Blazar spectral variability as explained by a twisted inhomogeneous jet.

abstract：:Pancreatic ductal adenocarcinoma (PDAC) remains recalcitrant to all forms of cancer treatment and carries a five-year survival rate of only 8%1. Inhibition of oncogenic KRAS (hereafter KRAS*), the earliest lesion in disease development that is present in more than 90% of PDACs, and its signalling surrogates has yielde...

journal_title：Nature

authors： Yao W,Rose JL,Wang W,Seth S,Jiang H,Taguchi A,Liu J,Yan L,Kapoor A,Hou P,Chen Z,Wang Q,Nezi L,Xu Z,Yao J,Hu B,Pettazzoni PF,Ho IL,Feng N,Ramamoorthy V,Jiang S,Deng P,Ma GJ,Den P,Tan Z,Zhang SX,Wang H,

更新日期：2019-04-01 00:00:00

abstract：:De novo-designed proteins1-3 hold great promise as building blocks for synthetic circuits, and can complement the use of engineered variants of natural proteins4-7. One such designer protein-degronLOCKR, which is based on 'latching orthogonal cage-key proteins' (LOCKR) technology8-is a switch that degrades a protein o...

journal_title：Nature

authors： Ng AH,Nguyen TH,Gómez-Schiavon M,Dods G,Langan RA,Boyken SE,Samson JA,Waldburger LM,Dueber JE,Baker D,El-Samad H

更新日期：2019-08-01 00:00:00

abstract：:Framework cavities are the largest but least explored coral reef habitat. Previous dive studies of caverns, spaces below plate corals, rubble and artificial cavities suggest that cavity-dwelling (coelobite) filter-feeders are important in the trophodynamics of reefs. Quantitative community data are lacking, however, a...

journal_title：Nature

authors： Richter C,Wunsch M,Rasheed M,Kötter I,Badran MI

更新日期：2001-10-18 00:00:00

abstract：:Topological states of matter are characterized by topological invariants, which are physical quantities whose values are quantized and do not depend on the details of the system (such as its shape, size and impurities). Of these quantities, the easiest to probe is the electrical Hall conductance, and fractional values...

journal_title：Nature

authors： Banerjee M,Heiblum M,Umansky V,Feldman DE,Oreg Y,Stern A

更新日期：2018-07-01 00:00:00

abstract：:Cellulose is the major polysaccharide component of plant cell walls and is the most abundant organic compound on the planet. A number of bacterial and fungal organisms can use cellulose as a food source, possessing cellulases (cellobiohydrolases and endoglucanases) that can catalyse the hydrolysis of the beta-(1,4) gl...

journal_title：Nature

authors： Davies GJ,Dodson GG,Hubbard RE,Tolley SP,Dauter Z,Wilson KS,Hjort C,Mikkelsen JM,Rasmussen G,Schülein M

更新日期：1993-09-23 00:00:00

abstract：:The North Atlantic Oscillation (NAO) is the major source of variability in winter atmospheric circulation in the Northern Hemisphere, with large impacts on temperature, precipitation and storm tracks, and therefore also on strategic sectors such as insurance, renewable energy production, crop yields and water manageme...

journal_title：Nature

authors： Ortega P,Lehner F,Swingedouw D,Masson-Delmotte V,Raible CC,Casado M,Yiou P

更新日期：2015-07-02 00:00:00

abstract：:Dopamine (DA) has largely been ignored in considering possible mechanisms underlying the therapeutic effects of tricyclic anti-depressants (TCA). Most previous work done has focused on the ability of some TCAs to block the in vitro re-uptake of DA--an effect which unfortunately requires very high doses. Recently, howe...

journal_title：Nature

authors： Chiodo LA,Antelman SM

更新日期：1980-10-02 00:00:00

abstract：:In mice gamma delta T-cell populations with distinct T-cell receptor (TCR) repertoires and homing properties have been identified. Diversified populations are found in lymphoid organs and intestinal epithelia. By contrast, the gamma delta T-cells that have been found in the murine skin are homogeneous. They express a ...

journal_title：Nature

authors： Itohara S,Farr AG,Lafaille JJ,Bonneville M,Takagaki Y,Haas W,Tonegawa S

更新日期：1990-02-22 00:00:00

abstract：:The histocompatibility-Y (H-Y) antigen is a minor histocompatibility antigen which has been detected on cell surfaces from the heterogametic sexes of mammalian, bird, amphibian, teleost and invertebrate species. H-Y is thought to be a male-determining substance in mammals because of its almost perfect correlation with...

journal_title：Nature

authors： Shapiro M,Erickson RP

更新日期：1981-04-09 00:00:00

abstract：:Grid cells in the entorhinal cortex of freely moving rats provide a strikingly periodic representation of self-location which is indicative of very specific computational mechanisms. However, the existence of grid cells in humans and their distribution throughout the brain are unknown. Here we show that the preferred ...

