347a0

    authors： Ramirez-Latorre J,Yu CR,Qu X,Perin F,Karlin A,Role L

    更新日期：1996-03-28 00:00:00

  • Blazar spectral variability as explained by a twisted inhomogeneous jet.

    abstract：:Blazars are active galactic nuclei, which are powerful sources of radiation whose central engine is located in the core of the host galaxy. Blazar emission is dominated by non-thermal radiation from a jet that moves relativistically towards us, and therefore undergoes Doppler beaming. This beaming causes flux enhancem...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature24623

    authors： Raiteri CM,Villata M,Acosta-Pulido JA,Agudo I,Arkharov AA,Bachev R,Baida GV,Benítez E,Borman GA,Boschin W,Bozhilov V,Butuzova MS,Calcidese P,Carnerero MI,Carosati D,Casadio C,Castro-Segura N,Chen WP,Damljanovic G,D'

    更新日期：2017-12-21 00:00:00

  • Elevation alters ecosystem properties across temperate treelines globally.

    abstract：:Temperature is a primary driver of the distribution of biodiversity as well as of ecosystem boundaries. Declining temperature with increasing elevation in montane systems has long been recognized as a major factor shaping plant community biodiversity, metabolic processes, and ecosystem dynamics. Elevational gradients,...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature21027

    authors： Mayor JR,Sanders NJ,Classen AT,Bardgett RD,Clément JC,Fajardo A,Lavorel S,Sundqvist MK,Bahn M,Chisholm C,Cieraad E,Gedalof Z,Grigulis K,Kudo G,Oberski DL,Wardle DA

    更新日期：2017-02-02 00:00:00

  • Genetic variants regulating expression levels and isoform diversity during embryogenesis.

    abstract：:Embryonic development is driven by tightly regulated patterns of gene expression, despite extensive genetic variation among individuals. Studies of expression quantitative trait loci (eQTL) indicate that genetic variation frequently alters gene expression in cell-culture models and differentiated tissues. However, the...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature20802

    authors： Cannavò E,Koelling N,Harnett D,Garfield D,Casale FP,Ciglar L,Gustafson HE,Viales RR,Marco-Ferreres R,Degner JF,Zhao B,Stegle O,Birney E,Furlong EE

    更新日期：2017-01-19 00:00:00

  • Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking.

    abstract：:The basolateral amygdala (BLA) has a crucial role in emotional learning irrespective of valence. The BLA projection to the nucleus accumbens (NAc) is thought to modulate cue-triggered motivated behaviours, but our understanding of the interaction between these two brain regions has been limited by the inability to man...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature10194

    authors： Stuber GD,Sparta DR,Stamatakis AM,van Leeuwen WA,Hardjoprajitno JE,Cho S,Tye KM,Kempadoo KA,Zhang F,Deisseroth K,Bonci A

    更新日期：2011-06-29 00:00:00

  • Does Q beta replicase synthesize RNA in the absence of template?

    abstract：:Q beta replicase, in the absence of added template, will synthesize RNA autocatalytically. A variety of small RNa species, termed '6S RNAs' are generated. As this reaction purportedly occurs in the absence of template, it has been termed 'de novo' RNA synthesis. The question of whether Q beta replicase can polymerize ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/301350a0

    authors： Hill D,Blumenthal T

    更新日期：1983-01-27 00:00:00

  • ATP-sensitive K+ channel in the mitochondrial inner membrane.

    abstract：:Mitochondria take up and extrude various inorganic and organic ions, as well as larger substances such as proteins. The technique of patch clamping should provide real-time information on such transport and on energy transduction in oxidative phosphorylation. It has been applied to detect microscopic currents from mit...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/352244a0

    authors： Inoue I,Nagase H,Kishi K,Higuti T

    更新日期：1991-07-18 00:00:00

  • Imprisoned academics, China's Moon lander and AI moral code.

    abstract：: ...

    journal_title：Nature

    pub_type： 新闻

    doi：10.1038/d41586-018-07667-5

    authors：

    更新日期：2018-12-01 00:00:00

  • Ebola virus antibody decay-stimulation in a high proportion of survivors.

