Genetic information and life insurance.

abstract：:The primary function of the nerve cell is to process electrical signals. Over the past fifteen years there has been renewed interest in the detailed spatial analysis of signalling in individual neurons owing to experimental evidence that the regional electrical properties of neurons are complex. Thus the behaviour of ...

journal_title：Nature

authors： Zecević D

更新日期：1996-05-23 00:00:00

abstract：:The biosynthesis of several protein cofactors is subject to feedback regulation by riboswitches. Flavin mononucleotide (FMN)-specific riboswitches, also known as RFN elements, direct expression of bacterial genes involved in the biosynthesis and transport of riboflavin (vitamin B(2)) and related compounds. Here we pre...

journal_title：Nature

authors： Serganov A,Huang L,Patel DJ

更新日期：2009-03-12 00:00:00

abstract：:The bithorax gene complex in Drosophila contains a minimum of eight genes that seem to code for substances controlling levels of thoracic and abdominal development. The state of repression of at least four of these genes is controlled by cis-regulatory elements and a separate locus (Polycomb) seems to code for a repre...

journal_title：Nature

authors： Lewis EB

更新日期：1978-12-07 00:00:00

abstract：:The imaginal discs of Drosophila, which give rise to the adult appendages, are patterned during a period of intense cell proliferation. The specification of differing regions occurs in some cases by subdividing the disc epithelium into lineage compartments. However, in most cases precise boundaries are formed between ...

journal_title：Nature

authors： Rulifson EJ,Micchelli CA,Axelrod JD,Perrimon N,Blair SS

更新日期：1996-11-07 00:00:00

abstract：: ...

journal_title：Nature

authors： Gewin V

更新日期：2018-10-01 00:00:00

abstract：:Elucidation of the molecular contacts between actin and myosin is central to understanding the force-generating process in muscle and other cells. Actin, a highly conserved globular protein found in all eukaryotes, polymerizes into filaments (F-actin) for most of its biological functions. Myosins, which are more diver...

journal_title：Nature

authors： Schröder RR,Manstein DJ,Jahn W,Holden H,Rayment I,Holmes KC,Spudich JA

更新日期：1993-07-08 00:00:00

abstract：:More than twelve morphologically and physiologically distinct subtypes of primary somatosensory neuron report salient features of our internal and external environments1-4. It is unclear how specialized gene expression programs emerge during development to endow these subtypes with their unique properties. To assess t...

journal_title：Nature

authors： Sharma N,Flaherty K,Lezgiyeva K,Wagner DE,Klein AM,Ginty DD

更新日期：2020-01-01 00:00:00

abstract：:The electronic properties of heterostructures of atomically thin van der Waals crystals can be modified substantially by moiré superlattice potentials from an interlayer twist between crystals1,2. Moiré tuning of the band structure has led to the recent discovery of superconductivity3,4 and correlated insulating phase...

journal_title：Nature

authors： Kerelsky A,McGilly LJ,Kennes DM,Xian L,Yankowitz M,Chen S,Watanabe K,Taniguchi T,Hone J,Dean C,Rubio A,Pasupathy AN

更新日期：2019-08-01 00:00:00

abstract：:Tracing the transient atomic motions that lie at the heart of chemical reactions requires high-resolution multidimensional structural information on the timescale of molecular vibrations, which commonly range from 10 fs to 1 ps. For simple chemical systems, it has been possible to map out in considerable detail the re...

journal_title：Nature

authors： Fang C,Frontiera RR,Tran R,Mathies RA

更新日期：2009-11-12 00:00:00

abstract：:The single endogenous DBA/2J ectropic provirus segregated concordantly with the dilute (d) coat colour mutation on chromosome 9 in 53/53 DBA/2J-derived recombinant inbred mouse strains and all seven inbred and mutant strains tested that carry the d allele. Analysis of DNA from a spontaneous DBA/2J d revertant (d+2J) s...

journal_title：Nature

authors： Jenkins NA,Copeland NG,Taylor BA,Lee BK

更新日期：1981-10-01 00:00:00

abstract：:First recognized as regulators of development in worms and fruitflies, microRNAs are emerging as pivotal modulators of mammalian cardiovascular development and disease. Individual microRNAs modulate the expression of collections of messenger RNA targets that often have related functions, thereby governing complex biol...

