Back the idea of human capital with solid research.

abstract：:Clouds on Titan result from the condensation of methane and ethane and, as on other planets, are primarily structured by circulation of the atmosphere. At present, cloud activity mainly occurs in the southern (summer) hemisphere, arising near the pole and at mid-latitudes from cumulus updrafts triggered by surface hea...

journal_title：Nature

authors： Rodriguez S,Le Mouélic S,Rannou P,Tobie G,Baines KH,Barnes JW,Griffith CA,Hirtzig M,Pitman KM,Sotin C,Brown RH,Buratti BJ,Clark RN,Nicholson PD

更新日期：2009-06-04 00:00:00

abstract：:Juxtaposition between endoplasmic reticulum (ER) and mitochondria is a common structural feature, providing the physical basis for intercommunication during Ca(2+) signalling; yet, the molecular mechanisms controlling this interaction are unknown. Here we show that mitofusin 2, a mitochondrial dynamin-related protein ...

journal_title：Nature

authors： de Brito OM,Scorrano L

更新日期：2008-12-04 00:00:00

abstract：:Polycomb group proteins have an essential role in the epigenetic maintenance of repressive chromatin states. The gene-silencing activity of the Polycomb repressive complex 2 (PRC2) depends on its ability to trimethylate lysine 27 of histone H3 (H3K27) by the catalytic SET domain of the EZH2 subunit, and at least two o...

journal_title：Nature

authors： Margueron R,Justin N,Ohno K,Sharpe ML,Son J,Drury WJ 3rd,Voigt P,Martin SR,Taylor WR,De Marco V,Pirrotta V,Reinberg D,Gamblin SJ

更新日期：2009-10-08 00:00:00

abstract：:Molecular cloning and DNA sequencing have yielded considerable structural information about proenkephalin. All previously characterized intermediate peptides of the enkephalin pathways in bovine adrenal medulla have now been aligned into an unambiguous primary structure. Two basic amino acid residues serve as processi...

journal_title：Nature

authors： Gubler U,Seeburg P,Hoffman BJ,Gage LP,Udenfriend S

更新日期：1982-01-21 00:00:00

abstract：:Proteomics, the large-scale analysis of proteins, will contribute greatly to our understanding of gene function in the post-genomic era. Proteomics can be divided into three main areas: (1) protein micro-characterization for large-scale identification of proteins and their post-translational modifications; (2) 'differ...

journal_title：Nature

authors： Pandey A,Mann M

更新日期：2000-06-15 00:00:00

abstract：:We report here the identification of human cell-surface glycoprotein with unusual and interesting properties. We initially detected this glycoprotein on the surface of cultured human haematopoietic cell lines by means of a monoclonal antibody. Although it is expressed on all cultured human haematopoietic cell lines te...

journal_title：Nature

authors： Omary MB,Trowbridge IS,Minowada J

更新日期：1980-08-28 00:00:00

abstract：: ...

journal_title：Nature

authors： Glausiusz J

更新日期：2019-01-01 00:00:00

abstract：:53BP1 governs a specialized, context-specific branch of the classical non-homologous end joining DNA double-strand break repair pathway. Mice lacking 53bp1 (also known as Trp53bp1) are immunodeficient owing to a complete loss of immunoglobulin class-switch recombination1,2, and reduced fidelity of long-range V(D)J rec...

journal_title：Nature

authors： Ghezraoui H,Oliveira C,Becker JR,Bilham K,Moralli D,Anzilotti C,Fischer R,Deobagkar-Lele M,Sanchiz-Calvo M,Fueyo-Marcos E,Bonham S,Kessler BM,Rottenberg S,Cornall RJ,Green CM,Chapman JR

更新日期：2018-08-01 00:00:00

abstract：:Chemokines are chemotactic cytokines that activate and direct the migration of leukocytes. There are two subfamilies, the CXC and the CC chemokines. We recently found that the CXC-chemokine stromal cell-derived factor-1 (SDF-1) is a highly efficacious lymphocyte chemoattractant. Chemokines act on responsive leukocyte ...

journal_title：Nature

authors： Bleul CC,Farzan M,Choe H,Parolin C,Clark-Lewis I,Sodroski J,Springer TA

更新日期：1996-08-29 00:00:00

abstract：:Calcium permeability of basophil and mast cell membranes is stimulated on allergen binding to its specific membrane-bound IgE. This entry of Ca2+ ions into the cell triggers the degranulation and secretion process. Disodium cromoglycate (cromolyn DSCG), the disodium salt of 1,3-bis(-2-carboxychromon-5-yloxy)-2-hydroxy...

journal_title：Nature

authors： Mazurek N,Berger G,Pecht I

更新日期：1980-08-14 00:00:00

abstract：:Networks of interacting proteins orchestrate the responses of living cells to a variety of external stimuli, but how sensitive is the functioning of these protein networks to variations in their biochemical parameters? One possibility is that to achieve appropriate function, the reaction rate constants and enzyme conc...