    abstract：:Neutralizing antibody function provides a foundation for the efficacy of vaccines and therapies1-3. Here, using a robust in vitro Ebola virus (EBOV) pseudo-particle infection assay and a well-defined set of solid-phase assays, we describe a wide spectrum of antibody responses in a cohort of healthy survivors of the Si...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/s41586-020-03146-y

    authors： Adaken C,Scott JT,Sharma R,Gopal R,Dicks S,Niazi S,Ijaz S,Edwards T,Smith CC,Cole CP,Kamara P,Kargbo O,Doughty HA,van Griensven J,Horby PW,Gevao SM,Sahr F,Ebola-CP Consortium.,Dimelow RJ,Tedder RS,Semple MG,Paxt

    更新日期：2021-01-27 00:00:00

  • Association between GTPase activators for Rho and Ras families.

    abstract：:The ras-related low-molecular-mass GTPases participate in signal transduction involving a variety of cellular functions, including cell-cycle progression, cellular differentiation, cytoskeletal organization, protein transport and secretion. The cycling of these proteins between GTP-bound and GDP-bound states is partia...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/359153a0

    authors： Settleman J,Albright CF,Foster LC,Weinberg RA

    更新日期：1992-09-10 00:00:00

  • Early Pleistocene human occupation at the edge of the boreal zone in northwest Europe.

    abstract：:The dispersal of early humans from Africa by 1.75 Myr ago led to a marked expansion of their range, from the island of Flores in the east to the Iberian peninsula in the west. This range encompassed tropical forest, savannah and Mediterranean habitats, but has hitherto not been demonstrated beyond 45 degrees N. Until ...

    journal_title：Nature

    pub_type： 历史文章,杂志文章

    doi：10.1038/nature09117

    authors： Parfitt SA,Ashton NM,Lewis SG,Abel RL,Coope GR,Field MH,Gale R,Hoare PG,Larkin NR,Lewis MD,Karloukovski V,Maher BA,Peglar SM,Preece RC,Whittaker JE,Stringer CB

    更新日期：2010-07-08 00:00:00

  • Correlation of structural elements and infectivity of the HET-s prion.

    abstract：:Prions are believed to be infectious, self-propagating polymers of otherwise soluble, host-encoded proteins. This concept is now strongly supported by the recent findings that amyloid fibrils of recombinant prion proteins from yeast, Podospora anserina and mammals can induce prion phenotypes in the corresponding hosts...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature03793

    authors： Ritter C,Maddelein ML,Siemer AB,Lührs T,Ernst M,Meier BH,Saupe SJ,Riek R

    更新日期：2005-06-09 00:00:00

  • Multidecadal variability in East African hydroclimate controlled by the Indian Ocean.

    abstract：:The recent decades-long decline in East African rainfall suggests that multidecadal variability is an important component of the climate of this vulnerable region. Prior work based on analysing the instrumental record implicates both Indian and Pacific ocean sea surface temperatures (SSTs) as possible drivers of East ...

    journal_title：Nature

    pub_type： 历史文章,杂志文章

    doi：10.1038/nature11785

    authors： Tierney JE,Smerdon JE,Anchukaitis KJ,Seager R

    更新日期：2013-01-17 00:00:00

  • A living display system resolved pixel by pixel.

    abstract：: ...

    journal_title：Nature

    pub_type： 评论,新闻

    doi：10.1038/d41586-018-05909-0

    authors： Jouary A,Machens CK

    更新日期：2018-10-01 00:00:00

  • p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes.

    abstract：:The tumour suppressor p53 is required to induce programmed cell death (apoptosis) by DNA-damaging agents. As p53 is a transcriptional activator that mediates gene induction after DNA damage, it has been proposed to be a genetic switch that activates apoptosis-mediator genes. Here we evaluate the role of p53 in DNA-dam...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/370220a0

    authors： Caelles C,Helmberg A,Karin M

    更新日期：1994-07-21 00:00:00

  • Aldehyde suppression of copepod recruitment in blooms of a ubiquitous planktonic diatom.

