Genome-wide association studies of brain imaging phenotypes in UK Biobank.

abstract：:N-glycosylation of proteins in the endoplasmic reticulum (ER) has a central role in protein quality control. Here we report that N-glycan serves as a signal for degradation by the Skp1-Cullin1-Fbx2-Roc1 (SCF(Fbx2)) ubiquitin ligase complex. The F-box protein Fbx2 (ref. 4) binds specifically to proteins attached to N-l...

journal_title：Nature

authors： Yoshida Y,Chiba T,Tokunaga F,Kawasaki H,Iwai K,Suzuki T,Ito Y,Matsuoka K,Yoshida M,Tanaka K,Tai T

更新日期：2002-07-25 00:00:00

abstract：:The advent of endothermy, which is achieved through the continuous homeostatic regulation of body temperature and metabolism1,2, is a defining feature of mammalian and avian evolution. However, when challenged by food deprivation or harsh environmental conditions, many mammalian species initiate adaptive energy-conser...

journal_title：Nature

authors： Hrvatin S,Sun S,Wilcox OF,Yao H,Lavin-Peter AJ,Cicconet M,Assad EG,Palmer ME,Aronson S,Banks AS,Griffith EC,Greenberg ME

更新日期：2020-07-01 00:00:00

abstract：:Locomotion relies on neural networks called central pattern generators (CPGs) that generate periodic motor commands for rhythmic movements. In vertebrates, the excitatory synaptic drive for inducing the spinal CPG can originate from either supraspinal glutamatergic inputs or from within the spinal cord. Here we identi...

journal_title：Nature

authors： Wyart C,Del Bene F,Warp E,Scott EK,Trauner D,Baier H,Isacoff EY

更新日期：2009-09-17 00:00:00

abstract：:The ice-rich surface of the jovian satellite Europa is sparsely cratered, suggesting that this moon might be geologically active today. Moreover, models of the satellite's interior indicate that tidal interactions with Jupiter might produce enough heat to maintain a subsurface liquid water layer. But the mechanisms of...

journal_title：Nature

authors： Pappalardo RT,Head JW,Greeley R,Sullivan RJ,Pilcher C,Schubert G,Moore WB,Carr MH,Moore JM,Belton MJ,Goldsby DL

更新日期：1998-01-22 00:00:00

abstract：:Nanofabrication strategies are becoming increasingly expensive and equipment-intensive, and consequently less accessible to researchers. As an alternative, scanning probe lithography has become a popular means of preparing nanoscale structures, in part owing to its relatively low cost and high resolution, and a regist...

journal_title：Nature

authors： Shim W,Braunschweig AB,Liao X,Chai J,Lim JK,Zheng G,Mirkin CA

更新日期：2011-01-27 00:00:00

abstract：:Quasicrystals are unique structures with long-range order but no periodicity. Their properties have intrigued scientists ever since their discovery and initial theoretical analysis. The lack of periodicity excludes the possibility of describing quasicrystal structures with well-established analytical tools, including ...

journal_title：Nature

authors： Freedman B,Bartal G,Segev M,Lifshitz R,Christodoulides DN,Fleischer JW

更新日期：2006-04-27 00:00:00

abstract：:The combination of complementary DNA expression and single-channel current analysis provides a powerful tool for studying the structure-function relationship of the nicotinic acetylcholine receptor (AChR) (refs 1-5). We have previously shown that AChR channels consisting of subunits from different species, expressed i...

journal_title：Nature

authors： Imoto K,Methfessel C,Sakmann B,Mishina M,Mori Y,Konno T,Fukuda K,Kurasaki M,Bujo H,Fujita Y

更新日期：1986-12-18 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-11-01 00:00:00

abstract：:An attempt is made to understand the characteristics of pulsar slowdown in terms of various possible emission mechanisms. Though magnetic-dipole radiation seems to be dominant, the deviations from a pure dipolar decay are large compared with errors in measurement and indicate the presence of more complicated braking m...

journal_title：Nature

authors： Papaliolios C,Carleton NP,Horowitz P

更新日期：1970-10-31 00:00:00

abstract：:An amino acid sequence analysis of the N-terminal immunoglobulin heavy and light chain variable regions (VH and VL) from 16 hybridoma proteins which bind phosphorylcholine as well as the complete sequence analysis of 9 of these VH regions is presented. There seem to be more VH regions participating in the phosphorylch...

journal_title：Nature

authors： Gearhart PJ,Johnson ND,Douglas R,Hood L

更新日期：1981-05-07 00:00:00

abstract：:Mutational activation of BRAF is the most prevalent genetic alteration in human melanoma, with ≥50% of tumours expressing the BRAF(V600E) oncoprotein. Moreover, the marked tumour regression and improved survival of late-stage BRAF-mutated melanoma patients in response to treatment with vemurafenib demonstrates the ess...

journal_title：Nature

authors： Das Thakur M,Salangsang F,Landman AS,Sellers WR,Pryer NK,Levesque MP,Dummer R,McMahon M,Stuart DD