journal_title：Nature

authors： Alon U,Surette MG,Barkai N,Leibler S

更新日期：1999-01-14 00:00:00

abstract：:The mechanism whereby eukaryotic pre-messenger RNAs are polyadenylated is unknown. Most models for polyadenylation invoke cleavage of precursor transcripts at the site of poly(A) addition followed by polymerization of A residues by poly(A) polymerase. Analysis of the sequences surrounding poly(A) addition sites has id...

journal_title：Nature

authors： Berget SM

更新日期：1984-05-10 00:00:00

abstract：:During the evolution of the beta-globin family gene in vertebrates, different globin genes acquired different developmental patterns of expression. In mammals, specific 'embryonic' beta-like globins are synthesized in the earliest erythroid cells, which differentiate in the yolk sac of the embryo. In most mammals the ...

journal_title：Nature

authors： Chada K,Magram J,Costantini F

更新日期：1986-02-20 00:00:00

abstract：:Mice of the AKR strain are characterised by a high incidence of spontaneous thymic lymphomas. AKR chromosomes contain the genomes of ecotropic murine leukaemia virus (MuLV) at two loci, termed Akv-1 and Akv-2 (refs 2-6). Shortly after birth, the normal tissues of AKR mice begin to produce high levels of this XC-positi...

journal_title：Nature

authors： Rein A,Athan E,Benjers BM,Bassin RH,Gerwin BI,Slocum DR

更新日期：1979-12-13 00:00:00

abstract：:A short, 14-amino-acid segment called SP1, located in the Gag structural protein1, has a critical role during the formation of the HIV-1 virus particle. During virus assembly, the SP1 peptide and seven preceding residues fold into a six-helix bundle, which holds together the Gag hexamer and facilitates the formation o...

journal_title：Nature

authors： Dick RA,Zadrozny KK,Xu C,Schur FKM,Lyddon TD,Ricana CL,Wagner JM,Perilla JR,Ganser-Pornillos BK,Johnson MC,Pornillos O,Vogt VM

更新日期：2018-08-01 00:00:00

abstract：:Thewissen et al. describe new fossils from India that apparently support a phylogeny that places Cetacea (that is, whales, dolphins, porpoises) as the sister group to the extinct family Raoellidae, and Hippopotamidae as more closely related to pigs and peccaries (that is, Suina) than to cetaceans. However, our reanaly...

journal_title：Nature

authors： Geisler JH,Theodor JM

更新日期：2009-03-19 00:00:00

abstract：:Lantibiotics are a class of peptide antibiotics that contain one or more thioether bonds. The lantibiotic nisin is an antimicrobial peptide that is widely used as a food preservative to combat food-borne pathogens. Nisin contains dehydroalanine and dehydrobutyrine residues that are formed by the dehydration of Ser/Thr...

journal_title：Nature

authors： Ortega MA,Hao Y,Zhang Q,Walker MC,van der Donk WA,Nair SK

更新日期：2015-01-22 00:00:00

abstract：:Susceptibility of rodent cells to infection by ecotropic murine leukaemia viruses (MuLV) is determined by binding of the virus envelope to a membrane receptor that has multiple membrane-spanning domains. Cells infected by ecotropic MuLV synthesize envelope protein, gp70, which binds to this receptor, thereby preventin...

journal_title：Nature

authors： Kim JW,Closs EI,Albritton LM,Cunningham JM

更新日期：1991-08-22 00:00:00

abstract：:The Haldane model on a honeycomb lattice is a paradigmatic example of a Hamiltonian featuring topologically distinct phases of matter. It describes a mechanism through which a quantum Hall effect can appear as an intrinsic property of a band structure, rather than being caused by an external magnetic field. Although p...

journal_title：Nature

authors： Jotzu G,Messer M,Desbuquois R,Lebrat M,Uehlinger T,Greif D,Esslinger T

更新日期：2014-11-13 00:00:00

abstract：:Activation of oncogenes by mechanisms other than genetic aberrations such as mutations, translocations, or amplifications is largely undefined. Here we report a novel isoform of the anaplastic lymphoma kinase (ALK) that is expressed in ∼11% of melanomas and sporadically in other human cancer types, but not in normal t...

journal_title：Nature

authors： Wiesner T,Lee W,Obenauf AC,Ran L,Murali R,Zhang QF,Wong EW,Hu W,Scott SN,Shah RH,Landa I,Button J,Lailler N,Sboner A,Gao D,Murphy DA,Cao Z,Shukla S,Hollmann TJ,Wang L,Borsu L,Merghoub T,Schwartz GK,Postow MA