    abstract：:The growth cycle in nutrient-rich, aquatic environments starts with a diatom bloom that ends in mass sinking of ungrazed cells and phytodetritus. The low grazing pressure on these blooms has been attributed to the inability of overwintering copepod populations to track them temporally. We tested an alternative explana...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature02526

    authors： Ianora A,Miralto A,Poulet SA,Carotenuto Y,Buttino I,Romano G,Casotti R,Pohnert G,Wichard T,Colucci-D'Amato L,Terrazzano G,Smetacek V

    更新日期：2004-05-27 00:00:00

  • X-chromosome inactivation may explain the difference in viability of XO humans and mice.

    abstract：:Only about 1% of human XO conceptuses survive to birth and these usually have the characteristics of Turner's syndrome, with a complex and variable phenotype including short stature, gonadal dysgenesis and anatomical defects. Both the embryonic lethality and Turner's syndrome are thought to be due to monosomy for a ge...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/351406a0

    authors： Ashworth A,Rastan S,Lovell-Badge R,Kay G

    更新日期：1991-05-30 00:00:00

  • A genetic basis for familial aggregation in multiple sclerosis. Canadian Collaborative Study Group.

    abstract：:Genetic-environmental interactions probably underlie spontaneous human autoimmune disorders, a category of complex traits thought to include multiple sclerosis (MS). The geographical distribution and familial aggregation of this disease have often been ascribed to the role of infectious agents, but there is no consens...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/377150a0

    authors： Ebers GC,Sadovnick AD,Risch NJ

    更新日期：1995-09-14 00:00:00

  • Transcripts of functionally rearranged gamma genes in primary T cells of adult immunocompetent mice.

    abstract：:The T-cell specific, rearranging gamma-chain genes bear striking resemblance to T-cell receptor and immunoglobulin genes, but the role of gamma remains unknown. A central problem is to understand the conditions under which gamma RNA is expressed in cells. The transcription of gamma is abundant in T cells of fetal thym...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/323635a0

    authors： Jones B,Mjolsness S,Janeway C Jr,Hayday AC

    更新日期：1986-10-16 00:00:00

  • Transient increase in obese gene expression after food intake or insulin administration.

    abstract：:Obesity is a disorder of energy balance, indicating a chronic disequilibrium between energy intake and expenditure. Recently, the mouse ob gene, and subsequently its human and rat homologues, have been cloned. The ob gene product, leptin, is expressed exclusively in adipose tissue, and appears to be a signalling facto...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/377527a0

    authors： Saladin R,De Vos P,Guerre-Millo M,Leturque A,Girard J,Staels B,Auwerx J

    更新日期：1995-10-12 00:00:00

  • Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II.

    abstract：:The RNA polymerase II general transcription factor TFIIH is composed of several polypeptides. The observation that the largest subunit of TFIIH is the excision-repair protein XPB/ERCC3 (ref. 1), a helicase implicated in the human DNA-repair disorders xeroderma pigmentosum (XP) and Cockayne's syndrome, suggests a funct...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/368769a0

    authors： Drapkin R,Reardon JT,Ansari A,Huang JC,Zawel L,Ahn K,Sancar A,Reinberg D

    更新日期：1994-04-21 00:00:00

  • HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase.

    abstract：:SAMHD1, an analogue of the murine interferon (IFN)-γ-induced gene Mg11 (ref. 1), has recently been identified as a human immunodeficiency virus-1 (HIV-1) restriction factor that blocks early-stage virus replication in dendritic and other myeloid cells and is the target of the lentiviral protein Vpx, which can relieve ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature10623

    authors： Goldstone DC,Ennis-Adeniran V,Hedden JJ,Groom HC,Rice GI,Christodoulou E,Walker PA,Kelly G,Haire LF,Yap MW,de Carvalho LP,Stoye JP,Crow YJ,Taylor IA,Webb M

    更新日期：2011-11-06 00:00:00

  • The confinement of Neptune's ring arcs by the moon Galatea.

    abstract：:Neptune has five narrow ring arcs, spanning about 40 degrees in longitude, which are apparently confined against the rapid azimuthal and radial spreading that normally results from inter-particle collisions. A gravitational resonance based on the vertical motion of the nearby neptunian moon Galatea was proposed to exp...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/417045a

    authors： Namouni F,Porco C

    更新日期：2002-05-02 00:00:00