Evolutionary origin of a calcium-dependent protease by fusion of genes for a thiol protease and a calcium-binding protein?

abstract：:Ecdysone in Drosophila has been a paradigm for steroid hormones since its ability to induce gene activity directly was demonstrated by its effects on moulting and polytene chromosome puffing. The ecdysone receptor (EcR) was recently confirmed as a member of the nuclear receptor superfamily by cloning and characterizat...

journal_title：Nature

authors： Thomas HE,Stunnenberg HG,Stewart AF

更新日期：1993-04-01 00:00:00

abstract：:Although cell adhesion to substrate must ultimately depend on 'sticking' by physical forces at the outer surface, we suggest that control is exercised through the 'grip' of the cytoskeleton. Our experiments indicate that grip can be relaxed by agents which release surface glycoproteins from some form of side-to-side o...

journal_title：Nature

authors： Rees DA,Lloyd CW,Thom D

更新日期：1977-05-12 00:00:00

abstract：:Little is known about the biochemical or functional nature of the proteins encoded by the bcl-2 gene, which undergoes chromosomal translocation in approximately 85% of follicular lymphoma, 20% of diffuse large cell lymphoma and 10% of chronic lymphocytic leukaemia of B cells. Translocation of bcl-2 sequences from chro...

journal_title：Nature

authors： Haldar S,Beatty C,Tsujimoto Y,Croce CM

更新日期：1989-11-09 00:00:00

abstract：:OTULIN (OTU deubiquitinase with linear linkage specificity) removes linear polyubiquitin from proteins that have been modified by LUBAC (linear ubiquitin chain assembly complex) and is critical for preventing auto-inflammatory disease1,2 and embryonic lethality during mouse development3. Here we show that OTULIN promo...

journal_title：Nature

authors： Heger K,Wickliffe KE,Ndoja A,Zhang J,Murthy A,Dugger DL,Maltzman A,de Sousa E Melo F,Hung J,Zeng Y,Verschueren E,Kirkpatrick DS,Vucic D,Lee WP,Roose-Girma M,Newman RJ,Warming S,Hsiao YC,Kőműves LG,Webster JD,Newto

更新日期：2018-07-01 00:00:00

abstract：:It is of fundamental importance to establish whether there is a limit to how thin a superconducting wire can be, while retaining its superconducting character--and if there is a limit, to determine what sets it. This issue may also be of practical importance in defining the limit to miniaturization of superconducting ...

journal_title：Nature

authors： Bezryadin A,Lau CN,Tinkham M

更新日期：2000-04-27 00:00:00

abstract：:Caste differentiation and division of labour are the hallmarks of insect societies and at the root of their ecological success. Kin selection predicts that caste determination should result from environmentally induced differences in gene expression, a prediction largely supported by empirical data. However, two excep...

journal_title：Nature

authors： Helms Cahan S,Keller L

更新日期：2003-07-17 00:00:00

abstract：:Nanomachines of the future will require molecular-scale motors that can perform work and collectively induce controlled motion of much larger objects. We have designed a synthetic, light-driven molecular motor that is embedded in a liquid-crystal film and can rotate objects placed on the film that exceed the size of t...

journal_title：Nature

authors： Eelkema R,Pollard MM,Vicario J,Katsonis N,Ramon BS,Bastiaansen CW,Broer DJ,Feringa BL

更新日期：2006-03-09 00:00:00

abstract：:Organ-specific metastasis is governed, in part, by interactions between chemokine receptors on cancer cells and matching chemokines in target organs. For example, malignant breast cancer cells express the chemokine receptor CXCR4 and commonly metastasize to organs that are an abundant source of the CXCR4-specific liga...

journal_title：Nature

authors： Staller P,Sulitkova J,Lisztwan J,Moch H,Oakeley EJ,Krek W

更新日期：2003-09-18 00:00:00

abstract：:In influenza the combined virus-bacterial pneumonia is approximately three times more common than primary viral pneumonia. The bacteria most commonly involved are Staphylococcus aureus, Streptococcus pneumoniae and Haemophilus influenzae. S. aureus co-infection is reported to have a fatality rate of up to 42% (ref. 2)...

journal_title：Nature

authors： Tashiro M,Ciborowski P,Klenk HD,Pulverer G,Rott R

更新日期：1987-02-05 00:00:00

abstract：:The preparation of synthetic molecules showing the remarkable efficiencies characteristic of natural biopolymer catalysts remains a formidable challenge for chemical biology. Although significant advances have been made in the understanding of protein structure and function, the de novo construction of such systems re...

