Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis.

abstract：:During formation of the neuromuscular junction, acetylcholine receptors in the endplate membrane become metabolically stabilized under neural control, their half-life increasing from about 1 day to about 10 days. The metabolic stability of the receptors is regulated by the electrical activity induced in the muscle by ...

journal_title：Nature

authors： Rotzler S,Schramek H,Brenner HR

更新日期：1991-01-24 00:00:00

abstract：:Complex-oxide materials exhibit a vast range of functional properties desirable for next-generation electronic, spintronic, magnetoelectric, neuromorphic, and energy conversion storage devices1-4. Their physical functionalities can be coupled by stacking layers of such materials to create heterostructures and can be f...

journal_title：Nature

authors： Kum HS,Lee H,Kim S,Lindemann S,Kong W,Qiao K,Chen P,Irwin J,Lee JH,Xie S,Subramanian S,Shim J,Bae SH,Choi C,Ranno L,Seo S,Lee S,Bauer J,Li H,Lee K,Robinson JA,Ross CA,Schlom DG,Rzchowski MS,Eom CB,Kim J

更新日期：2020-02-01 00:00:00

abstract：:On being heated, ice melts into liquid water. Although in practice this process tends to be heterogeneous, it can occur homogeneously inside bulk ice. The thermally induced homogeneous melting of solids is fairly well understood, and involves the formation and growth of melting nuclei. But in the case of water, resili...

journal_title：Nature

authors： Mochizuki K,Matsumoto M,Ohmine I

更新日期：2013-06-20 00:00:00

abstract：:The violation of a Bell inequality is an experimental observation that forces the abandonment of a local realistic viewpoint--namely, one in which physical properties are (probabilistically) defined before and independently of measurement, and in which no physical influence can propagate faster than the speed of light...

journal_title：Nature

authors： Giustina M,Mech A,Ramelow S,Wittmann B,Kofler J,Beyer J,Lita A,Calkins B,Gerrits T,Nam SW,Ursin R,Zeilinger A

更新日期：2013-05-09 00:00:00

abstract：:IgE and its receptors are believed to have evolved as a mechanism to protect mammals against parasites. But other and intrinsically innocuous antigens can subvert this system to provoke an allergic response. For human populations in industrialized countries, allergy and asthma now represent a far greater threat than p...

journal_title：Nature

authors： Sutton BJ,Gould HJ

更新日期：1993-12-02 00:00:00

abstract：:Explaining the large-scale diversity of soil organisms that drive biogeochemical processes-and their responses to environmental change-is critical. However, identifying consistent drivers of belowground diversity and abundance for some soil organisms at large spatial scales remains problematic. Here we investigate a m...

journal_title：Nature

authors： van der Linde S,Suz LM,Orme CDL,Cox F,Andreae H,Asi E,Atkinson B,Benham S,Carroll C,Cools N,De Vos B,Dietrich HP,Eichhorn J,Gehrmann J,Grebenc T,Gweon HS,Hansen K,Jacob F,Kristöfel F,Lech P,Manninger M,Martin J

更新日期：2018-06-01 00:00:00

abstract：:Japan's Ministry of Health will fund a major new heart transplantation project in an effort to resume heart transplants halted by a public outcry against the first such transplant 17 years ago. Opposition to organ donation, which has been attributed variously to Buddhist and Confucian views of the body and to Japanes...

journal_title：Nature

authors： Anderson A

更新日期：1985-01-31 00:00:00

abstract：:Alternative splicing of pre-messenger RNAs diversifies gene products in eukaryotes and is guided by factors that enable spliceosomes to recognize particular splice sites. Here we report that alternative splicing of Saccharomyces cerevisiae SRC1 pre-mRNA is promoted by the conserved ubiquitin-like protein Hub1. Structu...

journal_title：Nature

authors： Mishra SK,Ammon T,Popowicz GM,Krajewski M,Nagel RJ,Ares M Jr,Holak TA,Jentsch S

更新日期：2011-05-25 00:00:00

abstract：:In vitro studies of muscle mitochondrial metabolism in patients with mitochondrial myopathy have identified a variety of functional defects of the mitochondrial respiratory chain, predominantly affecting complex I (NADH-CoQ reductase) or complex III (ubiquinol-cytochrome c reductase) in adult cases. These two enzymes ...

journal_title：Nature

authors： Holt IJ,Harding AE,Morgan-Hughes JA

更新日期：1988-02-25 00:00:00

abstract：:The function and nature of inhibition of neurons in the visual cortex have been the focus of both experimental and theoretical investigations. There are two ways in which inhibition can suppress synaptic excitation. In hyperpolarizing inhibition, negative and positive currents sum linearly to produce a net change in m...