journal_title：Nature

authors： Small EM,Olson EN

更新日期：2011-01-20 00:00:00

abstract：:An increasing body of evidence points to mitochondrial dysfunction as a contributor to the molecular pathogenesis of neurodegenerative diseases such as Parkinson's disease. Recent studies of the Parkinson's disease associated genes PINK1 (ref. 2) and parkin (PARK2, ref. 3) indicate that they may act in a quality contr...

journal_title：Nature

authors： Hasson SA,Kane LA,Yamano K,Huang CH,Sliter DA,Buehler E,Wang C,Heman-Ackah SM,Hessa T,Guha R,Martin SE,Youle RJ

更新日期：2013-12-12 00:00:00

abstract：:Optical-frequency synthesizers, which generate frequency-stable light from a single microwave-frequency reference, are revolutionizing ultrafast science and metrology, but their size, power requirement and cost need to be reduced if they are to be more widely used. Integrated-photonics microchips can be used in high-c...

journal_title：Nature

authors： Spencer DT,Drake T,Briles TC,Stone J,Sinclair LC,Fredrick C,Li Q,Westly D,Ilic BR,Bluestone A,Volet N,Komljenovic T,Chang L,Lee SH,Oh DY,Suh MG,Yang KY,Pfeiffer MHP,Kippenberg TJ,Norberg E,Theogarajan L,Vahala K

更新日期：2018-05-01 00:00:00

abstract：:It is thought that immunity depends on naive CD4 T cells that proliferate in response to microbial antigens, differentiate into memory cells that produce anti-microbial lymphokines, and migrate to sites of infection. Here we use immunohistology to enumerate individual naive CD4 T cells, specific for a model antigen, i...

journal_title：Nature

authors： Reinhardt RL,Khoruts A,Merica R,Zell T,Jenkins MK

更新日期：2001-03-01 00:00:00

abstract：:The products of the classical human major histocompatibility complex (MHC) class I genes (HLA-A, -B, -C) are highly polymorphic molecules that bind peptides and present them to T lymphocytes. The non-polymorphic, non-classical MHC class I gene products (HLA-E, -F, -G) are not restricting elements for the majority of T...

journal_title：Nature

authors： Watkins DI,Chen ZW,Hughes AL,Evans MG,Tedder TF,Letvin NL

更新日期：1990-07-05 00:00:00

abstract：:Classical population-genetics theory suggests that reproductive isolation will evolve fastest in small isolated populations. In contrast, recent theory suggests that divergence should occur fastest in larger allopatric populations. The rationale behind this is that sexual conflict, potentially the strongest driver of ...

journal_title：Nature

authors： Martin OY,Hosken DJ

更新日期：2003-06-26 00:00:00

abstract：:High-energy cosmic-ray electrons and positrons (CREs), which lose energy quickly during their propagation, provide a probe of Galactic high-energy processes and may enable the observation of phenomena such as dark-matter particle annihilation or decay. The CRE spectrum has been measured directly up to approximately 2 ...

journal_title：Nature

authors： DAMPE Collaboration.

更新日期：2017-12-07 00:00:00

abstract：:A parliamentary and union delegation has expressed to the British government its concern over the possible demise of the Genetic Manipulation Advisory Group (GMAG). The delegation proposed that GMAG continue to ensure the safe development of recombinant DNA technology and extend its role to cover the ethics of human ...

journal_title：Nature

authors： Wynn J

更新日期：1982-09-30 00:00:00

abstract：:The discovery of the peptide hormone ghrelin, an endogenous ligand for the growth hormone secretagogue (GHS) receptor, yielded the surprising result that the principal site of ghrelin synthesis is the stomach and not the hypothalamus. Although ghrelin is likely to regulate pituitary growth hormone (GH) secretion along...

journal_title：Nature

authors： Tschöp M,Smiley DL,Heiman ML

更新日期：2000-10-19 00:00:00

abstract：:Thomas et al. argue, contrary to Sala et al. that climate change poses an equal or greater threat to global biodiversity than land-use change. We contest this claim, however, on the grounds that Thomas et al. incorrectly apply species-area relationships. ...