journal_title：Nature

authors： Severin K,Lee DH,Kennan AJ,Ghadiri MR

更新日期：1997-10-16 00:00:00

abstract：:Plasticity in neural circuits can result from alterations in synaptic strength or connectivity, as well as from changes in the excitability of the neurons themselves. To better understand the role of plasticity in the brain, we need to establish how brain circuits work and the kinds of computations that different circ...

journal_title：Nature

authors： Destexhe A,Marder E

更新日期：2004-10-14 00:00:00

abstract：:Nanofabrication strategies are becoming increasingly expensive and equipment-intensive, and consequently less accessible to researchers. As an alternative, scanning probe lithography has become a popular means of preparing nanoscale structures, in part owing to its relatively low cost and high resolution, and a regist...

journal_title：Nature

authors： Shim W,Braunschweig AB,Liao X,Chai J,Lim JK,Zheng G,Mirkin CA

更新日期：2011-01-27 00:00:00

abstract：:Juxtaposition between endoplasmic reticulum (ER) and mitochondria is a common structural feature, providing the physical basis for intercommunication during Ca(2+) signalling; yet, the molecular mechanisms controlling this interaction are unknown. Here we show that mitofusin 2, a mitochondrial dynamin-related protein ...

journal_title：Nature

authors： de Brito OM,Scorrano L

更新日期：2008-12-04 00:00:00

abstract：:Chick embryo fibroblasts (CEF) infected with avian sarcoma virus become rapidly transformed as a result of expression of the viral src gene in the form of a single polypeptide of molecular weight 60,000 (pp60src) with protein kinase activity and suggested preferential association with the plasma membrane. Studies with...

journal_title：Nature

authors： Witt DP,Gordon JA

更新日期：1980-09-18 00:00:00

abstract：:Planetary formation theories suggest that the giant planets formed on circular and coplanar orbits. The eccentricities of Jupiter, Saturn and Uranus, however, reach values of 6 per cent, 9 per cent and 8 per cent, respectively. In addition, the inclinations of the orbital planes of Saturn, Uranus and Neptune take maxi...

journal_title：Nature

authors： Tsiganis K,Gomes R,Morbidelli A,Levison HF

更新日期：2005-05-26 00:00:00

abstract：:Fluctuations in the counting rate of photons originating from uncorrelated point sources become, within the coherently illuminated area, slightly enhanced compared to a random sequence of classical particles. This phenomenon, known in astronomy as the Hanbury Brown-Twiss effect, is a consequence of quantum interferenc...

journal_title：Nature

authors： Kiesel H,Renz A,Hasselbach F

更新日期：2002-07-25 00:00:00

abstract：:Bacteria living within eukaryotic cells can be essential for the survival or reproduction of the host but in other cases are among the most successful pathogens. Environmental Chlamydiae, including strain UWE25, thrive as obligate intracellular symbionts within protozoa; are recently discovered relatives of major bact...

journal_title：Nature

authors： Haferkamp I,Schmitz-Esser S,Linka N,Urbany C,Collingro A,Wagner M,Horn M,Neuhaus HE

更新日期：2004-12-02 00:00:00

abstract：:Only 10 different V beta gene segments were found when the sequences of 15 variable (V beta) genes of the mouse T-cell receptor were examined. From this analysis we calculate that the total number of expressed V beta gene segments may be 21 or fewer, which makes the expressed germline V beta repertoire much smaller th...

journal_title：Nature

authors： Barth RK,Kim BS,Lan NC,Hunkapiller T,Sobieck N,Winoto A,Gershenfeld H,Okada C,Hansburg D,Weissman IL

更新日期：1985-08-08 00:00:00

abstract：:Large-scale chromosome structure and spatial nuclear arrangement have been linked to control of gene expression and DNA replication and repair. Genomic techniques based on chromosome conformation capture (3C) assess contacts for millions of loci simultaneously, but do so by averaging chromosome conformations from mill...

journal_title：Nature

authors： Nagano T,Lubling Y,Stevens TJ,Schoenfelder S,Yaffe E,Dean W,Laue ED,Tanay A,Fraser P

更新日期：2013-10-03 00:00:00

abstract：:Sodium channels in plasma membranes can be blocked by a large variety of toxins and local anaesthetics. This property, however, is not confined to relatively large molecules. For instance, extracellularly applied small ions like hydrogen may also prevent the passive transport of permeant cations across open Na+ channe...

journal_title：Nature

authors： Wanke E,Carbone E,Testa PL

更新日期：1980-09-04 00:00:00

abstract：:A grand challenge of systems biology is to predict the kinetic responses of living systems to perturbations starting from the underlying molecular interactions. Changes in the nutrient environment have long been used to study regulation and adaptation phenomena in microorganisms and they remain a topic of active inves...

