Drosophila Stardust is a partner of Crumbs in the control of epithelial cell polarity.

abstract：:Since the early 1980s, most electronics have relied on the use of complementary metal-oxide-semiconductor (CMOS) transistors. However, the principles of CMOS operation, involving a switchable semiconductor conductance controlled by an insulating gate, have remained largely unchanged, even as transistors are miniaturiz...

journal_title：Nature

authors： Manipatruni S,Nikonov DE,Lin CC,Gosavi TA,Liu H,Prasad B,Huang YL,Bonturim E,Ramesh R,Young IA

更新日期：2019-01-01 00:00:00

abstract：:Mice of the C57BL/6 strain are resistant to the development of skin squamous carcinomas (SCCs) induced by an activated Ras oncogene, whereas FVB/N mice are highly susceptible. The genetic basis of this difference in phenotype is unknown. Here we show that susceptibility to SCC is under the control of a carboxy-termina...

journal_title：Nature

authors： Wakabayashi Y,Mao JH,Brown K,Girardi M,Balmain A

更新日期：2007-02-15 00:00:00

abstract：:The key behavioural, physiological and anatomical components of a magnetite-based magnetic sense have been demonstrated in rainbow trout (Oncorhynchus mykiss). Candidate receptor cells located within a discrete sub-layer of the olfactory lamellae contained iron-rich crystals that were similar in size and shape to magn...

journal_title：Nature

authors： Diebel CE,Proksch R,Green CR,Neilson P,Walker MM

更新日期：2000-07-20 00:00:00

abstract：:Body size is intrinsically linked to metabolic rate and life-history traits, and is a crucial determinant of food webs and community dynamics1,2. The increased temperatures associated with the urban-heat-island effect result in increased metabolic costs and are expected to drive shifts to smaller body sizes 3 . Urban ...

journal_title：Nature

authors： Merckx T,Souffreau C,Kaiser A,Baardsen LF,Backeljau T,Bonte D,Brans KI,Cours M,Dahirel M,Debortoli N,De Wolf K,Engelen JMT,Fontaneto D,Gianuca AT,Govaert L,Hendrickx F,Higuti J,Lens L,Martens K,Matheve H,Matthysen

更新日期：2018-06-01 00:00:00

abstract：:Neuroprotectant strategies that have worked in rodent models of stroke have failed to provide protection in clinical trials. Here we show that the opposite circadian cycles in nocturnal rodents versus diurnal humans1,2 may contribute to this failure in translation. We tested three independent neuroprotective approache...

journal_title：Nature

authors： Esposito E,Li W,T Mandeville E,Park JH,Şencan I,Guo S,Shi J,Lan J,Lee J,Hayakawa K,Sakadžić S,Ji X,Lo EH

更新日期：2020-06-01 00:00:00

abstract：:Climate strongly affects the production of sediment from mountain catchments as well as its transport and deposition within adjacent sedimentary basins. However, identifying climatic influences on basin stratigraphy is complicated by nonlinearities, feedback loops, lag times, buffering and convergence among processes ...

journal_title：Nature

authors： Foreman BZ,Heller PL,Clementz MT

更新日期：2012-11-01 00:00:00

abstract：:The spectral purity of an oscillator is central to many applications, such as detecting gravity waves, defining the second, ground-state cooling and quantum manipulation of nanomechanical objects, and quantum computation. Recent proposals suggest that laser oscillators which use very narrow optical transitions in atom...

journal_title：Nature

authors： Bohnet JG,Chen Z,Weiner JM,Meiser D,Holland MJ,Thompson JK

更新日期：2012-04-04 00:00:00

abstract：:Antigenic variation in the haemagglutinin (HA) glycoprotein of influenza virus is associated with recurrent epidemics of respiratory disease in man (for review see ref. 1). We have examined the size of structural changes necessary to alter the antigenicity of HA by determining the three-dimensional structure of the HA...

journal_title：Nature

authors： Knossow M,Daniels RS,Douglas AR,Skehel JJ,Wiley DC

更新日期：1984-10-18 00:00:00

abstract：:Circadian rhythms have evolved to anticipate and adapt animals to the constraints of the earth's 24-hour light cycle. Although the molecular processes that establish periodicity in clock neurons of the suprachiasmatic nucleus (SCN) are well understood, the mechanisms by which axonal projections from the central clock ...

journal_title：Nature

authors： Gizowski C,Zaelzer C,Bourque CW

更新日期：2016-09-29 00:00:00

abstract：:During attempts to select nonsecretory variants from 0.467.3, and Epstein-Barr virus-transformed human lymphoblastoid cell line that secretes small amounts of IgM lambda, we exposed the cells to UV light. Cells that survived the irradiation were subcultured and their supernatants were screened for immunoglobulin produ...

