Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy.

abstract：:Viable tumour-derived epithelial cells (circulating tumour cells or CTCs) have been identified in peripheral blood from cancer patients and are probably the origin of intractable metastatic disease. Although extremely rare, CTCs represent a potential alternative to invasive biopsies as a source of tumour tissue for th...

journal_title：Nature

authors： Nagrath S,Sequist LV,Maheswaran S,Bell DW,Irimia D,Ulkus L,Smith MR,Kwak EL,Digumarthy S,Muzikansky A,Ryan P,Balis UJ,Tompkins RG,Haber DA,Toner M

更新日期：2007-12-20 00:00:00

abstract：:Calcium influx through voltage-sensitive Ca2+ channels is the normal physiological stimulus for the activity-dependent release of neurotransmitters at synaptic contacts. It has been postulated that presynaptic inhibition of transmitter release is due to a reduction in Ca2+ influx at the nerve terminal, which could res...

journal_title：Nature

authors： Toth PT,Bindokas VP,Bleakman D,Colmers WF,Miller RJ

更新日期：1993-08-12 00:00:00

abstract：:The crown-of-thorns starfish (COTS, the Acanthaster planci species group) is a highly fecund predator of reef-building corals throughout the Indo-Pacific region. COTS population outbreaks cause substantial loss of coral cover, diminishing the integrity and resilience of reef ecosystems. Here we sequenced genomes of CO...

journal_title：Nature

authors： Hall MR,Kocot KM,Baughman KW,Fernandez-Valverde SL,Gauthier MEA,Hatleberg WL,Krishnan A,McDougall C,Motti CA,Shoguchi E,Wang T,Xiang X,Zhao M,Bose U,Shinzato C,Hisata K,Fujie M,Kanda M,Cummins SF,Satoh N,Degnan SM

更新日期：2017-04-05 00:00:00

abstract：:Rheumatoid arthritis is a chronic autoinflammatory disease that affects 1-2% of the world's population and is characterized by widespread joint inflammation. Interleukin-1 is an important mediator of cartilage destruction in rheumatic diseases, but our understanding of the upstream mechanisms leading to production of ...

journal_title：Nature

authors： Vande Walle L,Van Opdenbosch N,Jacques P,Fossoul A,Verheugen E,Vogel P,Beyaert R,Elewaut D,Kanneganti TD,van Loo G,Lamkanfi M

更新日期：2014-08-07 00:00:00

abstract：:The hot streak-loosely defined as 'winning begets more winnings'-highlights a specific period during which an individual's performance is substantially better than his or her typical performance. Although hot streaks have been widely debated in sports1,2, gambling3-5 and financial markets6,7 over the past several deca...

journal_title：Nature

authors： Liu L,Wang Y,Sinatra R,Giles CL,Song C,Wang D

更新日期：2018-07-01 00:00:00

abstract：:Haemophilia B (Christmas disease) is an inherited, recessive, sex-linked, haemorrhagic condition caused by a defect in the intrinsic clotting factor IX. This disease occurs in males at a frequency of approximately 1 in 30,000. Patients differ in the severity of their clinical symptoms, and variation in the clotting ac...

journal_title：Nature

authors： Rees DJ,Rizza CR,Brownlee GG

更新日期：1985-08-15 00:00:00

abstract：:We describe an integrated physical, genetic and cytogenetic map of human chromosome 16 comprising both a low-resolution megaYAC map and a high-resolution cosmid contig/miniYAC map, which provides nearly complete coverage of the euchromatic arms of the chromosome. The physical map is anchored to a high-resolution cytog...

journal_title：Nature

authors： Doggett NA,Goodwin LA,Tesmer JG,Meincke LJ,Bruce DC,Clark LM,Altherr MR,Ford AA,Chi HC,Marrone BL

更新日期：1995-09-28 00:00:00

abstract：:Methane is a powerful greenhouse gas and is targeted for emissions mitigation by the US state of California and other jurisdictions worldwide1,2. Unique opportunities for mitigation are presented by point-source emitters-surface features or infrastructure components that are typically less than 10 metres in diameter a...

journal_title：Nature

authors： Duren RM,Thorpe AK,Foster KT,Rafiq T,Hopkins FM,Yadav V,Bue BD,Thompson DR,Conley S,Colombi NK,Frankenberg C,McCubbin IB,Eastwood ML,Falk M,Herner JD,Croes BE,Green RO,Miller CE

更新日期：2019-11-01 00:00:00

abstract：:The neurotransmitters glutamate and γ-aminobutyric acid (GABA) transmit synaptic signals by activating fast-acting ligand-gated ion channels and more slowly acting G-protein-coupled receptors (GPCRs). The GPCRs for these neurotransmitters, metabotropic glutamate (mGlu) and GABAB receptors, are atypical GPCRs with a la...