journal_title：Nature

authors： Buckley LB,Roughgarden J

更新日期：2004-07-01 00:00:00

abstract：:Ice volume (and hence sea level) and deep-sea temperature are key measures of global climate change. Sea level has been documented using several independent methods over the past 0.5 million years (Myr). Older periods, however, lack such independent validation; all existing records are related to deep-sea oxygen isoto...

journal_title：Nature

authors： Rohling EJ,Foster GL,Grant KM,Marino G,Roberts AP,Tamisiea ME,Williams F

更新日期：2014-04-24 00:00:00

abstract：:A variety of microbial communities and their genes (the microbiome) exist throughout the human body, with fundamental roles in human health and disease. The National Institutes of Health (NIH)-funded Human Microbiome Project Consortium has established a population-scale framework to develop metagenomic protocols, resu...

journal_title：Nature

authors： Human Microbiome Project Consortium.

更新日期：2012-06-13 00:00:00

abstract：:We have shown previously that chemically skinned fibre bundles from scallop muscle can be desensitized to the action of calcium by the removal of the regulatory light chains of myosin and that sensitivity can be restored by the re-addition of scallop light chains. We have now confirmed these results and extended our o...

journal_title：Nature

authors： Simmons RM,Szent-Györgyi AG

更新日期：1980-08-07 00:00:00

abstract：:The neocortex of the adult brain consists of neurons and glia that are generated by precursor cells of the embryonic ventricular zone. In general, glia are generated after neurons during development, but radial glia are an exception to this rule. Radial glia are generated before neurogenesis and guide neuronal migrati...

journal_title：Nature

authors： Noctor SC,Flint AC,Weissman TA,Dammerman RS,Kriegstein AR

更新日期：2001-02-08 00:00:00

abstract：:The evolution of snakes involved major changes in vertebrate body plan organization, but the developmental basis of those changes is unknown. The python axial skeleton consists of hundreds of similar vertebrae, forelimbs are absent and hindlimbs are severely reduced. Combined limb loss and trunk elongation is found in...

journal_title：Nature

authors： Cohn MJ,Tickle C

更新日期：1999-06-03 00:00:00

abstract：:Adult stem cells undergo asymmetric cell division to self-renew and give rise to differentiated cells that comprise mature tissue. Sister chromatids may be distinguished and segregated nonrandomly in asymmetrically dividing stem cells, although the underlying mechanism and the purpose it may serve remain elusive. Here...

journal_title：Nature

authors： Yadlapalli S,Yamashita YM

更新日期：2013-06-13 00:00:00

abstract：:TATA-binding protein (TBP) binds the minor groove of the TATA element with the DNA bent 80 degrees towards the major groove. A constrained minicircle strategy has been used to test the effect of DNA topology on the affinity of TBP for the TATA element. We report here that TBP bound to DNA which was slightly pre-bent t...

journal_title：Nature

authors： Parvin JD,McCormick RJ,Sharp PA,Fisher DE

更新日期：1995-02-23 00:00:00

abstract：:Why infer evolution when you can watch it happen in real time? This is the basic premise of using populations of fast-replicating microorganisms in test tubes to study evolution. The approach, known as experimental evolution, has provided a way of testing many of the key hypotheses that arose from the modern evolution...

journal_title：Nature

authors： Buckling A,Craig Maclean R,Brockhurst MA,Colegrave N

更新日期：2009-02-12 00:00:00

abstract：:Primitive chondritic meteorites contain material (presolar grains), at the level of a few parts per million, that predates the formation of our Solar System. Astronomical observations and the chemical composition of the Sun both suggest that silicates must have been the dominant solids in the protoplanetary disk from ...

journal_title：Nature

authors： Nagashima K,Krot AN,Yurimoto H

更新日期：2004-04-29 00:00:00

abstract：:The immunoglobulin superfamily is a group of proteins, each made of one or several domains sharing key structural features with either the variable (V) or the constant (C) immunoglobulin domains. It includes such functionally important members as the immunoglobulins themselves, major histocompatibility complex (MHC) c...

journal_title：Nature

authors： Brunet JF,Denizot F,Luciani MF,Roux-Dosseto M,Suzan M,Mattei MG,Golstein P

更新日期：1987-07-16 00:00:00