journal_title：Nature

authors： Rosén A,Klein G

更新日期：1983-11-10 00:00:00

abstract：:Regulated fusion of secretory granules with the plasma membrane in secretory cells requires ATP, Ca2+ and cytosolic as well as membrane proteins. ATP-dependent steps in Ca(2+)-activated secretion from PC12 cells require three cytosolic PEP proteins (priming in exocytosis proteins, PEP1-3), the identity of which will p...

journal_title：Nature

authors： Hay JC,Fisette PL,Jenkins GH,Fukami K,Takenawa T,Anderson RA,Martin TF

更新日期：1995-03-09 00:00:00

abstract：:Our understanding of Alzheimer's disease pathogenesis is currently limited by difficulties in obtaining live neurons from patients and the inability to model the sporadic form of the disease. It may be possible to overcome these challenges by reprogramming primary cells from patients into induced pluripotent stem cell...

journal_title：Nature

authors： Israel MA,Yuan SH,Bardy C,Reyna SM,Mu Y,Herrera C,Hefferan MP,Van Gorp S,Nazor KL,Boscolo FS,Carson CT,Laurent LC,Marsala M,Gage FH,Remes AM,Koo EH,Goldstein LS

更新日期：2012-01-25 00:00:00

abstract：:Storing and retrieving a quantum state of light on demand, without corrupting the information it carries, is an important challenge in the field of quantum information processing. Classical measurement and reconstruction strategies for storing light must necessarily destroy quantum information as a consequence of the ...

journal_title：Nature

authors： Hedges MP,Longdell JJ,Li Y,Sellars MJ

更新日期：2010-06-24 00:00:00

abstract：:Greek speakers say "omicronupsilonrho", Germans "schwanz" and the French "queue" to describe what English speakers call a 'tail', but all of these languages use a related form of 'two' to describe the number after one. Among more than 100 Indo-European languages and dialects, the words for some meanings (such as 'tail...

journal_title：Nature

authors： Pagel M,Atkinson QD,Meade A

更新日期：2007-10-11 00:00:00

abstract：:The B cells of the immune system, which secrete antibodies against foreign antigens, are fully specific and effective only after maturation in lymph nodes and other lymphoid tissues. Immunocompetent T cells play a crucial part in this process, but the molecular details of the way in which the two cell types interact h...

journal_title：Nature

authors： Clark EA,Ledbetter JA

更新日期：1994-02-03 00:00:00

abstract：:It has been speculated that brain activities might directly control adaptive immune responses in lymphoid organs, although there is little evidence for this. Here we show that splenic denervation in mice specifically compromises the formation of plasma cells during a T cell-dependent but not T cell-independent immune ...

journal_title：Nature

authors： Zhang X,Lei B,Yuan Y,Zhang L,Hu L,Jin S,Kang B,Liao X,Sun W,Xu F,Zhong Y,Hu J,Qi H

更新日期：2020-05-01 00:00:00

abstract：:Oxygenic photosynthesis in plants, algae and cyanobacteria is initiated at photosystem II, a homodimeric multisubunit protein-cofactor complex embedded in the thylakoid membrane. Photosystem II captures sunlight and powers the unique photo-induced oxidation of water to atmospheric oxygen. Crystallographic investigatio...

journal_title：Nature

authors： Loll B,Kern J,Saenger W,Zouni A,Biesiadka J

更新日期：2005-12-15 00:00:00

abstract：:Diapycnal mixing (across density surfaces) is an important process in the global ocean overturning circulation. Mixing in the interior of most of the ocean, however, is thought to have a magnitude just one-tenth of that required to close the global circulation by the downward mixing of less dense waters. Some of this ...

journal_title：Nature

authors： Watson AJ,Ledwell JR,Messias MJ,King BA,Mackay N,Meredith MP,Mills B,Naveira Garabato AC

更新日期：2013-09-19 00:00:00

abstract：:Cloning and sequencing of the complementary DNA for platelet-derived endothelial cell growth factor indicates that it is a novel factor distinct from previously characterized proteins. The factor, a protein with a relative molecular mass of about 45,000, stimulates endothelial cell growth and chemotaxis in vitro and a...

journal_title：Nature

authors： Ishikawa F,Miyazono K,Hellman U,Drexler H,Wernstedt C,Hagiwara K,Usuki K,Takaku F,Risau W,Heldin CH

更新日期：1989-04-13 00:00:00

abstract：:The human T cell erythrocyte receptor (CD2 antigen) allows thymocytes and mature T cells to adhere to thymic epithelium and target cells through a cell surface protein, LFA-3 (refs 1-6). Monoclonal antibodies recognizing CD2 can either block adhesion or, in certain combinations, induce an antigen-independent T cell ac...