journal_title：Nature

authors： Borg-Graham LJ,Monier C,Frégnac Y

更新日期：1998-05-28 00:00:00

abstract：:The classical strength profile of continents is derived from a quasi-static view of their rheological response to stress--one that does not consider dynamic interactions between brittle and ductile layers. Such interactions result in complexities of failure in the brittle-ductile transition and the need to couple ener...

journal_title：Nature

authors： Regenauer-Lieb K,Weinberg RF,Rosenbaum G

更新日期：2006-07-06 00:00:00

abstract：:Members of the Hedgehog family of secreted proteins control a number of important inductive interactions in the development of both vertebrates and Drosophila, but little is known about the ways in which their signalling activities are transduced. In Drosophila, hedgehog is one of the segment-polarity genes, mutations...

journal_title：Nature

authors： van den Heuvel M,Ingham PW

更新日期：1996-08-08 00:00:00

abstract：:Major depressive disorder (MDD), one of the most frequently encountered forms of mental illness and a leading cause of disability worldwide, poses a major challenge to genetic analysis. To date, no robustly replicated genetic loci have been identified, despite analysis of more than 9,000 cases. Here, using low-coverag...

journal_title：Nature

authors： CONVERGE consortium.

更新日期：2015-07-30 00:00:00

abstract：:Rivers sourced in the Himalayan mountain range carry some of the largest sediment loads on the planet, yet coarse gravel in these rivers vanishes within approximately 10-40 kilometres on entering the Ganga Plain (the part of the North Indian River Plain containing the Ganges River). Understanding the fate of gravel is...

journal_title：Nature

authors： Dingle EH,Attal M,Sinclair HD

更新日期：2017-04-26 00:00:00

abstract：:The canonical Wnt/β-catenin signalling pathway governs diverse developmental, homeostatic and pathological processes. Palmitoylated Wnt ligands engage cell-surface frizzled (FZD) receptors and LRP5 and LRP6 co-receptors, enabling β-catenin nuclear translocation and TCF/LEF-dependent gene transactivation. Mutations in ...

journal_title：Nature

authors： Yan KS,Janda CY,Chang J,Zheng GXY,Larkin KA,Luca VC,Chia LA,Mah AT,Han A,Terry JM,Ootani A,Roelf K,Lee M,Yuan J,Li X,Bolen CR,Wilhelmy J,Davies PS,Ueno H,von Furstenberg RJ,Belgrader P,Ziraldo SB,Ordonez H,H

更新日期：2017-05-11 00:00:00

abstract：:Calcium signalling in astrocytes couples changes in neural activity to alterations in cerebral blood flow by eliciting vasoconstriction or vasodilation of arterioles. However, the mechanism for how these opposite astrocyte influences provide appropriate changes in vessel tone within an environment that has dynamic met...

journal_title：Nature

authors： Gordon GR,Choi HB,Rungta RL,Ellis-Davies GC,MacVicar BA

更新日期：2008-12-11 00:00:00

abstract：:Haploids and double haploids are important resources for studying recessive traits and have large impacts on crop breeding, but natural haploids are rare in animals. Mammalian haploids are restricted to germline cells and are occasionally found in tumours with massive chromosome loss. Recent success in establishing ha...

journal_title：Nature

authors： Li W,Shuai L,Wan H,Dong M,Wang M,Sang L,Feng C,Luo GZ,Li T,Li X,Wang L,Zheng QY,Sheng C,Wu HJ,Liu Z,Liu L,Wang L,Wang XJ,Zhao XY,Zhou Q

更新日期：2012-10-18 00:00:00

abstract：:The foundation of western civilization owes much to the high fertility of bread wheat, which results from the stability of its polyploid genome. Despite possessing multiple sets of related chromosomes, hexaploid (bread) and tetraploid (pasta) wheat both behave as diploids at meiosis. Correct pairing of homologous chro...

journal_title：Nature

authors： Griffiths S,Sharp R,Foote TN,Bertin I,Wanous M,Reader S,Colas I,Moore G

更新日期：2006-02-09 00:00:00

abstract：:Atrial extracts contain factors which induce potent natriuresis changes in renal haemodynamics, and relax pre-contracted vascular smooth muscle. Low-molecular-weight peptides which mimic these actions have now been purified by several groups, including ours (see accompanying paper), and higher-molecular-weight protein...

journal_title：Nature

authors： Yamanaka M,Greenberg B,Johnson L,Seilhamer J,Brewer M,Friedemann T,Miller J,Atlas S,Laragh J,Lewicki J