journal_title：Nature

authors： Pin JP,Bettler B

更新日期：2016-12-01 00:00:00

abstract：:Experimental realization of a universal set of quantum logic gates is the central requirement for the implementation of a quantum computer. In an 'all-geometric' approach to quantum computation, the quantum gates are implemented using Berry phases and their non-Abelian extensions, holonomies, from geometric transforma...

journal_title：Nature

authors： Zu C,Wang WB,He L,Zhang WG,Dai CY,Wang F,Duan LM

更新日期：2014-10-02 00:00:00

abstract：:Sleep has been assumed to be necessary for development and to be a vital function in mammals and other animals. However, Lyamin et al. claim that in bottlenose dolphins (Tursiops truncatus) and killer whales (Orcinus orca), neonates and their mothers show almost no sleep behaviour for the first month after birth; this...

journal_title：Nature

authors： Sekiguchi Y,Arai K,Kohshima S

更新日期：2006-06-22 00:00:00

abstract：:Mutants of cdc2+ can disrupt the dependency of S phase on completion of the previous mitosis. By changing the state of p34cdc2 it is possible to reprogramme a cell from entering mitosis to undergoing S phase. This leads to the proposal that the cell cycle can be considered a p34cdc2 cycle, and has implications for the...

journal_title：Nature

authors： Broek D,Bartlett R,Crawford K,Nurse P

更新日期：1991-01-31 00:00:00

abstract：:Acetylcholine (ACh) released on vagal stimulation reduces the heart rate by increasing K+ conductance of pacemaker cells in the sinoatrial (S-A) node. Fluctuation analysis of ACh-activated currents in pacemaker tissue showed this to be due to opening of a separate class of K+ channels gated by muscarinic ACh receptors...

journal_title：Nature

authors： Sakmann B,Noma A,Trautwein W

更新日期：1983-05-19 00:00:00

abstract：:The 2.2 A crystal structure of activated rod transducin, Gt alpha.GTP gamma S, shows the bound GTP gamma S molecule occluded deep in a cleft between a domain structurally homologous to small GTPases and a helical domain unique to heterotrimeric G proteins. The structure, when combined with biochemical and genetic stud...

journal_title：Nature

authors： Noel JP,Hamm HE,Sigler PB

更新日期：1993-12-16 00:00:00

abstract：:Polar molecules have a rich internal structure and long-range dipole-dipole interactions, making them useful for quantum-controlled applications and fundamental investigations. Their potential fully unfolds at ultracold temperatures, where various effects are predicted in many-body physics, quantum information science...

journal_title：Nature

authors： Zeppenfeld M,Englert BG,Glöckner R,Prehn A,Mielenz M,Sommer C,van Buuren LD,Motsch M,Rempe G

更新日期：2012-11-22 00:00:00

abstract：:Short alanine peptides, containing 16 or 17 residues, appear to form alpha-helices in aqueous solution. But the main spectroscopic analyses used on helical peptides (circular dichroism and nuclear magnetic resonance) cannot distinguish between an alpha-helix (in which the ith residue is hydrogen-bonded to residue i + ...

journal_title：Nature

authors： Miick SM,Martinez GV,Fiori WR,Todd AP,Millhauser GL

更新日期：1992-10-15 00:00:00

abstract：:Extracellular signalling by the purine nucleotide ATP has long been associated with sensory function. In the periphery, ATP mediates nociception, mechanosensitivity, thermal sensitivity and O2 chemosensitivity. These processes share a common mechanism that involves the release of ATP to excite afferent fibres via acti...

journal_title：Nature

authors： Gourine AV,Llaudet E,Dale N,Spyer KM

更新日期：2005-07-07 00:00:00

abstract：:Transparent electronic devices formed on flexible substrates are expected to meet emerging technological demands where silicon-based electronics cannot provide a solution. Examples of active flexible applications include paper displays and wearable computers. So far, mainly flexible devices based on hydrogenated amorp...

journal_title：Nature

authors： Nomura K,Ohta H,Takagi A,Kamiya T,Hirano M,Hosono H

更新日期：2004-11-25 00:00:00

abstract：:Regulated fusion of secretory granules with the plasma membrane in secretory cells requires ATP, Ca2+ and cytosolic as well as membrane proteins. ATP-dependent steps in Ca(2+)-activated secretion from PC12 cells require three cytosolic PEP proteins (priming in exocytosis proteins, PEP1-3), the identity of which will p...