journal_title：Nature

authors： Peterson A,Seed B

更新日期：1987-10-29 00:00:00

abstract：:Because their molecular signatures are often prominent in extracts of sediments, bacteria are thought to be important contributors to petroleum source beds. It has been shown recently, however, that abundances of biomarkers do not always reflect relative contributions to sedimentary organic carbon (Corg). The contrib...

journal_title：Nature

authors： Hartgers WA,Sinninghe Damste JS,Requejo AG,Allan J,Hayes JM,de Leeuw JW

更新日期：1994-05-19 00:00:00

abstract：:How the brain selects appropriate sensory inputs and suppresses distractors is unknown. Given the well-established role of the prefrontal cortex (PFC) in executive function, its interactions with sensory cortical areas during attention have been hypothesized to control sensory selection. To test this idea and, more ge...

journal_title：Nature

authors： Wimmer RD,Schmitt LI,Davidson TJ,Nakajima M,Deisseroth K,Halassa MM

更新日期：2015-10-29 00:00:00

abstract：:Understanding the pathogenesis of neuropsychiatric disorders is a substantial challenge for neurobiologists. It has long been hoped that identifying alleles that confer increased risk of such disorders would provide clues for neurobiological investigation. But this quest has been stymied by a lack of validated biologi...

journal_title：Nature

authors： Hyman SE

更新日期：2008-10-16 00:00:00

abstract：:Most of the progress in human culture has required the exploitation of energy resources. About 100 years ago, the major source of energy shifted from recent solar to fossil hydrocarbons, including liquid and gaseous petroleum. Technology has generally led to a greater use of hydrocarbon fuels for most human activities...

journal_title：Nature

authors： Hall C,Tharakan P,Hallock J,Cleveland C,Jefferson M

更新日期：2003-11-20 00:00:00

abstract：:The generation of a double-strand break in the Saccharomyces cerevisiae genome is a potentially catastrophic event that can induce cell-cycle arrest or ultimately result in loss of cell viability. The repair of such lesions is strongly dependent on proteins encoded by the RAD52 epistasis group of genes (RAD50-55, RAD5...

journal_title：Nature

authors： New JH,Sugiyama T,Zaitseva E,Kowalczykowski SC

更新日期：1998-01-22 00:00:00

abstract：:Surgical, pharmacological and genetic lesion studies have revealed distinct anatomical sites involved with different forms of learning. Studies of patients with localized brain damage and work in rodent model systems, for example, have shown that the hippocampal formation participates in acquisition of declarative tas...

journal_title：Nature

authors： Dubnau J,Grady L,Kitamoto T,Tully T

更新日期：2001-05-24 00:00:00

abstract：:Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis, is a major cause of morbidity and mortality worldwide. Efforts to control it are hampered by difficulties with diagnosis, prevention and treatment. Most people infected with M. tuberculosis remain asymptomatic, termed latent TB, with a 10% lifetim...

journal_title：Nature

authors： Berry MP,Graham CM,McNab FW,Xu Z,Bloch SA,Oni T,Wilkinson KA,Banchereau R,Skinner J,Wilkinson RJ,Quinn C,Blankenship D,Dhawan R,Cush JJ,Mejias A,Ramilo O,Kon OM,Pascual V,Banchereau J,Chaussabel D,O'Garra A

更新日期：2010-08-19 00:00:00

abstract：:Activation of many T-cell functions depends on their interaction with antigen-presenting accessory cells which express I region associated (Ia) products. Cells expressing accessory cell function include those of the monocyte/macrophage lineage and dendritic cells. More recently, B cells and a number of tumour cell lin...

journal_title：Nature

authors： Ramila G,Erb P

更新日期：1983-08-04 00:00:00

abstract：:The quest for higher data density in information storage is motivating investigations into approaches for manipulating magnetization by means other than magnetic fields. This is evidenced by the recent boom in magnetoelectronics and 'spintronics', where phenomena such as carrier effects in magnetic semiconductors and ...

journal_title：Nature

authors： Lottermoser T,Lonkai T,Amann U,Hohlwein D,Ihringer J,Fiebig M

更新日期：2004-07-29 00:00:00

abstract：:Many small proteins seem to fold by a simple process explicable by conventional chemical kinetics and transition-state theory. This assumes an instant equilibrium between reactants and a high-energy activated state. In reality, equilibration occurs on timescales dependent on the molecules involved, below which such an...

journal_title：Nature

authors： Yang WY,Gruebele M

更新日期：2003-05-08 00:00:00