journal_title：Nature

authors： Erickson DW,Schink SJ,Patsalo V,Williamson JR,Gerland U,Hwa T

更新日期：2017-11-02 00:00:00

abstract：:Cutaneous malignant melanoma is a highly aggressive and frequently chemoresistant cancer, the incidence of which continues to rise. Epidemiological studies show that the major aetiological melanoma risk factor is ultraviolet (UV) solar radiation, with the highest risk associated with intermittent burning doses, especi...

journal_title：Nature

authors： Zaidi MR,Davis S,Noonan FP,Graff-Cherry C,Hawley TS,Walker RL,Feigenbaum L,Fuchs E,Lyakh L,Young HA,Hornyak TJ,Arnheiter H,Trinchieri G,Meltzer PS,De Fabo EC,Merlino G

更新日期：2011-01-27 00:00:00

abstract：:DNA lesions interfere with DNA and RNA polymerase activity. Cyclobutane pyrimidine dimers and photoproducts generated by ultraviolet irradiation cause stalling of RNA polymerase II, activation of transcription-coupled repair enzymes, and inhibition of RNA synthesis. During the S phase of the cell cycle, collision of r...

journal_title：Nature

authors： Kruhlak M,Crouch EE,Orlov M,Montaño C,Gorski SA,Nussenzweig A,Misteli T,Phair RD,Casellas R

更新日期：2007-06-07 00:00:00

abstract：:The genetic architecture of brain structure and function is largely unknown. To investigate this, we carried out genome-wide association studies of 3,144 functional and structural brain imaging phenotypes from UK Biobank (discovery dataset 8,428 subjects). Here we show that many of these phenotypes are heritable. We i...

journal_title：Nature

authors： Elliott LT,Sharp K,Alfaro-Almagro F,Shi S,Miller KL,Douaud G,Marchini J,Smith SM

更新日期：2018-10-01 00:00:00

abstract：:Oxygenic photosynthesis in plants, algae and cyanobacteria is initiated at photosystem II, a homodimeric multisubunit protein-cofactor complex embedded in the thylakoid membrane. Photosystem II captures sunlight and powers the unique photo-induced oxidation of water to atmospheric oxygen. Crystallographic investigatio...

journal_title：Nature

authors： Loll B,Kern J,Saenger W,Zouni A,Biesiadka J

更新日期：2005-12-15 00:00:00

abstract：:Fossil dinosaur embryos are surprisingly rare, being almost entirely restricted to Upper Cretaceous strata that record the late stages of non-avian dinosaur evolution. Notable exceptions are the oldest known embryos from the Early Jurassic South African sauropodomorph Massospondylus and Late Jurassic embryos of a ther...

journal_title：Nature

authors： Reisz RR,Huang TD,Roberts EM,Peng S,Sullivan C,Stein K,LeBlanc AR,Shieh D,Chang R,Chiang C,Yang C,Zhong S

更新日期：2013-04-11 00:00:00

abstract：:Cryptochromes are blue/ultraviolet-A light receptors that mediate various light responses in plants and animals. But the initial photochemical reaction of cryptochrome is still unclear. For example, although most photoreceptors are known to undergo light-dependent protein modification such as phosphorylation, no blue-...

journal_title：Nature

authors： Shalitin D,Yang H,Mockler TC,Maymon M,Guo H,Whitelam GC,Lin C

更新日期：2002-06-13 00:00:00

abstract：:In neuronal cells, opioid peptides and opiates inhibit neurotransmitter release, which is a calcium-dependent process. They also inhibit adenylyl cyclase, presumably via the membrane signal-transducing component, Gi, a guanine nucleotide-binding protein (G-protein). No causal relationship between these two events has ...

journal_title：Nature

authors： Hescheler J,Rosenthal W,Trautwein W,Schultz G

更新日期：1987-01-29 00:00:00

abstract：:When a force deforms an elastic object, practical experience suggests that the resulting displacement will be in the same direction as the force. This property is known as positive stiffness. Less familiar is the concept of negative stiffness, where the deforming force and the resulting displacement are in opposite di...

journal_title：Nature

authors： Lakes RS,Lee T,Bersie A,Wang YC

更新日期：2001-03-29 00:00:00

abstract：:Haptic (touch) perception normally entails an active exploration of object surfaces over time. This is called active touch. When exploring the shape of an object, we experience both geometrical and force cues. For example, when sliding a finger across a surface with a rigid bump on it, the finger moves over the bump w...

journal_title：Nature

authors： Robles-De-La-Torre G,Hayward V

更新日期：2001-07-26 00:00:00