journal_title：Nature

authors： Hay JC,Fisette PL,Jenkins GH,Fukami K,Takenawa T,Anderson RA,Martin TF

更新日期：1995-03-09 00:00:00

abstract：:Seismological studies have revealed that a complex texture or heterogeneity exists in the Earth's inner core and at the boundary between core and mantle. These studies highlight the importance of understanding the properties of iron when modelling the composition and dynamics of the core and the interaction of the cor...

journal_title：Nature

authors： Dubrovinsky L,Annersten H,Dubrovinskaia N,Westman F,Harryson H,Fabrichnaya O,Carlson S

更新日期：2001-08-02 00:00:00

abstract：:Disruption of the normal regulation of cell-cycle progression and division lies at the heart of the events leading to cancer. Complex networks of regulatory factors, the tumour microenvironment and stress signals, such as those resulting from damaged DNA, dictate whether cancer cells proliferate or die. Recent progres...

journal_title：Nature

authors： Sawyers C

更新日期：2004-11-18 00:00:00

abstract：:We are in the enviable position of having two distinct drafts of the human genome sequence. Although gaps, errors, redundancy and incomplete annotation mean that individually each falls short of the ideal, many of these problems can be assessed by comparison. Here we present some comparative analyses of these drafts. ...

journal_title：Nature

authors： Aach J,Bulyk ML,Church GM,Comander J,Derti A,Shendure J

更新日期：2001-02-15 00:00:00

abstract：:The metabolic basis of the autosomal recessive disease cystic fibrosis (CF) remains unidentified. Elevated levels of a serum protein in CF homozygotes and obligate heterozygotes have been described. As heterozygotes are clinically unaffected, any consistently observed abnormality in these individuals is a likely point...

journal_title：Nature

authors： Dorin JR,Novak M,Hill RE,Brock DJ,Secher DS,van Heyningen V

更新日期：1987-04-09 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-10-01 00:00:00

abstract：:The architecture of trabecular bone, the porous bone found in the spine and at articulating joints, provides the requirements for optimal load transfer, by pairing suitable strength and stiffness to minimal weight according to rules of mathematical design. But, as it is unlikely that the architecture is fully pre-prog...

journal_title：Nature

authors： Huiskes R,Ruimerman R,van Lenthe GH,Janssen JD

更新日期：2000-06-08 00:00:00

abstract：:The genome of the lower eukaryote Dictyostelium discoideum comprises six chromosomes. Here we report the sequence of the largest, chromosome 2, which at 8 megabases (Mb) represents about 25% of the genome. Despite an A + T content of nearly 80%, the chromosome codes for 2,799 predicted protein coding genes and 73 tran...

journal_title：Nature

authors： Glöckner G,Eichinger L,Szafranski K,Pachebat JA,Bankier AT,Dear PH,Lehmann R,Baumgart C,Parra G,Abril JF,Guigó R,Kumpf K,Tunggal B,Cox E,Quail MA,Platzer M,Rosenthal A,Noegel AA,Dictyostelium Genome Sequencing Consort

更新日期：2002-07-04 00:00:00

abstract：:Interest in attributing the risk of damaging weather-related events to anthropogenic climate change is increasing. Yet climate models used to study the attribution problem typically do not resolve the weather systems associated with damaging events such as the UK floods of October and November 2000. Occurring during t...

journal_title：Nature

authors： Pall P,Aina T,Stone DA,Stott PA,Nozawa T,Hilberts AG,Lohmann D,Allen MR

更新日期：2011-02-17 00:00:00

abstract：:Concentrating urine is mandatory for most mammals to prevent water loss from the body. Concentrated urine is produced in response to vasopressin by the transepithelial recovery of water from the lumen of the kidney collecting tubule through highly water-permeable membranes. In this nephron segment, vasopressin regulat...

journal_title：Nature

authors： Fushimi K,Uchida S,Hara Y,Hirata Y,Marumo F,Sasaki S

更新日期：1993-02-11 00:00:00

abstract：:Because it is so tall, the giraffe, Giraffa camelopardalis, provides an important animal model for investigating adaptive mechanisms to orthostatic (gravitational) pressure changes. Previous physiological studies of the giraffe have concentrated on arterial blood pressures in the heart and neck. Briefly, these investi...

journal_title：Nature

authors： Hargens AR,Millard RW,Pettersson K,Johansen K

更新日期：1987-09-03 00:00:00

abstract：:It is known that glucose-induced depolarization of pancreatic B-cells is due to reduced membrane K+-permeability and is coupled to an increase in the rate of glycolysis, but there has been no direct evidence linking specific metabolic processes or products to the closing of membrane K+ channels. During patch-clamp stu...

journal_title：Nature

authors： Cook DL,Hales CN

更新日期：1984-09-20 00:00:00