更新日期：2013-02-14 00:00:00

abstract：:Digital organisms are computer programs that self-replicate, mutate and adapt by natural selection. They offer an opportunity to test generalizations about living systems that may extend beyond the organic life that biologists usually study. Here we have generated two classes of digital organism: simple programs selec...

journal_title：Nature

authors： Lenski RE,Ofria C,Collier TC,Adami C

更新日期：1999-08-12 00:00:00

abstract：:The dwarfing of large mammals on islands occurred repeatedly in the Pleistocene. Elephants, deer, hippopotami and other species became dwarfed on islands in Indonesia, the Mediterranean, the east Pacific and elsewhere. In most cases, the full-sized ancestral form can be recognized among the adjacent mainland fauna, bu...

journal_title：Nature

authors： Lister AM

更新日期：1989-11-30 00:00:00

abstract：:Calcium signalling in astrocytes couples changes in neural activity to alterations in cerebral blood flow by eliciting vasoconstriction or vasodilation of arterioles. However, the mechanism for how these opposite astrocyte influences provide appropriate changes in vessel tone within an environment that has dynamic met...

journal_title：Nature

authors： Gordon GR,Choi HB,Rungta RL,Ellis-Davies GC,MacVicar BA

更新日期：2008-12-11 00:00:00

abstract：:In plants, the small GTP-binding proteins called Rops work as signalling switches that control growth, development and plant responses to various environmental stimuli. Rop proteins (Rho of plants, Rac-like and AtRac in Arabidopsis thaliana) belong to the Rho family of Ras-related GTP-binding proteins that turn on sig...

journal_title：Nature

authors： Berken A,Thomas C,Wittinghofer A

更新日期：2005-08-25 00:00:00

abstract：:Mammals form scars to quickly seal wounds and ensure survival by an incompletely understood mechanism1-5. Here we show that skin scars originate from prefabricated matrix in the subcutaneous fascia. Fate mapping and live imaging revealed that fascia fibroblasts rise to the skin surface after wounding, dragging their s...

journal_title：Nature

authors： Correa-Gallegos D,Jiang D,Christ S,Ramesh P,Ye H,Wannemacher J,Kalgudde Gopal S,Yu Q,Aichler M,Walch A,Mirastschijski U,Volz T,Rinkevich Y

更新日期：2019-12-01 00:00:00

abstract：:Blazars are active galactic nuclei, which are powerful sources of radiation whose central engine is located in the core of the host galaxy. Blazar emission is dominated by non-thermal radiation from a jet that moves relativistically towards us, and therefore undergoes Doppler beaming. This beaming causes flux enhancem...

journal_title：Nature

authors： Raiteri CM,Villata M,Acosta-Pulido JA,Agudo I,Arkharov AA,Bachev R,Baida GV,Benítez E,Borman GA,Boschin W,Bozhilov V,Butuzova MS,Calcidese P,Carnerero MI,Carosati D,Casadio C,Castro-Segura N,Chen WP,Damljanovic G,D'

更新日期：2017-12-21 00:00:00

abstract：:The brightness of type Ia supernovae, and their homogeneity as a class, makes them powerful tools in cosmology, yet little is known about the progenitor systems of these explosions. They are thought to arise when a white dwarf accretes matter from a companion star, is compressed and undergoes a thermonuclear explosion...

journal_title：Nature

authors： Ruiz-Lapuente P,Comeron F,Méndez J,Canal R,Smartt SJ,Filippenko AV,Kurucz RL,Chornock R,Foley RJ,Stanishev V,Ibata R

更新日期：2004-10-28 00:00:00

abstract：:The response of the terrestrial carbon cycle to climate change is among the largest uncertainties affecting future climate change projections. The feedback between the terrestrial carbon cycle and climate is partly determined by changes in the turnover time of carbon in land ecosystems, which in turn is an ecosystem p...

journal_title：Nature

authors： Carvalhais N,Forkel M,Khomik M,Bellarby J,Jung M,Migliavacca M,Mu M,Saatchi S,Santoro M,Thurner M,Weber U,Ahrens B,Beer C,Cescatti A,Randerson JT,Reichstein M

更新日期：2014-10-09 00:00:00

abstract：:Grid cells provide a neural representation of space, by discharging when an animal traverses through the vertices of a periodic hexagonal grid spanning the environment. Although grid cells have been characterized in detail in rats, the fundamental question of what neural dynamics give rise to the grid structure remain...

journal_title：Nature

authors： Yartsev MM,Witter MP,Ulanovsky N

更新日期：2011-11-02 00:00:00

abstract：:Pluto's tenuous nitrogen atmosphere was first detected by the imprint left on the light curve of a star that was occulted by the planet in 1985 (ref. 1), and studied more extensively during a second occultation event in 1988 (refs 2-6). These events are, however, quite rare and Pluto's atmosphere remains poorly unders...