journal_title：Nature

authors： Doeller CF,Barry C,Burgess N

更新日期：2010-02-04 00:00:00

abstract：:Quantum light is characterized by distinctive statistical distributions that are possible only because of quantum mechanical effects. For example, single photons and correlated photon pairs exhibit photon number distributions with variance lower than classically allowed limits. This enables high-fidelity transmission ...

journal_title：Nature

authors： Mittal S,Goldschmidt EA,Hafezi M

更新日期：2018-09-01 00:00:00

abstract：:Photoinduced electron transfer (PET) is a phenomenon whereby the absorption of light by a chemical species provides an energetic driving force for an electron-transfer reaction1-4. This mechanism is relevant in many areas of chemistry, including the study of natural and artificial photosynthesis, photovoltaics and pho...

journal_title：Nature

authors： MacKenzie IA,Wang L,Onuska NPR,Williams OF,Begam K,Moran AM,Dunietz BD,Nicewicz DA

更新日期：2020-04-01 00:00:00

abstract：:The neurotrophin receptor TrkB is essential for normal function of the mammalian brain. It is expressed in three splice variants. Full-length receptors (TrkB(FL)) possess an intracellular tyrosine kinase domain and are considered as those TrkB receptors that mediate the crucial effects of brain-derived neurotrophic fa...

journal_title：Nature

authors： Rose CR,Blum R,Pichler B,Lepier A,Kafitz KW,Konnerth A

更新日期：2003-11-06 00:00:00

abstract：:There is still no universally accepted theory of high-temperature superconductivity. Most models assume that doping creates 'holes' in the valence band of an insulating, antiferromagnetic 'parent' compound, and that antiferromagnetism and high-temperature superconductivity are intimately related. If their respective e...

journal_title：Nature

authors： Bozovic I,Logvenov G,Verhoeven MA,Caputo P,Goldobin E,Geballe TH

更新日期：2003-04-24 00:00:00

abstract：:Graphene oxide membranes-partially oxidized, stacked sheets of graphene-can provide ultrathin, high-flux and energy-efficient membranes for precise ionic and molecular sieving in aqueous solution. These materials have shown potential in a variety of applications, including water desalination and purification, gas and ...

journal_title：Nature

authors： Chen L,Shi G,Shen J,Peng B,Zhang B,Wang Y,Bian F,Wang J,Li D,Qian Z,Xu G,Liu G,Zeng J,Zhang L,Yang Y,Zhou G,Wu M,Jin W,Li J,Fang H

更新日期：2017-10-19 00:00:00

abstract：:Synapse assembly requires trans-synaptic signals between the pre- and postsynapse, but our understanding of the essential organizational molecules involved in this process remains incomplete. Teneurin proteins are conserved, epidermal growth factor (EGF)-repeat-containing transmembrane proteins with large extracellula...

journal_title：Nature

authors： Mosca TJ,Hong W,Dani VS,Favaloro V,Luo L

更新日期：2012-03-18 00:00:00

abstract：:The genes for the T-cell receptor, like the immunoglobulin genes, are rearranged as DNA. The mechanism of this rearrangement is not clear; unequal crossover between chromosomes and the looping-out and excision of the excess DNA have both been suggested. We isolated small polydisperse circular (spc) DNAs from mouse thy...

journal_title：Nature

authors： Fujimoto S,Yamagishi H

更新日期：1987-05-21 00:00:00

abstract：:There has been much interest in the biochemical and biophysical processes that couple extracellular signals to alterations in gene expression. While many early events associated with the treatment of cells with growth factors have been described (for example, ion flux and protein phosphorylation), it has proved diffic...

journal_title：Nature

authors： Morgan JI,Curran T

更新日期：1986-08-07 00:00:00

abstract：:The polarized architecture of epithelial cells depends on the highly stereotypic distribution of cellular junctions and other membrane-associated protein complexes. In epithelial cells of the Drosophila embryo, three distinct domains subdivide the lateral plasma membrane. The most apical one comprises the subapical co...

journal_title：Nature

authors： Bachmann A,Schneider M,Theilenberg E,Grawe F,Knust E

更新日期：2001-12-06 00:00:00

abstract：:Global patterns of species richness and their structuring forces have fascinated biologists since Darwin and provide critical context for contemporary studies in ecology, evolution and conservation. Anthropogenic impacts and the need for systematic conservation planning have further motivated the analysis of diversity...

