相关文献
NATURE文献大全abstract::Over the past eight hundred thousand years, glacial-interglacial cycles oscillated with a period of one hundred thousand years ('100k world'1). Ice core and ocean sediment data have shown that atmospheric carbon dioxide, Antarctic temperature, deep ocean temperature, and global ice volume correlated strongly with each...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1692-3
更新日期:2019-10-01 00:00:00
abstract::The promoter for a weakly expressed constitutive gene, the lactose repressor gene (lacI), has been sequenced, along with an 'up' promoter mutation Iq. The 10-fold enhancement in I expression found in Iq is the result of a single base change at position -35. To facilitate the sequencing, the lacI gene was cloned in a s...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/274762a0
更新日期:1978-08-24 00:00:00
abstract::In developed societies, chronic diseases such as diabetes, obesity, atherosclerosis and cancer are responsible for most deaths. These ailments have complex causes involving genetic, environmental and nutritional factors. There is evidence that a group of closely related nuclear receptors, called peroxisome proliferato...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/35013000
更新日期:2000-05-25 00:00:00
abstract::The GAL4 protein activates transcription of the genes required for galactose utilization in Saccharomyces cerevisiae. The protein, consisting of 881 amino acids, is dimeric when bound to one of the approximately twofold symmetrical DNA sites present in the galactose upstream activating sequence (UASG). Here we use two...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/356450a0
更新日期:1992-04-02 00:00:00
abstract::The mir-34/449 family consists of six homologous miRNAs at three genomic loci. Redundancy of miR-34/449 miRNAs and their dominant expression in multiciliated epithelia suggest a functional significance in ciliogenesis. Here we report that mice deficient for all miR-34/449 miRNAs exhibited postnatal mortality, infertil...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13413
更新日期:2014-06-05 00:00:00
abstract::Concern about the levels of lead in blood is widespread. There is uncertainty, however, about the relative importance of the various environmental sources. Lead in petrol is widely assumed to be one of the most important sources and air and dust have been identified as the main routes to man. Water is regarded as an i...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/310138a0
更新日期:1984-07-12 00:00:00
abstract::The partial amino-acid sequence of purified human transforming growth factor-beta (TGF-beta) was used to identify a series of cDNA clones encoding the protein. The cDNA sequence indicates that the 112-amino acid monomeric form of the natural TGF-beta homodimer is derived proteolytically from a much longer precursor po...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/316701a0
更新日期:1985-08-22 00:00:00
abstract::Deoxygenated sickle haemoglobin polymerizes into long 210-A diameter fibres that distort and decrease the deformability of red blood cells, and cause sickle cell disease. The fibres consist of seven intertwined double strands. They can form birefringent nematic liquid crystals (tactoids) and spherulites. Rheologically...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/345833a0
更新日期:1990-06-28 00:00:00
abstract::Many collective human activities, including violence, have been shown to exhibit universal patterns. The size distributions of casualties both in whole wars from 1816 to 1980 and terrorist attacks have separately been shown to follow approximate power-law distributions. However, the possibility of universal patterns r...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08631
更新日期:2009-12-17 00:00:00
abstract::It is thought that neutron stars in low-mass binary systems can accrete matter and angular momentum from the companion star and be spun-up to millisecond rotational periods. During the accretion stage, the system is called a low-mass X-ray binary, and bright X-ray emission is observed. When the rate of mass transfer d...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12470
更新日期:2013-09-26 00:00:00
abstract::Past sea-level records provide invaluable information about the response of ice sheets to climate forcing. Some such records suggest that the last deglaciation was punctuated by a dramatic period of sea-level rise, of about 20 metres, in less than 500 years. Controversy about the amplitude and timing of this meltwater...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature10902
更新日期:2012-03-28 00:00:00
abstract::Inhibition of the TOR signalling pathway by genetic or pharmacological intervention extends lifespan in invertebrates, including yeast, nematodes and fruitflies; however, whether inhibition of mTOR signalling can extend lifespan in a mammalian species was unknown. Here we report that rapamycin, an inhibitor of the mTO...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08221
更新日期:2009-07-16 00:00:00
abstract::Protein design provides a rigorous test of our knowledge about proteins and allows the creation of novel enzymes for biotechnological applications. Whereas progress has been made in designing proteins that mimic native proteins structurally, it is more difficult to design functional proteins. In comparison to recent s...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08620
更新日期:2009-12-24 00:00:00
abstract::The discovery of the basis of genetic variation has opened inroads to understanding our history as a species. It has revealed the remarkable genetic similarity we share with other individuals as well as with our closest primate relatives. To understand what make us unique, both as individuals and as a species, we need...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature01400