更新日期：1984-06-21 00:00:00

abstract：:Calcium-dependent protease (calcium protease) is apparently involved in a variety of cellular processes. Here we have attempted to clarify the role and regulatory mechanism of calcium protease by analysing its structure. The complete primary structure of calcium protease (relative molecular mass (Mr) 80,000 (80K), 705...

journal_title：Nature

authors： Ohno S,Emori Y,Imajoh S,Kawasaki H,Kisaragi M,Suzuki K

更新日期：1984-12-06 00:00:00

abstract：:An outstanding question is how cells control the number and size of membrane organelles. The small GTPase Rab5 has been proposed to be a master regulator of endosome biogenesis. Here, to test this hypothesis, we developed a mathematical model of endosome dependency on Rab5 and validated it by titrating down all three ...

journal_title：Nature

authors： Zeigerer A,Gilleron J,Bogorad RL,Marsico G,Nonaka H,Seifert S,Epstein-Barash H,Kuchimanchi S,Peng CG,Ruda VM,Del Conte-Zerial P,Hengstler JG,Kalaidzidis Y,Koteliansky V,Zerial M

更新日期：2012-05-23 00:00:00

abstract：: ...

journal_title：Nature

authors： Hills R,Kulkarni G,Meerburg PD,Puchwein E

更新日期：2018-12-01 00:00:00

abstract：:Crystal structures of insulin have been determined in various distinct forms, the relevance of which to receptor recognition has long been the subject of speculation. Recently the crystal structure of an inactive insulin analogue has been determined and, surprisingly, found to have a conformation identical to native i...

journal_title：Nature

authors： Hua QX,Shoelson SE,Kochoyan M,Weiss MA

更新日期：1991-11-21 00:00:00

abstract：:The cyclin-dependent kinases 4 and 6 (Cdk4/6) that control the G1 phase of the cell cycle and their inhibitor, the p16INK4a tumour suppressor, have a central role in cell proliferation and in tumorigenesis. The structures of Cdk6 bound to p16INK4a and to the related p19INK4d reveal that the INK4 inhibitors bind next t...

journal_title：Nature

authors： Russo AA,Tong L,Lee JO,Jeffrey PD,Pavletich NP

更新日期：1998-09-17 00:00:00

abstract：:Mechanical milling is an effective technique for the preparation of fine metallic and ceramic powders and can also be used to drive a wide range of chemical reactions. Milling devices include planetary machines, attritors and vibrational mills; products include amorphous, nanocrystalline and quasicrystalline materials...

journal_title：Nature

authors： Calka A,Wexler D

更新日期：2002-09-12 00:00:00

abstract：:Microbiome-wide association studies have established that numerous diseases are associated with changes in the microbiota. These studies typically generate a long list of commensals implicated as biomarkers of disease, with no clear relevance to disease pathogenesis. If the field is to move beyond correlations and beg...

journal_title：Nature

authors： Surana NK,Kasper DL

更新日期：2017-12-14 00:00:00

abstract：:Clonal deletion in the thymus plays a major part in T-cell tolerance to self antigens. But the mechanism of negative selection, its fine specificity and the threshold of affinity and avidity remains unknown. We have now examined these aspects of negative selection with mice expressing a transgenic T-cell receptor with...

journal_title：Nature

authors： Pircher H,Rohrer UH,Moskophidis D,Zinkernagel RM,Hengartner H

更新日期：1991-06-06 00:00:00

abstract：:The current picture of galaxy evolution advocates co-evolution of galaxies and their nuclear massive black holes, through accretion and galactic merging. Pairs of quasars, each with a massive black hole at the centre of its galaxy, have separations of 6,000 to 300,000 light years (refs 2 and 3; 1 parsec = 3.26 light y...

journal_title：Nature

authors： Fabbiano G,Wang J,Elvis M,Risaliti G

更新日期：2011-08-31 00:00:00

abstract：:The uranyl ion (UO22+; U(VI) oxidation state) is the most common form of uranium found in terrestrial and aquatic environments and is a central component in nuclear fuel processing and waste remediation efforts. Uranyl capture from either seawater or nuclear waste has been well studied and typically relies on extremel...

journal_title：Nature

authors： Keener M,Hunt C,Carroll TG,Kampel V,Dobrovetsky R,Hayton TW,Ménard G

更新日期：2020-01-01 00:00:00

abstract：:The presence of homoeo box sequences in the genomes of vertebrates has suggested that these metazoans possess the equivalent of the homoeotic genes that have a key role in regulating the development of the fruitfly Drosophila melanogaster. We report here that a novel murine homoeo box-containing gene is expressed in e...

journal_title：Nature

authors： Colberg-Poley AM,Voss SD,Chowdhury K,Gruss P

更新日期：1985-04-25 00:00:00