journal_title：Nature

authors： Tittensor DP,Mora C,Jetz W,Lotze HK,Ricard D,Berghe EV,Worm B

更新日期：2010-08-26 00:00:00

abstract：:Transmission of obligate bacterial symbionts between generations is vital for the survival of the host. Although the larvae of certain hydrothermal vent tubeworms (Vestimentifera, Siboglinidae) are symbiont-free and possess a transient digestive system, these structures are lost during development, resulting in adult ...

journal_title：Nature

authors： Nussbaumer AD,Fisher CR,Bright M

更新日期：2006-05-18 00:00:00

abstract：:Microbiome-wide association studies have established that numerous diseases are associated with changes in the microbiota. These studies typically generate a long list of commensals implicated as biomarkers of disease, with no clear relevance to disease pathogenesis. If the field is to move beyond correlations and beg...

journal_title：Nature

authors： Surana NK,Kasper DL

更新日期：2017-12-14 00:00:00

abstract：:Dysfunction in prosocial interactions is a core symptom of autism spectrum disorder. However, the neural mechanisms that underlie sociability are poorly understood, limiting the rational development of therapies to treat social deficits. Here we show in mice that bidirectional modulation of the release of serotonin (5...

journal_title：Nature

authors： Walsh JJ,Christoffel DJ,Heifets BD,Ben-Dor GA,Selimbeyoglu A,Hung LW,Deisseroth K,Malenka RC

更新日期：2018-08-01 00:00:00

abstract：:What limits the rate at which sensory information can be transmitted across synaptic connections in the brain? High-frequency signalling is restricted to brief bursts at many central excitatory synapses, whereas graded ribbon-type synapses can sustain release and transmit information at high rates. Here we investigate...

journal_title：Nature

authors： Saviane C,Silver RA

更新日期：2006-02-23 00:00:00

abstract：:There are large amounts of heavy alpha-emitters in nuclear waste and nuclear materials inventories stored in various sites around the world. These include plutonium and minor actinides such as americium and curium. In preparation for geological disposal there is consensus that actinides that have been separated from s...

journal_title：Nature

authors： Farnan I,Cho H,Weber WJ

更新日期：2007-01-11 00:00:00

abstract：:Classical novae are the most common astrophysical thermonuclear explosions, occurring on the surfaces of white dwarf stars accreting gas from companions in binary star systems. Novae typically expel about 10(-4) solar masses of material at velocities exceeding 1,000 kilometres per second. However, the mechanism of mas...

journal_title：Nature

authors： Chomiuk L,Linford JD,Yang J,O'Brien TJ,Paragi Z,Mioduszewski AJ,Beswick RJ,Cheung CC,Mukai K,Nelson T,Ribeiro VA,Rupen MP,Sokoloski JL,Weston J,Zheng Y,Bode MF,Eyres S,Roy N,Taylor GB

更新日期：2014-10-16 00:00:00

abstract：:The limited ranges of the wild progenitors of many of the primary European domestic species point to their origins further east in Anatolia or the fertile crescent. The wild ox (Bos primigenius), however, ranged widely and it is unknown whether it was domesticated within Europe as one feature of a local contribution t...

journal_title：Nature

authors： Troy CS,MacHugh DE,Bailey JF,Magee DA,Loftus RT,Cunningham P,Chamberlain AT,Sykes BC,Bradley DG

更新日期：2001-04-26 00:00:00

abstract：:Copy number variation (CNV) of DNA sequences is functionally significant but has yet to be fully ascertained. We have constructed a first-generation CNV map of the human genome through the study of 270 individuals from four populations with ancestry in Europe, Africa or Asia (the HapMap collection). DNA from these ind...

journal_title：Nature

authors： Redon R,Ishikawa S,Fitch KR,Feuk L,Perry GH,Andrews TD,Fiegler H,Shapero MH,Carson AR,Chen W,Cho EK,Dallaire S,Freeman JL,González JR,Gratacòs M,Huang J,Kalaitzopoulos D,Komura D,MacDonald JR,Marshall CR,Mei R,M

更新日期：2006-11-23 00:00:00

abstract：:Humans have engaged in endurance running for millions of years, but the modern running shoe was not invented until the 1970s. For most of human evolutionary history, runners were either barefoot or wore minimal footwear such as sandals or moccasins with smaller heels and little cushioning relative to modern running sh...

journal_title：Nature

authors： Lieberman DE,Venkadesan M,Werbel WA,Daoud AI,D'Andrea S,Davis IS,Mang'eni RO,Pitsiladis Y

更新日期：2010-01-28 00:00:00

abstract：:Animals learn that a tone can predict the occurrence of an electric shock through classical conditioning. Mice or rats trained in this manner display fear responses, such as freezing behaviour, when they hear the conditioned tone. Studies using amygdalectomized rats have shown that the amygdala is required for both th...

journal_title：Nature

authors： Garcia R,Vouimba RM,Baudry M,Thompson RF

更新日期：1999-11-18 00:00:00