更新日期:2003-01-23 00:00:00
abstract::Cancers emerge from an ongoing Darwinian evolutionary process, often leading to multiple competing subclones within a single primary tumour. This evolutionary process culminates in the formation of metastases, which is the cause of 90% of cancer-related deaths. However, despite its clinical importance, little is known...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14347
更新日期:2015-04-16 00:00:00
abstract::Protecting the world's freshwater resources requires diagnosing threats over a broad range of scales, from global to local. Here we present the first worldwide synthesis to jointly consider human and biodiversity perspectives on water security using a spatial framework that quantifies multiple stressors and accounts f...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09440
更新日期:2010-09-30 00:00:00
abstract::For many decades comparative analyses of protein sequences and structures have been used to investigate fundamental principles of molecular evolution. In contrast, relatively little is known about the long-term evolution of species' phenotypic and genetic properties. This represents an important gap in our understandi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13827
更新日期:2015-01-15 00:00:00
abstract::Intensive fisheries have reduced fish biodiversity and abundance in aquatic ecosystems worldwide1-3. 'No-take' marine reserves have become a cornerstone of marine ecosystem-based fisheries management4-6, and their benefits for adjacent fisheries are maximized when reserve design fosters synergies among nearby reserves...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2944-y
更新日期:2020-12-01 00:00:00
abstract::The UK Farm-Scale Evaluations (FSE) compared the effects on biodiversity of management of genetically modified herbicide-tolerant (GMHT) spring-sown crops with conventional crop management. The FSE reported larger weed abundance under GMHT management for fodder maize, one of three crops studied. Increased seed product...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02374
更新日期:2004-03-18 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 新闻
doi:10.1038/d41586-018-07372-3
更新日期:2018-12-01 00:00:00
abstract::The heat-shock protein Hsp90 supports diverse but specific signal transducers and lies at the interface of several developmental pathways. We report here that when Drosophila Hsp90 is mutant or pharmacologically impaired, phenotypic variation affecting nearly any adult structure is produced, with specific variants dep...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/24550
更新日期:1998-11-26 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41586-020-2064-8
更新日期:2020-03-01 00:00:00
abstract::The axial relationship between the collagen and mineral componetns in calcified turkey leg tendon was investigated using low-angle X-ray and neutron diffraction. The results indicate that the mineral is arranged with the same axial periodicity as the collagen and occupies the gap region of the collagen structure. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/266421a0
更新日期:1977-03-31 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 社论
doi:10.1038/d41586-018-07151-0
更新日期:2018-10-01 00:00:00
abstract::The biological importance of DNA methylation for gene expression in eukaryotes is becoming increasingly evident, and a direct role of methylation in gene expression has been suggested by an analysis of the infectivity of integrated retroviral genomes in a transfection assay. These studies, however, did not address whe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/304275a0
更新日期:1983-07-21 00:00:00
abstract::The editing of RNA in trypanosomatid mitochondria involves the insertion and occasional deletion of uridine residues within coding regions of maxicircle messenger RNA transcripts. The extent to which the transcripts of homologous genes undergo editing differs in different species. In some, entire genes are edited (pan...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/368345a0
更新日期:1994-03-24 00:00:00
abstract::Cocaine is a powerfully addictive substance and new strategies are needed to treat its abuse. Generating an active immunization to cocaine offers a means of blocking the actions of the drug by preventing it from entering the central nervous system, and should have fewer side effects than treatments based on manipulati...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/378727a0
更新日期:1995-12-14 00:00:00
abstract::High-harmonic generation by focusing a femtosecond laser onto a gas is a well-known method of producing coherent extreme-ultraviolet (EUV) light. This nonlinear conversion process requires high pulse intensities, greater than 10(13) W cm(-2), which are not directly attainable using only the output power of a femtoseco...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07012
更新日期:2008-06-05 00:00:00
abstract::Chromatin reorganization is governed by multiple post-translational modifications of chromosomal proteins and DNA. These histone modifications are reversible, dynamic events that can regulate DNA-driven cellular processes. However, the molecular mechanisms that coordinate histone modification patterns remain largely u...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10656
更新日期:2011-11-27 00:00:00
abstract::Carbonates on large Solar System bodies like Earth and Mars (the latter represented by the meteorite ALH84001) form through the weathering of silicates in a watery (CO3)2- solution. The presence of carbonates in interplanetary dust particles and asteroids (again, represented by meteorites) is not completely understood...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/415295a
更新日期:2002-01-17 00:00:00