更新日期：2015-10-15 00:00:00

abstract：:X-linked spinal and bulbar muscular atrophy (Kennedy's disease) is an adult-onset form of motorneuron disease which may be associated with signs of androgen insensitivity. We have now investigated whether the androgen receptor gene on the proximal long arm of the X chromosome is a candidate gene for this disease. In p...

journal_title：Nature

authors： La Spada AR,Wilson EM,Lubahn DB,Harding AE,Fischbeck KH

更新日期：1991-07-04 00:00:00

abstract：:Breast cancer patients with the same stage of disease can have markedly different treatment responses and overall outcome. The strongest predictors for metastases (for example, lymph node status and histological grade) fail to classify accurately breast tumours according to their clinical behaviour. Chemotherapy or ho...

journal_title：Nature

authors： van 't Veer LJ,Dai H,van de Vijver MJ,He YD,Hart AA,Mao M,Peterse HL,van der Kooy K,Marton MJ,Witteveen AT,Schreiber GJ,Kerkhoven RM,Roberts C,Linsley PS,Bernards R,Friend SH

更新日期：2002-01-31 00:00:00

abstract：:In Parkinson's disease, brain dopamine neurons degenerate most prominently in the substantia nigra. Neurotrophic factors promote survival, differentiation and maintenance of neurons in developing and adult vertebrate nervous system. The most potent neurotrophic factor for dopamine neurons described so far is the glial...

journal_title：Nature

authors： Lindholm P,Voutilainen MH,Laurén J,Peränen J,Leppänen VM,Andressoo JO,Lindahl M,Janhunen S,Kalkkinen N,Timmusk T,Tuominen RK,Saarma M

更新日期：2007-07-05 00:00:00

abstract：:The global mid-ocean ridge system is the most extensive magmatic system on our planet and is the site of 75 per cent of Earth's volcanism1. The vertical extent of mid-ocean-ridge magmatic systems has been considered to be restricted: even at the ultraslow-spreading Gakkel mid-ocean ridge under the Arctic Ocean, where ...

journal_title：Nature

authors： Bennett EN,Jenner FE,Millet MA,Cashman KV,Lissenberg CJ

更新日期：2019-08-01 00:00:00

abstract：:Plants encounter a myriad of microorganisms, particularly at the root-soil interface, that can invade with detrimental or beneficial outcomes. Prevalent beneficial associations between plants and microorganisms include those that promote plant growth by facilitating the acquisition of limiting nutrients such as nitrog...

journal_title：Nature

authors： Zipfel C,Oldroyd GE

更新日期：2017-03-15 00:00:00

abstract：:To ensure cell survival, it is essential that the ubiquitous pro-apoptotic machinery is kept quiescent. As death is irreversible, cells must continually integrate developmental information with regulatory inputs to control the switch between repressing and activating apoptosis. Inappropriate activation or suppression ...

journal_title：Nature

authors： Bloss TA,Witze ES,Rothman JH

更新日期：2003-08-28 00:00:00

abstract：:Interest in mapping the global distribution of malaria is motivated by a need to define populations at risk for appropriate resource allocation and to provide a robust framework for evaluating its global economic impact. Comparison of older and more recent malaria maps shows how the disease has been geographically res...

journal_title：Nature

authors： Snow RW,Guerra CA,Noor AM,Myint HY,Hay SI

更新日期：2005-03-10 00:00:00

abstract：:Cancer cells hijack and remodel existing metabolic pathways for their benefit. Argininosuccinate synthase (ASS1) is a urea cycle enzyme that is essential in the conversion of nitrogen from ammonia and aspartate to urea. A decrease in nitrogen flux through ASS1 in the liver causes the urea cycle disorder citrullinaemia...

journal_title：Nature

authors： Rabinovich S,Adler L,Yizhak K,Sarver A,Silberman A,Agron S,Stettner N,Sun Q,Brandis A,Helbling D,Korman S,Itzkovitz S,Dimmock D,Ulitsky I,Nagamani SC,Ruppin E,Erez A

更新日期：2015-11-19 00:00:00

abstract：:High-harmonic generation by focusing a femtosecond laser onto a gas is a well-known method of producing coherent extreme-ultraviolet (EUV) light. This nonlinear conversion process requires high pulse intensities, greater than 10(13) W cm(-2), which are not directly attainable using only the output power of a femtoseco...

journal_title：Nature

authors： Kim S,Jin J,Kim YJ,Park IY,Kim Y,Kim SW

更新日期：2008-06-05 00:00:00

abstract：:Elongation factor Tu is present in a fourfold excess over the amount seemingly involved in protein synthesis. It is identical to a major protein which we have found associated with the plasma membrane. The possibility of a specific role in that location is considered. ...

journal_title：Nature

authors： Jacobson GR,Rosenbusch JP

更新日期：1976-05-06 00:00:00