journal_title：Nature

authors： Sicardy B,Widemann T,Lellouch E,Veillet C,Cuillandre JC,Colas F,Roques F,Beisker W,Kretlow M,Lagrange AM,Gendron E,Lacombe F,Lecacheux J,Birnbaum C,Fienga A,Leyrat C,Maury A,Raynaud E,Renner S,Schultheis M,Brooks

更新日期：2003-07-10 00:00:00

abstract：:Exceptional genomic stability is one of the hallmarks of mouse embryonic stem (ES) cells. However, the genes contributing to this stability remain obscure. We previously identified Zscan4 as a specific marker for two-cell embryo and ES cells. Here we show that Zscan4 is involved in telomere maintenance and long-term g...

journal_title：Nature

authors： Zalzman M,Falco G,Sharova LV,Nishiyama A,Thomas M,Lee SL,Stagg CA,Hoang HG,Yang HT,Indig FE,Wersto RP,Ko MS

更新日期：2010-04-08 00:00:00

abstract：:Immunomodulatory drugs bind to cereblon (CRBN) to confer differentiated substrate specificity on the CRL4(CRBN) E3 ubiquitin ligase. Here we report the identification of a new cereblon modulator, CC-885, with potent anti-tumour activity. The anti-tumour activity of CC-885 is mediated through the cereblon-dependent ubi...

journal_title：Nature

authors： Matyskiela ME,Lu G,Ito T,Pagarigan B,Lu CC,Miller K,Fang W,Wang NY,Nguyen D,Houston J,Carmel G,Tran T,Riley M,Nosaka L,Lander GC,Gaidarova S,Xu S,Ruchelman AL,Handa H,Carmichael J,Daniel TO,Cathers BE,Lopez-Gi

更新日期：2016-07-14 00:00:00

abstract：:Formation of catalytically active RNA structures within the spliceosome requires the assistance of proteins. However, little is known about the number and nature of proteins needed to establish and maintain the spliceosome's active site. Here we affinity-purified human spliceosomal C complexes and show that they catal...

journal_title：Nature

authors： Bessonov S,Anokhina M,Will CL,Urlaub H,Lührmann R

更新日期：2008-04-17 00:00:00

abstract：:Genetic testing will become the future standard of medical care. Life insurers will also need access to genetic information if the insurance industry is to survive intact and if cover is to remain affordable. ...

journal_title：Nature

authors： Pokorski RJ

更新日期：1995-07-06 00:00:00

abstract：:High-pressure transitions are thought to modify hydrogen molecules to a molecular metallic solid and finally to an atomic metal1, which is predicted to have exotic physical properties and the topology of a two-component (electron and proton) superconducting superfluid condensate2,3. Therefore, understanding such trans...

journal_title：Nature

authors： Ji C,Li B,Liu W,Smith JS,Majumdar A,Luo W,Ahuja R,Shu J,Wang J,Sinogeikin S,Meng Y,Prakapenka VB,Greenberg E,Xu R,Huang X,Yang W,Shen G,Mao WL,Mao HK

更新日期：2019-09-01 00:00:00

abstract：:Mesolimbic dopamine-releasing neurons appear to be important in the brain reward system. One behavioural paradigm that supports this hypothesis is intracranial self-stimulation (ICS), during which animals repeatedly press a lever to stimulate their own dopamine-releasing neurons electrically. Here we study dopamine re...

journal_title：Nature

authors： Garris PA,Kilpatrick M,Bunin MA,Michael D,Walker QD,Wightman RM

更新日期：1999-03-04 00:00:00

abstract：:Improvement in the clinical outcome of lung cancer is likely to be achieved by identification of the molecular events that underlie its pathogenesis. Here we show that a small inversion within chromosome 2p results in the formation of a fusion gene comprising portions of the echinoderm microtubule-associated protein-l...

journal_title：Nature

authors： Soda M,Choi YL,Enomoto M,Takada S,Yamashita Y,Ishikawa S,Fujiwara S,Watanabe H,Kurashina K,Hatanaka H,Bando M,Ohno S,Ishikawa Y,Aburatani H,Niki T,Sohara Y,Sugiyama Y,Mano H

更新日期：2007-08-02 00:00:00

abstract：:Although many animals use the Earth's magnetic field for orientation and navigation, the precise biophysical mechanisms underlying magnetic sensing have been elusive. One theoretical model proposes that geomagnetic fields are perceived by chemical reactions involving specialized photoreceptors. However, the specific p...

journal_title：Nature

authors： Gegear RJ,Casselman A,Waddell S,Reppert SM

更新日期：2008-08-21 00:00:00

abstract：:The intestinal tract maintains proper function by replacing aged cells with freshly produced cells that arise from a population of self-renewing intestinal stem cells (ISCs). In the mammalian intestine, ISC self renewal, amplification and differentiation take place along the crypt-villus axis, and are controlled by th...

journal_title：Nature

authors： Takashima S,Mkrtchyan M,Younossi-Hartenstein A,Merriam JR,Hartenstein V

更新日期：2008-07-31 00:00:00